UniProtKB - O88410 (CXCR3_MOUSE)
Protein
C-X-C chemokine receptor type 3
Gene
Cxcr3
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response (By similarity). Binds to CCL21.By similarity2 Publications
GO - Molecular functioni
- C-C chemokine binding Source: GO_Central
- C-C chemokine receptor activity Source: GO_Central
- chemokine binding Source: MGI
- C-X-C chemokine binding Source: UniProtKB
- C-X-C chemokine receptor activity Source: MGI
- identical protein binding Source: MGI
- signaling receptor activity Source: UniProtKB
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGI
- angiogenesis Source: UniProtKB-KW
- calcium-mediated signaling Source: MGI
- cell chemotaxis Source: GO_Central
- cell surface receptor signaling pathway Source: MGI
- chemokine (C-C motif) ligand 11 production Source: UniProtKB
- chemotaxis Source: GO_Central
- G protein-coupled receptor signaling pathway Source: UniProtKB
- immune response Source: GO_Central
- inflammatory response Source: InterPro
- negative regulation of angiogenesis Source: MGI
- negative regulation of endothelial cell proliferation Source: MGI
- negative regulation of execution phase of apoptosis Source: UniProtKB
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of chemotaxis Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: MGI
- positive regulation of execution phase of apoptosis Source: MGI
- positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of cell adhesion Source: MGI
- regulation of leukocyte migration Source: InterPro
- T cell chemotaxis Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Angiogenesis, Chemotaxis |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C chemokine receptor type 3Short name: CXC-R3 Short name: CXCR-3 Alternative name(s): Interferon-inducible protein 10 receptor Short name: IP-10 receptor CD_antigen: CD183 |
Gene namesi | Name:Cxcr3 Synonyms:Cmkar3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1277207, Cxcr3 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- external side of plasma membrane Source: MGI
- plasma membrane Source: UniProtKB
Other locations
- cell surface Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 52 | ExtracellularSequence analysisAdd BLAST | 52 | |
Transmembranei | 53 – 79 | Helical; Name=1Sequence analysisAdd BLAST | 27 | |
Topological domaini | 80 – 88 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 89 – 109 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 110 – 124 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 125 – 146 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 147 – 168 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 169 – 188 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 189 – 211 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 212 – 232 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 233 – 254 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 255 – 276 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 277 – 297 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 298 – 320 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 321 – 367 | CytoplasmicSequence analysisAdd BLAST | 47 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069347 | 1 – 367 | C-X-C chemokine receptor type 3Add BLAST | 367 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 22 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 27 | SulfotyrosineBy similarity | 1 | |
Modified residuei | 29 | SulfotyrosineBy similarity | 1 | |
Glycosylationi | 32 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 123 ↔ 202 | PROSITE-ProRule annotation |
Post-translational modificationi
Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding.By similarity
N-glycosylated.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, SulfationProteomic databases
EPDi | O88410 |
PaxDbi | O88410 |
PRIDEi | O88410 |
PTM databases
GlyGeni | O88410, 2 sites |
iPTMneti | O88410 |
PhosphoSitePlusi | O88410 |
Expressioni
Tissue specificityi
Expresses in lymphoid organs and Th1 cells.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000050232, Expressed in secondary oocyte and 91 other tissues |
Genevisiblei | O88410, MM |
Interactioni
Subunit structurei
Homomer. Forms heteromers with ACKR4 (By similarity).
By similarityGO - Molecular functioni
- C-C chemokine binding Source: GO_Central
- chemokine binding Source: MGI
- C-X-C chemokine binding Source: UniProtKB
- identical protein binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000052444 |
Chemistry databases
BindingDBi | O88410 |
Miscellaneous databases
RNActi | O88410, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222321 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | O88410 |
OMAi | VWGLCLF |
OrthoDBi | 794531at2759 |
PhylomeDBi | O88410 |
TreeFami | TF330966 |
Family and domain databases
InterProi | View protein in InterPro IPR004070, Chemokine_CXCR3 IPR000355, Chemokine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR01532, CXCCHMKINER3 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O88410-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYLEVSERQV LDASDFAFLL ENSTSPYDYG ENESDFSDSP PCPQDFSLNF
60 70 80 90 100
DRTFLPALYS LLFLLGLLGN GAVAAVLLSQ RTALSSTDTF LLHLAVADVL
110 120 130 140 150
LVLTLPLWAV DAAVQWVFGP GLCKVAGALF NINFYAGAFL LACISFDRYL
160 170 180 190 200
SIVHATQIYR RDPRVRVALT CIVVWGLCLL FALPDFIYLS ANYDQRLNAT
210 220 230 240 250
HCQYNFPQVG RTALRVLQLV AGFLLPLLVM AYCYAHILAV LLVSRGQRRF
260 270 280 290 300
RAMRLVVVVV AAFAVCWTPY HLVVLVDILM DVGVLARNCG RESHVDVAKS
310 320 330 340 350
VTSGMGYMHC CLNPLLYAFV GVKFREQMWM LFTRLGRSDQ RGPQRQPSSS
360
RRESSWSETT EASYLGL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 16 | F → S in AAH96626 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 292 | E → K in AAC40163 (PubMed:9653165).Curated | 1 | |
Sequence conflicti | 327 | Q → K in AAC40163 (PubMed:9653165).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF045146 mRNA Translation: AAC40163.1 AB003174 mRNA Translation: BAA34045.1 BC096626 mRNA Translation: AAH96626.1 |
CCDSi | CCDS30319.1 |
PIRi | JE0349 |
RefSeqi | NP_034040.1, NM_009910.3 |
Genome annotation databases
Ensembli | ENSMUST00000056614; ENSMUSP00000052444; ENSMUSG00000050232 |
GeneIDi | 12766 |
KEGGi | mmu:12766 |
UCSCi | uc009tye.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF045146 mRNA Translation: AAC40163.1 AB003174 mRNA Translation: BAA34045.1 BC096626 mRNA Translation: AAH96626.1 |
CCDSi | CCDS30319.1 |
PIRi | JE0349 |
RefSeqi | NP_034040.1, NM_009910.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000052444 |
Chemistry databases
BindingDBi | O88410 |
ChEMBLi | CHEMBL5200 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | O88410, 2 sites |
iPTMneti | O88410 |
PhosphoSitePlusi | O88410 |
Proteomic databases
EPDi | O88410 |
PaxDbi | O88410 |
PRIDEi | O88410 |
Protocols and materials databases
Antibodypediai | 566, 1037 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000056614; ENSMUSP00000052444; ENSMUSG00000050232 |
GeneIDi | 12766 |
KEGGi | mmu:12766 |
UCSCi | uc009tye.1, mouse |
Organism-specific databases
CTDi | 2833 |
MGIi | MGI:1277207, Cxcr3 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222321 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | O88410 |
OMAi | VWGLCLF |
OrthoDBi | 794531at2759 |
PhylomeDBi | O88410 |
TreeFami | TF330966 |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 12766, 2 hits in 17 CRISPR screens |
PROi | PR:O88410 |
RNActi | O88410, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000050232, Expressed in secondary oocyte and 91 other tissues |
Genevisiblei | O88410, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004070, Chemokine_CXCR3 IPR000355, Chemokine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR01532, CXCCHMKINER3 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXCR3_MOUSE | |
Accessioni | O88410Primary (citable) accession number: O88410 Secondary accession number(s): Q4V9Y6, Q9QWN6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | September 27, 2005 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries