UniProtKB - O88420 (SCN8A_RAT)
Sodium channel protein type 8 subunit alpha
Scn8a
Functioni
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 891 – 898 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- sodium ion binding Source: RGD
- voltage-gated ion channel activity Source: UniProtKB-KW
- voltage-gated sodium channel activity Source: RGD
GO - Biological processi
- adult locomotory behavior Source: RGD
- adult walking behavior Source: RGD
- locomotory behavior Source: RGD
- membrane depolarization during action potential Source: GO_Central
- muscle organ development Source: RGD
- myelination Source: BHF-UCL
- neuromuscular process Source: RGD
- neuronal action potential Source: RGD
- peripheral nervous system development Source: BHF-UCL
- regulation of ion transmembrane transport Source: UniProtKB-KW
- response to toxic substance Source: RGD
- sensory perception of sound Source: RGD
- sodium ion transmembrane transport Source: GO_Central
- sodium ion transport Source: RGD
Keywordsi
Molecular function | Ion channel, Sodium channel, Voltage-gated channel |
Biological process | Ion transport, Sodium transport, Transport |
Ligand | ATP-binding, Nucleotide-binding, Sodium |
Enzyme and pathway databases
Reactomei | R-RNO-5576892, Phase 0 - rapid depolarisation |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium channel protein type 8 subunit alphaAlternative name(s): Peripheral nerve protein type 4 Short name: PN4 Sodium channel 6 Short name: NaCh6 Sodium channel protein type VIII subunit alpha Voltage-gated sodium channel subunit alpha Nav1.6 |
Gene namesi | Name:Scn8a |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3638, Scn8a |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein By similarity
Other locations
- axon By similarity
Note: Mainly localizes to the axon initial segment.By similarity
Plasma Membrane
- integral component of postsynaptic density membrane Source: SynGO
- integral component of presynaptic active zone membrane Source: SynGO
- plasma membrane Source: RGD
- voltage-gated sodium channel complex Source: RGD
Other locations
- axon Source: ARUK-UCL
- axon initial segment Source: BHF-UCL
- dendrite Source: RGD
- glutamatergic synapse Source: SynGO
- integral component of membrane Source: RGD
- membrane Source: RGD
- neuronal cell body Source: RGD
- node of Ranvier Source: BHF-UCL
- parallel fiber to Purkinje cell synapse Source: SynGO
- sodium channel complex Source: RGD
- Z disc Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 132 | CytoplasmicCuratedAdd BLAST | 132 | |
Transmembranei | 133 – 151 | Helical; Name=S1 of repeat IBy similarityAdd BLAST | 19 | |
Topological domaini | 152 – 158 | ExtracellularCurated | 7 | |
Transmembranei | 159 – 179 | Helical; Name=S2 of repeat IBy similarityAdd BLAST | 21 | |
Topological domaini | 180 – 193 | CytoplasmicCuratedAdd BLAST | 14 | |
Transmembranei | 194 – 211 | Helical; Name=S3 of repeat IBy similarityAdd BLAST | 18 | |
Topological domaini | 212 – 217 | ExtracellularCurated | 6 | |
Transmembranei | 218 – 234 | Helical; Name=S4 of repeat IBy similarityAdd BLAST | 17 | |
Topological domaini | 235 – 253 | CytoplasmicCuratedAdd BLAST | 19 | |
Transmembranei | 254 – 273 | Helical; Name=S5 of repeat IBy similarityAdd BLAST | 20 | |
Topological domaini | 274 – 355 | ExtracellularCuratedAdd BLAST | 82 | |
Intramembranei | 356 – 380 | Pore-formingBy similarityAdd BLAST | 25 | |
