UniProtKB - O88492 (PLIN4_MOUSE)
Protein
Perilipin-4
Gene
Plin4
Organism
Mus musculus (Mouse)
Status
Functioni
May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets.2 Publications
Names & Taxonomyi
Protein namesi | Recommended name: Perilipin-4Alternative name(s): Adipocyte protein S3-12 |
Gene namesi | Name:Plin4 Synonyms:Kiaa1881 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1929709 Plin4 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Other locations
- Cytoplasm 2 Publications
- Lipid droplet 2 Publications
Note: Nascent lipid droplet surface-associated; association with lipid droplets is triacylglycerol synthesis-dependent.2 Publications
Cytosol
- cytosol Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- intracellular membrane-bounded organelle Source: MGI
- lipid droplet Source: MGI
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Lipid droplet, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000297560 | 1 – 1403 | Perilipin-4Add BLAST | 1403 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | PhosphoserineCombined sources | 1 | |
Modified residuei | 31 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1281 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1287 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | O88492 |
MaxQBi | O88492 |
PaxDbi | O88492 |
PeptideAtlasi | O88492 |
PRIDEi | O88492 |
PTM databases
iPTMneti | O88492 |
PhosphoSitePlusi | O88492 |
SwissPalmi | O88492 |
Expressioni
Tissue specificityi
Specifically expressed in white adipose tissue and also weakly detected in heart and skeletal muscle (at protein level).3 Publications
Inductioni
Up-regulated by PPARG and during adipocyte differentiation.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000002831 Expressed in 145 organ(s), highest expression level in epididymal fat pad |
Genevisiblei | O88492 MM |
Interactioni
Protein-protein interaction databases
BioGridi | 208292, 2 interactors |
IntActi | O88492, 7 interactors |
MINTi | O88492 |
STRINGi | 10090.ENSMUSP00000002908 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 104 – 136 | 1Add BLAST | 33 | |
Repeati | 137 – 169 | 2Add BLAST | 33 | |
Repeati | 170 – 202 | 3Add BLAST | 33 | |
Repeati | 203 – 235 | 4Add BLAST | 33 | |
Repeati | 236 – 268 | 5Add BLAST | 33 | |
Repeati | 269 – 301 | 6Add BLAST | 33 | |
Repeati | 302 – 334 | 7Add BLAST | 33 | |
Repeati | 335 – 367 | 8Add BLAST | 33 | |
Repeati | 368 – 400 | 9Add BLAST | 33 | |
Repeati | 401 – 433 | 10Add BLAST | 33 | |
Repeati | 434 – 466 | 11Add BLAST | 33 | |
Repeati | 467 – 499 | 12Add BLAST | 33 | |
Repeati | 500 – 532 | 13Add BLAST | 33 | |
Repeati | 533 – 565 | 14Add BLAST | 33 | |
Repeati | 566 – 598 | 15Add BLAST | 33 | |
Repeati | 599 – 631 | 16Add BLAST | 33 | |
Repeati | 632 – 664 | 17Add BLAST | 33 | |
Repeati | 665 – 697 | 18Add BLAST | 33 | |
Repeati | 698 – 730 | 19Add BLAST | 33 | |
Repeati | 731 – 763 | 20Add BLAST | 33 | |
Repeati | 764 – 796 | 21Add BLAST | 33 | |
Repeati | 797 – 829 | 22Add BLAST | 33 | |
Repeati | 830 – 862 | 23Add BLAST | 33 | |
Repeati | 863 – 895 | 24Add BLAST | 33 | |
Repeati | 896 – 928 | 25Add BLAST | 33 | |
