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Protein

Solute carrier family 22 member 3

Gene

Slc22a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.Curated2 Publications

GO - Molecular functioni

  • dopamine transmembrane transporter activity Source: RGD
  • organic anion transmembrane transporter activity Source: GO_Central
  • organic cation transmembrane transporter activity Source: RGD
  • quaternary ammonium group transmembrane transporter activity Source: RGD
  • toxin transmembrane transporter activity Source: RGD

GO - Biological processi

  • dopamine transport Source: RGD
  • histamine uptake Source: Ensembl
  • organic cation transport Source: RGD
  • quaternary ammonium group transport Source: RGD
  • regulation of appetite Source: Ensembl

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-2161517 Abacavir transmembrane transport
R-RNO-549127 Organic cation transport

Protein family/group databases

TCDBi2.A.1.19.6 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 3
Alternative name(s):
Organic cation transporter 3
Gene namesi
Name:Slc22a3
Synonyms:Oct3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3701 Slc22a3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Transmembranei463 – 483HelicalSequence analysisAdd BLAST21
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1770033

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002205051 – 551Solute carrier family 22 member 3Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO88446

Expressioni

Tissue specificityi

Highly expressed in placenta. Moderate expression in intestine, heart and brain. In the brain, widely expressed, especially in hippocampus, cerebellum and cerebral cortex. Expression is low in kidney and lung and undetectable in liver.Curated2 Publications

Gene expression databases

BgeeiENSRNOG00000022946
GenevisibleiO88446 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029748

Structurei

3D structure databases

ProteinModelPortaliO88446
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIE Eukaryota
ENOG410XSRI LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234568
HOVERGENiHBG061545
InParanoidiO88446
KOiK08200
OMAiWSPEEEW
OrthoDBiEOG091G05AC
PhylomeDBiO88446
TreeFamiTF315847

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00898 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit

Sequencei

Sequence statusi: Complete.

O88446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTFDQALRK AGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGSQPDYYW
60 70 80 90 100
CRGPRATALA ERCAWSPEEE WNLTTPELHV PAERRGQGHC HRYLLEDTNT
110 120 130 140 150
SSELSCDPLA AFPNRSAPLV PCSGDWRYVE THSTIVSQFD LVCGNAWMLD
160 170 180 190 200
LTQAILNLGF LAGAFTLGYA ADRYGRLIVY LISCFGVGIT GVVVAFAPNF
210 220 230 240 250
SVFVIFRFLQ GVFGKGAWMT CFVIVTEIVG SKQRRIVGIV IQMFFTLGII
260 270 280 290 300
ILPGIAYFTP SWQGIQLAIS LPSFLFLLYY WVVPESPRWL ITRKQGEKAL
310 320 330 340 350
QILRRVAKCN GKHLSSNYSE ITVTDEEVSN PSCLDLVRTP QMRKCTLILM
360 370 380 390 400
FAWFTSAVVY QGLVMRLGLI GGNLYMDFFI SGLVELPGAL LILLTIERLG
410 420 430 440 450
RRLPFAASNI VAGVSCLVTA FLPEGIPWLR TTVATLGRLG ITMAFEIVYL
460 470 480 490 500
VNSELYPTTL RNFGVSLCSG LCDFGGIIAP FLLFRLAAIW LELPLIIFGI
510 520 530 540 550
LASVCGGLVM LLPETKGIAL PETVEDVEKL GSSQLHQCGR KKKTQVSTSN

V
Length:551
Mass (Da):61,050
Last modified:November 1, 1998 - v1
Checksum:i23F0EBC24E4F3DE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055286 mRNA Translation: AAC40150.1
RefSeqiNP_062103.1, NM_019230.1
UniGeneiRn.24231

Genome annotation databases

EnsembliENSRNOT00000037369; ENSRNOP00000029748; ENSRNOG00000022946
GeneIDi29504
KEGGirno:29504

Similar proteinsi

Entry informationi

Entry nameiS22A3_RAT
AccessioniPrimary (citable) accession number: O88446
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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