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Protein

Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific

Gene

Nsd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of negatively influencing transcription. May also positively influence transcription. Essential for early post-implantation development.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1963S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei1969S-adenosyl-L-methioninePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1441 – 1487PHD-type 1PROSITE-ProRule annotationAdd BLAST47
Zinc fingeri1488 – 1544PHD-type 2PROSITE-ProRule annotationAdd BLAST57
Zinc fingeri1605 – 1649PHD-type 3PROSITE-ProRule annotationAdd BLAST45
Zinc fingeri2016 – 2063PHD-type 4; atypicalPROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Developmental protein, Methyltransferase, Receptor, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC:2.1.1.43)
Alternative name(s):
H3-K36-HMTase
H4-K20-HMTase
Nuclear receptor-binding SET domain-containing protein 1
Short name:
NR-binding SET domain-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nsd1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1276545 Nsd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi803F → A or Y: No effect on interaction with nuclear receptors. 1 Publication1
Mutagenesisi804 – 805ST → AA: Abolishes interaction with nuclear receptors. 1 Publication2
Mutagenesisi806 – 807LL → AA: Strongly decreases interaction with liganded nuclear receptors. No effect on interaction with non-liganded nuclear receptors. 1 Publication2
Mutagenesisi1920C → S: Increases methyltransferase activity towards H3 and H4. Increases methyltransferase activity; when associated with E-1950. 1 Publication1
Mutagenesisi1950T → E: Does not affect histone methyltransferase activity. Increases methyltransferase activity; when associated with S-1920. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001860711 – 2588Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificAdd BLAST2588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei110PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei380PhosphoserineBy similarity1
Modified residuei383PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki802Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1408PhosphoserineCombined sources1
Modified residuei2267PhosphoserineBy similarity1
Modified residuei2360PhosphothreonineBy similarity1
Modified residuei2369PhosphoserineCombined sources1
Cross-linki2509Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O88491

MaxQB - The MaxQuant DataBase

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MaxQBi
O88491

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O88491

PeptideAtlas

More...
PeptideAtlasi
O88491

PRoteomics IDEntifications database

More...
PRIDEi
O88491

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O88491

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O88491

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the embryo and the outer region of the uterine decidua at early post-implantation E5.5 stage. Uniformly expressed in embryonic and extraembryonic tissues during gastrulation stage E7.5. Expressed differentially after stage 14.5 with highest expression in proliferating cells. Enriched in the telencephalic region of the brain, spinal cord, intestinal crypt, tooth buds, thymus and salivary glands at stage E16.5. Also expressed in the ossification region of developing bones and in the periosteum.1 Publication

Gene expression databases

CleanEx database of gene expression profiles

More...
CleanExi
MM_NSD1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AR DNA- and ligand-binding domains (By similarity). Interacts with the ligand-binding domains of RARA and THRA in the absence of ligand; in the presence of ligand the interaction is severely disrupted but some binding still occurs. Interacts with the ligand-binding domains of RXRA and ESRRA only in the presence of ligand. Interacts with ZNF496.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
O88491, 2 interactors

Molecular INTeraction database

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MINTi
O88491

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000097089

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12588
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O88491

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O88491

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1654 – 1716PWWPPROSITE-ProRule annotationAdd BLAST63
Domaini1788 – 1838AWSPROSITE-ProRule annotationAdd BLAST51
Domaini1840 – 1957SETPROSITE-ProRule annotationAdd BLAST118
Domaini1964 – 1980Post-SETPROSITE-ProRule annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1850 – 1852S-adenosyl-L-methionine bindingBy similarity3
Regioni1892 – 1895S-adenosyl-L-methionine bindingBy similarity4
Regioni1918 – 1919S-adenosyl-L-methionine bindingBy similarity2
Regioni1958 – 1964Inhibits enzyme activity in the absence of bound histoneBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi841 – 896Ser-richSequence analysisAdd BLAST56
Compositional biasi2213 – 2251Pro-richSequence analysisAdd BLAST39

