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Protein

7-dehydrocholesterol reductase

Gene

Dhcr7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).

Catalytic activityi

Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

Pathwayi: cholesterol biosynthesis

This protein is involved in the pathway cholesterol biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway cholesterol biosynthesis and in Steroid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei354NADPBy similarity1
Binding sitei358NADPBy similarity1
Binding sitei391NADP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei396NADPBy similarity1
Binding sitei443NADPBy similarity1
Binding sitei458NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi403 – 404NADPBy similarity2
Nucleotide bindingi447 – 451NADPBy similarity5

GO - Molecular functioni

  • 7-dehydrocholesterol reductase activity Source: MGI
  • NADP binding Source: UniProtKB
  • sterol delta7 reductase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandNADP

Enzyme and pathway databases

ReactomeiR-MMU-6807047 Cholesterol biosynthesis via desmosterol
R-MMU-6807062 Cholesterol biosynthesis via lathosterol
UniPathwayi
UPA00063

Chemistry databases

SwissLipidsiSLP:000001320

Names & Taxonomyi

Protein namesi
Recommended name:
7-dehydrocholesterol reductase (EC:1.3.1.21)
Short name:
7-DHC reductase
Alternative name(s):
Sterol Delta(7)-reductase
Gene namesi
Name:Dhcr7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1298378 Dhcr7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075031 – 4717-dehydrocholesterol reductaseAdd BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO88455
MaxQBiO88455
PaxDbiO88455
PeptideAtlasiO88455
PRIDEiO88455
TopDownProteomicsiO88455

PTM databases

iPTMnetiO88455
PhosphoSitePlusiO88455
SwissPalmiO88455

Expressioni

Gene expression databases

BgeeiENSMUSG00000058454 Expressed in 283 organ(s), highest expression level in adrenal gland
CleanExiMM_DHCR7
ExpressionAtlasiO88455 baseline and differential
GenevisibleiO88455 MM

Interactioni

Protein-protein interaction databases

BioGridi199217, 1 interactor
STRINGi10090.ENSMUSP00000073541

Structurei

3D structure databases

ProteinModelPortaliO88455
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERG4/ERG24 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1435 Eukaryota
ENOG410XP67 LUCA
GeneTreeiENSGT00390000000417
HOGENOMiHOG000193296
HOVERGENiHBG007825
InParanoidiO88455
KOiK00213
OrthoDBiEOG091G0F22
PhylomeDBiO88455
TreeFamiTF101180

Family and domain databases

InterProiView protein in InterPro
IPR001171 Ergosterol_biosynth_ERG4_ERG24
IPR018083 Sterol_reductase_CS
PfamiView protein in Pfam
PF01222 ERG4_ERG24, 1 hit
PROSITEiView protein in PROSITE
PS01017 STEROL_REDUCT_1, 1 hit
PS01018 STEROL_REDUCT_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

O88455-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKSQHNAP KVKSPNGKAG SQGQWGRAWE VDWFSLASII FLLLFAPFIV
60 70 80 90 100
YYFIMACDQY SCSLTAPALD IATGHASLAD IWAKTPPVTA KAAQLYALWV
110 120 130 140 150
SFQVLLYSWL PDFCHRFLPG YVGGVQEGAI TPAGVVNKYE VNGLQAWLIT
160 170 180 190 200
HILWFVNAYL LSWFSPTIIF DNWIPLLWCA NILGYAVSTF AMIKGYLFPT
210 220 230 240 250
SAEDCKFTGN FFYNYMMGIE FNPRIGKWFD FKLFFNGRPG IVAWTLINLS
260 270 280 290 300
FAAKQQELYG HVTNSMILVN VLQAIYVLDF FWNETWYLKT IDICHDHFGW
310 320 330 340 350
YLGWGDCVWL PYLYTLQGLY LVYHPVQLST PNALGILLLG LVGYYIFRMT
360 370 380 390 400
NHQKDLFRRT DGRCLIWGKK PKAIECSYTS ADGLKHHSKL LVSGFWGVAR
410 420 430 440 450
HFNYTGDLMG SLAYCLACGG GHLLPYFYII YMTILLTHRC LRDEHRCANK
460 470
YGRDWERYTA AVPYRLLPGI F
Length:471
Mass (Da):53,919
Last modified:November 1, 1998 - v1
Checksum:i6B1BC356CC539290
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YXR4D3YXR4_MOUSE
7-dehydrocholesterol reductase
Dhcr7
225Annotation score:
A0A140LIT2A0A140LIT2_MOUSE
7-dehydrocholesterol reductase
Dhcr7
474Annotation score:
D3Z7G1D3Z7G1_MOUSE
7-dehydrocholesterol reductase
Dhcr7
215Annotation score:
A0A140LI18A0A140LI18_MOUSE
7-dehydrocholesterol reductase
Dhcr7
71Annotation score:
Q711T1Q711T1_MOUSE
7-dehydrocholesterol reductase
Dhcr7
12Annotation score:
A0A140LIS4A0A140LIS4_MOUSE
7-dehydrocholesterol reductase
Dhcr7
23Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057368 mRNA Translation: AAC40164.1
BC006854 mRNA Translation: AAH06854.1
CCDSiCCDS22048.1
RefSeqiNP_031882.1, NM_007856.2
XP_006508541.1, XM_006508478.1
XP_006508542.1, XM_006508479.3
XP_006508543.1, XM_006508480.2
XP_006508544.1, XM_006508481.2
UniGeneiMm.249342

