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Protein

Zinc finger protein 106

Gene

Znf106

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein (PubMed:27418600, PubMed:28072389). Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA (PubMed:28072389). Essential for maintenance of peripheral motor neuron and skeletal muscle function (PubMed:26604141, PubMed:27418600, PubMed:28072389). Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4 (PubMed:26604141, PubMed:27418600). Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism (PubMed:26604141).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri5 – 29C2H2-type 1; atypicalAdd BLAST25
Zinc fingeri43 – 67C2H2-type 2; atypicalAdd BLAST25
Zinc fingeri1818 – 1843C2H2-type 3; atypicalAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • opioid peptide activity Source: MGI
  • RNA binding Source: UniProtKB-KW
  • SH3 domain binding Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 106
Short name:
Zfp-106
Alternative name(s):
H3a minor histocompatibility antigen
Son of insulin receptor mutant
Zinc finger protein 474
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Znf106
Synonyms:H3a, Sh3bp3, Sirm, Zfp106, Znf474
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1270153 Zfp106

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000514681 – 1888Zinc finger protein 106Add BLAST1888

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki91Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki155Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki265Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki309Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki375Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki384Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki390Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki435Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki469Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki479Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki524Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki534Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki544Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki577Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki620Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei657PhosphoserineBy similarity1
Modified residuei677PhosphoserineBy similarity1
Cross-linki687Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki700Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki721Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki738Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki758Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki792Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki824Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei876PhosphoserineCombined sources1
Modified residuei878PhosphoserineCombined sources1
Modified residuei881PhosphoserineBy similarity1
Modified residuei909PhosphoserineBy similarity1
Cross-linki921Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei953PhosphoserineCombined sources1
Modified residuei1036PhosphothreonineBy similarity1
Modified residuei1040PhosphoserineCombined sources1
Modified residuei1041PhosphoserineCombined sources1
Modified residuei1046PhosphoserineBy similarity1
Modified residuei1291PhosphoserineCombined sources1
Modified residuei1293PhosphoserineCombined sources1
Modified residuei1296PhosphoserineCombined sources1
Cross-linki1310Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1313PhosphoserineBy similarity1
Cross-linki1335Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1339PhosphoserineCombined sources1
Modified residuei1381PhosphoserineCombined sources1
Modified residuei1383PhosphothreonineCombined sources1
Cross-linki1391Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1403Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1406Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1460Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1474PhosphoserineBy similarity1
Cross-linki1492Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1509Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1590Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1742Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1869Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by FYN in vitro.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O88466

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O88466

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O88466

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O88466

PeptideAtlas

More...
PeptideAtlasi
O88466

PRoteomics IDEntifications database

More...
PRIDEi
O88466

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O88466

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O88466

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with strongest expression in skeletal muscle, heart and brain (at protein level) (PubMed:9507006, PubMed:26604141, PubMed:27418600, PubMed:28072389). Detected in spinal cord motor neurons (PubMed:28072389).4 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During embryonic stages E12.5 and E15.5, highly expressed in skeletal muscle and cardiac tissue.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Isoform 3: Down-regulated in response to insulin.1 Publication

Gene expression databases

CleanEx database of gene expression profiles

More...
CleanExi
MM_ZFP106

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KNOP1 (PubMed:15833274). Interacts with TARDBP and NUP107 (PubMed:28072389). Interacts (via N-terminus) with RBM39 (PubMed:27418600). Interacts with the SH3 domains of FYN and GRB2 (PubMed:9507006).4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
203204, 4 interactors

Protein interaction database and analysis system

More...
IntActi
O88466, 1 interactor

Molecular INTeraction database

More...
MINTi
O88466

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000055602

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1534 – 1573WD 1Add BLAST40
Repeati1575 – 1618WD 2Add BLAST44
Repeati1659 – 1700WD 3Add BLAST42
Repeati1703 – 1742WD 4Add BLAST40
Repeati1743 – 1780WD 5Add BLAST38
Repeati1783 – 1820WD 6Add BLAST38

