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Protein

Probable G-protein coupled receptor 33

Gene

Gpr33

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor; could be a chemoattractant receptor.

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 33
Gene namesi
Name:Gpr33
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1277106 Gpr33

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 53Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini54 – 64CytoplasmicSequence analysisAdd BLAST11
Transmembranei65 – 86Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini87 – 103ExtracellularSequence analysisAdd BLAST17
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 143CytoplasmicSequence analysisAdd BLAST19
Transmembranei144 – 165Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini166 – 209ExtracellularSequence analysisAdd BLAST44
Transmembranei210 – 230Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini231 – 246CytoplasmicSequence analysisAdd BLAST16
Transmembranei247 – 268Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini269 – 283ExtracellularSequence analysisAdd BLAST15
Transmembranei284 – 303Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini304 – 339CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695541 – 339Probable G-protein coupled receptor 33Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88416
PRIDEiO88416

PTM databases

PhosphoSitePlusiO88416

Expressioni

Tissue specificityi

Expressed predominantly in lung, spleen and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000035148 Expressed in 23 organ(s), highest expression level in liver
CleanExiMM_GPR33
ExpressionAtlasiO88416 baseline and differential
GenevisibleiO88416 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048059

Structurei

3D structure databases

ProteinModelPortaliO88416
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKP8 Eukaryota
ENOG4111ISS LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000112790
HOVERGENiHBG096748
InParanoidiO88416
KOiK08382
OMAiFVCWMPY
OrthoDBiEOG091G0B9S
PhylomeDBiO88416
TreeFamiTF330976

Family and domain databases

InterProiView protein in InterPro
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O88416-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLINSSTHV INVSTSLTNS TGVPTPAPKT IIAASLFMAF IIGVISNGLY
60 70 80 90 100
LWMLQFKMQR TVNTLLFFHL ILSYFISTLI LPFMATSFLQ DNHWVFGSVL
110 120 130 140 150
CKAFNSTLSV SMFASVFFLS AISVARYYLI LHPVWSQQHR TPHWASRIAL
160 170 180 190 200
QIWISATILS IPYLVFRTTH DDHKGRIKCQ NNYIVSTDWE SKEHQTLGQW
210 220 230 240 250
IHAACFVGRF LLGFLLPFLV IIFCYKRVAT KMKEKGLFKS SKPFKVMVTA
260 270 280 290 300
VISFFVCWMP YHVHSGLVLT KSQPLPLHLT LGLAVVTISF NTVVSPVLYL
310 320 330
FTGENFKVFK KSILALFNST FSDISSTERT QTLNSETEI
Length:339
Mass (Da):38,446
Last modified:November 1, 1998 - v1
Checksum:iCCA468A38B55A1FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045766 mRNA Translation: AAC40152.1
BC064084 mRNA Translation: AAH64084.1
CCDSiCCDS25904.1
RefSeqiNP_032185.1, NM_008159.2
UniGeneiMm.12890

Genome annotation databases

EnsembliENSMUST00000040161; ENSMUSP00000048059; ENSMUSG00000035148
GeneIDi14762
KEGGimmu:14762
UCSCiuc007nnf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045766 mRNA Translation: AAC40152.1
BC064084 mRNA Translation: AAH64084.1
CCDSiCCDS25904.1
RefSeqiNP_032185.1, NM_008159.2
UniGeneiMm.12890

3D structure databases

ProteinModelPortaliO88416
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048059

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO88416

Proteomic databases

PaxDbiO88416
PRIDEiO88416

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040161; ENSMUSP00000048059; ENSMUSG00000035148
GeneIDi14762
KEGGimmu:14762
UCSCiuc007nnf.1 mouse

Organism-specific databases

CTDi2856
MGIiMGI:1277106 Gpr33

Phylogenomic databases

eggNOGiENOG410IKP8 Eukaryota
ENOG4111ISS LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000112790
HOVERGENiHBG096748
InParanoidiO88416
KOiK08382
OMAiFVCWMPY
OrthoDBiEOG091G0B9S
PhylomeDBiO88416
TreeFamiTF330976

Miscellaneous databases

PROiPR:O88416
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035148 Expressed in 23 organ(s), highest expression level in liver
CleanExiMM_GPR33
ExpressionAtlasiO88416 baseline and differential
GenevisibleiO88416 MM

Family and domain databases

InterProiView protein in InterPro
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPR33_MOUSE
AccessioniPrimary (citable) accession number: O88416
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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