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1441 – 1487PHD-type 1PROSITE-ProRule annotationAdd BLAST47
Zinc fingeri1488 – 1544PHD-type 2PROSITE-ProRule annotationAdd BLAST57
Zinc fingeri1605 – 1649PHD-type 3PROSITE-ProRule annotationAdd BLAST45
Zinc fingeri2016 – 2063PHD-type 4; atypicalPROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1081 Eukaryota
COG2940 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113857

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG007518

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O88491

Database for complete collections of gene phylogenies

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PhylomeDBi
O88491

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006560 AWS_dom
IPR003616 Post-SET_dom
IPR000313 PWWP_dom
IPR001214 SET_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

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Pfami
View protein in Pfam
PF00855 PWWP, 1 hit
PF00856 SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00570 AWS, 1 hit
SM00249 PHD, 5 hits
SM00508 PostSET, 1 hit
SM00293 PWWP, 1 hit
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57903 SSF57903, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51215 AWS, 1 hit
PS50868 POST_SET, 1 hit
PS50812 PWWP, 1 hit
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 2 hits
PS50016 ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O88491-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRTCELSRR NCLLSFSNPV NLDASEDKDS PFGNGQSNFS EPLNGCTMQL
60 70 80 90 100
PTAASGTSQN AYGQDSPSCY IPLRRLQDLA SMINVEYLSG SADGSESFQD
110 120 130 140 150
PAKSDSRAQS PIVCTSLSPG GPTALAMKQE PTCNNSPELQ LRVTKTTKNG
160 170 180 190 200
FLHFENFTGV DDADVDSEMD PEQPVTEDES IEEIFEETQT NATCNYEPKS
210 220 230 240 250
ENGVEVAMGS EQDSMPESRH GAVERPFLPL APQTEKQKNK QRSEVDGSNE
260 270 280 290 300
KTALLPAPTS LGDTNVTVEE QFNSINLSFQ DDPDSSPSPL GNMLEIPGTS
310 320 330 340 350
SPSTSQELPF VPQKILSKWE ASVGLAEQYD VPKGSKNQKC VSSSVKLDSE
360 370 380 390 400
EDMPFEDCTN DPDSEHLLLN GCLKSLAFDS EHSADEKEKP CAKSRVRKSS
410 420 430 440 450
DNIKRTSVKK DLVPFESRKE ERRGKIPDNL GLDFISGGVS DKQASNELSR
460 470 480 490 500
IANSLTGSST APGSFLFSSS VQNTAKTDFE TPDCDSLSGL SESALISKHS
510 520 530 540 550
GEKKKLHPGQ VCSSKVQLCY VGAGDEEKRS NSVSVSTTSD DGCSDLDPTE
560 570 580 590 600
HNSGFQNSVL GITDAFDKTE NALSVHKNET QYSRYPVTNR IKEKQKSLIT
610 620 630 640 650
NSHADHLMGS TKTMEPETAE LSQVNLSDLK ISSPIPKPQP EFRNDGLTTK
660 670 680 690 700
FSAPPGIRNE NPLTKGGLAN QTLLPLKCRQ PKFRSIKCKH KESPAVAETS
710 720 730 740 750
ATSEDLSLKC CSSDTNGSPL ANISKSGKGE GLKLLNNMHE KTRDSSDIET
760 770 780 790 800
AVVKHVLSEL KELSYRSLSE DVSDSGTAKA SKPLLFSSAS SQNHIPIEPD
810 820 830 840 850
YKFSTLLMML KDMHDSKTKE QRLMTAQNLA SYRTPDRGDC SSGSPVGTSK
860 870 880 890 900
VLVLGSSTPN SEKPGDSTQD SVHQSPGGGD SALSGELSSS LSSLASDKRE
910 920 930 940 950
LPACGKIRSN CIPRRNCGRA KPSSKLRETI SAQMVKPSVN PKALKTERKR
960 970 980 990 1000
KFSRLPAVTL AANRLGNKES GSVNGPSRGG AEDPGKEEPL QQMDLLRNED
1010 1020 1030 1040 1050
THFSDVHFDS KAKQSDPDKN LEKEPSFENR KGPELGSEMN TENDELHGVN
1060 1070 1080 1090 1100
QVVPKKRWQR LNQRRPKPGK RANRFREKEN SEGAFGVLLP ADAVQKARED
1110 1120 1130 1140 1150
