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Protein

Perilipin-4

Gene

Plin4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets.2 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-4
Alternative name(s):
Adipocyte protein S3-12
Gene namesi
Name:Plin4
Synonyms:Kiaa1881
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1929709 Plin4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Lipid droplet, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002975601 – 1403Perilipin-4Add BLAST1403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei1281PhosphoserineCombined sources1
Modified residuei1287PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO88492
PaxDbiO88492
PeptideAtlasiO88492
PRIDEiO88492

PTM databases

iPTMnetiO88492
PhosphoSitePlusiO88492
SwissPalmiO88492

Expressioni

Tissue specificityi

Specifically expressed in white adipose tissue and also weakly detected in heart and skeletal muscle (at protein level).3 Publications

Inductioni

Up-regulated by PPARG and during adipocyte differentiation.1 Publication

Gene expression databases

BgeeiENSMUSG00000002831 Expressed in 145 organ(s), highest expression level in epididymal fat pad
CleanExiMM_S3-12
GenevisibleiO88492 MM

Interactioni

Protein-protein interaction databases

BioGridi208292, 2 interactors
IntActiO88492, 7 interactors
MINTiO88492
STRINGi10090.ENSMUSP00000002908

Structurei

3D structure databases

SMRiO88492
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati104 – 1361Add BLAST33
Repeati137 – 1692Add BLAST33
Repeati170 – 2023Add BLAST33
Repeati203 – 2354Add BLAST33
Repeati236 – 2685Add BLAST33
Repeati269 – 3016Add BLAST33
Repeati302 – 3347Add BLAST33
Repeati335 – 3678Add BLAST33
Repeati368 – 4009Add BLAST33
Repeati401 – 43310Add BLAST33
Repeati434 – 46611Add BLAST33
Repeati467 – 49912Add BLAST33
Repeati500 – 53213Add BLAST33
Repeati533 – 56514Add BLAST33
Repeati566 – 59815Add BLAST33
Repeati599 – 63116Add BLAST33
Repeati632 – 66417Add BLAST33
Repeati665 – 69718Add BLAST33
Repeati698 – 73019Add BLAST33
Repeati731 – 76320Add BLAST33
Repeati764 – 79621Add BLAST33
Repeati797 – 82922Add BLAST33
Repeati830 – 86223Add BLAST33
Repeati863 – 89524Add BLAST33
Repeati896 – 92825Add BLAST33
Repeati929 – 96126Add BLAST33
Repeati962 – 99427Add BLAST33
Repeati995 – 102728Add BLAST33
Repeati1028 – 106029Add BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 106029 X 33 AA approximate tandem repeatAdd BLAST957

Sequence similaritiesi

Belongs to the perilipin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHSW Eukaryota
ENOG4112C4W LUCA
GeneTreeiENSGT00500000044795
HOGENOMiHOG000113183
HOVERGENiHBG099259
InParanoidiO88492
KOiK20254
OMAiTGAVNMA
OrthoDBiEOG091G017D
TreeFamiTF328397

Family and domain databases

InterProiView protein in InterPro
IPR004279 Perilipin
PfamiView protein in Pfam
PF03036 Perilipin, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O88492-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSASGDGTRV PPKSKGKTLS SFFGSLPGFS SARNLVSHTH SSTSTKDLQT
60 70 80 90 100
ATDPSGTPAP SSKVSTNSQM AGDAAGLLQP SEQTAGDKDM GSFSVTSSED
110 120 130 140 150
AFSGVFGIMD AAKGMVQGGL GATQSALVGT KEAVSGGVMG AVGVAKGLVK
160 170 180 190 200
GGLDTSKNVL TNTKDTVTTG VMGAANMAKG TVQTGLDTTK SVVMGTKDTV
210 220 230 240 250
ATGLAGAVNV AKGTIQGGLD TTKSVVMGTK DTVTTGLTGA VNVAKGVVQG
260 270 280 290 300
GLDTTKSVVM GTKDTVTTGL TGAMNVAKGT AQMGIDTSKT VLTGTKDTVC
310 320 330 340 350
AGATGAINVA KGAAQGGLDT TKSVLIGTKD TVTTGLTGAV NVAKGAVQGG
360 370 380 390 400
LDTTKSVVMG TKDTVTTGLT GAMNVAKGTA QMGLGTSKTV LTGTKDTVCA
410 420 430 440 450
GLTGAINVAK GAAQGGLDTT KSVLMGTKDT VTTGLTGAVN VAKGTIQGGL
460 470 480 490 500
DTTKSVVMGT KDTVTTGLTG AVNVAKGTIQ GGLDTTKSVV MGTKDTVTTG
510 520 530 540 550
LTGAVNVAKG AAQGGLDTTK SVVMGTKDTV TTGLTGAMNV AKGTAQMGLG
560 570 580 590 600
TSKTVLTGTK DTVCAGLTGA INVAKGAAQG GLDTTKSVLM GTKDTVTTGL
610 620 630 640 650
TGAVNVAKGT IQGGLDTTKS VVMGTKDTVT TGLTGAVNVA KGAVQGGLDT
660 670 680 690 700
TKSVVMGTKD TVTTGLTGAL NVAKGTAQMG IDTSKTVLIG TKDTVCAGAT
710 720 730 740 750
GAINMAKGAA QGGLDTTKSV LMGTKDTVTT GLTGAINVAK GSAQGGLDTT
760 770 780 790 800
KSVLIGTKDT VTTGLTGALN VAKGTVQTGL DTSQRVLTGT KDNVYAGVTG
810 820 830 840 850
AVNVAKGTIQ GGLDTTKSVV MGTKDTVTTG LTGAVNVAKG AVQGGLDTTK
860 870 880 890 900
SVVMGTKDTV TTGLTGAMNV AKGTAQMGID TSKTVLTGTK DTVCAGLTGA
910 920 930 940 950
INVAKGATQG GLDTTKSVLM GTKDTVTTGL TGAINVAKGA AQGGLDTTKS
960 970 980 990 1000
VLLGTKDTVT TGLTGAANVA KETVQMGLDT SKNILMDTKD SICAGATGAI
1010 1020 1030 1040 1050
TVVKGAAQGG LDTSNAALTG TMDTAKGTVQ TSLDTSKHML IGMKDTVCAG
1060 1070 1080 1090 1100
VTSAMNMAKG IHKNTDTTRD TQSSVLAHSG NVATNAIHTG VHTVPSSLSG
1110 1120 1130 1140 1150
SHSIICHEPS IYRATNHGVG QAILTSTESL CCETSSFSDK YGLGHVTEPR
1160 1170 1180 1190 1200
ADTKTLVSGM ASSACAATRS VEECGQLAAT GFAALPDELK GLGDIFQPMT
1210 1220 1230 1240 1250
TEEQAQLAVS ESGPRVLSAD RGSYYIRLGD LAPSFRQRAF EHALSHIQHN
1260 1270 1280 1290 1300
QFQARAALAQ LQEAFQMTDM TMEAACGKLC SDQSLNTMVE AVGSHEMRAS
1310 1320 1330 1340 1350
VAQDRLCTLA HQLHAAYSSL VTSLQGLPEV QQQAGQARHS LCKLYGLVSS
1360 1370 1380 1390 1400
EAGSELQTEQ LAQSSAGVVE AWQGLEVLLE KLQQNPPLSW LVGPFTSMPC

