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Protein

Leucine-rich repeat protein SHOC-2

Gene

Shoc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat protein SHOC-2
Alternative name(s):
Protein soc-2 homolog
Protein sur-8 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Shoc2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1927197 Shoc2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000977381 – 582Leucine-rich repeat protein SHOC-2Add BLAST582

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O88520

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O88520

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O88520

PeptideAtlas

More...
PeptideAtlasi
O88520

PRoteomics IDEntifications database

More...
PRIDEi
O88520

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O88520

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O88520

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024976 Expressed in 287 organ(s), highest expression level in pineal body

CleanEx database of gene expression profiles

More...
CleanExi
MM_SHOC2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O88520 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with M-Ras/MRAS, and RAF1. Forms a multiprotein complex with Ras (M-Ras/MRAS), Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts with ERBIN; disrupts the interaction with RAF1 and Ras, leading to prevent activation of the Ras signaling pathway. Specifically binds K-Ras/KRAS, M-Ras/MRAS and N-Ras/NRAS but not H-Ras/HRAS (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
207949, 51 interactors

Protein interaction database and analysis system

More...
IntActi
O88520, 49 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000025932

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O88520

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati101 – 122LRR 1Add BLAST22
Repeati124 – 145LRR 2Add BLAST22
Repeati147 – 169LRR 3Add BLAST23
Repeati170 – 191LRR 4Add BLAST22
Repeati193 – 215LRR 5Add BLAST23
Repeati216 – 237LRR 6Add BLAST22
Repeati239 – 260LRR 7Add BLAST22
Repeati262 – 283LRR 8Add BLAST22
Repeati285 – 307LRR 9Add BLAST23
Repeati308 – 329LRR 10Add BLAST22
Repeati332 – 353LRR 11Add BLAST22
Repeati356 – 377LRR 12Add BLAST22
Repeati380 – 400LRR 13Add BLAST21
Repeati403 – 424LRR 14Add BLAST22
Repeati426 – 448LRR 15Add BLAST23
Repeati449 – 470LRR 16Add BLAST22
Repeati472 – 494LRR 17Add BLAST23
Repeati495 – 516LRR 18Add BLAST22
Repeati518 – 540LRR 19Add BLAST23
Repeati542 – 563LRR 20Add BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SHOC2 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156270

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000116557

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG055661

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O88520

KEGG Orthology (KO)

More...
KOi
K19613

Identification of Orthologs from Complete Genome Data

More...
OMAi
NQFTSYP

Database of Orthologous Groups

More...
OrthoDBi
287114at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O88520

TreeFam database of animal gene trees

More...
TreeFami
TF315742

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 16 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O88520-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSLGKEKD SKEKDPKVPS AKEREKESKA SGGFGKESKE KEPKAKGKDA
60 70 80 90 100
KDGKKESSAA QPGVAFSVDN TIKRPNPAPG TRKKSSNAEV IKELNKCREE
110 120 130 140 150
NSMRLDLSKR SIHILPPSVK ELTQLTELYL YSNKLQSLPA EVGCLVNLMT
160 170 180 190 200
LALSENSLTS LPDSLDNLKK LRMLDLRHNK LREIPSVVYR LDSLTTLYLR
210 220 230 240 250
FNRITTVEKD IKNLPKLSML SIRENKIKQL PAEIGELCNL ITLDVAHNQL
260 270 280 290 300
EHLPKEIGNC TQITNLDLQH NDLLDLPDTI GNLSSLNRLG LRYNRLSAIP
310 320 330 340 350
RSLAKCSALE ELNLENNNIS TLPESLLSSL VKLNSLTLAR NCFQLYPVGG
360 370 380 390 400
PSQFSTIYSL NMEHNRINKI PFGIFSRAKV LSKLNMKDNQ LTSLPLDFGT
410 420 430 440 450
WTSMVELNLA TNQLTKIPED VSGLVSLEVL ILSNNLLKKL PHGLGNLRKL
460 470 480 490 500
RELDLEENKL ESLPNEIAYL KDLQKLVLTN NQLSTLPRGI GHLTNLTHLG
510 520 530 540 550
LGENLLTHLP EEIGTLENLE ELYLNDNPNL HSLPFELALC SKLSIMSIEN
560 570 580
CPLSHLPPQI VAGGPSFIIQ FLKMQGPYRA MV
Length:582
Mass (Da):64,893
Last modified:August 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i154B38C4909FB0AD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11S → F in AAC40175 (PubMed:9674433).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF068921 mRNA Translation: AAC40175.1
DQ479926 Genomic DNA Translation: ABF48505.1
AK077798 mRNA Translation: BAC37016.1
AK146447 mRNA Translation: BAE27179.1
BC013722 mRNA Translation: AAH13722.1
BC049775 mRNA Translation: AAH49775.1
BC083060 mRNA Translation: AAH83060.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29904.1

NCBI Reference Sequences

More...
RefSeqi
NP_001161977.1, NM_001168505.1
NP_062632.2, NM_019658.6
XP_006527291.1, XM_006527228.3
XP_011245601.1, XM_011247299.2
XP_017173749.1, XM_017318260.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.228669

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000025932; ENSMUSP00000025932; ENSMUSG00000024976
ENSMUST00000169861; ENSMUSP00000127932; ENSMUSG00000024976

Database of genes from NCBI RefSeq genomes

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GeneIDi
56392

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:56392

UCSC genome browser

More...
UCSCi
uc008hxg.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068921 mRNA Translation: AAC40175.1
DQ479926 Genomic DNA Translation: ABF48505.1
AK077798 mRNA Translation: BAC37016.1
AK146447 mRNA Translation: BAE27179.1
BC013722 mRNA Translation: AAH13722.1
BC049775 mRNA Translation: AAH49775.1
BC083060 mRNA Translation: AAH83060.1
CCDSiCCDS29904.1
RefSeqiNP_001161977.1, NM_001168505.1
NP_062632.2, NM_019658.6
XP_006527291.1, XM_006527228.3
XP_011245601.1, XM_011247299.2
XP_017173749.1, XM_017318260.1
UniGeneiMm.228669

3D structure databases

ProteinModelPortaliO88520
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207949, 51 interactors
IntActiO88520, 49 interactors
STRINGi10090.ENSMUSP00000025932

PTM databases

iPTMnetiO88520
PhosphoSitePlusiO88520

Proteomic databases

EPDiO88520
MaxQBiO88520
PaxDbiO88520
PeptideAtlasiO88520
PRIDEiO88520

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025932; ENSMUSP00000025932; ENSMUSG00000024976
ENSMUST00000169861; ENSMUSP00000127932; ENSMUSG00000024976
GeneIDi56392
KEGGimmu:56392
UCSCiuc008hxg.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8036
MGIiMGI:1927197 Shoc2

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000156270
HOGENOMiHOG000116557
HOVERGENiHBG055661
InParanoidiO88520
KOiK19613
OMAiNQFTSYP
OrthoDBi287114at2759
PhylomeDBiO88520
TreeFamiTF315742

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O88520

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024976 Expressed in 287 organ(s), highest expression level in pineal body
CleanExiMM_SHOC2
GenevisibleiO88520 MM

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 4 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 16 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 17 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHOC2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88520
Secondary accession number(s): Q3UJH6, Q8BVL0, Q91VH8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 16, 2004
Last modified: January 16, 2019
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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