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Protein

Voltage-dependent T-type calcium channel subunit alpha-1H

Gene

Cacna1h

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi140ZincBy similarity1
Metal bindingi189ZincBy similarity1
Metal bindingi191ZincBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei378Calcium ion selectivity and permeabilityBy similarity1
Sitei971Calcium ion selectivity and permeabilityBy similarity1
Sitei1515Calcium ion selectivity and permeabilityBy similarity1
Sitei1819Calcium ion selectivity and permeabilityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent T-type calcium channel subunit alpha-1H
Alternative name(s):
Voltage-gated calcium channel subunit alpha Cav3.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cacna1h
Synonyms:Kiaa1120
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1928842 Cacna1h

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 100CytoplasmicSequence analysisAdd BLAST100
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei101 – 119Helical; Name=S1 of repeat ISequence analysisAdd BLAST19
Topological domaini120 – 141ExtracellularSequence analysisAdd BLAST22
Transmembranei142 – 160Helical; Name=S2 of repeat ISequence analysisAdd BLAST19
Topological domaini161 – 169CytoplasmicSequence analysis9
Transmembranei170 – 184Helical; Name=S3 of repeat ISequence analysisAdd BLAST15
Topological domaini185 – 193ExtracellularSequence analysis9
Transmembranei194 – 212Helical; Name=S4 of repeat ISequence analysisAdd BLAST19
Topological domaini213 – 232CytoplasmicSequence analysisAdd BLAST20
Transmembranei233 – 253Helical; Name=S5 of repeat ISequence analysisAdd BLAST21
Topological domaini254 – 394ExtracellularSequence analysisAdd BLAST141
Transmembranei395 – 419Helical; Name=S6 of repeat ISequence analysisAdd BLAST25
Topological domaini420 – 790CytoplasmicSequence analysisAdd BLAST371
Transmembranei791 – 811Helical; Name=S1 of repeat IISequence analysisAdd BLAST21
Topological domaini812 – 824ExtracellularSequence analysisAdd BLAST13
Transmembranei825 – 846Helical; Name=S2 of repeat IISequence analysisAdd BLAST22
Topological domaini847 – 852CytoplasmicSequence analysis6
Transmembranei853 – 871Helical; Name=S3 of repeat IISequence analysisAdd BLAST19
Topological domaini872 – 879ExtracellularSequence analysis8
Transmembranei880 – 903Helical; Name=S4 of repeat IISequence analysisAdd BLAST24
Topological domaini904 – 914CytoplasmicSequence analysisAdd BLAST11
Transmembranei915 – 935Helical; Name=S5 of repeat IISequence analysisAdd BLAST21
Topological domaini936 – 987ExtracellularSequence analysisAdd BLAST52
Transmembranei988 – 1012Helical; Name=S6 of repeat IISequence analysisAdd BLAST25
Topological domaini1013 – 1301CytoplasmicSequence analysisAdd BLAST289
Transmembranei1302 – 1324Helical; Name=S1 of repeat IIISequence analysisAdd BLAST23
Topological domaini1325 – 1342ExtracellularSequence analysisAdd BLAST18
Transmembranei1343 – 1363Helical; Name=S2 of repeat IIISequence analysisAdd BLAST21
Topological domaini1364 – 1373CytoplasmicSequence analysis10
Transmembranei1374 – 1393Helical; Name=S3 of repeat IIISequence analysisAdd BLAST20
Topological domaini1394 – 1407ExtracellularSequence analysisAdd BLAST14
Transmembranei1408 – 1429Helical; Name=S4 of repeat IIISequence analysisAdd BLAST22
Topological domaini1430 – 1439CytoplasmicSequence analysis10
Transmembranei1440 – 1463Helical; Name=S5 of repeat IIISequence analysisAdd BLAST24
Topological domaini1464 – 1540ExtracellularSequence analysisAdd BLAST77
Transmembranei1541 – 1566Helical; Name=S6 of repeat IIISequence analysisAdd BLAST26
Topological domaini1567 – 1627CytoplasmicSequence analysisAdd BLAST61
Transmembranei1628 – 1648Helical; Name=S1 of repeat IVSequence analysisAdd BLAST21
Topological domaini1649 – 1662ExtracellularSequence analysisAdd BLAST14
Transmembranei1663 – 1684Helical; Name=S2 of repeat IVSequence analysisAdd BLAST22
Topological domaini1685 – 1691CytoplasmicSequence analysis7
Transmembranei1692 – 1710Helical; Name=S3 of repeat IVSequence analysisAdd BLAST19
Topological domaini1711 – 1724ExtracellularSequence analysisAdd BLAST14
Transmembranei1725 – 1748Helical; Name=S4 of repeat IVSequence analysisAdd BLAST24
Topological domaini1749 – 1762CytoplasmicSequence analysisAdd BLAST14
Transmembranei1763 – 1783Helical; Name=S5 of repeat IVSequence analysisAdd BLAST21
Topological domaini1784 – 1846ExtracellularSequence analysisAdd BLAST63
Transmembranei1847 – 1874Helical; Name=S6 of repeat IVSequence analysisAdd BLAST28
Topological domaini1875 – 2365CytoplasmicSequence analysisAdd BLAST491

