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Protein

Ciliary neurotrophic factor receptor subunit alpha

Gene

Cntfr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity).By similarity

GO - Molecular functioni

  • ciliary neurotrophic factor receptor activity Source: MGI
  • cytokine binding Source: MGI
  • signaling receptor binding Source: MGI

GO - Biological processi

  • brainstem development Source: MGI
  • ciliary neurotrophic factor-mediated signaling pathway Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • sex differentiation Source: MGI
  • skeletal muscle organ development Source: MGI
  • suckling behavior Source: MGI

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-6788467 IL-6-type cytokine receptor ligand interactions
SABIO-RKiO88507

Names & Taxonomyi

Protein namesi
Recommended name:
Ciliary neurotrophic factor receptor subunit alpha
Short name:
CNTF receptor subunit alpha
Short name:
CNTFR-alpha
Gene namesi
Name:Cntfr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:99605 Cntfr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001099323 – 342Ciliary neurotrophic factor receptor subunit alphaAdd BLAST320
PropeptideiPRO_0000010994343 – 372Removed in mature formSequence analysisAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 89PROSITE-ProRule annotation
Glycosylationi60N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi70N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi342GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiO88507
PaxDbiO88507
PRIDEiO88507

PTM databases

iPTMnetiO88507

Expressioni

Gene expression databases

BgeeiENSMUSG00000028444
CleanExiMM_CNTFR
ExpressionAtlasiO88507 baseline and differential
GenevisibleiO88507 MM

Interactioni

Subunit structurei

Heterotrimer of the alpha subunit, LIFR and IL6ST.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198796, 2 interactors
IntActiO88507, 4 interactors
MINTiO88507
STRINGi10090.ENSMUSP00000100026

Structurei

3D structure databases

ProteinModelPortaliO88507
SMRiO88507
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 104Ig-like C2-typeAdd BLAST78
Domaini108 – 205Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini206 – 306Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi290 – 294WSXWS motif5

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.By similarity

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IH2U Eukaryota
ENOG4110HUW LUCA
GeneTreeiENSGT00530000063103
HOGENOMiHOG000171060
HOVERGENiHBG051048
InParanoidiO88507
KOiK05059
OMAiQETPHVQ
OrthoDBiEOG091G0B8P
PhylomeDBiO88507
TreeFamiTF331210

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003530 Hematopoietin_rcpt_L_F3_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS01354 HEMATOPO_REC_L_F3, 1 hit
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88507-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASVPWACC AVLAAAAAAV YTQKHSPQEA PHVQYERLGA DVTLPCGTAS
60 70 80 90 100
WDAAVTWRVN GTDLAPDLLN GSQLILRSLE LGHSGLYACF HRDSWHLRHQ
110 120 130 140 150
VLLHVGLPPR EPVLSCRSNT YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK
160 170 180 190 200
IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS ISVSNALGHN TTAITFDEFT
210 220 230 240 250
IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL KFFLRYRPLI
260 270 280 290 300
LDQWQHVELS DGTAHTITDA YAGKEYIIQV AAKDNEIGTW SDWSVAAHAT
310 320 330 340 350
PWTEEPRHLT TEAQAPETTT STTSSLAPPP TTKICDPGEL GSGGGPSILF
360 370
LTSVPVTLVL AAAAATANNL LI
Length:372
Mass (Da):40,801
Last modified:April 26, 2005 - v2
Checksum:i0704AA35CF1BBE12
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2A → T in AAC25711 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068615 mRNA Translation: AAC25711.1
BC046974 mRNA Translation: AAH46974.1
BC050928 mRNA Translation: AAH50928.1
CCDSiCCDS18067.1
RefSeqiNP_001129528.1, NM_001136056.3
NP_057882.2, NM_016673.2
XP_006537660.1, XM_006537597.3
XP_006537661.1, XM_006537598.2
XP_006537662.1, XM_006537599.3
XP_011248218.1, XM_011249916.2
XP_011248219.1, XM_011249917.2
XP_017175430.1, XM_017319941.1
XP_017175431.1, XM_017319942.1
UniGeneiMm.425178

Genome annotation databases

EnsembliENSMUST00000102961; ENSMUSP00000100026; ENSMUSG00000028444
ENSMUST00000102962; ENSMUSP00000100027; ENSMUSG00000028444
GeneIDi12804
KEGGimmu:12804
UCSCiuc008sje.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCNTFR_MOUSE
AccessioniPrimary (citable) accession number: O88507
Secondary accession number(s): Q80T01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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