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Protein

Melatonin-related receptor

Gene

Gpr50

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Does not bind melatonin.

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin-related receptor
Alternative name(s):
G protein-coupled receptor 50
H9
Gene namesi
Name:Gpr50
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1333877 Gpr50

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 59Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini60 – 72CytoplasmicSequence analysisAdd BLAST13
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 111ExtracellularSequence analysisAdd BLAST18
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini133 – 151CytoplasmicSequence analysisAdd BLAST19
Transmembranei152 – 172Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini173 – 196ExtracellularSequence analysisAdd BLAST24
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 247CytoplasmicSequence analysisAdd BLAST30
Transmembranei248 – 268Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini269 – 281ExtracellularSequence analysisAdd BLAST13
Transmembranei282 – 302Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini303 – 591CytoplasmicSequence analysisAdd BLAST289

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698791 – 591Melatonin-related receptorAdd BLAST591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi109 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO88495
PeptideAtlasiO88495
PRIDEiO88495

PTM databases

iPTMnetiO88495
PhosphoSitePlusiO88495

Expressioni

Gene expression databases

BgeeiENSMUSG00000056380 Expressed in 91 organ(s), highest expression level in median eminence of neurohypophysis
CleanExiMM_GPR50
GenevisibleiO88495 MM

Interactioni

Subunit structurei

Homodimer, and heterodimer with MTNR1A and MTNR1B.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064608

Structurei

3D structure databases

ProteinModelPortaliO88495
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHFY Eukaryota
ENOG4111ZZV LUCA
GeneTreeiENSGT00440000033318
HOGENOMiHOG000133094
HOVERGENiHBG052529
InParanoidiO88495
KOiK04287
OMAiQPDYPPA
OrthoDBiEOG091G0GO0
PhylomeDBiO88495
TreeFamiTF331693

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002280 Mel_rcpt_1X
IPR000025 Melatonin_rcpt
PANTHERiPTHR45535 PTHR45535, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01151 MELATONIN1XR
PR00857 MELATONINR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O88495-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATVPKSNMG PTKAVPTPFG CIGCKLPKPD YPPALIIFMF CAMVITVVVD
60 70 80 90 100
LIGNSMVILA VTKNKKLRNS GNIFVASLSV ADMLVAIYPY PLMLYAMSVG
110 120 130 140 150
GWDLSQLQCQ MVGLVTGLSV VGSIFNITAI AINRYCYICH SLQYKRIFSL
160 170 180 190 200
RNTCIYLVVT WVMTVLAVLP NMYIGTIEYD PRTYTCIFNY VNNPAFTVTI
210 220 230 240 250
VCIHFVLPLI IVGYCYTKIW IKVLAARDPA GQNPDNQFAE VRNFLTMFVI
260 270 280 290 300
FLLFAVCWCP VNVLTVLVAV IPKEMAGKIP NWLYLAAYCI AYFNSCLNAI
310 320 330 340 350
IYGILNESFR REYWTIFHAM RHPILFISHL ISDIRETWET RALTRARVRA
360 370 380 390 400
RDQVREQERA RACVAVEGTP RNVRNVLLPG DASAPHSDRA SVRPKPQTRS
410 420 430 440 450
TSVYRKPASI HHKSISGHPK SASVYPKPAS SVHCKPASVH FKPASVHFKG
460 470 480 490 500
DSVYFKGDTV HYRAASKLVT SHRISAGPST SHPTSMAGYI KSGTSHPATT
510 520 530 540 550
TVDYLEPATT SHSVLTAVDL PEVSASHCLE MTSTGHLRAD ISASVLPSVP
560 570 580 590
FELAATPPDT TAIPIASGDY RKVVLIDDDS DDSDCSDEMA V
Length:591
Mass (Da):65,130
Last modified:October 16, 2013 - v3
Checksum:i12576D50C20E216A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065145 mRNA Translation: AAC21462.1
AK132272 mRNA Translation: BAE21072.1
AL840624 Genomic DNA No translation available.
CH466624 Genomic DNA Translation: EDL26572.1
BC137982 mRNA Translation: AAI37983.1
CCDSiCCDS30181.1
RefSeqiNP_001295430.1, NM_001308501.1
NP_034470.1, NM_010340.2
UniGeneiMm.33336

Genome annotation databases

EnsembliENSMUST00000070449; ENSMUSP00000064608; ENSMUSG00000056380
GeneIDi14765
KEGGimmu:14765
UCSCiuc009tke.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065145 mRNA Translation: AAC21462.1
AK132272 mRNA Translation: BAE21072.1
AL840624 Genomic DNA No translation available.
CH466624 Genomic DNA Translation: EDL26572.1
BC137982 mRNA Translation: AAI37983.1
CCDSiCCDS30181.1
RefSeqiNP_001295430.1, NM_001308501.1
NP_034470.1, NM_010340.2
UniGeneiMm.33336

3D structure databases

ProteinModelPortaliO88495
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064608

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO88495
PhosphoSitePlusiO88495

Proteomic databases

PaxDbiO88495
PeptideAtlasiO88495
PRIDEiO88495

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070449; ENSMUSP00000064608; ENSMUSG00000056380
GeneIDi14765
KEGGimmu:14765
UCSCiuc009tke.1 mouse

Organism-specific databases

CTDi9248
MGIiMGI:1333877 Gpr50

Phylogenomic databases

eggNOGiENOG410IHFY Eukaryota
ENOG4111ZZV LUCA
GeneTreeiENSGT00440000033318
HOGENOMiHOG000133094
HOVERGENiHBG052529
InParanoidiO88495
KOiK04287
OMAiQPDYPPA
OrthoDBiEOG091G0GO0
PhylomeDBiO88495
TreeFamiTF331693

Miscellaneous databases

PROiPR:O88495
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056380 Expressed in 91 organ(s), highest expression level in median eminence of neurohypophysis
CleanExiMM_GPR50
GenevisibleiO88495 MM

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002280 Mel_rcpt_1X
IPR000025 Melatonin_rcpt
PANTHERiPTHR45535 PTHR45535, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01151 MELATONIN1XR
PR00857 MELATONINR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTR1L_MOUSE
AccessioniPrimary (citable) accession number: O88495
Secondary accession number(s): Q3V1S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 16, 2013
Last modified: November 7, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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