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 29C2H2-type 1; atypicalAdd BLAST25
Zinc fingeri43 – 67C2H2-type 2; atypicalAdd BLAST25
Zinc fingeri1818 – 1843C2H2-type 3; atypicalAdd BLAST26

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITHG Eukaryota
ENOG410ZV7Z LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079376

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O88466

TreeFam database of animal gene trees

More...
TreeFami
TF105569

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018391 PQQ_beta_propeller_repeat
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00564 PQQ, 4 hits
SM00320 WD40, 6 hits
SM00355 ZnF_C2H2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O88466-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRERKCILC HIVYGSKKEM DEHMRSMLHH RELENLKGRD ISHECRVCRV
60 70 80 90 100
TEVGLSAYAK HISGQLHKDN VDAQEREDDG KEEEEEEYFD KELVQLIQER
110 120 130 140 150
KEQSRQDEPP SNSQEVNSDD RQPQWRREDR IPYQDRESYS QPPRHHRGPP
160 170 180 190 200
QRDWKWEKDG FNSTRKNSFP HSLRNSGGPR GSSVWHKGAT RGSSTWFLNH
210 220 230 240 250
SNSGGGWHSN NGMVDWNYNG TGRNSSWHSE GTGGFPSWHM NNSNGNWKSS
260 270 280 290 300
VRGTNSWNYN GLGDKFQQGR NRNPNYQMED MTKMWNKKSN KPSKYSQERC
310 320 330 340 350
KWQRQDRDKA AKYRSPPEGY ASDTFPSEGL LEFNFEQRES QTTKQTDTAA
360 370 380 390 400
SKINGKNGTK ARDKFRRWTP YPSQKTLDLQ SALKEVIGSK SDTLEKPLFN
410 420 430 440 450
FSLITAGLRK PVDKTSNPPV IKTQKAGPPG SPSHKAISDG TAFCEVARAC
460 470 480 490 500
SITEQSEPHQ KSNKIPLLKS PLLPLPTPKS GPHKQNLKNR SKNKETKSFP
510 520 530 540 550
SGDHSHLLNT STLEGSHGSS YTSKSLGLCP RVLKENKTVS GTQKEPDEKL
560 570 580 590 600
NNTSQKAQDT VLQCPKTLQN PLPTTPKRME NDAKESSVEE SAKDSLSIES
610 620 630 640 650
QPHSAGNSAM TSDAENHGIK SEGVASLTTE VVSCSTHTVD KEQGSQIPGT
660 670 680 690 700
PENLSTSPRN STVLQKEAEV QVSAATSPHS GLLLDLKTSL EDAQDNNLVK
710 720 730 740 750
SDGPFETESF EDTSLDTELQ KPDLNNQPPG TLLPELSKLG FPASLQRDLS
760 770 780 790 800
RHISLKSKTG THLPEPNLNS ARRIRNVSGH RKNETEKESG LKPTLRQILN
810 820 830 840 850
ASRRNVNWEQ VIQQVTKKKQ ELGKGLPRFG IEMVPLVQNE QEVLDLDEEP
860 870 880 890 900
DLSSLEGFQW EGVSIPSSSG LARKRSLSES SVVMDRAPVY SFFTGEGTGK
910 920 930 940 950
ENEAQQSPSP NTALSAAQSQ KTAMYLEQEV APLTPSVGTG ERVGNIPTQR
960 970 980 990 1000
RHSAQLPSGH IMPVMHSARD LHSQERSTPL SERHAQESTG EGNSLSSNAS
1010 1020 1030 1040 1050
SGHAVSSLAD AATDSSCTSG AEQTDGHSIR KKRRATGDGS SPELPSLERK
1060 1070 1080 1090 1100
NKRRKIKGKK ERSQVDQLLT ISLREEELSK SLQCMDNKLL QARAALQTAY
1110 1120 1130 1140 1150
VEVQRLLVLK QQITVEMSAL RTHRIQILQG LQETYEPPEH PDQAPCSLIS
1160 1170 1180 1190 1200
REQRNSRSQT SFETALLPAP FFPGFLDPPP SHASLPSPGN PLQITMSTFQ
1210 1220 1230 1240 1250
AHGTAPDSSV QIKQEPMSPE QEGNMNALPQ GCASNVSKEL LQTNRVVDDG
1260 1270 1280 1290 1300
SSVYPAIPAV IASESTENCQ EVSKDLNFSV EQGNSRSKGN SPSCQSPDLP
1310 1320 1330 1340 1350
GINRGEETAK GSSGSEACSS SFLRLSFTPE TPAEKETQSP ADQPEQQAES
1360 1370 1380 1390 1400
TLASAETRGS KKKKKLRKKK TLRATHVPEN SDTEQDVFTA KPARKVKTAK
1410 1420 1430 1440 1450
AAKGAKVTTS QTGQEQGTAR DEPDSDSSLE VLEVTNPQLE VVAIDTSESG
1460 1470 1480 1490 1500
DEKPDSPSKK DAWIAAEQNP IETSRSGCDE VSSTSELGTR YKDGVPVSVA
1510 1520 1530 1540 1550
ETQTVISIKA SKHSSEISSE PGDDEEPTEG SFEGHQAAVN AIQIFGNFLY
1560 1570 1580 1590 1600
TCSADTTVRV YNLVSRKCVG VFEGHTSKVN CLLVTHTSGK SSVLYTGSSD
1610 1620 1630 1640 1650
HTIRCYNIKT RECMEQLQLE DRVLCLHNRW RTLYAGLANG TVVTFDIKNN
1660 1670 1680 1690 1700
KRQEIFECHG PRAVSCLATA QEGARKLLVV GSYDCTISVR DARNGLLLRT
1710 1720 1730 1740 1750
LEGHSKTVLC MKVVNDLVFS GSSDQSVHAH NIHTGELVRI YKGHNHAVTV
1760 1770 1780 1790 1800
VNILGKVMVT ACLDKFVRVY ELQSHDRLQV YGGHKDMIMC MTIHKSVIYT
1810 1820 1830 1840 1850
GCYDGSIQAV RLNLMQNYRC WWYGCTLIFG VVDHLKQHLL TDHTNPNFQT
1860 1870 1880
LKCRWRNCDA FFTARKGSKQ DVAGHIERHA EDDSKIDS
Length:1,888
Mass (Da):208,964
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73C37BF7A188A061
GO
Isoform 2 (identifier: O88466-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1245-1246: RV → SK
     1247-1888: Missing.

