Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Voltage-dependent T-type calcium channel subunit alpha-1H

Gene

Cacna1h

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi140ZincBy similarity1
Metal bindingi189ZincBy similarity1
Metal bindingi191ZincBy similarity1
Sitei378Calcium ion selectivity and permeabilityBy similarity1
Sitei971Calcium ion selectivity and permeabilityBy similarity1
Sitei1515Calcium ion selectivity and permeabilityBy similarity1
Sitei1819Calcium ion selectivity and permeabilityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent T-type calcium channel subunit alpha-1H
Alternative name(s):
Voltage-gated calcium channel subunit alpha Cav3.2
Gene namesi
Name:Cacna1h
Synonyms:Kiaa1120
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1928842 Cacna1h

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 100CytoplasmicSequence analysisAdd BLAST100
Transmembranei101 – 119Helical; Name=S1 of repeat ISequence analysisAdd BLAST19
Topological domaini120 – 141ExtracellularSequence analysisAdd BLAST22
Transmembranei142 – 160Helical; Name=S2 of repeat ISequence analysisAdd BLAST19
Topological domaini161 – 169CytoplasmicSequence analysis9
Transmembranei170 – 184Helical; Name=S3 of repeat ISequence analysisAdd BLAST15
Topological domaini185 – 193ExtracellularSequence analysis9
Transmembranei194 – 212Helical; Name=S4 of repeat ISequence analysisAdd BLAST19
Topological domaini213 – 232CytoplasmicSequence analysisAdd BLAST20
Transmembranei233 – 253Helical; Name=S5 of repeat ISequence analysisAdd BLAST21
Topological domaini254 – 394ExtracellularSequence analysisAdd BLAST141
Transmembranei395 – 419Helical; Name=S6 of repeat ISequence analysisAdd BLAST25
Topological domaini420 – 790CytoplasmicSequence analysisAdd BLAST371
Transmembranei791 – 811Helical; Name=S1 of repeat IISequence analysisAdd BLAST21
Topological domaini812 – 824ExtracellularSequence analysisAdd BLAST13
Transmembranei825 – 846Helical; Name=S2 of repeat IISequence analysisAdd BLAST22
Topological domaini847 – 852CytoplasmicSequence analysis6
Transmembranei853 – 871Helical; Name=S3 of repeat IISequence analysisAdd BLAST19
Topological domaini872 – 879ExtracellularSequence analysis8
Transmembranei880 – 903Helical; Name=S4 of repeat IISequence analysisAdd BLAST24
Topological domaini904 – 914CytoplasmicSequence analysisAdd BLAST11
Transmembranei915 – 935Helical; Name=S5 of repeat IISequence analysisAdd BLAST21
Topological domaini936 – 987ExtracellularSequence analysisAdd BLAST52
Transmembranei988 – 1012Helical; Name=S6 of repeat IISequence analysisAdd BLAST25
Topological domaini1013 – 1301CytoplasmicSequence analysisAdd BLAST289
Transmembranei1302 – 1324Helical; Name=S1 of repeat IIISequence analysisAdd BLAST23
Topological domaini1325 – 1342ExtracellularSequence analysisAdd BLAST18
Transmembranei1343 – 1363Helical; Name=S2 of repeat IIISequence analysisAdd BLAST21
Topological domaini1364 – 1373CytoplasmicSequence analysis10
Transmembranei1374 – 1393Helical; Name=S3 of repeat IIISequence analysisAdd BLAST20
Topological domaini1394 – 1407ExtracellularSequence analysisAdd BLAST14
Transmembranei1408 – 1429Helical; Name=S4 of repeat IIISequence analysisAdd BLAST22
Topological domaini1430 – 1439CytoplasmicSequence analysis10
Transmembranei1440 – 1463Helical; Name=S5 of repeat IIISequence analysisAdd BLAST24
Topological domaini1464 – 1540ExtracellularSequence analysisAdd BLAST77
Transmembranei1541 – 1566Helical; Name=S6 of repeat IIISequence analysisAdd BLAST26
Topological domaini1567 – 1627CytoplasmicSequence analysisAdd BLAST61
Transmembranei1628 – 1648Helical; Name=S1 of repeat IVSequence analysisAdd BLAST21
Topological domaini1649 – 1662ExtracellularSequence analysisAdd BLAST14
Transmembranei1663 – 1684Helical; Name=S2 of repeat IVSequence analysisAdd BLAST22
Topological domaini1685 – 1691CytoplasmicSequence analysis7
Transmembranei1692 – 1710Helical; Name=S3 of repeat IVSequence analysisAdd BLAST19
Topological domaini1711 – 1724ExtracellularSequence analysisAdd BLAST14
Transmembranei1725 – 1748Helical; Name=S4 of repeat IVSequence analysisAdd BLAST24
Topological domaini1749 – 1762CytoplasmicSequence analysisAdd BLAST14
Transmembranei1763 – 1783Helical; Name=S5 of repeat IVSequence analysisAdd BLAST21
Topological domaini1784 – 1846ExtracellularSequence analysisAdd BLAST63
Transmembranei1847 – 1874Helical; Name=S6 of repeat IVSequence analysisAdd BLAST28
Topological domaini1875 – 2365CytoplasmicSequence analysisAdd BLAST491

