Sodium channel protein type 8 subunit alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• cation channel activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sodium ion binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Molecular diversity of voltage-gated sodium channel alpha subunits expressed in neuronal and non-neuronal excitable cells."
    Mechaly I., Scamps F., Chabbert C., Sans A., Valmier J.
    Neuroscience 130:389-396(2005) [PubMed] [Europe PMC] [Abstract]
• voltage-gated ion channel activity Source: UniProtKB-KW
• voltage-gated sodium channel activity Source: RGDInferred from direct assayⁱ
  • "Molecular diversity of voltage-gated sodium channel alpha subunits expressed in neuronal and non-neuronal excitable cells."
    Mechaly I., Scamps F., Chabbert C., Sans A., Valmier J.
    Neuroscience 130:389-396(2005) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Functional analysis of a voltage-gated sodium channel and its splice variant from rat dorsal root ganglia."
    Dietrich P.S., McGivern J.G., Delgado S.G., Koch B.D., Eglen R.M., Hunter J.C., Sangameswaran L.
    J. Neurochem. 70:2262-2272(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

GO - Biological processⁱ

• adult locomotory behavior Source: RGDInferred from sequence orthologyⁱ
  • "Behavioral audiograms of homozygous med(J) mutant mice with sodium channel deficiency and unaffected controls."
    Koay G., Heffner R., Heffner H.
    Hear. Res. 171:111-118(2002) [PubMed] [Europe PMC] [Abstract]
• adult walking behavior Source: RGDInferred from sequence orthologyⁱ
  • "Mutation of a new sodium channel gene, Scn8a, in the mouse mutant 'motor endplate disease'."
    Burgess D.L., Kohrman D.C., Galt J., Plummer N.W., Jones J.M., Spear B., Meisler M.H.
    Nat. Genet. 10:461-465(1995) [PubMed] [Europe PMC] [Abstract]
• locomotory behavior Source: RGDInferred from sequence orthologyⁱ
  • "SCNM1, a putative RNA splicing factor that modifies disease severity in mice."
    Buchner D.A., Trudeau M., Meisler M.H.
    Science 301:967-969(2003) [PubMed] [Europe PMC] [Abstract]
• membrane depolarization during action potential Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• muscle organ development Source: RGDInferred from sequence orthologyⁱ
  • "Three ENU-induced neurological mutations in the pore loop of sodium channel Scn8a (Na(v)1.6) and a genetically linked retinal mutation, rd13."
    Buchner D.A., Seburn K.L., Frankel W.N., Meisler M.H.
    Mamm. Genome 15:344-351(2004) [PubMed] [Europe PMC] [Abstract]
• myelination Source: BHF-UCL <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Early events in node of Ranvier formation during myelination and remyelination in the PNS."
    Schafer D.P., Custer A.W., Shrager P., Rasband M.N.
    Neuron Glia Biol. 2:69-79(2006) [PubMed] [Europe PMC] [Abstract]
• neuromuscular process Source: RGDInferred from sequence orthologyⁱ
  • "Behavioral audiograms of homozygous med(J) mutant mice with sodium channel deficiency and unaffected controls."
    Koay G., Heffner R., Heffner H.
    Hear. Res. 171:111-118(2002) [PubMed] [Europe PMC] [Abstract]
• neuronal action potential Source: RGDInferred from direct assayⁱ
  • "Molecular diversity of voltage-gated sodium channel alpha subunits expressed in neuronal and non-neuronal excitable cells."
    Mechaly I., Scamps F., Chabbert C., Sans A., Valmier J.
    Neuroscience 130:389-396(2005) [PubMed] [Europe PMC] [Abstract]
  • "Sodium currents in medullary neurons isolated from the pre-Botzinger complex region."
    Ptak K., Zummo G.G., Alheid G.F., Tkatch T., Surmeier D.J., McCrimmon D.R.
    J. Neurosci. 25:5159-5170(2005) [PubMed] [Europe PMC] [Abstract]
• peripheral nervous system development Source: BHF-UCLInferred from expression patternⁱ
  • "Early events in node of Ranvier formation during myelination and remyelination in the PNS."
    Schafer D.P., Custer A.W., Shrager P., Rasband M.N.
    Neuron Glia Biol. 2:69-79(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of ion transmembrane transport Source: UniProtKB-KW
• response to toxic substance Source: RGDInferred from sequence orthologyⁱ
  • "Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons."