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3600280

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539551 – 2365Voltage-dependent T-type calcium channel subunit alpha-1HAdd BLAST2365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1477N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O88427

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O88427

PRoteomics IDEntifications database

More...
PRIDEi
O88427

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O88427

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O88427

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O88427

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminal cytoplasmic domain) with STAC.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
O88427, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000077586

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O88427

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati87 – 422IAdd BLAST336
Repeati776 – 1015IIAdd BLAST240
Repeati1292 – 1569IIIAdd BLAST278
Repeati1613 – 1874IVAdd BLAST262

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi521 – 531Poly-HisAdd BLAST11
Compositional biasi1594 – 1597Poly-Arg4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2302 Eukaryota
ENOG410XNP6 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007742

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050764

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O88427

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR027359 Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01629 TVDCCALPHA1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O88427-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEGTLAADE VRVPLGASPS APAAPVRASP ASPGVPGREE QRGSGSSVLA
60 70 80 90 100
PESPGTECGA DLGADEEQPV PYPALAATVF FCLGQTTRPR SWCLRLVSRR
110 120 130 140 150
WFEHISMLVI MLNCVTLGMF RPCEDVECRS ERCSILEAFD DFIFAFFAVE
160 170 180 190 200
MVIKMVALGL FGQKCYLGDT WNRLDFFIVM AGMMEYSLDG HNVSLSAIRT
210 220 230 240 250
VRVLRPLRAI NRVPSMRILV TLLLDTLPML GNVLLLCFFV FFIFGIVGVQ
260 270 280 290 300
LWAGLLRNRC FLDSAFVRNN NLTFLRPYYQ TEEGEENPFI CSSRRDNGMQ
310 320 330 340 350
KCSHIPSRRE LRVQCTLGWE AYGQPQAEDG GAGRNACINW NQYYNVCRSG
360 370 380 390 400
EFNPHNGAIN FDNIGYAWIA IFQVITLEGW VDIMYYVMDA HSFYNFIYFI
410 420 430 440 450
LLIIVGSFFM INLCLVVIAT QFSETKQREN QLMREQRARY LSNDSTLASF
460 470 480 490 500
SEPGSCYEEL LKYVGHIFRK VKRRSLRLYA RWQSRWRKKV DPSSTLHGQG
510 520 530 540 550
PRRRPRRAGR RTASVHHLVY HHHHHHHHHY HFSHGGPRRP SPEPGAGDTR
560 570 580 590 600
LVRACVPPSP PSPGHGPPDS ESVHSIYHAD CHVEGPQERA RVAHTIATAA
610 620 630 640 650
SLKLASGLGT MNYPTILPSG AVNSKGSTSS RPKGLRSAGT PGATAHSPLS
660 670 680 690 700
LGSPSPYEKI QHVVGEQGLG RASSHLSGLS VPCPLPSPQA GTLTCELKSC
710 720 730 740 750
PYCASALEDP EFEFSGSESG DSDAHGVYEF TQDVRHGDCR DPVQQPHEGG
