Cxcr3

Functionⁱ

Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response (By similarity). Binds to CCL21.By similarity2 Publications

GO - Molecular functionⁱ

C-C chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
C-C chemokine receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine binding Source: MGI
C-X-C chemokine binding Source: UniProtKB
C-X-C chemokine receptor activity Source: MGI
signaling receptor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGI
angiogenesis Source: UniProtKB-KW
calcium-mediated signaling Source: MGI
cell chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell surface receptor signaling pathway Source: MGI
chemokine (C-C motif) ligand 11 production Source: UniProtKB
chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway Source: UniProtKB
immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
inflammatory response Source: InterPro
negative regulation of angiogenesis Source: MGI
negative regulation of endothelial cell proliferation Source: MGI
negative regulation of execution phase of apoptosis Source: UniProtKB
positive regulation of angiogenesis Source: UniProtKB
positive regulation of cAMP-mediated signaling Source: MGI
positive regulation of cell proliferation Source: UniProtKB
positive regulation of chemotaxis Source: UniProtKB
positive regulation of cytosolic calcium ion concentration Source: MGI
positive regulation of execution phase of apoptosis Source: MGI
positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
positive regulation of transcription by RNA polymerase II Source: MGI
regulation of leukocyte migration Source: InterPro
T cell chemotaxis Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Angiogenesis, Chemotaxis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-380108 Chemokine receptors bind chemokines R-MMU-418594 G alpha (i) signalling events

Reactomeⁱ

R-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-X-C chemokine receptor type 3 Short name: CXC-R3 Short name: CXCR-3 Alternative name(s): Interferon-inducible protein 10 receptor Short name: IP-10 receptor CD_antigen: CD183
Gene namesⁱ	Name:Cxcr3 Synonyms:Cmkar3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome X

Organism-specific databases

MGIⁱ	MGI:1277207 Cxcr3

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 52	ExtracellularSequence analysisAdd BLAST	52
Transmembraneⁱ	53 – 79	Helical; Name=1Sequence analysisAdd BLAST	27
Topological domainⁱ	80 – 88	CytoplasmicSequence analysis	9
Transmembraneⁱ	89 – 109	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	110 – 124	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	125 – 146	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	147 – 168	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	169 – 188	Helical; Name=4Sequence analysisAdd BLAST	20
Topological domainⁱ	189 – 211	ExtracellularSequence analysisAdd BLAST	23
Transmembraneⁱ	212 – 232	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	233 – 254	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	255 – 276	Helical; Name=6Sequence analysisAdd BLAST	22
Topological domainⁱ	277 – 297	ExtracellularSequence analysisAdd BLAST	21
Transmembraneⁱ	298 – 320	Helical; Name=7Sequence analysisAdd BLAST	23
Topological domainⁱ	321 – 367	CytoplasmicSequence analysisAdd BLAST	47

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL5200

ChEMBLⁱ

CHEMBL5200

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069347	1 – 367	C-X-C chemokine receptor type 3Add BLAST		367

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	22	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	27	SulfotyrosineBy similarity	1
Modified residueⁱ	29	SulfotyrosineBy similarity	1
Glycosylationⁱ	32	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	123 ↔ 202	PROSITE-ProRule annotation

Post-translational modificationⁱ

Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding.By similarity

N-glycosylated.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

PaxDbⁱ	O88410
PRIDEⁱ	O88410

PTM databases

iPTMnetⁱ	O88410
PhosphoSitePlusⁱ	O88410

Expressionⁱ

Tissue specificityⁱ

Expresses in lymphoid organs and Th1 cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000050232 Expressed in 72 organ(s), highest expression level in secondary oocyte
CleanExⁱ	MM_CXCR3
Genevisibleⁱ	O88410 MM

Interactionⁱ

Subunit structureⁱ

Homomer. Forms heteromers with ACKR4 (By similarity).By similarity

GO - Molecular functionⁱ

C-C chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine binding Source: MGI
C-X-C chemokine binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000052444

STRINGⁱ

10090.ENSMUSP00000052444

Chemistry databases

BindingDBⁱ

O88410

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O88410
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IE41 Eukaryota ENOG410YWPA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150843
HOGENOMⁱ	HOG000234122
HOVERGENⁱ	HBG106917
InParanoidⁱ	O88410
KEGG Orthology (KO) More...KOⁱ	K04188
OMAⁱ	AYCYARI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EDT
PhylomeDBⁱ	O88410
TreeFamⁱ	TF330966