    Rush A.M., Craner M.J., Kageyama T., Dib-Hajj S.D., Waxman S.G., Ranscht B.
    Eur. J. Neurosci. 22:39-49(2005) [PubMed] [Europe PMC] [Abstract]
• sensory perception of sound Source: RGDInferred from sequence orthologyⁱ
  • "Behavioral audiograms of homozygous med(J) mutant mice with sodium channel deficiency and unaffected controls."
    Koay G., Heffner R., Heffner H.
    Hear. Res. 171:111-118(2002) [PubMed] [Europe PMC] [Abstract]
• sodium ion transmembrane transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sodium ion transport Source: RGDInferred from direct assayⁱ
  • Ref.1

    "Functional analysis of a voltage-gated sodium channel and its splice variant from rat dorsal root ganglia."
    Dietrich P.S., McGivern J.G., Delgado S.G., Koch B.D., Eglen R.M., Hunter J.C., Sangameswaran L.
    J. Neurochem. 70:2262-2272(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MAARLLAPPG PDSFKPFTPE SLANIERRIA ESKLKKPPKA DGSHREDDED 
        60         70         80         90        100
SKPKPNSDLE AGKSLPFIYG DIPQGLVAVP LEDFDPYYLT QKTFVVLNRG 
       110        120        130        140        150
KTLFRFSATP ALYILSPFNL IRRIAIKILI HSVFSMIIMC TILTNCVFMT 
       160        170        180        190        200
FSNPPEWSKN VEYTFTGIYT FESLVKIIAR GFCIDGFTFL RDPWNWLDFS 
       210        220        230        240        250
VIMMAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI VGALIQSVKK 
       260        270        280        290        300
LSDVMILTVF CLSVFALIGL QLFMGNLRNK CVVWPINFNE SYLENGTRGF 
       310        320        330        340        350
DWEEYINNKT NFYMVPGMLE PLLCGNSSDA GQCPEGFQCM KAGRNPNYGY 
       360        370        380        390        400
TSFDTFSWAF LALFRLMTQD YWENLYQLTL RAAGKTYMIF FVLVIFVGSF 
       410        420        430        440        450
YLVNLILAVV AMAYEEQNQA TLEEAEQKEA EFKAMLEQLK KQQEEAQAAA 
       460        470        480        490        500
MATSAGTVSE DAIEEEGEDG VGSPRSSSEL SKLSSKSAKE RRNRRKKRKQ 
       510        520        530        540        550
KELSEGEEKG DPEKVFKSES EDGMRRKAFR LPDNRIGRKF SIMNQSLLSI 
       560        570        580        590        600
PGSPFLSRHN SKSSIFSFRG PGRFRDPGSE NEFADDEHST VEESEGRRDS 
       610        620        630        640        650
LFIPIRARER RSSYSGYSGY SQCSRSSRIF PSLRRSVKRN STVDCNGVVS 
       660        670        680        690        700
LIGPGSHIGR LLPEATTEVE IKKKGPGSLL VSMDQLASYG RKDRINSIMS 
       710        720        730        740        750
VVTNTLVEEL EESQRKCPPC WYKFANTFLI WECHPYWIKL KEIVNLIVMD 
       760        770        780        790        800
PFVDLAITIC IVLNTLFMAM EHHPMTPQFE HVLAVGNLVF TGIFTAEMFL 
       810        820        830        840        850
KLIAMDPYYY FQEGWNIFDG FIVSLSLMEL SLADVEGLSV LRSFRLLRVF 
       860        870        880        890        900
KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGKSYK 
       910        920        930        940        950
ECVCKINQEC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW DCMEVAGQAM 
       960        970        980        990       1000
CLIVFMMVMV IGNLVVLNLF LALLLSSFSA DNLAATDDDG EMNNLQISVI 
      1010       1020       1030       1040       1050
RIKKGVAWTK VKVHAFMQAH FKQREADEVK PLDELYEKKA NCIANHTGVD 
      1060       1070       1080       1090       1100