Topological domaini | 381 – 387 | ExtracellularCurated | 7 | |
Transmembranei | 388 – 408 | Helical; Name=S6 of repeat IBy similarityAdd BLAST | 21 | |
Topological domaini | 409 – 751 | CytoplasmicCuratedAdd BLAST | 343 | |
Transmembranei | 752 – 770 | Helical; Name=S1 of repeat IIBy similarityAdd BLAST | 19 | |
Topological domaini | 771 – 781 | ExtracellularCuratedAdd BLAST | 11 | |
Transmembranei | 782 – 801 | Helical; Name=S2 of repeat IIBy similarityAdd BLAST | 20 | |
Topological domaini | 802 – 815 | CytoplasmicCuratedAdd BLAST | 14 | |
Transmembranei | 816 – 835 | Helical; Name=S3 of repeat IIBy similarityAdd BLAST | 20 | |
Topological domaini | 836 – 837 | ExtracellularCurated | 2 | |
Transmembranei | 838 – 855 | Helical; Name=S4 of repeat IIBy similarityAdd BLAST | 18 | |
Topological domaini | 856 – 871 | CytoplasmicCuratedAdd BLAST | 16 | |
Transmembranei | 872 – 890 | Helical; Name=S5 of repeat IIBy similarityAdd BLAST | 19 | |
Topological domaini | 891 – 919 | ExtracellularCuratedAdd BLAST | 29 | |
Intramembranei | 920 – 940 | Pore-formingBy similarityAdd BLAST | 21 | |
Topological domaini | 941 – 953 | ExtracellularCuratedAdd BLAST | 13 | |
Transmembranei | 954 – 974 | Helical; Name=S6 of repeat IIBy similarityAdd BLAST | 21 | |
Topological domaini | 975 – 1197 | CytoplasmicCuratedAdd BLAST | 223 | |
Transmembranei | 1198 – 1215 | Helical; Name=S1 of repeat IIIBy similarityAdd BLAST | 18 | |
Topological domaini | 1216 – 1228 | ExtracellularCuratedAdd BLAST | 13 | |
Transmembranei | 1229 – 1247 | Helical; Name=S2 of repeat IIIBy similarityAdd BLAST | 19 | |
Topological domaini | 1248 – 1261 | CytoplasmicCuratedAdd BLAST | 14 | |
Transmembranei | 1262 – 1280 | Helical; Name=S3 of repeat IIIBy similarityAdd BLAST | 19 | |
Topological domaini | 1281 – 1288 | ExtracellularCurated | 8 | |
Transmembranei | 1289 – 1307 | Helical; Name=S4 of repeat IIIBy similarityAdd BLAST | 19 | |
Topological domaini | 1308 – 1324 | CytoplasmicCuratedAdd BLAST | 17 | |
Transmembranei | 1325 – 1344 | Helical; Name=S5 of repeat IIIBy similarityAdd BLAST | 20 | |
Topological domaini | 1345 – 1397 | ExtracellularCuratedAdd BLAST | 53 | |
Intramembranei | 1398 – 1419 | Pore-formingBy similarityAdd BLAST | 22 | |
Topological domaini | 1420 – 1436 | ExtracellularCuratedAdd BLAST | 17 | |
Transmembranei | 1437 – 1458 | Helical; Name=S6 of repeat IIIBy similarityAdd BLAST | 22 | |
Topological domaini | 1459 – 1521 | CytoplasmicCuratedAdd BLAST | 63 | |
Transmembranei | 1522 – 1539 | Helical; Name=S1 of repeat IVBy similarityAdd BLAST | 18 | |
Topological domaini | 1540 – 1550 | ExtracellularCuratedAdd BLAST | 11 | |
Transmembranei | 1551 – 1569 | Helical; Name=S2 of repeat IVBy similarityAdd BLAST | 19 | |
Topological domaini | 1570 – 1581 | CytoplasmicCuratedAdd BLAST | 12 | |
Transmembranei | 1582 – 1599 | Helical; Name=S3 of repeat IVBy similarityAdd BLAST | 18 | |
Topological domaini | 1600 – 1612 | ExtracellularCuratedAdd BLAST | 13 | |
Transmembranei | 1613 – 1629 | Helical; Name=S4 of repeat IVBy similarityAdd BLAST | 17 | |
Topological domaini | 1630 – 1648 | CytoplasmicCuratedAdd BLAST | 19 | |
Transmembranei | 1649 – 1666 | Helical; Name=S5 of repeat IVBy similarityAdd BLAST | 18 | |
Topological domaini | 1667 – 1688 | ExtracellularCuratedAdd BLAST | 22 | |
Intramembranei | 1689 – 1711 | Pore-formingBy similarityAdd BLAST | 23 | |