Note: May be due to an intron retention. No experimental confirmation available.
Show »
Length:1,246
Mass (Da):138,487
Checksum:i91B70BC748EB0E44
GO
Isoform 3 (identifier: O88466-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-839: FGIEMVPLVQN → CVPLIPVLGFF
     840-1888: Missing.

Note: May be due to an intron retention. No experimental confirmation available.
Show »
Length:839
Mass (Da):94,224
Checksum:i5FC8D1DC7BCF2503
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GML0R4GML0_MOUSE
Zinc finger protein 106
Zfp106
1,888Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q7S1E9Q7S1_MOUSE
Zinc finger protein 106
Zfp106
1,865Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PVH6E9PVH6_MOUSE
Zinc finger protein 106
Zfp106
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SID8F6SID8_MOUSE
Zinc finger protein 106
Zfp106
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QFS1F6QFS1_MOUSE
Zinc finger protein 106
Zfp106
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UL00F6UL00_MOUSE
Zinc finger protein 106
Zfp106
264Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB96870 differs from that shown. Reason: Frameshift at positions 805 and 816.Curated
The sequence BAC26389 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19Missing in AAH25424 (PubMed:15489334).Curated1
Sequence conflicti1263S → P in AAD04329 (PubMed:9846490).Curated1
Sequence conflicti1608I → V in AAD04327 (PubMed:9846490).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti253G → S in strain: C57BL/6 and Swiss Webster. 1
Natural varianti262L → P in strain: C57BL/6 and Swiss Webster. 1
Natural varianti269G → D in strain: Swiss Webster. 1
Natural varianti293S → T in strain: Swiss Webster. 1
Natural varianti447A → P in strain: C57BL/6 and Swiss Webster. 1
Natural varianti451S → P in strain: C57BL/6 and Swiss Webster. 1
Natural varianti526L → R in strain: C57BL/6 and Swiss Webster. 1
Natural varianti552N → S in strain: C57BL/6. 1
Natural varianti579M → T in strain: C57BL/6. 1
Natural varianti656T → A in strain: C57BL/10. 1
Natural varianti659R → C in strain: C57BL/10. 1
Natural varianti685D → N in strain: C57BL/10. 1
Natural varianti706E → G in strain: Swiss Webster. 1
Natural varianti711E → G in strain: Swiss Webster. 1
Natural varianti717T → A in strain: C57BL/10. 1
Natural varianti778S → C in strain: 129/J. 1
Natural varianti996S → T in strain: C57BL/6. 1
Natural varianti1188P → S in strain: C57BL/6. 1 Publication1
Natural varianti1196 – 1199MSTF → TCTL in strain: C57BL/6. 4