IHRNGDFQKN GNGTTSGIGS SVEKYIIDED HMSFINNPNL TVRVPIAVGE 
      1110       1120       1130       1140       1150
SDFENLNTED VSSESDPEGS KDKLDDTSSS EGSTIDIKPE VEEVPVEQPE 
      1160       1170       1180       1190       1200
EYLDPDACFT EGCVQRFKCC QVNIEEGLGK SWWILRKTCF LIVEHNWFET 
      1210       1220       1230       1240       1250
FIIFMILLSS GALAFEDIYI EQRKTIRTIL EYADKVFTYI FILEMLLKWT 
      1260       1270       1280       1290       1300
AYGFVKFFTN AWCWLDFLIV AVSLVSLIAN ALGYSELGAI KSLRTLRALR 
      1310       1320       1330       1340       1350
PLRALSRFEG MRVVVNALVG AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK 
      1360       1370       1380       1390       1400
YHYCFNETSE IRFEIDIVNN KTDCEKLMEG NSTEIRWKNV KINFDNVGAG 
      1410       1420       1430       1440       1450
YLALLQVATF KGWMDIMYAA VDSRKPDEQP DYEGNIYMYI YFVIFIIFGS 
      1460       1470       1480       1490       1500
FFTLNLFIGV IIDNFNQQKK KFGGQDIFMT EEQKKYYNAM KKLGSKKPQK 
      1510       1520       1530       1540       1550
PIPRPLNKIQ GIVFDFVTQQ AFDIVIMMLI CLNMVTMMVE TDTQSKQMEN 
      1560       1570       1580       1590       1600
ILYWINLVFV IFFTCECVLK MFALRHYYFT IGWNIFDFVV VILSIVGMFL 
      1610       1620       1630       1640       1650
ADIIEKYFVS PTLFRVIRLA RIGRILRLIK GAKGIRTLLF ALMMSLPALF 
      1660       1670       1680       1690       1700
NIGLLLFLVM FIFSIFGMSN FAYVKHEAGI DDMFNFETFG NSMICLFQIT 
      1710       1720       1730       1740       1750
TSAGWDGLLL PILNRPPDCS LDKEHPGSGF KGDCGNPSVG IFFFVSYIII 
      1760       1770       1780       1790       1800
SFLIVVNMYI AIILENFSVA TEESADPLSE DDFETFYEIW EKFDPDATQF 
      1810       1820       1830       1840       1850
IEYCKLADFA DALEHPLRVP KPNTIELIAM DLPMVSGDRI HCLDILFAFT 
      1860       1870       1880       1890       1900
KRVLGDSGEL DILRQQMEER FVASNPSKVS YEPITTTLRR KQEEVSAVVL 
      1910       1920       1930       1940       1950
QRAYRGHLAR RGFICRKMAS NKLENGGTHR DKKESTPSTA SLPSYDSVTK 
      1960       1970 
PDKEKQQRAE EGRRERAKRQ KEVRESKC                         

        10         20         30         40         50
MAARLLAPPG PDSFKPFTPE SLANIERRIA ESKLKKPPKA DGSHREDDED 
        60         70         80         90        100
SKPKPNSDLE AGKSLPFIYG DIPQGLVAVP LEDFDPYYLT QKTFVVLNRG 
       110        120        130        140        150
KTLFRFSATP ALYILSPFNL IRRIAIKILI HSVFSMIIMC TILTNCVFMT 
       160        170        180        190        200
FSNPPEWSKN VEYTFTGIYT FESLVKIIAR GFCIDGFTFL RDPWNWLDFS 
       210        220        230        240        250
VIMMAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI VGALIQSVKK 
       260        270        280        290        300
LSDVMILTVF CLSVFALIGL QLFMGNLRNK CVVWPINFNE SYLENGTRGF 
       310        320        330        340        350
DWEEYINNKT NFYMVPGMLE PLLCGNSSDA GQCPEGFQCM KAGRNPNYGY 
       360        370        380        390        400
TSFDTFSWAF LALFRLMTQD YWENLYQLTL RAAGKTYMIF FVLVIFVGSF 
       410        420        430        440        450
YLVNLILAVV AMAYEEQNQA TLEEAEQKEA EFKAMLEQLK KQQEEAQAAA 
       460        470        480        490        500
MATSAGTVSE DAIEEEGEDG VGSPRSSSEL SKLSSKSAKE RRNRRKKRKQ 
       510        520        530        540        550
KELSEGEEKG DPEKVFKSES EDGMRRKAFR LPDNRIGRKF SIMNQSLLSI 