YLEQRAPPTS KPEDSAADPN HGSHSESVAP RLNVCEKSSV GMGDVEKETG
1160 1170 1180 1190 1200
IPSLMPQTKL PEPAIRSEKK RLRKPSKWLL EYTEEYDQIF APKKKQKKVQ
1210 1220 1230 1240 1250
EQVHKVSSRC EDESLLARCQ PSAQNKQVDE NSLISTKEEP PVLEREAPFL
1260 1270 1280 1290 1300
EGPLAQSDLG VTHAELPQLT LSVPVAPEAS PRPALESEEL LVKTPGNYES
1310 1320 1330 1340 1350
KRQRKPTKKL LESNDLDPGF MPKKGDLGLS RKCFEASRSG NGIVESRATS
1360 1370 1380 1390 1400
HLKEFSGGTT KIFDKPRKRK RQRLVTARVH YKKVKKEDLT KDTPSSEGEL
1410 1420 1430 1440 1450
LIHRTAASPK EILEEGVEHD PGMSASKKLQ VERGGGAALK ENVCQNCEKL
1460 1470 1480 1490 1500
GELLLCEAQC CGAFHLECLG LPEMPRGKFI CNECHTGIHT CFVCKQSGED
1510 1520 1530 1540 1550
VKRCLLPLCG KFYHEECVQK YPPTVTQNKG FRCPLHICIT CHAANPANVS
1560 1570 1580 1590 1600
ASKGRLMRCV RCPVAYHAND FCLAAGSKIL ASNSIICPNH FTPRRGCRNH
1610 1620 1630 1640 1650
EHVNVSWCFV CSEGGSLLCC DSCPAAFHRE CLNIDIPEGN WYCNDCKAGK
1660 1670 1680 1690 1700
KPHYREIVWV KVGRYRWWPA EICHPRAVPS NIDKMRHDVG EFPVLFFGSN
1710 1720 1730 1740 1750
DYLWTHQARV FPYMEGDVSS KDKMGKGVDG TYKKALQEAA ARFEELKARK
1760 1770 1780 1790 1800
ELRQLQEDRK NDKKPPPYKH IKVNRPIGRV QIFTADLSEI PRCNCKATDE
1810 1820 1830 1840 1850
NPCGIDSECI NRMLLYECHP TVCPAGVRCQ NQCFSKRQYP DVEIFRTLQR
1860 1870 1880 1890 1900
GWGLRTKTDI KKGEFVNEYV GELIDEEECR ARIRYAQEHD ITNFYMLTLD
1910 1920 1930 1940 1950
KDRIIDAGPK GNYARFMNHC CQPNCETQKW SVNGDTRVGL FALSDIKAGT
1960 1970 1980 1990 2000
ELTFNYNLEC LGNGKTVCKC GAPNCSGFLG VRPKNQPIVT EEKSRKFKRK
2010 2020 2030 2040 2050
PHGKRRSQGE VTKEREDECF SCGDAGQLVS CKKPGCPKVY HADCLNLTKR
2060 2070 2080 2090 2100
PAGKWECPWH QCDVCGKEAA SFCEMCPSSF CKQHREGMLF ISKLDGRLSC
2110 2120 2130 2140 2150
TEHDPCGPNP LEPGEIREYV PPTATSPPSP GTQPKEQSSE MATQGPKKSD
2160 2170 2180 2190 2200
QPPTDATQLL PLSKKALTGS CQRPLLPERP PERTDSSSHL LDRIRDLAGS
2210 2220 2230 2240 2250
GTKSQSLVSS QRPQDRPPAK EGPRPQPPDR ASPMTRPSSS PSVSSLPLER
2260 2270 2280 2290 2300
PLRMTDSRLD KSIGAASPKS QAVEKTPAST GLRLSSPDRL LTTNSPKPQI
2310 2320 2330 2340 2350
SDRPPEKSHA SLTQRLPPPE KVLSAVVQSL VAKEKALRPV DQNTQSKHRP
2360 2370 2380 2390 2400
AVVMDLIDLT PRQKERAASP QEVTPQADEK TAMLESSSWP SSKGLGHIPR
2410 2420 2430 2440 2450
ATEKISVSES LQPSGKVAAP SEHPWQAVKS LTHARFLSPP SAKAFLYESA
2460 2470 2480 2490 2500
TQASGRTPVG AEQTPGPPSP APGLVKQVKQ LSRGLTAKSG QSFRSLGKIS
2510 2520 2530 2540 2550
ASLPNEEKKL TTTEQSPWGL GKASPGAGLW PIVAGQTLAQ ACWSAGGTQT
2560 2570 2580
LAQTCWSLGR GQDPKPENAI QALNQAPSSR KCADSEKK
Length:2,588
Mass (Da):284,084
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i145DFCF2F285A959
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QAE4E9QAE4_MOUSE
Histone-lysine N-methyltransferase,...
Nsd1
2,691Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YE36A0A286YE36_MOUSE
Histone-lysine N-methyltransferase,...
Nsd1 mCG_3208
2,588Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YDS9A0A286YDS9_MOUSE
Histone-lysine N-methyltransferase,...
Nsd1
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YDN7A0A286YDN7_MOUSE
Histone-lysine N-methyltransferase,...
Nsd1
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF064553 mRNA Translation: AAC40182.1
AK082820 mRNA Translation: BAC38635.1
AK004485 mRNA Translation: BAB23326.1