Genome annotation databases

EnsembliENSMUST00000073878; ENSMUSP00000073541; ENSMUSG00000058454
ENSMUST00000124340; ENSMUSP00000117659; ENSMUSG00000058454
ENSMUST00000141916; ENSMUSP00000121782; ENSMUSG00000058454
GeneIDi13360
KEGGimmu:13360
UCSCiuc009kqc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057368 mRNA Translation: AAC40164.1
BC006854 mRNA Translation: AAH06854.1
CCDSiCCDS22048.1
RefSeqiNP_031882.1, NM_007856.2
XP_006508541.1, XM_006508478.1
XP_006508542.1, XM_006508479.3
XP_006508543.1, XM_006508480.2
XP_006508544.1, XM_006508481.2
UniGeneiMm.249342

3D structure databases

ProteinModelPortaliO88455
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199217, 1 interactor
STRINGi10090.ENSMUSP00000073541

Chemistry databases

SwissLipidsiSLP:000001320

PTM databases

iPTMnetiO88455
PhosphoSitePlusiO88455
SwissPalmiO88455

Proteomic databases

EPDiO88455
MaxQBiO88455
PaxDbiO88455
PeptideAtlasiO88455
PRIDEiO88455
TopDownProteomicsiO88455

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073878; ENSMUSP00000073541; ENSMUSG00000058454
ENSMUST00000124340; ENSMUSP00000117659; ENSMUSG00000058454
ENSMUST00000141916; ENSMUSP00000121782; ENSMUSG00000058454
GeneIDi13360
KEGGimmu:13360
UCSCiuc009kqc.1 mouse

Organism-specific databases

CTDi1717
MGIiMGI:1298378 Dhcr7

Phylogenomic databases

eggNOGiKOG1435 Eukaryota
ENOG410XP67 LUCA
GeneTreeiENSGT00390000000417
HOGENOMiHOG000193296
HOVERGENiHBG007825
InParanoidiO88455
KOiK00213
OrthoDBiEOG091G0F22
PhylomeDBiO88455
TreeFamiTF101180

Enzyme and pathway databases

UniPathwayi
UPA00063

ReactomeiR-MMU-6807047 Cholesterol biosynthesis via desmosterol
R-MMU-6807062 Cholesterol biosynthesis via lathosterol

Miscellaneous databases

PROiPR:O88455
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058454 Expressed in 283 organ(s), highest expression level in adrenal gland
CleanExiMM_DHCR7
ExpressionAtlasiO88455 baseline and differential
GenevisibleiO88455 MM

Family and domain databases

InterProiView protein in InterPro
IPR001171 Ergosterol_biosynth_ERG4_ERG24
IPR018083 Sterol_reductase_CS
PfamiView protein in Pfam
PF01222 ERG4_ERG24, 1 hit
PROSITEiView protein in PROSITE
PS01017 STEROL_REDUCT_1, 1 hit
PS01018 STEROL_REDUCT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDHCR7_MOUSE
AccessioniPrimary (citable) accession number: O88455
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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