UniProtKB - O88455 (DHCR7_MOUSE)

BLAST

>sp|O88455|DHCR7_MOUSE 7-dehydrocholesterol reductase OS=Mus musculus OX=10090 GN=Dhcr7 PE=1 SV=1
MASKSQHNAPKVKSPNGKAGSQGQWGRAWEVDWFSLASIIFLLLFAPFIVYYFIMACDQY
SCSLTAPALDIATGHASLADIWAKTPPVTAKAAQLYALWVSFQVLLYSWLPDFCHRFLPG
YVGGVQEGAITPAGVVNKYEVNGLQAWLITHILWFVNAYLLSWFSPTIIFDNWIPLLWCA
NILGYAVSTFAMIKGYLFPTSAEDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPG
IVAWTLINLSFAAKQQELYGHVTNSMILVNVLQAIYVLDFFWNETWYLKTIDICHDHFGW
YLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPNALGILLLGLVGYYIFRMTNHQKDLFRRT
DGRCLIWGKKPKAIECSYTSADGLKHHSKLLVSGFWGVARHFNYTGDLMGSLAYCLACGG
GHLLPYFYIIYMTILLTHRCLRDEHRCANKYGRDWERYTAAVPYRLLPGIF

Align
Format
Add to basket Added to basket
History
Entry version 137 (12 Sep 2018)
Sequence version 1 (01 Nov 1998)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

7-dehydrocholesterol reductase

Gene

Dhcr7

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).

Catalytic activityⁱ

Cholesterol + NADP⁺ = cholesta-5,7-dien-3-beta-ol + NADPH.

Pathwayⁱ: cholesterol biosynthesis

This protein is involved in the pathway cholesterol biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway cholesterol biosynthesis and in Steroid biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	354	NADPBy similarity	1
Binding siteⁱ	358	NADPBy similarity	1
Binding siteⁱ	391	NADP; via amide nitrogen and carbonyl oxygenBy similarity	1
Binding siteⁱ	396	NADPBy similarity	1
Binding siteⁱ	443	NADPBy similarity	1
Binding siteⁱ	458	NADPBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	403 – 404	NADPBy similarity		2
Nucleotide bindingⁱ	447 – 451	NADPBy similarity		5

GO - Molecular functionⁱ

7-dehydrocholesterol reductase activity
Source: MGI
Inferred from direct assayⁱ
- 11792727
NADP binding Source: UniProtKB
sterol delta7 reductase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood vessel development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15005800
brassinosteroid biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15005800
cholesterol biosynthetic process Source: MGI
lung development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15005800
multicellular organism growth
Source: MGI
Inferred from mutant phenotypeⁱ
- 15005800
post-embryonic development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15005800
regulation of cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15005800
regulation of cholesterol biosynthetic process Source: MGI
sterol biosynthetic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 15005800

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
Ligand	NADP

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6807047 Cholesterol biosynthesis via desmosterol R-MMU-6807062 Cholesterol biosynthesis via lathosterol
UniPathwayⁱ	UPA00063

Chemistry databases

SwissLipidsⁱ	SLP:000001320

SwissLipidsⁱ

SLP:000001320

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 7-dehydrocholesterol reductase (EC:1.3.1.21) Short name: 7-DHC reductase Alternative name(s): Sterol Delta(7)-reductase
Gene namesⁱ	Name:Dhcr7
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1298378 Dhcr7

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	36 – 56	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	95 – 115	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	144 – 164	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	173 – 193	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	233 – 253	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	262 – 282	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	302 – 322	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	327 – 347	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	416 – 436	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000207503	1 – 471	7-dehydrocholesterol reductaseAdd BLAST		471

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	14	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O88455
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O88455
PaxDbⁱ	O88455
PeptideAtlas More...PeptideAtlasⁱ	O88455
PRIDEⁱ	O88455
TopDownProteomicsⁱ	O88455

PTM databases

iPTMnetⁱ	O88455
PhosphoSitePlusⁱ	O88455
SwissPalmⁱ	O88455

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000058454 Expressed in 283 organ(s), highest expression level in adrenal gland
CleanExⁱ	MM_DHCR7
ExpressionAtlasⁱ	O88455 baseline and differential
Genevisibleⁱ	O88455 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	199217, 1 interactor
STRINGⁱ	10090.ENSMUSP00000073541

