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Protein

Stanniocalcin-2

Gene

Stc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has an anti-hypocalcemic action on calcium and phosphate homeostasis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Stanniocalcin-2
Short name:
STC-2
Gene namesi
Name:Stc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1316731 Stc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000003330525 – 296Stanniocalcin-2Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88452
PeptideAtlasiO88452
PRIDEiO88452

PTM databases

PhosphoSitePlusiO88452

Expressioni

Tissue specificityi

Found in a variety of tissues including skeletal muscle, small intestine, kidney, liver and brain.

Gene expression databases

BgeeiENSMUSG00000020303 Expressed in 161 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_STC2
ExpressionAtlasiO88452 baseline and differential
GenevisibleiO88452 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020546

Structurei

3D structure databases

ProteinModelPortaliO88452
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the stanniocalcin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIGP Eukaryota
ENOG410XT17 LUCA
GeneTreeiENSGT00390000005989
HOGENOMiHOG000220830
HOVERGENiHBG001048
InParanoidiO88452
OMAiMCAERLG
OrthoDBiEOG091G0HC1
PhylomeDBiO88452
TreeFamiTF324693

Family and domain databases

InterProiView protein in InterPro
IPR004978 Stanniocalcin
PANTHERiPTHR11245 PTHR11245, 1 hit
PfamiView protein in Pfam
PF03298 Stanniocalcin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88452-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCAERLGQFV TLALVFATLD PAQGTDSTNP PEGPQDRSSQ QKGRLSLQNT
60 70 80 90 100
AEIQHCLVNA GDVGCGVFEC FENNSCEIQG LHGICMTFLH NAGKFDAQGK
110 120 130 140 150
SFIKDALRCK AHALRHKFGC ISRKCPAIRE MVFQLQRECY LKHDLCSAAQ
160 170 180 190 200
ENVGVIVEMI HFKDLLLHEP YVDLVNLLLT CGEDVKEAVT RSVQAQCEQS
210 220 230 240 250
WGGLCSILSF CTSNIQRPPT AAPEHQPLAD RAQLSRPHHR DTDHHLTANR
260 270 280 290
GAKGERGSKS HPNAHARGRT GGQSAQGPSG SSEWEDEQSE YSDIRR
Length:296
Mass (Da):32,602
Last modified:November 1, 1998 - v1
Checksum:i0C1EF4008912DE68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056244 mRNA Translation: AAC27507.1
AF031035 mRNA Translation: AAD01921.1
BC012206 mRNA Translation: AAH12206.1
CCDSiCCDS24512.1
RefSeqiNP_035621.1, NM_011491.3
UniGeneiMm.32506

Genome annotation databases

EnsembliENSMUST00000020546; ENSMUSP00000020546; ENSMUSG00000020303
GeneIDi20856
KEGGimmu:20856
UCSCiuc007iik.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056244 mRNA Translation: AAC27507.1
AF031035 mRNA Translation: AAD01921.1
BC012206 mRNA Translation: AAH12206.1
CCDSiCCDS24512.1
RefSeqiNP_035621.1, NM_011491.3
UniGeneiMm.32506

3D structure databases

ProteinModelPortaliO88452
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020546

PTM databases

PhosphoSitePlusiO88452

Proteomic databases

PaxDbiO88452
PeptideAtlasiO88452
PRIDEiO88452

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020546; ENSMUSP00000020546; ENSMUSG00000020303
GeneIDi20856
KEGGimmu:20856
UCSCiuc007iik.1 mouse

Organism-specific databases

CTDi8614
MGIiMGI:1316731 Stc2

Phylogenomic databases

eggNOGiENOG410IIGP Eukaryota
ENOG410XT17 LUCA
GeneTreeiENSGT00390000005989
HOGENOMiHOG000220830
HOVERGENiHBG001048
InParanoidiO88452
OMAiMCAERLG
OrthoDBiEOG091G0HC1
PhylomeDBiO88452
TreeFamiTF324693

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

PROiPR:O88452
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020303 Expressed in 161 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_STC2
ExpressionAtlasiO88452 baseline and differential
GenevisibleiO88452 MM

Family and domain databases

InterProiView protein in InterPro
IPR004978 Stanniocalcin
PANTHERiPTHR11245 PTHR11245, 1 hit
PfamiView protein in Pfam
PF03298 Stanniocalcin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTC2_MOUSE
AccessioniPrimary (citable) accession number: O88452
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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