Repeati | 929 – 961 | 26Add BLAST | 33 | |
Repeati | 962 – 994 | 27Add BLAST | 33 | |
Repeati | 995 – 1027 | 28Add BLAST | 33 | |
Repeati | 1028 – 1060 | 29Add BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 104 – 1060 | 29 X 33 AA approximate tandem repeatAdd BLAST | 957 |
Sequence similaritiesi
Belongs to the perilipin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG410IHSW Eukaryota ENOG4112C4W LUCA |
GeneTreei | ENSGT00940000153161 |
HOGENOMi | HOG000113183 |
HOVERGENi | HBG099259 |
InParanoidi | O88492 |
KOi | K20254 |
OMAi | TGAVNMA |
OrthoDBi | 1318335at2759 |
TreeFami | TF328397 |
Family and domain databases
InterProi | View protein in InterPro IPR004279 Perilipin |
Pfami | View protein in Pfam PF03036 Perilipin, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: O88492-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSASGDGTRV PPKSKGKTLS SFFGSLPGFS SARNLVSHTH SSTSTKDLQT
60 70 80 90 100
ATDPSGTPAP SSKVSTNSQM AGDAAGLLQP SEQTAGDKDM GSFSVTSSED
110 120 130 140 150
AFSGVFGIMD AAKGMVQGGL GATQSALVGT KEAVSGGVMG AVGVAKGLVK
160 170 180 190 200
GGLDTSKNVL TNTKDTVTTG VMGAANMAKG TVQTGLDTTK SVVMGTKDTV
210 220 230 240 250
ATGLAGAVNV AKGTIQGGLD TTKSVVMGTK DTVTTGLTGA VNVAKGVVQG
260 270 280 290 300
GLDTTKSVVM GTKDTVTTGL TGAMNVAKGT AQMGIDTSKT VLTGTKDTVC
310 320 330 340 350
AGATGAINVA KGAAQGGLDT TKSVLIGTKD TVTTGLTGAV NVAKGAVQGG
360 370 380 390 400
LDTTKSVVMG TKDTVTTGLT GAMNVAKGTA QMGLGTSKTV LTGTKDTVCA
410 420 430 440 450
GLTGAINVAK GAAQGGLDTT KSVLMGTKDT VTTGLTGAVN VAKGTIQGGL
460 470 480 490 500
DTTKSVVMGT KDTVTTGLTG AVNVAKGTIQ GGLDTTKSVV MGTKDTVTTG
510 520 530 540 550
LTGAVNVAKG AAQGGLDTTK SVVMGTKDTV TTGLTGAMNV AKGTAQMGLG
560 570 580 590 600
TSKTVLTGTK DTVCAGLTGA INVAKGAAQG GLDTTKSVLM GTKDTVTTGL
610 620 630 640 650
TGAVNVAKGT IQGGLDTTKS VVMGTKDTVT TGLTGAVNVA KGAVQGGLDT
660 670 680 690 700
TKSVVMGTKD TVTTGLTGAL NVAKGTAQMG IDTSKTVLIG TKDTVCAGAT
710 720 730 740 750
GAINMAKGAA QGGLDTTKSV LMGTKDTVTT GLTGAINVAK GSAQGGLDTT
760 770 780 790 800
KSVLIGTKDT VTTGLTGALN VAKGTVQTGL DTSQRVLTGT KDNVYAGVTG
810 820 830 840 850
AVNVAKGTIQ GGLDTTKSVV MGTKDTVTTG LTGAVNVAKG AVQGGLDTTK
860 870 880 890 900
SVVMGTKDTV TTGLTGAMNV AKGTAQMGID TSKTVLTGTK DTVCAGLTGA
910 920 930 940 950
INVAKGATQG GLDTTKSVLM GTKDTVTTGL TGAINVAKGA AQGGLDTTKS
960 970 980 990 1000
VLLGTKDTVT TGLTGAANVA KETVQMGLDT SKNILMDTKD SICAGATGAI
1010 1020 1030 1040 1050
TVVKGAAQGG LDTSNAALTG TMDTAKGTVQ TSLDTSKHML IGMKDTVCAG
1060 1070 1080 1090 1100
VTSAMNMAKG IHKNTDTTRD TQSSVLAHSG NVATNAIHTG VHTVPSSLSG
1110 1120 1130 1140 1150
SHSIICHEPS IYRATNHGVG QAILTSTESL CCETSSFSDK YGLGHVTEPR
1160 1170 1180 1190 1200
ADTKTLVSGM ASSACAATRS VEECGQLAAT GFAALPDELK GLGDIFQPMT
1210 1220 1230 1240 1250
TEEQAQLAVS ESGPRVLSAD RGSYYIRLGD LAPSFRQRAF EHALSHIQHN
1260 1270 1280 1290 1300
QFQARAALAQ LQEAFQMTDM TMEAACGKLC SDQSLNTMVE AVGSHEMRAS
1310 1320 1330 1340 1350
VAQDRLCTLA HQLHAAYSSL VTSLQGLPEV QQQAGQARHS LCKLYGLVSS
1360 1370 1380 1390 1400
EAGSELQTEQ LAQSSAGVVE AWQGLEVLLE KLQQNPPLSW LVGPFTSMPC
GQL
Sequence cautioni
The sequence BAC37834 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD32564 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 241 | V → A in AAC23666 (PubMed:9624692).Curated | 1 | |