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15180 7tmA_CXCR3, 1 hit
InterProⁱ	View protein in InterPro IPR004070 Chemokine_CXCR3 IPR000355 Chemokine_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00657 CCCHEMOKINER PR01532 CXCCHMKINER3 PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O88410-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MYLEVSERQV LDASDFAFLL ENSTSPYDYG ENESDFSDSP PCPQDFSLNF 
        60         70         80         90        100
DRTFLPALYS LLFLLGLLGN GAVAAVLLSQ RTALSSTDTF LLHLAVADVL 
       110        120        130        140        150
LVLTLPLWAV DAAVQWVFGP GLCKVAGALF NINFYAGAFL LACISFDRYL 
       160        170        180        190        200
SIVHATQIYR RDPRVRVALT CIVVWGLCLL FALPDFIYLS ANYDQRLNAT 
       210        220        230        240        250
HCQYNFPQVG RTALRVLQLV AGFLLPLLVM AYCYAHILAV LLVSRGQRRF 
       260        270        280        290        300
RAMRLVVVVV AAFAVCWTPY HLVVLVDILM DVGVLARNCG RESHVDVAKS 
       310        320        330        340        350
VTSGMGYMHC CLNPLLYAFV GVKFREQMWM LFTRLGRSDQ RGPQRQPSSS 
       360 
RRESSWSETT EASYLGL

Length:367

Mass (Da):41,018

Last modified:September 27, 2005 - v2

Checksum:ⁱEF0348A8358AD951

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	16	F → S in AAH96626 (PubMed:15489334).Curated	1
Sequence conflictⁱ	292	E → K in AAC40163 (PubMed:9653165).Curated	1
Sequence conflictⁱ	327	Q → K in AAC40163 (PubMed:9653165).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF045146 mRNA Translation: AAC40163.1 AB003174 mRNA Translation: BAA34045.1 BC096626 mRNA Translation: AAH96626.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30319.1
PIRⁱ	JE0349
NCBI Reference Sequences More...RefSeqⁱ	NP_034040.1, NM_009910.3
UniGeneⁱ	Mm.12876

Genome annotation databases

Ensemblⁱ	ENSMUST00000056614; ENSMUSP00000052444; ENSMUSG00000050232
GeneIDⁱ	12766
KEGGⁱ	mmu:12766
UCSC genome browser More...UCSCⁱ	uc009tye.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O88410	C-X-C chemokine receptor type 3		RAT		367	UniRef90_O88410
Uncharacterized protein		NEOLE		366
UPI000A31562C		MUSCR		367
UPI00038BDB9A		MICOH		366
UPI00042AE9E9		PERMB		366
+1

Protein	Similar proteins		Species	Score	Length	Source
O88410	C-X-C chemokine receptor type 3		HUMAN		368	UniRef50_P49682
C-X-C chemokine receptor type 3		BOVIN		366
C-X-C chemokine receptor type 3		CAPHI		366
C-X-C chemokine receptor type 3		CANLF		365
C-X-C chemokine receptor type 3		RAT		367
+134

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF045146 mRNA Translation: AAC40163.1 AB003174 mRNA Translation: BAA34045.1 BC096626 mRNA Translation: AAH96626.1
CCDSⁱ	CCDS30319.1
PIRⁱ	JE0349
RefSeqⁱ	NP_034040.1, NM_009910.3
UniGeneⁱ	Mm.12876

3D structure databases

ProteinModelPortalⁱ	O88410
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000052444

STRINGⁱ

10090.ENSMUSP00000052444

Chemistry databases

BindingDBⁱ	O88410
ChEMBLⁱ	CHEMBL5200

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	O88410
PhosphoSitePlusⁱ	O88410

Proteomic databases

PaxDbⁱ	O88410
PRIDEⁱ	O88410

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000056614; ENSMUSP00000052444; ENSMUSG00000050232
GeneIDⁱ	12766
KEGGⁱ	mmu:12766
UCSCⁱ	uc009tye.1 mouse

Organism-specific databases

CTDⁱ	2833
MGIⁱ	MGI:1277207 Cxcr3

Phylogenomic databases

eggNOGⁱ	ENOG410IE41 Eukaryota ENOG410YWPA LUCA
GeneTreeⁱ	ENSGT00930000150843
HOGENOMⁱ	HOG000234122
HOVERGENⁱ	HBG106917
InParanoidⁱ	O88410
KOⁱ	K04188
OMAⁱ	AYCYARI
OrthoDBⁱ	EOG091G0EDT
PhylomeDBⁱ	O88410
TreeFamⁱ	TF330966

Enzyme and pathway databases

Reactomeⁱ	R-MMU-380108 Chemokine receptors bind chemokines R-MMU-418594 G alpha (i) signalling events

Reactomeⁱ

R-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O88410
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000050232 Expressed in 72 organ(s), highest expression level in secondary oocyte
CleanExⁱ	MM_CXCR3
Genevisibleⁱ	O88410 MM

Family and domain databases

CDDⁱ	cd15180 7tmA_CXCR3, 1 hit
InterProⁱ	View protein in InterPro IPR004070 Chemokine_CXCR3 IPR000355 Chemokine_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00657 CCCHEMOKINER PR01532 CXCCHMKINER3 PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXCR3_MOUSE
Accessionⁱ	O88410Primary (citable) accession number: O88410 Secondary accession number(s): Q4V9Y6, Q9QWN6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	September 27, 2005
	Last modified:	November 7, 2018
	This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - O88410 (CXCR3_MOUSE)

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C-X-C chemokine receptor type 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