UniProtKB - O88501 (CAN6_RAT)
Protein
Calpain-6
Gene
Capn6
Organism
Rattus norvegicus (Rat)
Status
Functioni
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).By similarity
GO - Molecular functioni
- microtubule binding Source: UniProtKB
GO - Biological processi
- microtubule bundle formation Source: UniProtKB
- proteolysis Source: GOC
- regulation of cytoskeleton organization Source: UniProtKB
Enzyme and pathway databases
Reactomei | R-RNO-1474228, Degradation of the extracellular matrix |
Protein family/group databases
MEROPSi | C02.971 |
Names & Taxonomyi
Protein namesi | Recommended name: Calpain-6 |
Gene namesi | Name:Capn6 Synonyms:Capa6 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 70960, Capn6 |
Subcellular locationi
Cytoskeleton
- spindle By similarity
Other locations
- perinuclear region By similarity
Cytoskeleton
- microtubule Source: RGD
- spindle microtubule Source: RGD
Other locations
- cytoplasm Source: GO_Central
- perinuclear region of cytoplasm Source: RGD
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000207719 | 1 – 641 | Calpain-6Add BLAST | 641 |
Proteomic databases
PaxDbi | O88501 |
PRIDEi | O88501 |
Interactioni
Subunit structurei
Interacts (via domain III) with microtubules.
Interacts (via domain II) with ARHGEF2 (via the N-terminal zinc finger).
By similarityGO - Molecular functioni
- microtubule binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000006638 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 343 | Calpain catalyticPROSITE-ProRule annotationAdd BLAST | 318 | |
Domaini | 498 – 621 | C2PROSITE-ProRule annotationAdd BLAST | 124 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 344 – 495 | Domain IIIAdd BLAST | 152 |
Sequence similaritiesi
Belongs to the peptidase C2 family.Curated
Phylogenomic databases
eggNOGi | KOG0045, Eukaryota |
InParanoidi | O88501 |
OrthoDBi | 704215at2759 |
PhylomeDBi | O88501 |
Family and domain databases
CDDi | cd04046, C2_Calpain, 1 hit cd00214, Calpain_III, 1 hit cd00044, CysPc, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR033884, C2_Calpain IPR000008, C2_dom IPR035892, C2_domain_sf IPR033883, C2_III IPR022684, Calpain_cysteine_protease IPR022682, Calpain_domain_III IPR022683, Calpain_III IPR036213, Calpain_III_sf IPR038765, Papain-like_cys_pep_sf IPR001300, Peptidase_C2_calpain_cat |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF01067, Calpain_III, 1 hit PF00648, Peptidase_C2, 1 hit |
PRINTSi | PR00704, CALPAIN |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00720, calpain_III, 1 hit SM00230, CysPc, 1 hit |
SUPFAMi | SSF49758, SSF49758, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50203, CALPAIN_CAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O88501-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPPLKLFKN QKYQELKQDC MKDGRLFCDP TFLPENDSLF FNRLLPGKVV
60 70 80 90 100
WKRPQDISDD PHLIVGNISN HQLIQGRLGN KAMISAFSCL AVQESHWTKA
110 120 130 140 150
IPNHKEQEWD PRKPEKYAGI FRFRFWHFGE WTEVVIDDLL PTINGDLVFS
160 170 180 190 200
FSTSMNEFWN ALLEKAYAKL LGCYEALDGL TITDIIMDFT GTLAEIIDMQ
210 220 230 240 250
KGRYTDLVEE KYKLFGELYK TFTKGGLISC SIESPSQEEQ EVETDWGLLK
260 270 280 290 300
GYTYTMTDIR KLRLGERLVE VFSTEKLYMV RLRNPLGRQE WSGPWSEISE
310 320 330 340 350
EWQQLTVTDR KNLGLVMSDD GEFWMSLEDF CHNFHKLNVC RNVNNPVFGR
360 370 380 390 400
KELESVVGCW TVDDDPLMNR SGGCYNNRDT FLQNPQYIFT VPEDGHKVIM
410 420 430 440 450
SLQQKDLRTY RRMGRPDNYI IGFELFKVEM NRRFRLHHLY IQERAGTSTY
460 470 480 490 500
IDTRTVFLSK YLKKGNYVLV PTMFQHGRTS EFLLRIFSEV PVQLRELTLD
510 520 530 540 550
MPKMSCWNLA RGYPKVVTQI TVHSAEGLEK KYANETVNPY LTIKCGKEEV
560 570 580 590 600
RSPVQKNTVH AIFDTQAIFY RRTTDIPIII QVWNSRKFCD QFLGQVTLDA
610 620 630 640
DPSDCRDLKS LYLRKKGGPT AKVKQGHISF KVISSDDLTE L
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V6M4 | G3V6M4_RAT | Calpain-6 | Capn6 rCG_23172 | 641 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF067793 mRNA Translation: AAC19367.1 |
RefSeqi | NP_113996.1, NM_031808.1 |
Genome annotation databases
GeneIDi | 83685 |
KEGGi | rno:83685 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF067793 mRNA Translation: AAC19367.1 |
RefSeqi | NP_113996.1, NM_031808.1 |
3D structure databases
SMRi | O88501 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000006638 |
Protein family/group databases
MEROPSi | C02.971 |
Proteomic databases
PaxDbi | O88501 |
PRIDEi | O88501 |
Genome annotation databases
GeneIDi | 83685 |
KEGGi | rno:83685 |
Organism-specific databases
CTDi | 827 |
RGDi | 70960, Capn6 |
Phylogenomic databases
eggNOGi | KOG0045, Eukaryota |
InParanoidi | O88501 |
OrthoDBi | 704215at2759 |
PhylomeDBi | O88501 |
Enzyme and pathway databases
Reactomei | R-RNO-1474228, Degradation of the extracellular matrix |
Miscellaneous databases
PROi | PR:O88501 |
Family and domain databases
CDDi | cd04046, C2_Calpain, 1 hit cd00214, Calpain_III, 1 hit cd00044, CysPc, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR033884, C2_Calpain IPR000008, C2_dom IPR035892, C2_domain_sf IPR033883, C2_III IPR022684, Calpain_cysteine_protease IPR022682, Calpain_domain_III IPR022683, Calpain_III IPR036213, Calpain_III_sf IPR038765, Papain-like_cys_pep_sf IPR001300, Peptidase_C2_calpain_cat |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF01067, Calpain_III, 1 hit PF00648, Peptidase_C2, 1 hit |
PRINTSi | PR00704, CALPAIN |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00720, calpain_III, 1 hit SM00230, CysPc, 1 hit |
SUPFAMi | SSF49758, SSF49758, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50203, CALPAIN_CAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAN6_RAT | |
Accessioni | O88501Primary (citable) accession number: O88501 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 12, 2003 |
Last sequence update: | November 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Peptidase families
Classification of peptidase families and list of entries