Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O88492 (PLIN4_MOUSE)

Protein

Perilipin-4

Gene

Plin4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets.2 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-4
Alternative name(s):
Adipocyte protein S3-12
Gene namesi
Name:Plin4
Synonyms:Kiaa1881
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1929709 Plin4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Lipid droplet, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002975601 – 1403Perilipin-4Add BLAST1403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei1281PhosphoserineCombined sources1
Modified residuei1287PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO88492
PaxDbiO88492
PeptideAtlasiO88492
PRIDEiO88492

PTM databases

iPTMnetiO88492
PhosphoSitePlusiO88492
SwissPalmiO88492

Expressioni

Tissue specificityi

Specifically expressed in white adipose tissue and also weakly detected in heart and skeletal muscle (at protein level).3 Publications

Inductioni

Up-regulated by PPARG and during adipocyte differentiation.1 Publication

Gene expression databases

BgeeiENSMUSG00000002831 Expressed in 145 organ(s), highest expression level in epididymal fat pad
CleanExiMM_S3-12
GenevisibleiO88492 MM

Interactioni

Protein-protein interaction databases

BioGridi208292, 2 interactors
IntActiO88492, 7 interactors
MINTiO88492
STRINGi10090.ENSMUSP00000002908

Structurei

3D structure databases

SMRiO88492
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati104 – 1361Add BLAST33
Repeati137 – 1692Add BLAST33
Repeati170 – 2023Add BLAST33
Repeati203 – 2354Add BLAST33
Repeati236 – 2685Add BLAST33
Repeati269 – 3016Add BLAST33
Repeati302 – 3347Add BLAST33
Repeati335 – 3678Add BLAST33
Repeati368 – 4009Add BLAST33
Repeati401 – 43310Add BLAST33
Repeati434 – 46611Add BLAST33
Repeati467 – 49912Add BLAST33
Repeati500 – 53213Add BLAST33
Repeati533 – 56514Add BLAST33
Repeati566 – 59815Add BLAST33
Repeati599 – 63116Add BLAST33
Repeati632 – 66417Add BLAST33
Repeati665 – 69718Add BLAST33
Repeati698 – 73019Add BLAST33
Repeati731 – 76320Add BLAST33
Repeati764 – 79621Add BLAST33
Repeati797 – 82922Add BLAST33
Repeati830 – 86223Add BLAST33
Repeati863 – 89524Add BLAST33
Repeati896 – 92825Add BLAST33
Repeati929 – 96126Add BLAST33
Repeati962 – 99427Add BLAST33
Repeati995 – 102728Add BLAST33
Repeati1028 – 106029Add BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 106029 X 33 AA approximate tandem repeatAdd BLAST957

Sequence similaritiesi

Belongs to the perilipin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHSW Eukaryota
ENOG4112C4W LUCA
GeneTreeiENSGT00500000044795
HOGENOMiHOG000113183
HOVERGENiHBG099259
InParanoidiO88492
KOiK20254
OMAiTGAVNMA
OrthoDBiEOG091G017D
TreeFamiTF328397

Family and domain databases

InterProiView protein in InterPro
IPR004279 Perilipin
PfamiView protein in Pfam
PF03036 Perilipin, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O88492-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSASGDGTRV PPKSKGKTLS SFFGSLPGFS SARNLVSHTH SSTSTKDLQT 
        60         70         80         90        100
ATDPSGTPAP SSKVSTNSQM AGDAAGLLQP SEQTAGDKDM GSFSVTSSED 
       110        120        130        140        150
AFSGVFGIMD AAKGMVQGGL GATQSALVGT KEAVSGGVMG AVGVAKGLVK 
       160        170        180        190        200
GGLDTSKNVL TNTKDTVTTG VMGAANMAKG TVQTGLDTTK SVVMGTKDTV 
       210        220        230        240        250
ATGLAGAVNV AKGTIQGGLD TTKSVVMGTK DTVTTGLTGA VNVAKGVVQG 
       260        270        280        290        300
GLDTTKSVVM GTKDTVTTGL TGAMNVAKGT AQMGIDTSKT VLTGTKDTVC 
       310        320        330        340        350
AGATGAINVA KGAAQGGLDT TKSVLIGTKD TVTTGLTGAV NVAKGAVQGG 
       360        370        380        390        400
LDTTKSVVMG TKDTVTTGLT GAMNVAKGTA QMGLGTSKTV LTGTKDTVCA 
       410        420        430        440        450
GLTGAINVAK GAAQGGLDTT KSVLMGTKDT VTTGLTGAVN VAKGTIQGGL 
       460        470        480        490        500
DTTKSVVMGT KDTVTTGLTG AVNVAKGTIQ GGLDTTKSVV MGTKDTVTTG 
       510        520        530        540        550
LTGAVNVAKG AAQGGLDTTK SVVMGTKDTV TTGLTGAMNV AKGTAQMGLG 
       560        570        580        590        600
TSKTVLTGTK DTVCAGLTGA INVAKGAAQG GLDTTKSVLM GTKDTVTTGL 
       610        620        630        640        650
TGAVNVAKGT IQGGLDTTKS VVMGTKDTVT TGLTGAVNVA KGAVQGGLDT 
       660        670        680        690        700
TKSVVMGTKD TVTTGLTGAL NVAKGTAQMG IDTSKTVLIG TKDTVCAGAT 
       710        720        730        740        750
GAINMAKGAA QGGLDTTKSV LMGTKDTVTT GLTGAINVAK GSAQGGLDTT 
       760        770        780        790        800
KSVLIGTKDT VTTGLTGALN VAKGTVQTGL DTSQRVLTGT KDNVYAGVTG 
       810        820        830        840        850
AVNVAKGTIQ GGLDTTKSVV MGTKDTVTTG LTGAVNVAKG AVQGGLDTTK 
       860        870        880        890        900
SVVMGTKDTV TTGLTGAMNV AKGTAQMGID TSKTVLTGTK DTVCAGLTGA 
       910        920        930        940        950
INVAKGATQG GLDTTKSVLM GTKDTVTTGL TGAINVAKGA AQGGLDTTKS 
       960        970        980        990       1000
VLLGTKDTVT TGLTGAANVA KETVQMGLDT SKNILMDTKD SICAGATGAI 
      1010       1020       1030       1040       1050
TVVKGAAQGG LDTSNAALTG TMDTAKGTVQ TSLDTSKHML IGMKDTVCAG 
      1060       1070       1080       1090       1100
VTSAMNMAKG IHKNTDTTRD TQSSVLAHSG NVATNAIHTG VHTVPSSLSG 
      1110       1120       1130       1140       1150
SHSIICHEPS IYRATNHGVG QAILTSTESL CCETSSFSDK YGLGHVTEPR 
      1160       1170       1180       1190       1200
ADTKTLVSGM ASSACAATRS VEECGQLAAT GFAALPDELK GLGDIFQPMT 
      1210       1220       1230       1240       1250
TEEQAQLAVS ESGPRVLSAD RGSYYIRLGD LAPSFRQRAF EHALSHIQHN 
      1260       1270       1280       1290       1300
QFQARAALAQ LQEAFQMTDM TMEAACGKLC SDQSLNTMVE AVGSHEMRAS 
      1310       1320       1330       1340       1350
VAQDRLCTLA HQLHAAYSSL VTSLQGLPEV QQQAGQARHS LCKLYGLVSS 
      1360       1370       1380       1390       1400
EAGSELQTEQ LAQSSAGVVE AWQGLEVLLE KLQQNPPLSW LVGPFTSMPC 