Topological domaini | 1712 – 1740 | ExtracellularCuratedAdd BLAST | 29 | |
Transmembranei | 1741 – 1763 | Helical; Name=S6 of repeat IVBy similarityAdd BLAST | 23 | |
Topological domaini | 1764 – 1978 | CytoplasmicCuratedAdd BLAST | 215 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000390890 | 1 – 1978 | Sodium channel protein type 8 subunit alphaAdd BLAST | 1978 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 215 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 281 ↔ 333 | By similarity | ||
Glycosylationi | 289 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 295 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 308 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 326 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 518 | PhosphoserineCombined sources | 1 | |
Modified residuei | 520 | PhosphoserineCombined sources | 1 | |
Disulfide bondi | 902 | Interchain; with SCN2B or SCN4BBy similarity | ||
Disulfide bondi | 902 | Interchain; with the conotoxin GVIIJ (when the channel is not linked to SCN2B or SCN4B; the bond to SCN2B or SCN4B protects the channel from the inhibition by toxin)By similarity | ||
Disulfide bondi | 942 ↔ 951 | By similarity | ||
Glycosylationi | 1356 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1370 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1381 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1495 | Phosphoserine; by PKCBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | O88420 |
PTM databases
CarbonylDBi | O88420 |
GlyGeni | O88420, 8 sites |
iPTMneti | O88420 |
PhosphoSitePlusi | O88420 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1 (SCN1B), beta-2 (SCN2B), beta-3 (SCN3B) and/or beta-4 (SCN4B). Beta-1 (SCN1B) and beta-3 (SCN3B) are non-covalently associated with alpha, while beta-2 (SCN2B) and beta-4 (SCN4B) are covalently linked by disulfide bonds.
Interacts with NEDD4 and NEDD4L (By similarity).
Interacts with FGF13 (PubMed:15282281).
Interacts with FGF14, GBG3, GBB2 and SCN1B (By similarity).
Interacts with the conotoxin GVIIJ (PubMed:24497506).
Interacts with CALM1; the interaction modulates the inactivation rate of SCN8A (By similarity).
By similarity2 PublicationsProtein-protein interaction databases
BioGRIDi | 248327, 2 interactors |
STRINGi | 10116.ENSRNOP00000008160 |
Chemistry databases
BindingDBi | O88420 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 114 – 442 | ICuratedAdd BLAST | 329 | |
Repeati | 733 – 1005 | IICuratedAdd BLAST | 273 | |
Repeati | 1178 – 1493 | IIICuratedAdd BLAST | 316 | |
Repeati | 1502 – 1799 | IVCuratedAdd BLAST | 298 | |
Domaini | 1893 – 1922 | IQPROSITE-ProRule annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 28 – 62 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 446 – 530 | DisorderedSequence analysisAdd BLAST | 85 | |
Regioni | 576 – 597 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1105 – 1146 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 1923 – 1978 | DisorderedSequence analysisAdd BLAST | 56 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 28 – 57 | Basic and acidic residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 500 – 530 | Basic and acidic residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 1114 – 1129 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1948 – 1978 | Basic and acidic residuesSequence analysisAdd BLAST | 31 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2301, Eukaryota |
