UniProtKB - O88393 (TGBR3_MOUSE)
Protein
Transforming growth factor beta receptor type 3
Gene
Tgfbr3
Organism
Mus musculus (Mouse)
Status
Functioni
Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors (By similarity).By similarity
GO - Molecular functioni
- activin binding Source: MGI
- coreceptor activity Source: MGI
- fibroblast growth factor binding Source: MGI
- glycosaminoglycan binding Source: BHF-UCL
- heparin binding Source: MGI
- PDZ domain binding Source: BHF-UCL
- SMAD binding Source: BHF-UCL
- transforming growth factor beta-activated receptor activity Source: MGI
- transforming growth factor beta binding Source: BHF-UCL
- transforming growth factor beta receptor activity, type III Source: MGI
- transforming growth factor beta receptor binding Source: MGI
- type II transforming growth factor beta receptor binding Source: MGI
GO - Biological processi
- angiogenesis Source: GO_Central
- blastocyst development Source: MGI
- blood vessel development Source: MGI
- blood vessel remodeling Source: MGI
- BMP signaling pathway Source: MGI
- cardiac epithelial to mesenchymal transition Source: MGI
- cardiac muscle cell proliferation Source: BHF-UCL
- cell migration Source: GO_Central
- collagen metabolic process Source: BHF-UCL
- coronary vasculature development Source: DFLAT
- coronary vasculature morphogenesis Source: DFLAT
- definitive erythrocyte differentiation Source: BHF-UCL
- definitive hemopoiesis Source: BHF-UCL
- epicardial cell to mesenchymal cell transition Source: DFLAT
- epicardium-derived cardiac fibroblast cell development Source: BHF-UCL
- epithelial to mesenchymal transition Source: MGI
- heart trabecula formation Source: BHF-UCL
- heart trabecula morphogenesis Source: BHF-UCL
- immune response Source: MGI
- intracellular signal transduction Source: MGI
- in utero embryonic development Source: MGI
- liver development Source: BHF-UCL
- muscular septum morphogenesis Source: BHF-UCL
- negative regulation of apoptotic process involved in morphogenesis Source: MGI
- negative regulation of cellular component movement Source: MGI
- negative regulation of epithelial cell migration Source: MGI
- negative regulation of epithelial cell proliferation Source: BHF-UCL
- negative regulation of epithelial to mesenchymal transition Source: MGI
- negative regulation of gene expression Source: BHF-UCL
- negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
- osteoblast differentiation Source: MGI
- outflow tract morphogenesis Source: BHF-UCL
- pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
- positive regulation of BMP signaling pathway Source: MGI
- positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
- positive regulation of cell population proliferation Source: MGI
- positive regulation of NF-kappaB transcription factor activity Source: MGI
- positive regulation of transforming growth factor beta receptor signaling pathway Source: MGI
- protein-containing complex assembly Source: MGI
- regulation of blood vessel diameter Source: DFLAT
- regulation of protein binding Source: MGI
- regulation of transforming growth factor beta receptor signaling pathway Source: GO_Central
- response to follicle-stimulating hormone Source: MGI
- response to luteinizing hormone Source: MGI
- response to prostaglandin E Source: MGI
- roof of mouth development Source: MGI
- secondary palate development Source: BHF-UCL
- transforming growth factor beta receptor complex assembly Source: MGI
- transforming growth factor beta receptor signaling pathway Source: BHF-UCL
- vasculogenesis Source: MGI
- vasculogenesis involved in coronary vascular morphogenesis Source: BHF-UCL
- ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
- ventricular compact myocardium morphogenesis Source: BHF-UCL
- ventricular septum morphogenesis Source: BHF-UCL
- visceral serous pericardium development Source: DFLAT
Keywordsi
Molecular function | Receptor |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor beta receptor type 3Short name: TGF-beta receptor type 3 Short name: TGFR-3 Alternative name(s): Betaglycan Transforming growth factor beta receptor III Short name: TGF-beta receptor type III |
Gene namesi | Name:Tgfbr3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104637, Tgfbr3 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
- extracellular matrix By similarity
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Note: Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
Extracellular region or secreted
- extracellular matrix Source: MGI
- extracellular space Source: MGI
Plasma Membrane
- external side of plasma membrane Source: MGI
- inhibin-betaglycan-ActRII complex Source: MGI
- integral component of plasma membrane Source: MGI
Other locations
- cell surface Source: BHF-UCL
- cytoplasm Source: MGI
- integral component of membrane Source: MGI
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 785 | ExtracellularSequence analysisAdd BLAST | 763 | |
Transmembranei | 786 – 808 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 809 – 850 | CytoplasmicSequence analysisAdd BLAST | 42 |
Keywords - Cellular componenti
Cell membrane, Extracellular matrix, Membrane, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 533 | S → A: Loss of glycosaminoglycan chains; when associated with A-544. 1 Publication | 1 | |
Mutagenesisi | 544 | S → A: Loss of glycosaminoglycan chains; when associated with A-533. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000041664 | 23 – 850 | Transforming growth factor beta receptor type 3Add BLAST | 828 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 143 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 491 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 533 | O-linked (Xyl...) (glycosaminoglycan) serine1 Publication | 1 | |
Glycosylationi | 544 | O-linked (Xyl...) (glycosaminoglycan) serine1 Publication | 1 | |
Glycosylationi | 570 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 589 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 638 ↔ 704 | 1 Publication | ||
Disulfide bondi | 659 ↔ 728 | 1 Publication | ||
Glycosylationi | 696 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 709 ↔ 721 | 1 Publication |
Post-translational modificationi
Extensively modified by glycosaminoglycan (GAG), either chondroitin sulfate or heparan sulfate depending upon the tissue of origin.
Keywords - PTMi
Disulfide bond, Glycoprotein, ProteoglycanProteomic databases
MaxQBi | O88393 |
PaxDbi | O88393 |
PeptideAtlasi | O88393 |
PRIDEi | O88393 |
PTM databases
GlyGeni | O88393, 7 sites |
iPTMneti | O88393 |
PhosphoSitePlusi | O88393 |
Interactioni
Subunit structurei
Interacts with TCTEX1D4.
By similarityGO - Molecular functioni
- fibroblast growth factor binding Source: MGI
- PDZ domain binding Source: BHF-UCL
- SMAD binding Source: BHF-UCL
- transforming growth factor beta binding Source: BHF-UCL
- transforming growth factor beta receptor binding Source: MGI
- type II transforming growth factor beta receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204165, 2 interactors |
STRINGi | 10090.ENSMUSP00000031224 |
Miscellaneous databases
RNActi | O88393, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O88393 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 454 – 728 | ZPPROSITE-ProRule annotationAdd BLAST | 275 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 735 – 749 | Interaction with TGF-beta ligandAdd BLAST | 15 |
