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Protein

Leucine-rich repeat protein SHOC-2

Gene

Shoc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat protein SHOC-2
Alternative name(s):
Protein soc-2 homolog
Protein sur-8 homolog
Gene namesi
Name:Shoc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1927197 Shoc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977381 – 582Leucine-rich repeat protein SHOC-2Add BLAST582

Proteomic databases

EPDiO88520
MaxQBiO88520
PaxDbiO88520
PeptideAtlasiO88520
PRIDEiO88520

PTM databases

iPTMnetiO88520
PhosphoSitePlusiO88520

Expressioni

Gene expression databases

BgeeiENSMUSG00000024976 Expressed in 287 organ(s), highest expression level in pineal body
CleanExiMM_SHOC2
GenevisibleiO88520 MM

Interactioni

Subunit structurei

Interacts with M-Ras/MRAS, and RAF1. Forms a multiprotein complex with Ras (M-Ras/MRAS), Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts with ERBIN; disrupts the interaction with RAF1 and Ras, leading to prevent activation of the Ras signaling pathway. Specifically binds K-Ras/KRAS, M-Ras/MRAS and N-Ras/NRAS but not H-Ras/HRAS (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207949, 51 interactors
IntActiO88520, 49 interactors
STRINGi10090.ENSMUSP00000025932

Structurei

3D structure databases

ProteinModelPortaliO88520
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati101 – 122LRR 1Add BLAST22
Repeati124 – 145LRR 2Add BLAST22
Repeati147 – 169LRR 3Add BLAST23
Repeati170 – 191LRR 4Add BLAST22
Repeati193 – 215LRR 5Add BLAST23
Repeati216 – 237LRR 6Add BLAST22
Repeati239 – 260LRR 7Add BLAST22
Repeati262 – 283LRR 8Add BLAST22
Repeati285 – 307LRR 9Add BLAST23
Repeati308 – 329LRR 10Add BLAST22
Repeati332 – 353LRR 11Add BLAST22
Repeati356 – 377LRR 12Add BLAST22
Repeati380 – 400LRR 13Add BLAST21
Repeati403 – 424LRR 14Add BLAST22
Repeati426 – 448LRR 15Add BLAST23
Repeati449 – 470LRR 16Add BLAST22
Repeati472 – 494LRR 17Add BLAST23
Repeati495 – 516LRR 18Add BLAST22
Repeati518 – 540LRR 19Add BLAST23
Repeati542 – 563LRR 20Add BLAST22

Sequence similaritiesi

Belongs to the SHOC2 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00840000129686
HOGENOMiHOG000116557
HOVERGENiHBG055661
InParanoidiO88520
KOiK19613
OMAiNQFTSYP
OrthoDBiEOG091G05NZ
PhylomeDBiO88520
TreeFamiTF315742

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 4 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 16 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 17 hits

Sequencei

Sequence statusi: Complete.

