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Protein

Aurora kinase C

Gene

Aurkc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Activity regulationi

Okadaic acid, an inhibitor of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein phosphatase 5 (PP5), increases AURKC activity. AURKC is also stabilized through its interaction with INCENP, which acts also as an activator (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45ATPPROSITE-ProRule annotation1
Active sitei139Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 30ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • histone serine kinase activity Source: GO_Central
  • protein kinase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Meiosis, Mitosis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aurora kinase C (EC:2.7.11.1)
Alternative name(s):
Aurora 3
Aurora/IPL1-related kinase 3
Short name:
ARK-3
Short name:
Aurora-related kinase 3
Aurora/IPL1/Eg2 protein 1
Serine/threonine-protein kinase 13
Serine/threonine-protein kinase aurora-C
Gene namesi
Name:Aurkc
Synonyms:Aie1, Aik3, Airk3, Ark3, Stk13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1321119 Aurkc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi171T → A: Impairs kinase activity, when associated with A-175. 1 Publication1
Mutagenesisi175T → A: Impairs kinase activity, when associated with A-171. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856611 – 282Aurora kinase CAdd BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171Phosphothreonine; by PKA1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO88445
PRIDEiO88445

PTM databases

iPTMnetiO88445
PhosphoSitePlusiO88445

Expressioni

Tissue specificityi

Expressed only in testis.

Developmental stagei

Expressed on day 14 dpc in prepubertal testis, expression reached its plateau on day 21 dpc and remained at a high level in adult.

Gene expression databases

CleanExiMM_AURKC

Interactioni

Subunit structurei

Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist; in the complex interacts directly with BIRC5/survivin and INCENP. Interacts with TACC1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000083426

Structurei

3D structure databases

ProteinModelPortaliO88445
SMRiO88445
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 266Protein kinasePROSITE-ProRule annotationAdd BLAST251

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0580 Eukaryota
ENOG410XNRB LUCA
HOVERGENiHBG108519
InParanoidiO88445

Family and domain databases

InterProiView protein in InterPro
IPR030616 Aur
IPR030613 AURKC
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24350 PTHR24350, 1 hit
PTHR24350:SF3 PTHR24350:SF3, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O88445-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPSTSTRKH FTINDFEIGR PLGRGKFGRV YLARLKENHF IVALKVLFKS
60 70 80 90 100
EIEKEGLEHQ LRREVEIQAH LQHRNILRLY NYFYDDTRIY LILEYAPGGE
110 120 130 140 150
LYKELQRHQK LDQQRTATII QELSDALTYC HEKKVIHRDI KPENLLLGLN
160 170 180 190 200
GEVKISDFGW SVHTPSLRRK TMCGTLDYLP PEMIAQKPYN EMVDLWCIGV
210 220 230 240 250
LCYELLVGKP PFESSTSSET YRRIRQVDFK FPSSVPAGAQ DLISKLLRYH
260 270 280
PSERLSLAQV LKHPWVREHS RRVLPPCVHG AS
Length:282
Mass (Da):32,907
Last modified:November 1, 1998 - v1
Checksum:i7CB8AEC4984B7883
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QL04E9QL04_MOUSE
Aurora kinase C
Aurkc
315Annotation score:
Q6P209Q6P209_MOUSE
Aurora kinase C
Aurkc
276Annotation score:
A0A140LIP1A0A140LIP1_MOUSE
Aurora kinase C
Aurkc
146Annotation score:
A0A140LJ30A0A140LJ30_MOUSE
Aurora kinase C
Aurkc
184Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74R → P in AAF25838 (PubMed:11098217).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054620 mRNA Translation: AAC25954.1
AF195272 Genomic DNA Translation: AAF25838.1
UniGeneiMm.261572

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054620 mRNA Translation: AAC25954.1
AF195272 Genomic DNA Translation: AAF25838.1
UniGeneiMm.261572

3D structure databases

ProteinModelPortaliO88445
SMRiO88445
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000083426

PTM databases

iPTMnetiO88445
PhosphoSitePlusiO88445

Proteomic databases

PaxDbiO88445
PRIDEiO88445

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1321119 Aurkc

Phylogenomic databases

eggNOGiKOG0580 Eukaryota
ENOG410XNRB LUCA
HOVERGENiHBG108519
InParanoidiO88445

Miscellaneous databases

PROiPR:O88445
SOURCEiSearch...

Gene expression databases

CleanExiMM_AURKC

Family and domain databases

InterProiView protein in InterPro
IPR030616 Aur
IPR030613 AURKC
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24350 PTHR24350, 1 hit
PTHR24350:SF3 PTHR24350:SF3, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAURKC_MOUSE
AccessioniPrimary (citable) accession number: O88445
Secondary accession number(s): Q9JLC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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