       560        570        580        590        600
PGSPFLSRHN SKSSIFSFRG PGRFRDPGSE NEFADDEHST VEESEGRRDS 
       610        620        630        640        650
LFIPIRARER RSSYSGYSGY SQCSRSSRIF PSLRRSVKRN STVDCNGVVS 
       660        670        680        690        700
LIGPGSHIGR LLPEVKIDKA ATDSATTEVE IKKKGPGSLL VSMDQLASYG 
       710        720        730        740        750
RKDRINSIMS VVTNTLVEEL EESQRKCPPC WYKFANTFLI WECHPYWIKL 
       760        770        780        790        800
KEIVNLIVMD PFVDLAITIC IVLNTLFMAM EHHPMTPQFE HVLAVGNLVF 
       810        820        830        840        850
TGIFTAEMFL KLIAMDPYYY FQEGWNIFDG FIVSLSLMEL SLADVEGLSV 
       860        870        880        890        900
LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV 
       910        920        930        940        950
GMQLFGKSYK ECVCKINQEC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW 
       960        970        980        990       1000
DCMEVAGQAM CLIVFMMVMV IGNLVVLNLF LALLLSSFSA DNLAATDDDG 
      1010       1020       1030       1040       1050
EMNNLQISVI RIKKGVAWTK VKVHAFMQAH FKQREADEVK PLDELYEKKA 
      1060       1070       1080       1090       1100
NCIANHTGVD IHRNGDFQKN GNGTTSGIGS SVEKYIIDED HMSFINNPNL 
      1110       1120       1130       1140       1150
TVRVPIAVGE SDFENLNTED VSSESDPEGS KDKLDDTSSS EGSTIDIKPE 
      1160       1170       1180       1190       1200
VEEVPVEQPE EYLDPDACFT EGCVQRFKCC QVNIEEGLGK SWWILRKTCF 
      1210       1220       1230       1240       1250
LIVEHNWFET FIIFMILLSS GALAFEDIYI EQRKTIRTIL EYADKVFTYI 
      1260       1270       1280       1290       1300
FILEMLLKWT AYGFVKFFTN AWCWLDFLIV AVSLVSLIAN ALGYSELGAI 
      1310       1320       1330       1340       1350
KSLRTLRALR PLRALSRFEG MRVVVNALVG AIPSIMNVLL VCLIFWLIFS 
      1360       1370       1380       1390       1400
IMGVNLFAGK YHYCFNETSE IRFEIDIVNN KTDCEKLMEG NSTEIRWKNV 
      1410       1420       1430       1440       1450
KINFDNVGAG YLALLQVATF KGWMDIMYAA VDSRKPDEQP DYEGNIYMYI 
      1460       1470       1480       1490       1500
YFVIFIIFGS FFTLNLFIGV IIDNFNQQKK KFGGQDIFMT EEQKKYYNAM 
      1510       1520       1530       1540       1550
KKLGSKKPQK PIPRPLNKIQ GIVFDFVTQQ AFDIVIMMLI CLNMVTMMVE 
      1560       1570       1580       1590       1600
TDTQSKQMEN ILYWINLVFV IFFTCECVLK MFALRHYYFT IGWNIFDFVV 
      1610       1620       1630       1640       1650
VILSIVGMFL ADIIEKYFVS PTLFRVIRLA RIGRILRLIK GAKGIRTLLF 
      1660       1670       1680       1690       1700
ALMMSLPALF NIGLLLFLVM FIFSIFGMSN FAYVKHEAGI DDMFNFETFG 
      1710       1720       1730       1740       1750
NSMICLFQIT TSAGWDGLLL PILNRPPDCS LDKEHPGSGF KGDCGNPSVG 
      1760       1770       1780       1790       1800
IFFFVSYIII SFLIVVNMYI AIILENFSVA TEESADPLSE DDFETFYEIW 
      1810       1820       1830       1840       1850
EKFDPDATQF IEYCKLADFA DALEHPLRVP KPNTIELIAM DLPMVSGDRI 
      1860       1870       1880       1890       1900
HCLDILFAFT KRVLGDSGEL DILRQQMEER FVASNPSKVS YEPITTTLRR 
      1910       1920       1930       1940       1950
KQEEVSAVVL QRAYRGHLAR RGFICRKMAS NKLENGGTHR DKKESTPSTA 
      1960       1970       1980 
SLPSYDSVTK PDKEKQQRAE EGRRERAKRQ KEVRESKC              

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families