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Protein

Tumor necrosis factor receptor superfamily member 17

Gene

Tnfrsf17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • lymphocyte homeostasis Source: MGI
  • signal transduction Source: InterPro

Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-MMU-5669034 TNFs bind their physiological receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 17
Alternative name(s):
B-cell maturation protein
CD_antigen: CD269
Gene namesi
Name:Tnfrsf17
Synonyms:Bcm, Bcma
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1343050 Tnfrsf17

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49ExtracellularSequence analysisAdd BLAST49
Transmembranei50 – 70Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini71 – 185CytoplasmicSequence analysisAdd BLAST115

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1250345

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000589361 – 185Tumor necrosis factor receptor superfamily member 17Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi5 ↔ 18By similarity
Disulfide bondi21 ↔ 32By similarity
Disulfide bondi25 ↔ 36By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO88472
PRIDEiO88472

PTM databases

PhosphoSitePlusiO88472

Expressioni

Tissue specificityi

Detected in spleen, thymus, bone marrow and heart, and at lower levels in kidney and lung.

Gene expression databases

BgeeiENSMUSG00000022496 Expressed in 31 organ(s), highest expression level in kidney blood vessel
GenevisibleiO88472 MM

Interactioni

Subunit structurei

Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023140

Structurei

3D structure databases

ProteinModelPortaliO88472
SMRiO88472
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 36TNFR-CysAdd BLAST33

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW7R Eukaryota
ENOG4111D91 LUCA
GeneTreeiENSGT00390000011914
HOGENOMiHOG000129926
HOVERGENiHBG062796
InParanoidiO88472
KOiK05153
OMAiACKPCHL
OrthoDBiEOG091G0S5G
PhylomeDBiO88472
TreeFamiTF337842

Family and domain databases

CDDicd13414 TNFRSF17, 1 hit
InterProiView protein in InterPro
IPR015337 BCMA_Tall-1-bd
IPR022320 TNFR_17
PfamiView protein in Pfam
PF09257 BCMA-Tall_bind, 1 hit
PIRSFiPIRSF011859 BCMA_Tall-1_bd, 1 hit
PRINTSiPR01967 TNFACTORR17

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O88472-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQQCFHSEY FDSLLHACKP CHLRCSNPPA TCQPYCDPSV TSSVKGTYTV
60 70 80 90 100
LWIFLGLTLV LSLALFTISF LLRKMNPEAL KDEPQSPGQL DGSAQLDKAD
110 120 130 140 150
TELTRIRAGD DRIFPRSLEY TVEECTCEDC VKSKPKGDSD HFFPLPAMEE
160 170 180
GATILVTTKT GDYGKSSVPT ALQSVMGMEK PTHTR
Length:185
Mass (Da):20,442
Last modified:November 1, 1998 - v1
Checksum:i8806352B4FD26A8E
GO
Isoform 2 (identifier: O88472-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-91: Missing.

Show »
Length:180
Mass (Da):19,932
Checksum:iE774EEB8D12FF79F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00650787 – 91Missing in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061505 mRNA Translation: AAC23799.1
AK020247 mRNA Translation: BAB32038.1
BC027519 mRNA Translation: AAH27519.1
CCDSiCCDS27962.1 [O88472-1]
RefSeqiNP_035738.1, NM_011608.1 [O88472-1]
UniGeneiMm.12935

Genome annotation databases

EnsembliENSMUST00000023140; ENSMUSP00000023140; ENSMUSG00000022496 [O88472-1]
GeneIDi21935
KEGGimmu:21935
UCSCiuc007yfh.1 mouse [O88472-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061505 mRNA Translation: AAC23799.1
AK020247 mRNA Translation: BAB32038.1
BC027519 mRNA Translation: AAH27519.1
CCDSiCCDS27962.1 [O88472-1]
RefSeqiNP_035738.1, NM_011608.1 [O88472-1]
UniGeneiMm.12935

3D structure databases

ProteinModelPortaliO88472
SMRiO88472
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023140

Chemistry databases

ChEMBLiCHEMBL1250345

PTM databases

PhosphoSitePlusiO88472

Proteomic databases

PaxDbiO88472
PRIDEiO88472

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023140; ENSMUSP00000023140; ENSMUSG00000022496 [O88472-1]
GeneIDi21935
KEGGimmu:21935
UCSCiuc007yfh.1 mouse [O88472-1]

Organism-specific databases

CTDi608
MGIiMGI:1343050 Tnfrsf17

Phylogenomic databases

eggNOGiENOG410IW7R Eukaryota
ENOG4111D91 LUCA
GeneTreeiENSGT00390000011914
HOGENOMiHOG000129926
HOVERGENiHBG062796
InParanoidiO88472
KOiK05153
OMAiACKPCHL
OrthoDBiEOG091G0S5G
PhylomeDBiO88472
TreeFamiTF337842

Enzyme and pathway databases

ReactomeiR-MMU-5669034 TNFs bind their physiological receptors

Miscellaneous databases

PROiPR:O88472
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022496 Expressed in 31 organ(s), highest expression level in kidney blood vessel
GenevisibleiO88472 MM

Family and domain databases

CDDicd13414 TNFRSF17, 1 hit
InterProiView protein in InterPro
IPR015337 BCMA_Tall-1-bd
IPR022320 TNFR_17
PfamiView protein in Pfam
PF09257 BCMA-Tall_bind, 1 hit
PIRSFiPIRSF011859 BCMA_Tall-1_bd, 1 hit
PRINTSiPR01967 TNFACTORR17
ProtoNetiSearch...

Entry informationi

Entry nameiTNR17_MOUSE
AccessioniPrimary (citable) accession number: O88472
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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