O88520-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSLGKEKD SKEKDPKVPS AKEREKESKA SGGFGKESKE KEPKAKGKDA
60 70 80 90 100
KDGKKESSAA QPGVAFSVDN TIKRPNPAPG TRKKSSNAEV IKELNKCREE
110 120 130 140 150
NSMRLDLSKR SIHILPPSVK ELTQLTELYL YSNKLQSLPA EVGCLVNLMT
160 170 180 190 200
LALSENSLTS LPDSLDNLKK LRMLDLRHNK LREIPSVVYR LDSLTTLYLR
210 220 230 240 250
FNRITTVEKD IKNLPKLSML SIRENKIKQL PAEIGELCNL ITLDVAHNQL
260 270 280 290 300
EHLPKEIGNC TQITNLDLQH NDLLDLPDTI GNLSSLNRLG LRYNRLSAIP
310 320 330 340 350
RSLAKCSALE ELNLENNNIS TLPESLLSSL VKLNSLTLAR NCFQLYPVGG
360 370 380 390 400
PSQFSTIYSL NMEHNRINKI PFGIFSRAKV LSKLNMKDNQ LTSLPLDFGT
410 420 430 440 450
WTSMVELNLA TNQLTKIPED VSGLVSLEVL ILSNNLLKKL PHGLGNLRKL
460 470 480 490 500
RELDLEENKL ESLPNEIAYL KDLQKLVLTN NQLSTLPRGI GHLTNLTHLG
510 520 530 540 550
LGENLLTHLP EEIGTLENLE ELYLNDNPNL HSLPFELALC SKLSIMSIEN
560 570 580
CPLSHLPPQI VAGGPSFIIQ FLKMQGPYRA MV
Length:582
Mass (Da):64,893
Last modified:August 16, 2004 - v2
Checksum:i154B38C4909FB0AD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11S → F in AAC40175 (PubMed:9674433).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068921 mRNA Translation: AAC40175.1
DQ479926 Genomic DNA Translation: ABF48505.1
AK077798 mRNA Translation: BAC37016.1
AK146447 mRNA Translation: BAE27179.1
BC013722 mRNA Translation: AAH13722.1
BC049775 mRNA Translation: AAH49775.1
BC083060 mRNA Translation: AAH83060.1
CCDSiCCDS29904.1
RefSeqiNP_001161977.1, NM_001168505.1
NP_062632.2, NM_019658.6
XP_006527291.1, XM_006527228.3
XP_011245601.1, XM_011247299.2
XP_017173749.1, XM_017318260.1
UniGeneiMm.228669

Genome annotation databases

EnsembliENSMUST00000025932; ENSMUSP00000025932; ENSMUSG00000024976
ENSMUST00000169861; ENSMUSP00000127932; ENSMUSG00000024976
GeneIDi56392
KEGGimmu:56392
UCSCiuc008hxg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068921 mRNA Translation: AAC40175.1
DQ479926 Genomic DNA Translation: ABF48505.1
AK077798 mRNA Translation: BAC37016.1
AK146447 mRNA Translation: BAE27179.1
BC013722 mRNA Translation: AAH13722.1
BC049775 mRNA Translation: AAH49775.1
BC083060 mRNA Translation: AAH83060.1
CCDSiCCDS29904.1
RefSeqiNP_001161977.1, NM_001168505.1
NP_062632.2, NM_019658.6
XP_006527291.1, XM_006527228.3
XP_011245601.1, XM_011247299.2
XP_017173749.1, XM_017318260.1
UniGeneiMm.228669

3D structure databases

ProteinModelPortaliO88520
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207949, 51 interactors
IntActiO88520, 49 interactors
STRINGi10090.ENSMUSP00000025932

PTM databases

iPTMnetiO88520
PhosphoSitePlusiO88520

Proteomic databases

EPDiO88520
MaxQBiO88520
PaxDbiO88520
PeptideAtlasiO88520
PRIDEiO88520

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025932; ENSMUSP00000025932; ENSMUSG00000024976
ENSMUST00000169861; ENSMUSP00000127932; ENSMUSG00000024976
GeneIDi56392
KEGGimmu:56392
UCSCiuc008hxg.2 mouse

Organism-specific databases

CTDi8036
MGIiMGI:1927197 Shoc2

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00840000129686
HOGENOMiHOG000116557
HOVERGENiHBG055661
InParanoidiO88520
KOiK19613
OMAiNQFTSYP
OrthoDBiEOG091G05NZ
PhylomeDBiO88520
TreeFamiTF315742

Miscellaneous databases

PROiPR:O88520
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024976 Expressed in 287 organ(s), highest expression level in pineal body
CleanExiMM_SHOC2
GenevisibleiO88520 MM

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 4 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 16 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 17 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSHOC2_MOUSE
AccessioniPrimary (citable) accession number: O88520
Secondary accession number(s): Q3UJH6, Q8BVL0, Q91VH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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