InParanoidi | O88420 |
OrthoDBi | 172471at2759 |
PhylomeDBi | O88420 |
Family and domain databases
CDDi | cd13433, Na_channel_gate, 1 hit |
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR000048, IQ_motif_EF-hand-BS IPR008054, Na_channel_a8su IPR001696, Na_channel_asu IPR044564, Na_chnl_inactivation_gate IPR010526, Na_trans_assoc IPR024583, Na_trans_cytopl IPR043203, VGCC_Ca_Na IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR10037, PTHR10037, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 4 hits PF00612, IQ, 1 hit PF06512, Na_trans_assoc, 1 hit PF11933, Na_trans_cytopl, 1 hit |
PRINTSi | PR00170, NACHANNEL PR01667, NACHANNEL8 |
SMARTi | View protein in SMART SM00015, IQ, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAARLLAPPG PDSFKPFTPE SLANIERRIA ESKLKKPPKA DGSHREDDED
60 70 80 90 100
SKPKPNSDLE AGKSLPFIYG DIPQGLVAVP LEDFDPYYLT QKTFVVLNRG
110 120 130 140 150
KTLFRFSATP ALYILSPFNL IRRIAIKILI HSVFSMIIMC TILTNCVFMT
160 170 180 190 200
FSNPPEWSKN VEYTFTGIYT FESLVKIIAR GFCIDGFTFL RDPWNWLDFS
210 220 230 240 250
VIMMAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI VGALIQSVKK
260 270 280 290 300
LSDVMILTVF CLSVFALIGL QLFMGNLRNK CVVWPINFNE SYLENGTRGF
310 320 330 340 350
DWEEYINNKT NFYMVPGMLE PLLCGNSSDA GQCPEGFQCM KAGRNPNYGY
360 370 380 390 400
TSFDTFSWAF LALFRLMTQD YWENLYQLTL RAAGKTYMIF FVLVIFVGSF
410 420 430 440 450
YLVNLILAVV AMAYEEQNQA TLEEAEQKEA EFKAMLEQLK KQQEEAQAAA
460 470 480 490 500
MATSAGTVSE DAIEEEGEDG VGSPRSSSEL SKLSSKSAKE RRNRRKKRKQ
510 520 530 540 550
KELSEGEEKG DPEKVFKSES EDGMRRKAFR LPDNRIGRKF SIMNQSLLSI
560 570 580 590 600
PGSPFLSRHN SKSSIFSFRG PGRFRDPGSE NEFADDEHST VEESEGRRDS
610 620 630 640 650
LFIPIRARER RSSYSGYSGY SQCSRSSRIF PSLRRSVKRN STVDCNGVVS
660 670 680 690 700
LIGPGSHIGR LLPEATTEVE IKKKGPGSLL VSMDQLASYG RKDRINSIMS
710 720 730 740 750
VVTNTLVEEL EESQRKCPPC WYKFANTFLI WECHPYWIKL KEIVNLIVMD
760 770 780 790 800
PFVDLAITIC IVLNTLFMAM EHHPMTPQFE HVLAVGNLVF TGIFTAEMFL
810 820 830 840 850
KLIAMDPYYY FQEGWNIFDG FIVSLSLMEL SLADVEGLSV LRSFRLLRVF
860 870 880 890 900
KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGKSYK
910 920 930 940 950
ECVCKINQEC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW DCMEVAGQAM
960 970 980 990 1000
CLIVFMMVMV IGNLVVLNLF LALLLSSFSA DNLAATDDDG EMNNLQISVI
1010 1020 1030 1040 1050
RIKKGVAWTK VKVHAFMQAH FKQREADEVK PLDELYEKKA NCIANHTGVD
1060 1070 1080 1090 1100
IHRNGDFQKN GNGTTSGIGS SVEKYIIDED HMSFINNPNL TVRVPIAVGE
1110 1120 1130 1140 1150
SDFENLNTED VSSESDPEGS KDKLDDTSSS EGSTIDIKPE VEEVPVEQPE
1160 1170 1180 1190 1200
EYLDPDACFT EGCVQRFKCC QVNIEEGLGK SWWILRKTCF LIVEHNWFET
1210 1220 1230 1240 1250
FIIFMILLSS GALAFEDIYI EQRKTIRTIL EYADKVFTYI FILEMLLKWT
1260 1270 1280 1290 1300
AYGFVKFFTN AWCWLDFLIV AVSLVSLIAN ALGYSELGAI KSLRTLRALR
1310 1320 1330 1340 1350
PLRALSRFEG MRVVVNALVG AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK
1360 1370 1380 1390 1400
YHYCFNETSE IRFEIDIVNN KTDCEKLMEG NSTEIRWKNV KINFDNVGAG
1410 1420 1430 1440 1450
YLALLQVATF KGWMDIMYAA VDSRKPDEQP DYEGNIYMYI YFVIFIIFGS
1460 1470 1480 1490 1500
FFTLNLFIGV IIDNFNQQKK KFGGQDIFMT EEQKKYYNAM KKLGSKKPQK
1510 1520 1530 1540 1550
PIPRPLNKIQ GIVFDFVTQQ AFDIVIMMLI CLNMVTMMVE TDTQSKQMEN
1560 1570 1580 1590 1600
ILYWINLVFV IFFTCECVLK MFALRHYYFT IGWNIFDFVV VILSIVGMFL
1610 1620 1630 1640 1650
ADIIEKYFVS PTLFRVIRLA RIGRILRLIK GAKGIRTLLF ALMMSLPALF
1660 1670 1680 1690 1700