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011438829 – 839FGIEMVPLVQN → CVPLIPVLGFF in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_011439840 – 1888Missing in isoform 3. 1 PublicationAdd BLAST1049
Alternative sequenceiVSP_0114401245 – 1246RV → SK in isoform 2. 1 Publication2
Alternative sequenceiVSP_0114411247 – 1888Missing in isoform 2. 1 PublicationAdd BLAST642

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF067397 Genomic DNA Translation: AAD04340.1
AF067398 Genomic DNA Translation: AAD04341.1
AF067399 Genomic DNA Translation: AAD04342.1
AL772299, AL935121 Genomic DNA Translation: CAM15725.1
AL935121, AL772299 Genomic DNA Translation: CAM24138.1
AF060243, AF060242 Genomic DNA Translation: AAG27479.1
AF060244 mRNA Translation: AAD04327.1
AF060245 mRNA Translation: AAD04328.1
AF060246 mRNA Translation: AAD04329.1
AF060247 mRNA Translation: AAD04330.1
BC025424 mRNA Translation: AAH25424.1
U59739 mRNA Translation: AAB96870.1 Frameshift.
AK029313 mRNA Translation: BAC26389.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16621.1 [O88466-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T14273

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.485295

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067397 Genomic DNA Translation: AAD04340.1
AF067398 Genomic DNA Translation: AAD04341.1
AF067399 Genomic DNA Translation: AAD04342.1
AL772299, AL935121 Genomic DNA Translation: CAM15725.1
AL935121, AL772299 Genomic DNA Translation: CAM24138.1
AF060243, AF060242 Genomic DNA Translation: AAG27479.1
AF060244 mRNA Translation: AAD04327.1
AF060245 mRNA Translation: AAD04328.1
AF060246 mRNA Translation: AAD04329.1
AF060247 mRNA Translation: AAD04330.1
BC025424 mRNA Translation: AAH25424.1
U59739 mRNA Translation: AAB96870.1 Frameshift.
AK029313 mRNA Translation: BAC26389.1 Different initiation.
CCDSiCCDS16621.1 [O88466-1]
PIRiT14273
UniGeneiMm.485295

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

BioGridi203204, 4 interactors
IntActiO88466, 1 interactor
MINTiO88466
STRINGi10090.ENSMUSP00000055602

PTM databases

iPTMnetiO88466
PhosphoSitePlusiO88466

Proteomic databases

EPDiO88466
jPOSTiO88466
MaxQBiO88466
PaxDbiO88466
PeptideAtlasiO88466
PRIDEiO88466

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1270153 Zfp106

Phylogenomic databases

eggNOGiENOG410ITHG Eukaryota
ENOG410ZV7Z LUCA
HOVERGENiHBG079376
InParanoidiO88466
TreeFamiTF105569

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Zfp106 mouse

Protein Ontology

More...
PROi
PR:O88466

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

CleanExiMM_ZFP106

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR018391 PQQ_beta_propeller_repeat
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00564 PQQ, 4 hits
SM00320 WD40, 6 hits
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN106_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88466
Secondary accession number(s): A2AKH3
, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 27, 2011
Last modified: January 16, 2019
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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