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Protein

AP-1 complex subunit gamma-like 2

Gene

Ap1g2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).By similarity

GO - Biological processi

  • intracellular protein transport Source: MGI
  • vesicle-mediated transport Source: MGI

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-432720 Lysosome Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit gamma-like 2
Alternative name(s):
Gamma2-adaptin
Short name:
G2ad
Gene namesi
Name:Ap1g2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1328307 Ap1g2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937611 – 791AP-1 complex subunit gamma-like 2Add BLAST791

Proteomic databases

EPDiO88512
MaxQBiO88512
PaxDbiO88512
PeptideAtlasiO88512
PRIDEiO88512

PTM databases

iPTMnetiO88512
PhosphoSitePlusiO88512

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000040701 Expressed in 175 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_AP1G2
ExpressionAtlasiO88512 baseline and differential
GenevisibleiO88512 MM

Interactioni

Subunit structurei

Probably interacts with AP1S1/Sigma1A-adaptin AP1S2/Sigma1B-adaptin. Probably does not interact with APB1. Interacts with HBV major surface antigen L. Interacts with HBV core protein C in a ubiquitin-dependent manner. Binds ubiquitin.By similarity

Protein-protein interaction databases

BioGridi198124, 1 interactor
STRINGi10090.ENSMUSP00000043996

Structurei

3D structure databases

ProteinModelPortaliO88512
SMRiO88512
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini671 – 786GAEPROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1062 Eukaryota
ENOG410XPKK LUCA
GeneTreeiENSGT00390000012618
HOGENOMiHOG000210271
HOVERGENiHBG067473
InParanoidiO88512
KOiK12391
OMAiMCRDLAT
OrthoDBiEOG091G01RV
TreeFamiTF300367

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR017107 AP1_complex_gsu
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
IPR008153 GAE_dom
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit
PIRSFiPIRSF037094 AP1_complex_gamma, 1 hit
SMARTiView protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
PROSITEiView protein in PROSITE
PS50180 GAE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O88512-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVHSLRLQD LIEEIRGAKT QAQEREVIQK ECAQIRASFR DGDPLQRHRQ
60 70 80 90 100
LAKLLYVHML GYPAHFGQME CLKLIASPRF TDKRVGYLGA MLLLDERHDS
110 120 130 140 150
HLLITNSIKN DLSQGNQPVQ GLALCTLSTM GSAEMCRDLA PEVEKLLLQP
160 170 180 190 200
SPYVRKKAIL TAVHMIRKDP ELSGIFLPPC TKLLRERHHG IQLGTVTLIT
210 220 230 240 250
ELCERNPAAL RHFRKVVPQL VQILRTLVTT GYSTEHSISG VSDPFLQVQI
260 270 280 290 300
LRLLRILGRN HEESSETMND LLAQVATNTD TSRNAGNAVL LETVLTIMAI
310 320 330 340 350
HSAAGLRVLA VNILGRFLLN NDKNIRYVAL TSLLQLVQSD HSAVQRHRST
360 370 380 390 400
VVECLQETDA SLSRRALELS LALVNSSNVR AMMQELQAFL ESCPPDLRAD
410 420 430 440 450
CASGILLAAE RFAPSKRWHI DTILHVLTTA GAHVRDDAVA NLTQLIGEAE
460 470 480 490 500
ELHTYSVRRL YSALAEDISQ QPLVQVAAWC IGEYGDLLLE GNCEETEPFQ
510 520 530 540 550
VEEEDVLALL EKVLQSHMSL PATRGYAITA LMKLSTRLRG DNNRIRQVVS
560 570 580 590 600
IYGSCVDLEL QQRAVEYNTL FQKYDHMRAA ILEKMPLVER GDPHVKEGGK
610 620 630 640 650
EKQTEAQPLE VTAPAPTEPQ ATKLLDLLDL LGDTSEPLSS GHAQHLPPQT
660 670 680 690 700
PSPGEALIHL LDLPCTPPPP APIPSVRVFE REGLQLDLSF MRPLETPALL
710 720 730 740 750
LVTATTTNSS KEDVTHFVCQ AAVPKSFQLQ LQAPSGNTIP AQGGLPITQV
760 770 780 790
FRILNPNQAP LRLKLRLTYN HSGQPVQEIF EVDNLPVETW Q
Length:791
Mass (Da):87,863
Last modified:July 27, 2011 - v2
Checksum:i21F744FC8EEFB932
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFT7D6RFT7_MOUSE
AP-1 complex subunit gamma-like 2
Ap1g2
235Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19K → E in AAC67391 (PubMed:9762922).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068707 mRNA Translation: AAC67391.1
CH466535 Genomic DNA Translation: EDL36306.1
CH466535 Genomic DNA Translation: EDL36307.1
BC108374 mRNA Translation: AAI08375.1
CCDSiCCDS36929.1
RefSeqiNP_031481.2, NM_007455.5
UniGeneiMm.238879

Genome annotation databases

EnsembliENSMUST00000036041; ENSMUSP00000043996; ENSMUSG00000040701
ENSMUST00000170285; ENSMUSP00000128427; ENSMUSG00000040701
GeneIDi11766
KEGGimmu:11766
UCSCiuc007tyd.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068707 mRNA Translation: AAC67391.1
CH466535 Genomic DNA Translation: EDL36306.1
CH466535 Genomic DNA Translation: EDL36307.1
BC108374 mRNA Translation: AAI08375.1
CCDSiCCDS36929.1
RefSeqiNP_031481.2, NM_007455.5
UniGeneiMm.238879

3D structure databases

ProteinModelPortaliO88512
SMRiO88512
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198124, 1 interactor
STRINGi10090.ENSMUSP00000043996

PTM databases

iPTMnetiO88512
PhosphoSitePlusiO88512

Proteomic databases

EPDiO88512
MaxQBiO88512
PaxDbiO88512
PeptideAtlasiO88512
PRIDEiO88512

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036041; ENSMUSP00000043996; ENSMUSG00000040701
ENSMUST00000170285; ENSMUSP00000128427; ENSMUSG00000040701
GeneIDi11766
KEGGimmu:11766
UCSCiuc007tyd.3 mouse

Organism-specific databases

CTDi8906
MGIiMGI:1328307 Ap1g2

Phylogenomic databases

eggNOGiKOG1062 Eukaryota
ENOG410XPKK LUCA
GeneTreeiENSGT00390000012618
HOGENOMiHOG000210271
HOVERGENiHBG067473
InParanoidiO88512
KOiK12391
OMAiMCRDLAT
OrthoDBiEOG091G01RV
TreeFamiTF300367

Enzyme and pathway databases

ReactomeiR-MMU-432720 Lysosome Vesicle Biogenesis

Miscellaneous databases

PROiPR:O88512
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040701 Expressed in 175 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_AP1G2
ExpressionAtlasiO88512 baseline and differential
GenevisibleiO88512 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR017107 AP1_complex_gsu
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
IPR008153 GAE_dom
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit
PIRSFiPIRSF037094 AP1_complex_gamma, 1 hit
SMARTiView protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
PROSITEiView protein in PROSITE
PS50180 GAE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAP1G2_MOUSE
AccessioniPrimary (citable) accession number: O88512
Secondary accession number(s): Q2YDV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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