Protein sequence database of the Protein Information Resource

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PIRi
T14342

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.168965

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064553 mRNA Translation: AAC40182.1
AK082820 mRNA Translation: BAC38635.1
AK004485 mRNA Translation: BAB23326.1
PIRiT14342
UniGeneiMm.168965

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NAANMR-A2014-2104[»]
ProteinModelPortaliO88491
SMRiO88491
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88491, 2 interactors
MINTiO88491
STRINGi10090.ENSMUSP00000097089

PTM databases

iPTMnetiO88491
PhosphoSitePlusiO88491

Proteomic databases

EPDiO88491
MaxQBiO88491
PaxDbiO88491
PeptideAtlasiO88491
PRIDEiO88491

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1276545 Nsd1

Phylogenomic databases

eggNOGiKOG1081 Eukaryota
COG2940 LUCA
HOGENOMiHOG000113857
HOVERGENiHBG007518
InParanoidiO88491
PhylomeDBiO88491

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Nsd1 mouse

Protein Ontology

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PROi
PR:O88491

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

CleanExiMM_NSD1

Family and domain databases

Gene3Di3.30.40.10, 4 hits
InterProiView protein in InterPro
IPR006560 AWS_dom
IPR003616 Post-SET_dom
IPR000313 PWWP_dom
IPR001214 SET_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00855 PWWP, 1 hit
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00570 AWS, 1 hit
SM00249 PHD, 5 hits
SM00508 PostSET, 1 hit
SM00293 PWWP, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF57903 SSF57903, 3 hits
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS50868 POST_SET, 1 hit
PS50812 PWWP, 1 hit
PS50280 SET, 1 hit
PS01359 ZF_PHD_1, 2 hits
PS50016 ZF_PHD_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNSD1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88491
Secondary accession number(s): Q8C480, Q9CT70
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 1, 1998
Last modified: December 5, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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