Sequence conflicti | 1121 | Q → H in AAC23666 (PubMed:9624692).Curated | 1 | |
Sequence conflicti | 1258 | L → V in AAC23666 (PubMed:9624692).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027279 | 206 – 601 | Missing in isoform 2. 1 PublicationAdd BLAST | 396 | |
Alternative sequenceiVSP_027280 | 1267 – 1271 | Missing in isoform 2. 1 Publication | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF064748 mRNA Translation: AAC23666.1 AK173286 Transcribed RNA Translation: BAD32564.1 Different initiation. CT009719 Genomic DNA No translation available. AK080156 mRNA Translation: BAC37834.1 Different initiation. |
CCDSi | CCDS79565.1 [O88492-1] |
PIRi | T17372 |
RefSeqi | NP_065593.2, NM_020568.3 [O88492-1] |
UniGenei | Mm.12966 |
Genome annotation databases
Ensembli | ENSMUST00000002908; ENSMUSP00000002908; ENSMUSG00000002831 [O88492-1] ENSMUST00000190703; ENSMUSP00000139859; ENSMUSG00000002831 [O88492-1] |
GeneIDi | 57435 |
KEGGi | mmu:57435 |
UCSCi | uc008day.2 mouse [O88492-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF064748 mRNA Translation: AAC23666.1 AK173286 Transcribed RNA Translation: BAD32564.1 Different initiation. CT009719 Genomic DNA No translation available. AK080156 mRNA Translation: BAC37834.1 Different initiation. |
CCDSi | CCDS79565.1 [O88492-1] |
PIRi | T17372 |
RefSeqi | NP_065593.2, NM_020568.3 [O88492-1] |
UniGenei | Mm.12966 |
3D structure databases
SMRi | O88492 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 208292, 2 interactors |
IntActi | O88492, 7 interactors |
MINTi | O88492 |
STRINGi | 10090.ENSMUSP00000002908 |
PTM databases
iPTMneti | O88492 |
PhosphoSitePlusi | O88492 |
SwissPalmi | O88492 |
Proteomic databases
jPOSTi | O88492 |
MaxQBi | O88492 |
PaxDbi | O88492 |
PeptideAtlasi | O88492 |
PRIDEi | O88492 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000002908; ENSMUSP00000002908; ENSMUSG00000002831 [O88492-1] ENSMUST00000190703; ENSMUSP00000139859; ENSMUSG00000002831 [O88492-1] |
GeneIDi | 57435 |
KEGGi | mmu:57435 |
UCSCi | uc008day.2 mouse [O88492-1] |
Organism-specific databases
CTDi | 729359 |
MGIi | MGI:1929709 Plin4 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | ENOG410IHSW Eukaryota ENOG4112C4W LUCA |
GeneTreei | ENSGT00940000153161 |
HOGENOMi | HOG000113183 |
HOVERGENi | HBG099259 |
InParanoidi | O88492 |
KOi | K20254 |
OMAi | TGAVNMA |
OrthoDBi | 1318335at2759 |
TreeFami | TF328397 |
Miscellaneous databases
PROi | PR:O88492 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000002831 Expressed in 145 organ(s), highest expression level in epididymal fat pad |
Genevisiblei | O88492 MM |
Family and domain databases
InterProi | View protein in InterPro IPR004279 Perilipin |
Pfami | View protein in Pfam PF03036 Perilipin, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | PLIN4_MOUSE | |
Accessioni | O88492Primary (citable) accession number: O88492 Secondary accession number(s): E9QN72, Q69Z80, Q8BNV5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 13, 2019 | |
This is version 112 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot