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Protein

C-C motif chemokine 22

Gene

Ccl22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B-lymphocytes with T-cells in immune responses.

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 22
Alternative name(s):
Activated B and dendritic cell-derived
CC chemokine ABCD-1
Small-inducible cytokine A22
Gene namesi
Name:Ccl22
Synonyms:Abcd1, Scya22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1306779 Ccl22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000522825 – 92C-C motif chemokine 22Add BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 60By similarity
Disulfide bondi37 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO88430
PRIDEiO88430

PTM databases

PhosphoSitePlusiO88430

Expressioni

Tissue specificityi

Expressed by activated splenic B-lymphocytes and dendritic cells. Low expression in lung, thymocytes, lymph node, and unstimulated splenic cells.

Gene expression databases

BgeeiENSMUSG00000031779 Expressed in 35 organ(s), highest expression level in peripheral lymph node
CleanExiMM_CCL22
ExpressionAtlasiO88430 baseline and differential
GenevisibleiO88430 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034231

Structurei

3D structure databases

ProteinModelPortaliO88430
SMRiO88430
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J20K Eukaryota
ENOG41113E8 LUCA
GeneTreeiENSGT00530000064374
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiO88430
KOiK21095
OMAiVEDSICC
OrthoDBiEOG091G13Z3
PhylomeDBiO88430
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR030598 CCL22
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PTHR12015:SF102 PTHR12015:SF102, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88430-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLRVPLLV ALVLLAVAIQ TSDAGPYGAN VEDSICCQDY IRHPLPSRLV
60 70 80 90
KEFFWTSKSC RKPGVVLITV KNRDICADPR QVWVKKLLHK LS
Length:92
Mass (Da):10,302
Last modified:November 1, 1998 - v1
Checksum:i39859881CDAE07CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052505 mRNA Translation: AAC40200.1
BC012658 mRNA Translation: AAH12658.1
CCDSiCCDS40441.1
RefSeqiNP_033163.1, NM_009137.2
UniGeneiMm.12895

Genome annotation databases

EnsembliENSMUST00000034231; ENSMUSP00000034231; ENSMUSG00000031779
GeneIDi20299
KEGGimmu:20299
UCSCiuc009mww.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052505 mRNA Translation: AAC40200.1
BC012658 mRNA Translation: AAH12658.1
CCDSiCCDS40441.1
RefSeqiNP_033163.1, NM_009137.2
UniGeneiMm.12895

3D structure databases

ProteinModelPortaliO88430
SMRiO88430
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034231

PTM databases

PhosphoSitePlusiO88430

Proteomic databases

PaxDbiO88430
PRIDEiO88430

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034231; ENSMUSP00000034231; ENSMUSG00000031779
GeneIDi20299
KEGGimmu:20299
UCSCiuc009mww.1 mouse

Organism-specific databases

CTDi6367
MGIiMGI:1306779 Ccl22

Phylogenomic databases

eggNOGiENOG410J20K Eukaryota
ENOG41113E8 LUCA
GeneTreeiENSGT00530000064374
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiO88430
KOiK21095
OMAiVEDSICC
OrthoDBiEOG091G13Z3
PhylomeDBiO88430
TreeFamiTF334888

Miscellaneous databases

PROiPR:O88430
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031779 Expressed in 35 organ(s), highest expression level in peripheral lymph node
CleanExiMM_CCL22
ExpressionAtlasiO88430 baseline and differential
GenevisibleiO88430 MM

Family and domain databases

InterProiView protein in InterPro
IPR030598 CCL22
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PTHR12015:SF102 PTHR12015:SF102, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL22_MOUSE
AccessioniPrimary (citable) accession number: O88430
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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