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3600280

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000539551 – 2365Voltage-dependent T-type calcium channel subunit alpha-1HAdd BLAST2365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1477N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO88427
PaxDbiO88427
PRIDEiO88427

PTM databases

iPTMnetiO88427
PhosphoSitePlusiO88427
SwissPalmiO88427

Interactioni

Subunit structurei

Interacts (via N-terminal cytoplasmic domain) with STAC.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiO88427, 1 interactor
STRINGi10090.ENSMUSP00000077586

Structurei

3D structure databases

ProteinModelPortaliO88427
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati87 – 422IAdd BLAST336
Repeati776 – 1015IIAdd BLAST240
Repeati1292 – 1569IIIAdd BLAST278
Repeati1613 – 1874IVAdd BLAST262

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi521 – 531Poly-HisAdd BLAST11
Compositional biasi1594 – 1597Poly-Arg4

Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2302 Eukaryota
ENOG410XNP6 LUCA
HOGENOMiHOG000007742
HOVERGENiHBG050764
InParanoidiO88427

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PRINTSiPR01629 TVDCCALPHA1

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O88427-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEGTLAADE VRVPLGASPS APAAPVRASP ASPGVPGREE QRGSGSSVLA
60 70 80 90 100
PESPGTECGA DLGADEEQPV PYPALAATVF FCLGQTTRPR SWCLRLVSRR
110 120 130 140 150
WFEHISMLVI MLNCVTLGMF RPCEDVECRS ERCSILEAFD DFIFAFFAVE
160 170 180 190 200
MVIKMVALGL FGQKCYLGDT WNRLDFFIVM AGMMEYSLDG HNVSLSAIRT
210 220 230 240 250
VRVLRPLRAI NRVPSMRILV TLLLDTLPML GNVLLLCFFV FFIFGIVGVQ
260 270 280 290 300
LWAGLLRNRC FLDSAFVRNN NLTFLRPYYQ TEEGEENPFI CSSRRDNGMQ
310 320 330 340 350
KCSHIPSRRE LRVQCTLGWE AYGQPQAEDG GAGRNACINW NQYYNVCRSG
360 370 380 390 400
EFNPHNGAIN FDNIGYAWIA IFQVITLEGW VDIMYYVMDA HSFYNFIYFI
410 420 430 440 450
LLIIVGSFFM INLCLVVIAT QFSETKQREN QLMREQRARY LSNDSTLASF
460 470 480 490 500
SEPGSCYEEL LKYVGHIFRK VKRRSLRLYA RWQSRWRKKV DPSSTLHGQG
510 520 530 540 550
PRRRPRRAGR RTASVHHLVY HHHHHHHHHY HFSHGGPRRP SPEPGAGDTR
560 570 580 590 600
LVRACVPPSP PSPGHGPPDS ESVHSIYHAD CHVEGPQERA RVAHTIATAA
610 620 630 640 650
SLKLASGLGT MNYPTILPSG AVNSKGSTSS RPKGLRSAGT PGATAHSPLS
660 670 680 690 700
LGSPSPYEKI QHVVGEQGLG RASSHLSGLS VPCPLPSPQA GTLTCELKSC
710 720 730 740 750
PYCASALEDP EFEFSGSESG DSDAHGVYEF TQDVRHGDCR DPVQQPHEGG
760 770 780 790 800
TPGHGNERWR PPLRTASQPG GLGRLWASFS SKLRRIVDSK YFNRGIMAAI
810 820 830 840 850
LVNTLSMGVE YHEQPDELTN ALEISNIVFT SMFALEMLLK LLACGPLGYI
860 870 880 890 900