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O88455
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ERG4/ERG24 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1435 Eukaryota ENOG410XP67 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000417
HOGENOMⁱ	HOG000193296
HOVERGENⁱ	HBG007825
InParanoidⁱ	O88455
KEGG Orthology (KO) More...KOⁱ	K00213
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0F22
PhylomeDBⁱ	O88455
TreeFamⁱ	TF101180

Family and domain databases

InterProⁱ	View protein in InterPro IPR001171 Ergosterol_biosynth_ERG4_ERG24 IPR018083 Sterol_reductase_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01222 ERG4_ERG24, 1 hit
PROSITEⁱ	View protein in PROSITE PS01017 STEROL_REDUCT_1, 1 hit PS01018 STEROL_REDUCT_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show all Align All

O88455-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASKSQHNAP KVKSPNGKAG SQGQWGRAWE VDWFSLASII FLLLFAPFIV 
        60         70         80         90        100
YYFIMACDQY SCSLTAPALD IATGHASLAD IWAKTPPVTA KAAQLYALWV 
       110        120        130        140        150
SFQVLLYSWL PDFCHRFLPG YVGGVQEGAI TPAGVVNKYE VNGLQAWLIT 
       160        170        180        190        200
HILWFVNAYL LSWFSPTIIF DNWIPLLWCA NILGYAVSTF AMIKGYLFPT 
       210        220        230        240        250
SAEDCKFTGN FFYNYMMGIE FNPRIGKWFD FKLFFNGRPG IVAWTLINLS 
       260        270        280        290        300
FAAKQQELYG HVTNSMILVN VLQAIYVLDF FWNETWYLKT IDICHDHFGW 
       310        320        330        340        350
YLGWGDCVWL PYLYTLQGLY LVYHPVQLST PNALGILLLG LVGYYIFRMT 
       360        370        380        390        400
NHQKDLFRRT DGRCLIWGKK PKAIECSYTS ADGLKHHSKL LVSGFWGVAR 
       410        420        430        440        450
HFNYTGDLMG SLAYCLACGG GHLLPYFYII YMTILLTHRC LRDEHRCANK 
       460        470 
YGRDWERYTA AVPYRLLPGI F

Length:471

Mass (Da):53,919

Last modified:November 1, 1998 - v1

Checksum:ⁱ6B1BC356CC539290

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3YXR4	D3YXR4_MOUSE	7-dehydrocholesterol reductase 7-dehydrocholesterol reductase	Dhcr7	225	Annotation score:
A0A140LIT2	A0A140LIT2_MOUSE	7-dehydrocholesterol reductase 7-dehydrocholesterol reductase	Dhcr7	474	Annotation score:
D3Z7G1	D3Z7G1_MOUSE	7-dehydrocholesterol reductase 7-dehydrocholesterol reductase	Dhcr7	215	Annotation score:
A0A140LI18	A0A140LI18_MOUSE	7-dehydrocholesterol reductase 7-dehydrocholesterol reductase	Dhcr7	71	Annotation score:
Q711T1	Q711T1_MOUSE	7-dehydrocholesterol reductase 7-dehydrocholesterol reductase (Delta 7-sterol reductase)	Dhcr7	12	Annotation score:
A0A140LIS4	A0A140LIS4_MOUSE	7-dehydrocholesterol reductase 7-dehydrocholesterol reductase	Dhcr7	23	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF057368 mRNA Translation: AAC40164.1 BC006854 mRNA Translation: AAH06854.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22048.1
NCBI Reference Sequences More...RefSeqⁱ	NP_031882.1, NM_007856.2 XP_006508541.1, XM_006508478.1 XP_006508542.1, XM_006508479.3 XP_006508543.1, XM_006508480.2 XP_006508544.1, XM_006508481.2
UniGeneⁱ	Mm.249342

Genome annotation databases

Ensemblⁱ	ENSMUST00000073878; ENSMUSP00000073541; ENSMUSG00000058454 ENSMUST00000124340; ENSMUSP00000117659; ENSMUSG00000058454 ENSMUST00000141916; ENSMUSP00000121782; ENSMUSG00000058454
GeneIDⁱ	13360
KEGGⁱ	mmu:13360
UCSC genome browser More...UCSCⁱ	uc009kqc.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O88455	7-dehydrocholesterol reductase		MOUSE		474	UniRef100_O88455
7-dehydrocholesterol reductase (Fragment)		MOUSE		215
7-dehydrocholesterol reductase (Fragment)		MOUSE		71
7-dehydrocholesterol reductase (Fragment)		MOUSE		12