GQL
Length:1,403
Mass (Da):139,415
Last modified:July 27, 2011 - v2
Checksum:iD1A3A8F9C787FE07
GO
Isoform 2 (identifier: O88492-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-601: Missing.
     1267-1271: Missing.

Show »
Length:1,002
Mass (Da):100,772
Checksum:i20A4010442349F4A
GO

Sequence cautioni

The sequence BAC37834 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD32564 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti241V → A in AAC23666 (PubMed:9624692).Curated1
Sequence conflicti1121Q → H in AAC23666 (PubMed:9624692).Curated1
Sequence conflicti1258L → V in AAC23666 (PubMed:9624692).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027279206 – 601Missing in isoform 2. 1 PublicationAdd BLAST396
Alternative sequenceiVSP_0272801267 – 1271Missing in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064748 mRNA Translation: AAC23666.1
AK173286 Transcribed RNA Translation: BAD32564.1 Different initiation.
CT009719 Genomic DNA No translation available.
AK080156 mRNA Translation: BAC37834.1 Different initiation.
CCDSiCCDS79565.1 [O88492-1]
PIRiT17372
RefSeqiNP_065593.2, NM_020568.3 [O88492-1]
UniGeneiMm.12966

Genome annotation databases

EnsembliENSMUST00000002908; ENSMUSP00000002908; ENSMUSG00000002831 [O88492-1]
ENSMUST00000190703; ENSMUSP00000139859; ENSMUSG00000002831 [O88492-1]
GeneIDi57435
KEGGimmu:57435
UCSCiuc008day.2 mouse [O88492-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064748 mRNA Translation: AAC23666.1
AK173286 Transcribed RNA Translation: BAD32564.1 Different initiation.
CT009719 Genomic DNA No translation available.
AK080156 mRNA Translation: BAC37834.1 Different initiation.
CCDSiCCDS79565.1 [O88492-1]
PIRiT17372
RefSeqiNP_065593.2, NM_020568.3 [O88492-1]
UniGeneiMm.12966

3D structure databases

SMRiO88492
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208292, 2 interactors
IntActiO88492, 7 interactors
MINTiO88492
STRINGi10090.ENSMUSP00000002908

PTM databases

iPTMnetiO88492
PhosphoSitePlusiO88492
SwissPalmiO88492

Proteomic databases

MaxQBiO88492
PaxDbiO88492
PeptideAtlasiO88492
PRIDEiO88492

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002908; ENSMUSP00000002908; ENSMUSG00000002831 [O88492-1]
ENSMUST00000190703; ENSMUSP00000139859; ENSMUSG00000002831 [O88492-1]
GeneIDi57435
KEGGimmu:57435
UCSCiuc008day.2 mouse [O88492-1]

Organism-specific databases

CTDi729359
MGIiMGI:1929709 Plin4
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IHSW Eukaryota
ENOG4112C4W LUCA
GeneTreeiENSGT00500000044795
HOGENOMiHOG000113183
HOVERGENiHBG099259
InParanoidiO88492
KOiK20254
OMAiTGAVNMA
OrthoDBiEOG091G017D
TreeFamiTF328397

Miscellaneous databases

PROiPR:O88492
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002831 Expressed in 145 organ(s), highest expression level in epididymal fat pad
CleanExiMM_S3-12
GenevisibleiO88492 MM

Family and domain databases

InterProiView protein in InterPro
IPR004279 Perilipin
PfamiView protein in Pfam
PF03036 Perilipin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLIN4_MOUSE
AccessioniPrimary (citable) accession number: O88492
Secondary accession number(s): E9QN72, Q69Z80, Q8BNV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again