RNPYNIFDGI VVIISVWEIV GQADGGLSVL RTFRLLRVLK LVRFLPALRR
910 920 930 940 950
QLVVLMRTMD NVATFCMLLM LFIFIFSILG MHLFGCKFSL KTDSGDTVPD
960 970 980 990 1000
RKNFDSLLWA IVTVFQILTQ EDWNVVLYNG MASTSSWAAL YFVALMTFGN
1010 1020 1030 1040 1050
YVLFNLLVAI LVEGFQAEGD ATRSDTDEDK TSTHLEEDFD KLRDVQATEM
1060 1070 1080 1090 1100
KMYSLAVTPN GHLEGRGSLP PPLITHTAAT PMPTPKSSPH LDMAHTLLDS
1110 1120 1130 1140 1150
RRSSSGSVDP QLGDQKSLAS LRSSPCAPWG PNSAGSSRRS SWNSLGRAPS
1160 1170 1180 1190 1200
LKRRSQCGER ESLLSGEGKG STDDEAEDSR PNSGTHPGAS PGPRATPLRR
1210 1220 1230 1240 1250
AESLGHRSTM DLCPPRPATL LPTKFRDCNG QMVALPSEFF LRIDSHKEDA
1260 1270 1280 1290 1300
AEFDDDIEDS CCFRLHKVLE PYAPQWCSSR ESWALYLFPP QNRLRVSCQK
1310 1320 1330 1340 1350
VIAHKMFDHV VLVFIFLNCI TIALERPDID PGSTERAFLS VSNYIFTAIF
1360 1370 1380 1390 1400
VVEMMVKVVA LGLLWGEHAY LQSSWNVLDG LLVLVSLVDI IVAVASAGGA
1410 1420 1430 1440 1450
KILGVLRVLR LLRTLRPLRV ISRAPGLKLV VETLISSLRP IGNIVLICCA
1460 1470 1480 1490 1500
FFIIFGILGV QLFKGKFYYC EGTDTRNITT KAECHAAHYR WVRRKYNFDN
1510 1520 1530 1540 1550
LGQALMSLFV LSSKDGWVNI MYDGLDAVGI DQQPVQNHNP WMLLYFISFL
1560 1570 1580 1590 1600
LIVSFFVLNM FVGVVVENFH KCRQHQEAEE ARRREEKRLR RLERRRRSTF
1610 1620 1630 1640 1650
PNPEAQRRPY YADYSHTRRS IHSLCTSHYL DLFITFIICL NVITMSMEHY
1660 1670 1680 1690 1700
NQPKSLDEAL KYCNYVFTIV FVFEAALKLV AFGFRRFFKD RWNQLDLAIV
1710 1720 1730 1740 1750
LLSIMGIALE EIEMNAALPI NPTIIRIMRV LRIARVLKLL KMATGMRALL
1760 1770 1780 1790 1800
DTVVQALPQV GNLGLLFMLL FFIYAALGVE LFGRLECSED NPCEGLSRHA
1810 1820 1830 1840 1850
TFTNFGMAFL TLFRVSTGDN WNGIMKDTLR ECTREDKHCL SYLPALSPVY
1860 1870 1880 1890 1900
FVTFVLVAQF VLVNVVVAVL MKHLEESNKE AREDAEMDAE IELEIAQGST
1910 1920 1930 1940 1950
AQPPSTAQES QGTEPDTPNL LVVRKVSVSR MLSLPNDSYM FRPVAPAAAP
1960 1970 1980 1990 2000
HSHPLQEVEM ETYTGPVTSA HSPSLEPRTS FQVPSAASSP ARVSDPLCAL
2010 2020 2030 2040 2050
SPRDTPRSLS LSRILCRQEA MHAESLEGQI DDAGEDSIPD YTEPAENISM
2060 2070 2080 2090 2100
SQAPLGTLRS PPCSPRPASV RTRKHTFGQH CISSRPPTLG GDDAEAADPA
2110 2120 2130 2140 2150
DEEVSHITSS AHPWPATEPH SPEASPTASP AKGTVGSGRD PHRFCSVDAQ
2160 2170 2180 2190 2200
SFLDKPGRPD AQRWSSVELD NGDGHLESGE VRARASELEP ALGARRKKKM
2210 2220 2230 2240 2250
SPPCISIDPP TEDEGSSRPP AAEGGNTTLR RRTPSCEAAL HRDCPESTEG
2260 2270 2280 2290 2300
PGTGGDPVAK GERWGQASCR AEHLTVPNFA FEPLDMGGPG GDCFLDSDQS
2310 2320 2330 2340 2350
VTPEPRVSSL GAIVPLILET ELSMPSGDPP EKEQGLYLTV PQTPLKKPGS
2360
PPATPAPDDS GDEPV
Note: No experimental confirmation available.
Length:2,365
Mass (Da):262,030
Last modified:July 27, 2011 - v3
Checksum:i8F1915047A25A10A
GO
Isoform 2 (identifier: O88427-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1598-1604: STFPNPE → K

