Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Forkhead box protein L2

Gene

Foxl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Is a regulator of CYP19 expression. Is a transcriptional repressor of STAR. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element.5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi50 – 144Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-3232118 SUMOylation of transcription factors

Protein family/group databases

MoonDBiO88470 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein L2
Alternative name(s):
Pituitary forkhead factor
Short name:
P-Frk
Gene namesi
Name:Foxl2
Synonyms:Pfrk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1349428 Foxl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918621 – 375Forkhead box protein L2Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki25Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei33PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiO88470
PRIDEiO88470

PTM databases

PhosphoSitePlusiO88470

Expressioni

Tissue specificityi

Expressed in the mesenchyme of developing eyelids. Expressed in ovaries throughout development and adulthood, localized to the undifferentiated granulosa cells in small and medium follicles as well as cumulus cells of preovulatory follicles. Expressed in the pituitary.2 Publications

Gene expression databases

BgeeiENSMUSG00000050397 Expressed in 22 organ(s), highest expression level in eyelid
CleanExiMM_FOXL2
ExpressionAtlasiO88470 baseline and differential
GenevisibleiO88470 MM

Interactioni

Subunit structurei

Interacts with ESR1. Interacts with UBE2I/UBC9 (By similarity). Interacts with SMAD3. Interacts with DDX20.By similarity4 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205068, 25 interactors
IntActiO88470, 2 interactors
STRINGi10090.ENSMUSP00000053297

Structurei

3D structure databases

ProteinModelPortaliO88470
SMRiO88470
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi217 – 230Poly-AlaAdd BLAST14
Compositional biasi280 – 287Poly-Pro8
Compositional biasi300 – 303Poly-Ala4

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000218632
HOVERGENiHBG051651
InParanoidiO88470
KOiK09405
OMAiSMMHCSY
OrthoDBiEOG091G0ESH
PhylomeDBiO88470
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

O88470-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMASYPEPED TAGTLLAPES GRAVKEAEAS PPSPGKGGGT TPEKPDPAQK
60 70 80 90 100
PPYSYVALIA MAIRESAEKR LTLSGIYQYI IAKFPFYEKN KKGWQNSIRH
110 120 130 140 150
NLSLNECFIK VPREGGGERK GNYWTLDPAC EDMFEKGNYR RRRRMKRPFR
160 170 180 190 200
PPPAHFQPGK GLFGSGGAAG GCGVPGAGAD GYGYLAPPKY LQSGFLNNSW
210 220 230 240 250
PLPQPPSPMP YASCQMAAAA AAAAAAAAAA GPGSPGAAAV VKGLAGPAAS
260 270 280 290 300
YGPYSRVQSM ALPPGVVNSY NGLGGPPAAP PPPPPPPHPH PHPHAHHLHA
310 320 330 340 350
AAAPPPAPPH HGAAAPPPGQ LSPASPATAA PPAPAPTSAP GLQFACARQP
360 370
ELAMMHCSYW DHDSKTGALH SRLDL
Length:375
Mass (Da):38,887
Last modified:March 15, 2005 - v2
Checksum:iF920C8407686C4B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522275 Genomic DNA Translation: AAN04088.1
AF060873 mRNA Translation: AAC27508.1
CCDSiCCDS23430.1
RefSeqiNP_036150.1, NM_012020.2
UniGeneiMm.151239

Genome annotation databases

EnsembliENSMUST00000051312; ENSMUSP00000053297; ENSMUSG00000050397
GeneIDi26927
KEGGimmu:26927
UCSCiuc009rdr.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522275 Genomic DNA Translation: AAN04088.1
AF060873 mRNA Translation: AAC27508.1
CCDSiCCDS23430.1
RefSeqiNP_036150.1, NM_012020.2
UniGeneiMm.151239

3D structure databases

ProteinModelPortaliO88470
SMRiO88470
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205068, 25 interactors
IntActiO88470, 2 interactors
STRINGi10090.ENSMUSP00000053297

Protein family/group databases

MoonDBiO88470 Predicted

PTM databases

PhosphoSitePlusiO88470

Proteomic databases

PaxDbiO88470
PRIDEiO88470

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051312; ENSMUSP00000053297; ENSMUSG00000050397
GeneIDi26927
KEGGimmu:26927
UCSCiuc009rdr.2 mouse

Organism-specific databases

CTDi668
MGIiMGI:1349428 Foxl2

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000218632
HOVERGENiHBG051651
InParanoidiO88470
KOiK09405
OMAiSMMHCSY
OrthoDBiEOG091G0ESH
PhylomeDBiO88470
TreeFamiTF316127

Enzyme and pathway databases

ReactomeiR-MMU-3232118 SUMOylation of transcription factors

Miscellaneous databases

PROiPR:O88470
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050397 Expressed in 22 organ(s), highest expression level in eyelid
CleanExiMM_FOXL2
ExpressionAtlasiO88470 baseline and differential
GenevisibleiO88470 MM

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOXL2_MOUSE
AccessioniPrimary (citable) accession number: O88470
Secondary accession number(s): Q8K3X9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 15, 2005
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again