Protein	Similar proteins		Species	Score	Length	Source
O88455	7-dehydrocholesterol reductase		RAT		471	UniRef90_O88455
7-dehydrocholesterol reductase		MOUSE		474
7-dehydrocholesterol reductase isoform X1		MESAU		498
7-dehydrocholesterol reductase		CASCN		475
7-dehydrocholesterol reductase		CRIGR		471
+14

Protein	Similar proteins		Species	Score	Length	Source
O88455	7-dehydrocholesterol reductase		HUMAN		475	UniRef50_Q9UBM7
7-dehydrocholesterol reductase		XENTR		473
7-dehydrocholesterol reductase		XENLA		473
7-dehydrocholesterol reductase		DANRE		478
7-dehydrocholesterol reductase		RAT		471
+291

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF057368 mRNA Translation: AAC40164.1 BC006854 mRNA Translation: AAH06854.1
CCDSⁱ	CCDS22048.1
RefSeqⁱ	NP_031882.1, NM_007856.2 XP_006508541.1, XM_006508478.1 XP_006508542.1, XM_006508479.3 XP_006508543.1, XM_006508480.2 XP_006508544.1, XM_006508481.2
UniGeneⁱ	Mm.249342

3D structure databases

ProteinModelPortalⁱ	O88455
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199217, 1 interactor
STRINGⁱ	10090.ENSMUSP00000073541

Chemistry databases

SwissLipidsⁱ	SLP:000001320

SwissLipidsⁱ

SLP:000001320

PTM databases

iPTMnetⁱ	O88455
PhosphoSitePlusⁱ	O88455
SwissPalmⁱ	O88455

Proteomic databases

EPDⁱ	O88455
MaxQBⁱ	O88455
PaxDbⁱ	O88455
PeptideAtlasⁱ	O88455
PRIDEⁱ	O88455
TopDownProteomicsⁱ	O88455

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000073878; ENSMUSP00000073541; ENSMUSG00000058454 ENSMUST00000124340; ENSMUSP00000117659; ENSMUSG00000058454 ENSMUST00000141916; ENSMUSP00000121782; ENSMUSG00000058454
GeneIDⁱ	13360
KEGGⁱ	mmu:13360
UCSCⁱ	uc009kqc.1 mouse

Organism-specific databases

CTDⁱ	1717
MGIⁱ	MGI:1298378 Dhcr7

Phylogenomic databases

eggNOGⁱ	KOG1435 Eukaryota ENOG410XP67 LUCA
GeneTreeⁱ	ENSGT00390000000417
HOGENOMⁱ	HOG000193296
HOVERGENⁱ	HBG007825
InParanoidⁱ	O88455
KOⁱ	K00213
OrthoDBⁱ	EOG091G0F22
PhylomeDBⁱ	O88455
TreeFamⁱ	TF101180

Enzyme and pathway databases

UniPathwayⁱ	UPA00063
Reactomeⁱ	R-MMU-6807047 Cholesterol biosynthesis via desmosterol R-MMU-6807062 Cholesterol biosynthesis via lathosterol

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O88455
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000058454 Expressed in 283 organ(s), highest expression level in adrenal gland
CleanExⁱ	MM_DHCR7
ExpressionAtlasⁱ	O88455 baseline and differential
Genevisibleⁱ	O88455 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR001171 Ergosterol_biosynth_ERG4_ERG24 IPR018083 Sterol_reductase_CS
Pfamⁱ	View protein in Pfam PF01222 ERG4_ERG24, 1 hit
PROSITEⁱ	View protein in PROSITE PS01017 STEROL_REDUCT_1, 1 hit PS01018 STEROL_REDUCT_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DHCR7_MOUSE
Accessionⁱ	O88455Primary (citable) accession number: O88455
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
	Last sequence update:	November 1, 1998
	Last modified:	September 12, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O88455 (DHCR7_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

7-dehydrocholesterol reductase

Dhcr7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: cholesterol biosynthesis

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Cytosol

Endoplasmic reticulum

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: cholesterol biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