760 770 780 790 800
TPGHGNERWR PPLRTASQPG GLGRLWASFS SKLRRIVDSK YFNRGIMAAI
810 820 830 840 850
LVNTLSMGVE YHEQPDELTN ALEISNIVFT SMFALEMLLK LLACGPLGYI
860 870 880 890 900
RNPYNIFDGI VVIISVWEIV GQADGGLSVL RTFRLLRVLK LVRFLPALRR
910 920 930 940 950
QLVVLMRTMD NVATFCMLLM LFIFIFSILG MHLFGCKFSL KTDSGDTVPD
960 970 980 990 1000
RKNFDSLLWA IVTVFQILTQ EDWNVVLYNG MASTSSWAAL YFVALMTFGN
1010 1020 1030 1040 1050
YVLFNLLVAI LVEGFQAEGD ATRSDTDEDK TSTHLEEDFD KLRDVQATEM
1060 1070 1080 1090 1100
KMYSLAVTPN GHLEGRGSLP PPLITHTAAT PMPTPKSSPH LDMAHTLLDS
1110 1120 1130 1140 1150
RRSSSGSVDP QLGDQKSLAS LRSSPCAPWG PNSAGSSRRS SWNSLGRAPS
1160 1170 1180 1190 1200
LKRRSQCGER ESLLSGEGKG STDDEAEDSR PNSGTHPGAS PGPRATPLRR
1210 1220 1230 1240 1250
AESLGHRSTM DLCPPRPATL LPTKFRDCNG QMVALPSEFF LRIDSHKEDA
1260 1270 1280 1290 1300
AEFDDDIEDS CCFRLHKVLE PYAPQWCSSR ESWALYLFPP QNRLRVSCQK
1310 1320 1330 1340 1350
VIAHKMFDHV VLVFIFLNCI TIALERPDID PGSTERAFLS VSNYIFTAIF
1360 1370 1380 1390 1400
VVEMMVKVVA LGLLWGEHAY LQSSWNVLDG LLVLVSLVDI IVAVASAGGA
1410 1420 1430 1440 1450
KILGVLRVLR LLRTLRPLRV ISRAPGLKLV VETLISSLRP IGNIVLICCA
1460 1470 1480 1490 1500
FFIIFGILGV QLFKGKFYYC EGTDTRNITT KAECHAAHYR WVRRKYNFDN
1510 1520 1530 1540 1550
LGQALMSLFV LSSKDGWVNI MYDGLDAVGI DQQPVQNHNP WMLLYFISFL
1560 1570 1580 1590 1600
LIVSFFVLNM FVGVVVENFH KCRQHQEAEE ARRREEKRLR RLERRRRSTF
1610 1620 1630 1640 1650
PNPEAQRRPY YADYSHTRRS IHSLCTSHYL DLFITFIICL NVITMSMEHY
1660 1670 1680 1690 1700
NQPKSLDEAL KYCNYVFTIV FVFEAALKLV AFGFRRFFKD RWNQLDLAIV
1710 1720 1730 1740 1750
LLSIMGIALE EIEMNAALPI NPTIIRIMRV LRIARVLKLL KMATGMRALL
1760 1770 1780 1790 1800
DTVVQALPQV GNLGLLFMLL FFIYAALGVE LFGRLECSED NPCEGLSRHA
1810 1820 1830 1840 1850
TFTNFGMAFL TLFRVSTGDN WNGIMKDTLR ECTREDKHCL SYLPALSPVY
1860 1870 1880 1890 1900
FVTFVLVAQF VLVNVVVAVL MKHLEESNKE AREDAEMDAE IELEIAQGST
1910 1920 1930 1940 1950
AQPPSTAQES QGTEPDTPNL LVVRKVSVSR MLSLPNDSYM FRPVAPAAAP
1960 1970 1980 1990 2000
HSHPLQEVEM ETYTGPVTSA HSPSLEPRTS FQVPSAASSP ARVSDPLCAL
2010 2020 2030 2040 2050
SPRDTPRSLS LSRILCRQEA MHAESLEGQI DDAGEDSIPD YTEPAENISM
2060 2070 2080 2090 2100
SQAPLGTLRS PPCSPRPASV RTRKHTFGQH CISSRPPTLG GDDAEAADPA
2110 2120 2130 2140 2150
DEEVSHITSS AHPWPATEPH SPEASPTASP AKGTVGSGRD PHRFCSVDAQ
2160 2170 2180 2190 2200
SFLDKPGRPD AQRWSSVELD NGDGHLESGE VRARASELEP ALGARRKKKM
2210 2220 2230 2240 2250
SPPCISIDPP TEDEGSSRPP AAEGGNTTLR RRTPSCEAAL HRDCPESTEG
2260 2270 2280 2290 2300
PGTGGDPVAK GERWGQASCR AEHLTVPNFA FEPLDMGGPG GDCFLDSDQS
2310 2320 2330 2340 2350
VTPEPRVSSL GAIVPLILET ELSMPSGDPP EKEQGLYLTV PQTPLKKPGS
2360
PPATPAPDDS GDEPV
Note: No experimental confirmation available.
Length:2,365
Mass (Da):262,030
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F1915047A25A10A
GO
Isoform 2 (identifier: O88427-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1598-1604: STFPNPE → K

