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Protein

Kinesin light chain 2

Gene

Klc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

GO - Molecular functioni

  • kinesin binding Source: BHF-UCL
  • microtubule motor activity Source: InterPro

GO - Biological processi

  • axo-dendritic transport Source: MGI
  • microtubule-based movement Source: HGNC

Keywordsi

Molecular functionMotor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin light chain 2
Short name:
KLC 2
Gene namesi
Name:Klc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107953 Klc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002150961 – 599Kinesin light chain 2Add BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei443PhosphoserineCombined sources1
Modified residuei505PhosphoserineCombined sources1
Modified residuei515PhosphoserineBy similarity1
Modified residuei574PhosphoserineBy similarity1
Modified residuei575PhosphoserineCombined sources1
Modified residuei582PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO88448
MaxQBiO88448
PaxDbiO88448
PeptideAtlasiO88448
PRIDEiO88448

PTM databases

iPTMnetiO88448
PhosphoSitePlusiO88448
SwissPalmiO88448

Expressioni

Gene expression databases

CleanExiMM_KLC2

Interactioni

Subunit structurei

Oligomeric complex composed of two heavy chains and two light chains.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

CORUMiO88448
DIPiDIP-31518N
ELMiO88448
IntActiO88448, 16 interactors
MINTiO88448
STRINGi10090.ENSMUSP00000112262

Structurei

Secondary structure

1599
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO88448
SMRiO88448
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati197 – 230TPR 1Add BLAST34
Repeati239 – 272TPR 2Add BLAST34
Repeati281 – 314TPR 3Add BLAST34
Repeati323 – 356TPR 4Add BLAST34
Repeati365 – 398TPR 5Add BLAST34
Repeati447 – 480TPR 6Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili78 – 143Sequence analysisAdd BLAST66

Sequence similaritiesi

Belongs to the kinesin light chain family.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840 Eukaryota
COG0457 LUCA
HOVERGENiHBG006217
InParanoidiO88448

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR002151 Kinesin_light
IPR015792 Kinesin_light_repeat
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PRINTSiPR00381 KINESINLIGHT
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS01160 KINESIN_LIGHT, 2 hits
PS50005 TPR, 5 hits
PS50293 TPR_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O88448-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATMVLPREE KLSQDEIVLG TKAVIQGLET LRGEHRALLA PLASHEAGEA
60 70 80 90 100
EPGSQERCLL LRRSLEAIEL GLGEAQVILA LSSHLGAVES EKQKLRAQVR
110 120 130 140 150
RLVQENQWLR EELAGTQQKL QRSEQAVAQL EEEKQHLLFM SQIRKLDEML
160 170 180 190 200
PQEEKGDVPK DSLDDLFPNE DEQSPAPSPG GGDVAAQHGG YEIPARLRTL
210 220 230 240 250
HNLVIQYASQ GRYEVAVPLC KQALEDLEKT SGHDHPDVAT MLNILALVYR
260 270 280 290 300
DQNKYKDAAH LLNDALAIRE KTLGKDHPAV AATLNNLAVL YGKRGKYKEA
310 320 330 340 350
EPLCKRALEI REKVLGKFHP DVAKQLSNLA LLCQNQGKAE EVEYYYRRAL
360 370 380 390 400
EIYATRLGPD DPNVAKTKNN LASCYLKQGK YQDAETLYKE ILTRAHEKEF
410 420 430 440 450
GSVNGENKPI WMHAEEREES KDKRRDRRPM EYGSWYKACK VDSPTVNTTL
460 470 480 490 500
RTLGALYRPE GKLEAAHTLE DCASRSRKQG LDPASQTKVV ELLKDGSGRG
510 520 530 540 550
HRRGSRDVAG PQSESDLEES GPAAEWSGDG SGSLRRSGSF GKLRDALRRS
560 570 580 590
SEMLVRKLQG GGPQEPNSRM KRASSLNFLN KSVEEPVQPG GRVFLTAAL
Length:599
Mass (Da):66,662
Last modified:November 1, 1998 - v1
Checksum:iA5E6F9081609E1CE
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q91YS4Q91YS4_MOUSE
Kinesin light chain 2
Klc2 mCG_8395
619Annotation score:
D3YXZ3D3YXZ3_MOUSE
Kinesin light chain 2
Klc2
617Annotation score:
D3Z5Y7D3Z5Y7_MOUSE
Kinesin light chain 2
Klc2
166Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055666 mRNA Translation: AAC27741.1
UniGeneiMm.271648

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055666 mRNA Translation: AAC27741.1
UniGeneiMm.271648

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZFWX-ray2.90A/B217-478[»]
5FJYX-ray4.00A/B/C160-478[»]
ProteinModelPortaliO88448
SMRiO88448
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiO88448
DIPiDIP-31518N
ELMiO88448
IntActiO88448, 16 interactors
MINTiO88448
STRINGi10090.ENSMUSP00000112262

PTM databases

iPTMnetiO88448
PhosphoSitePlusiO88448
SwissPalmiO88448

Proteomic databases

EPDiO88448
MaxQBiO88448
PaxDbiO88448
PeptideAtlasiO88448
PRIDEiO88448

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:107953 Klc2

Phylogenomic databases

eggNOGiKOG1840 Eukaryota
COG0457 LUCA
HOVERGENiHBG006217
InParanoidiO88448

Miscellaneous databases

ChiTaRSiKlc2 mouse
PROiPR:O88448
SOURCEiSearch...

Gene expression databases

CleanExiMM_KLC2

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR002151 Kinesin_light
IPR015792 Kinesin_light_repeat
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PRINTSiPR00381 KINESINLIGHT
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS01160 KINESIN_LIGHT, 2 hits
PS50005 TPR, 5 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKLC2_MOUSE
AccessioniPrimary (citable) accession number: O88448
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: July 18, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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