NIGLLLFLVM FIFSIFGMSN FAYVKHEAGI DDMFNFETFG NSMICLFQIT
1710 1720 1730 1740 1750
TSAGWDGLLL PILNRPPDCS LDKEHPGSGF KGDCGNPSVG IFFFVSYIII
1760 1770 1780 1790 1800
SFLIVVNMYI AIILENFSVA TEESADPLSE DDFETFYEIW EKFDPDATQF
1810 1820 1830 1840 1850
IEYCKLADFA DALEHPLRVP KPNTIELIAM DLPMVSGDRI HCLDILFAFT
1860 1870 1880 1890 1900
KRVLGDSGEL DILRQQMEER FVASNPSKVS YEPITTTLRR KQEEVSAVVL
1910 1920 1930 1940 1950
QRAYRGHLAR RGFICRKMAS NKLENGGTHR DKKESTPSTA SLPSYDSVTK
1960 1970
PDKEKQQRAE EGRRERAKRQ KEVRESKC
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2KB93 | A0A0G2KB93_RAT | Sodium channel protein | Scn8a | 1,977 | Annotation score: | ||
F1LMH2 | F1LMH2_RAT | Sodium channel protein | Scn8a | 1,978 | Annotation score: | ||
A0A8I5ZX68 | A0A8I5ZX68_RAT | Sodium channel protein type 8 subun... | Scn8a | 1,937 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038652 | 664 | E → EVKIDKAATDS in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF049239 mRNA Translation: AAC26014.1 AF049240 mRNA Translation: AAC26015.1 |
RefSeqi | NP_062139.2, NM_019266.2 [O88420-1] |
Genome annotation databases
Ensembli | ENSRNOT00000080923; ENSRNOP00000075703; ENSRNOG00000005309 [O88420-2] |
GeneIDi | 29710 |
KEGGi | rno:29710 |
UCSCi | RGD:3638, rat [O88420-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF049239 mRNA Translation: AAC26014.1 AF049240 mRNA Translation: AAC26015.1 |
RefSeqi | NP_062139.2, NM_019266.2 [O88420-1] |
3D structure databases
AlphaFoldDBi | O88420 |
BMRBi | O88420 |
SMRi | O88420 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 248327, 2 interactors |
STRINGi | 10116.ENSRNOP00000008160 |
Chemistry databases
BindingDBi | O88420 |
ChEMBLi | CHEMBL2752 |
GuidetoPHARMACOLOGYi | 583 |
PTM databases
CarbonylDBi | O88420 |
GlyGeni | O88420, 8 sites |
iPTMneti | O88420 |
PhosphoSitePlusi | O88420 |
Proteomic databases
PaxDbi | O88420 |
Protocols and materials databases
ABCDi | O88420, 1 sequenced antibody |
Genome annotation databases
Ensembli | ENSRNOT00000080923; ENSRNOP00000075703; ENSRNOG00000005309 [O88420-2] |
GeneIDi | 29710 |
KEGGi | rno:29710 |
UCSCi | RGD:3638, rat [O88420-1] |
Organism-specific databases
CTDi | 6334 |
RGDi | 3638, Scn8a |
Phylogenomic databases
eggNOGi | KOG2301, Eukaryota |
InParanoidi | O88420 |
OrthoDBi | 172471at2759 |
PhylomeDBi | O88420 |
Enzyme and pathway databases
Reactomei | R-RNO-5576892, Phase 0 - rapid depolarisation |
Miscellaneous databases
PROi | PR:O88420 |
Family and domain databases
CDDi | cd13433, Na_channel_gate, 1 hit |
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR000048, IQ_motif_EF-hand-BS IPR008054, Na_channel_a8su IPR001696, Na_channel_asu IPR044564, Na_chnl_inactivation_gate IPR010526, Na_trans_assoc IPR024583, Na_trans_cytopl IPR043203, VGCC_Ca_Na IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR10037, PTHR10037, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 4 hits PF00612, IQ, 1 hit PF06512, Na_trans_assoc, 1 hit PF11933, Na_trans_cytopl, 1 hit |
PRINTSi | PR00170, NACHANNEL PR01667, NACHANNEL8 |
SMARTi | View protein in SMART SM00015, IQ, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SCN8A_RAT | |
Accessioni | O88420Primary (citable) accession number: O88420 Secondary accession number(s): O88421 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 19, 2010 |
Last sequence update: | November 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families