Show »
Length:2,359
Mass (Da):261,385
Checksum:i211CA02DD33AD9A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q6P9E9Q6P9_MOUSE
Voltage-dependent T-type calcium ch...
Cacna1h
2,359Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6USE5F6USE5_MOUSE
Voltage-dependent T-type calcium ch...
Cacna1h
293Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CYZ3E0CYZ3_MOUSE
Voltage-dependent T-type calcium ch...
Cacna1h
1,901Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6U5P7F6U5P7_MOUSE
Voltage-dependent T-type calcium ch...
Cacna1h
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q6E4E9Q6E4_MOUSE
Voltage-dependent T-type calcium ch...
Cacna1h
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti98 – 100SRR → CNP in AAK21607 (Ref. 1) Curated3
Sequence conflicti98 – 100SRR → CNP in AAI38027 (PubMed:15489334).Curated3
Sequence conflicti863I → V in AAK21607 (Ref. 1) Curated1
Sequence conflicti863I → V in AAI38027 (PubMed:15489334).Curated1
Sequence conflicti1046Q → R in AAK21607 (Ref. 1) Curated1
Sequence conflicti1046Q → R in AAI38027 (PubMed:15489334).Curated1
Sequence conflicti1046Q → R in BAC65734 (PubMed:12693553).Curated1
Sequence conflicti1823 – 1825GIM → ARG in AAC67240 (PubMed:9670923).Curated3
Sequence conflicti1914E → D in AAK21607 (Ref. 1) Curated1
Sequence conflicti1914E → D in AAI38027 (PubMed:15489334).Curated1
Sequence conflicti1914E → D in BAC65734 (PubMed:12693553).Curated1
Sequence conflicti1945 – 1947APA → LLQ in AAC67240 (PubMed:9670923).Curated3
Sequence conflicti1952S → A in AAC67240 (PubMed:9670923).Curated1
Sequence conflicti1953 – 2351Missing in AAC67240 (PubMed:9670923).CuratedAdd BLAST399
Sequence conflicti1993V → A in AAK21607 (Ref. 1) Curated1
Sequence conflicti1993V → A in AAI38027 (PubMed:15489334).Curated1
Sequence conflicti1993V → A in BAC65734 (PubMed:12693553).Curated1
Sequence conflicti2016C → Y in AAK21607 (Ref. 1) Curated1
Sequence conflicti2016C → Y in AAI38027 (PubMed:15489334).Curated1
Sequence conflicti2016C → Y in BAC65734 (PubMed:12693553).Curated1
Sequence conflicti2037S → G in AAK21607 (Ref. 1) Curated1
Sequence conflicti2037S → G in AAI38027 (PubMed:15489334).Curated1
Sequence conflicti2037S → G in BAC65734 (PubMed:12693553).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0136751598 – 1604STFPNPE → K in isoform 2. 2 Publications7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF226868, AY026385 Genomic DNA Translation: AAK21607.2
AC122454 Genomic DNA No translation available.
AC131323 Genomic DNA No translation available.
BC138026 mRNA Translation: AAI38027.1
AK122452 mRNA Translation: BAC65734.1
AF051947 mRNA Translation: AAC67240.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS37501.1 [O88427-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.268378

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226868, AY026385 Genomic DNA Translation: AAK21607.2
AC122454 Genomic DNA No translation available.
AC131323 Genomic DNA No translation available.
BC138026 mRNA Translation: AAI38027.1
AK122452 mRNA Translation: BAC65734.1
AF051947 mRNA Translation: AAC67240.1
CCDSiCCDS37501.1 [O88427-2]
UniGeneiMm.268378

3D structure databases

ProteinModelPortaliO88427
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88427, 1 interactor
STRINGi10090.ENSMUSP00000077586

Chemistry databases

ChEMBLiCHEMBL3600280

PTM databases

iPTMnetiO88427
PhosphoSitePlusiO88427
SwissPalmiO88427

Proteomic databases

MaxQBiO88427
PaxDbiO88427
PRIDEiO88427

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1928842 Cacna1h

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG2302 Eukaryota
ENOG410XNP6 LUCA
HOGENOMiHOG000007742
HOVERGENiHBG050764
InParanoidiO88427

Miscellaneous databases

Protein Ontology

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PROi
PR:O88427

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PRINTSiPR01629 TVDCCALPHA1

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAC1H_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88427
Secondary accession number(s): B2RQQ0
, E9QNT0, Q80TJ2, Q9JKU5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: January 16, 2019
This is version 144 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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