GQL
Length:1,403
Mass (Da):139,415
Last modified:July 27, 2011 - v2
Checksum:iD1A3A8F9C787FE07
GO
Isoform 2 (identifier: O88492-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-601: Missing.
     1267-1271: Missing.

Show »
Length:1,002
Mass (Da):100,772
Checksum:i20A4010442349F4A
GO

Sequence cautioni

The sequence BAC37834 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD32564 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti241V → A in AAC23666 (PubMed:9624692).Curated1
Sequence conflicti1121Q → H in AAC23666 (PubMed:9624692).Curated1
Sequence conflicti1258L → V in AAC23666 (PubMed:9624692).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027279206 – 601Missing in isoform 2. 1 PublicationAdd BLAST396
Alternative sequenceiVSP_0272801267 – 1271Missing in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064748 mRNA Translation: AAC23666.1
AK173286 Transcribed RNA Translation: BAD32564.1 Different initiation.
CT009719 Genomic DNA No translation available.
AK080156 mRNA Translation: BAC37834.1 Different initiation.
CCDSiCCDS79565.1 [O88492-1]
PIRiT17372
RefSeqiNP_065593.2, NM_020568.3 [O88492-1]
UniGeneiMm.12966

Genome annotation databases

EnsembliENSMUST00000002908; ENSMUSP00000002908; ENSMUSG00000002831 [O88492-1]
ENSMUST00000190703; ENSMUSP00000139859; ENSMUSG00000002831 [O88492-1]
GeneIDi57435
KEGGimmu:57435
UCSCiuc008day.2 mouse [O88492-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064748 mRNA Translation: AAC23666.1
AK173286 Transcribed RNA Translation: BAD32564.1 Different initiation.
CT009719 Genomic DNA No translation available.
AK080156 mRNA Translation: BAC37834.1 Different initiation.
CCDSiCCDS79565.1 [O88492-1]
PIRiT17372
RefSeqiNP_065593.2, NM_020568.3 [O88492-1]
UniGeneiMm.12966

3D structure databases

SMRiO88492
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208292, 2 interactors
IntActiO88492, 7 interactors
MINTiO88492
STRINGi10090.ENSMUSP00000002908

PTM databases

iPTMnetiO88492
PhosphoSitePlusiO88492
SwissPalmiO88492

Proteomic databases

MaxQBiO88492
PaxDbiO88492
PeptideAtlasiO88492
PRIDEiO88492

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002908; ENSMUSP00000002908; ENSMUSG00000002831 [O88492-1]
ENSMUST00000190703; ENSMUSP00000139859; ENSMUSG00000002831 [O88492-1]
GeneIDi57435
KEGGimmu:57435
UCSCiuc008day.2 mouse [O88492-1]

Organism-specific databases

CTDi729359
MGIiMGI:1929709 Plin4
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IHSW Eukaryota
ENOG4112C4W LUCA
GeneTreeiENSGT00500000044795
HOGENOMiHOG000113183
HOVERGENiHBG099259
InParanoidiO88492
KOiK20254
OMAiTGAVNMA
OrthoDBiEOG091G017D
TreeFamiTF328397

Miscellaneous databases

PROiPR:O88492
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002831 Expressed in 145 organ(s), highest expression level in epididymal fat pad
CleanExiMM_S3-12
GenevisibleiO88492 MM

Family and domain databases

InterProiView protein in InterPro
IPR004279 Perilipin
PfamiView protein in Pfam
PF03036 Perilipin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLIN4_MOUSE
AccessioniPrimary (citable) accession number: O88492
Secondary accession number(s): E9QN72, Q69Z80, Q8BNV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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