Show »
Length:2,359
Mass (Da):261,385
Checksum:i211CA02DD33AD9A0
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q6P9E9Q6P9_MOUSE
Voltage-dependent T-type calcium ch...
Cacna1h
2,359Annotation score:
F6USE5F6USE5_MOUSE
Voltage-dependent T-type calcium ch...
Cacna1h
293Annotation score:
E0CYZ3E0CYZ3_MOUSE
Voltage-dependent T-type calcium ch...
Cacna1h
1,901Annotation score:
F6U5P7F6U5P7_MOUSE
Voltage-dependent T-type calcium ch...
Cacna1h
49Annotation score:
E9Q6E4E9Q6E4_MOUSE
Voltage-dependent T-type calcium ch...
Cacna1h
147Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98 – 100SRR → CNP in AAK21607 (Ref. 1) Curated3
Sequence conflicti98 – 100SRR → CNP in AAI38027 (PubMed:15489334).Curated3
Sequence conflicti863I → V in AAK21607 (Ref. 1) Curated1
Sequence conflicti863I → V in AAI38027 (PubMed:15489334).Curated1
Sequence conflicti1046Q → R in AAK21607 (Ref. 1) Curated1
Sequence conflicti1046Q → R in AAI38027 (PubMed:15489334).Curated1
Sequence conflicti1046Q → R in BAC65734 (PubMed:12693553).Curated1
Sequence conflicti1823 – 1825GIM → ARG in AAC67240 (PubMed:9670923).Curated3
Sequence conflicti1914E → D in AAK21607 (Ref. 1) Curated1
Sequence conflicti1914E → D in AAI38027 (PubMed:15489334).Curated1
Sequence conflicti1914E → D in BAC65734 (PubMed:12693553).Curated1
Sequence conflicti1945 – 1947APA → LLQ in AAC67240 (PubMed:9670923).Curated3
Sequence conflicti1952S → A in AAC67240 (PubMed:9670923).Curated1
Sequence conflicti1953 – 2351Missing in AAC67240 (PubMed:9670923).CuratedAdd BLAST399
Sequence conflicti1993V → A in AAK21607 (Ref. 1) Curated1
Sequence conflicti1993V → A in AAI38027 (PubMed:15489334).Curated1
Sequence conflicti1993V → A in BAC65734 (PubMed:12693553).Curated1
Sequence conflicti2016C → Y in AAK21607 (Ref. 1) Curated1
Sequence conflicti2016C → Y in AAI38027 (PubMed:15489334).Curated1
Sequence conflicti2016C → Y in BAC65734 (PubMed:12693553).Curated1
Sequence conflicti2037S → G in AAK21607 (Ref. 1) Curated1
Sequence conflicti2037S → G in AAI38027 (PubMed:15489334).Curated1
Sequence conflicti2037S → G in BAC65734 (PubMed:12693553).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0136751598 – 1604STFPNPE → K in isoform 2. 2 Publications7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226868, AY026385 Genomic DNA Translation: AAK21607.2
AC122454 Genomic DNA No translation available.
AC131323 Genomic DNA No translation available.
BC138026 mRNA Translation: AAI38027.1
AK122452 mRNA Translation: BAC65734.1
AF051947 mRNA Translation: AAC67240.1
CCDSiCCDS37501.1 [O88427-2]
UniGeneiMm.268378

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226868, AY026385 Genomic DNA Translation: AAK21607.2
AC122454 Genomic DNA No translation available.
AC131323 Genomic DNA No translation available.
BC138026 mRNA Translation: AAI38027.1
AK122452 mRNA Translation: BAC65734.1
AF051947 mRNA Translation: AAC67240.1
CCDSiCCDS37501.1 [O88427-2]
UniGeneiMm.268378

3D structure databases

ProteinModelPortaliO88427
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88427, 1 interactor
STRINGi10090.ENSMUSP00000077586

Chemistry databases

ChEMBLiCHEMBL3600280

PTM databases

iPTMnetiO88427
PhosphoSitePlusiO88427
SwissPalmiO88427

Proteomic databases

MaxQBiO88427
PaxDbiO88427
PRIDEiO88427

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1928842 Cacna1h
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2302 Eukaryota
ENOG410XNP6 LUCA
HOGENOMiHOG000007742
HOVERGENiHBG050764
InParanoidiO88427

Miscellaneous databases

PROiPR:O88427
SOURCEiSearch...

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PRINTSiPR01629 TVDCCALPHA1
ProtoNetiSearch...

Entry informationi

Entry nameiCAC1H_MOUSE
AccessioniPrimary (citable) accession number: O88427
Secondary accession number(s): B2RQQ0
, E9QNT0, Q80TJ2, Q9JKU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again