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWNZ, Eukaryota |
InParanoidi | O88393 |
OrthoDBi | 1263397at2759 |
PhylomeDBi | O88393 |
TreeFami | TF337375 |
Family and domain databases
InterProi | View protein in InterPro IPR001507, ZP_dom IPR017977, ZP_dom_CS |
Pfami | View protein in Pfam PF00100, Zona_pellucida, 1 hit |
PRINTSi | PR00023, ZPELLUCIDA |
SMARTi | View protein in SMART SM00241, ZP, 1 hit |
PROSITEi | View protein in PROSITE PS00682, ZP_1, 1 hit PS51034, ZP_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O88393-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVTSHHMVP VFVLMSACLA TAGPEPSTRC ELSPISASHP VQALMESFTV
60 70 80 90 100
LSGCASRGTT GLPREVHILN LRSTDQGLGQ PQREVTLHLN PIASVHTHHK
110 120 130 140 150
PVVFLLNSPQ PLVWHVKTER LAAGVPRLFL VSEGSVVQFS SGNFSLTAET
160 170 180 190 200
EERSFPQENE HLLHWAQKEY GAVTSFTELK IARNIYIKVG EDQVFPPTCN
210 220 230 240 250
IGKNFLSLNY LAEYLQPKAA EGCVLASQPH EKEVHIIELI SPNSNPYSTF
260 270 280 290 300
QVDIIIDIRP AREDPEVVKN LVLILKCKKS VNWVIKSFDV KGNLKVIAPD
310 320 330 340 350
SIGFGKESER SMTVTKLVRN DYPSTQENLM KWALDNGYSP VTSYTIAPVA
360 370 380 390 400
NRFHLRLENN EEMRDEEVHT IPPELRILLG PDHLPALDSP PFQGEIPNGG
410 420 430 440 450
FPFPFPDIPR RGWKEGEDRI PRPKEPIIPR VQLLPDHREP EEVQGGVNIA
460 470 480 490 500
LSVKCDNEKM VVAVDKDSFQ TNGYSGMELT LLDPSCKAKM NGTHFVLESP
510 520 530 540 550
LNGCGTRHRR SAPDGVVYYN SIVVQAPSPG DSSGWPDGYE DLESGDNGFP
560 570 580 590 600
GDTDEGETAP LSRAGVVVFN CSLRQLRSPS GFQDQLDGNA TFNMELYNTD
610 620 630 640 650
LFLVPSPGVF SVAENEHVYV EVSVTKADQD LGFAIQTCFI SPYSNPDRMS
660 670 680 690 700
DYTIIENICP KDDSVKFYSS KRVHFPIPHA EVDKKRFSFV FKSVFNTSLL
710 720 730 740 750
FLHCELTLCS RNKGSQKLPK CVTPDDACTS LDATMIWTMM QNKKTFTKPL
760 770 780 790 800
AVVLQVDYKE NVPNMKESSP VPPPPQIFHG LDTLTVMGIA FAAFVIGALL
810 820 830 840 850
TGALWYIYSH TGETARRQQV PTSPPASENS SAAHSIGSTQ STPCSSSSTA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J097 | A0A0R4J097_MOUSE | Transforming growth factor beta rec... | Tgfbr3 | 850 | Annotation score: | ||
F6VPT9 | F6VPT9_MOUSE | Transforming growth factor beta rec... | Tgfbr3 | 156 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 322 | Y → I in AAH70428 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 391 | P → S in AAH70428 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 712 | N → K in AAH70428 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF039601 mRNA Translation: AAC28564.1 BC070428 mRNA Translation: AAH70428.1 |
CCDSi | CCDS19499.1 |
RefSeqi | NP_035708.2, NM_011578.4 |
Genome annotation databases
GeneIDi | 21814 |
KEGGi | mmu:21814 |
UCSCi | uc008ylz.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF039601 mRNA Translation: AAC28564.1 BC070428 mRNA Translation: AAH70428.1 |
CCDSi | CCDS19499.1 |
RefSeqi | NP_035708.2, NM_011578.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4AJV | X-ray | 2.70 | A | 591-757 | [»] | |
SMRi | O88393 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 204165, 2 interactors |
STRINGi | 10090.ENSMUSP00000031224 |
PTM databases
GlyGeni | O88393, 7 sites |
iPTMneti | O88393 |
PhosphoSitePlusi | O88393 |
Proteomic databases
MaxQBi | O88393 |
PaxDbi | O88393 |
PeptideAtlasi | O88393 |
PRIDEi | O88393 |
Genome annotation databases
GeneIDi | 21814 |
KEGGi | mmu:21814 |
UCSCi | uc008ylz.2, mouse |
Organism-specific databases
CTDi | 7049 |
MGIi | MGI:104637, Tgfbr3 |
Phylogenomic databases
eggNOGi | ENOG502QWNZ, Eukaryota |
InParanoidi | O88393 |
OrthoDBi | 1263397at2759 |
PhylomeDBi | O88393 |
TreeFami | TF337375 |
Miscellaneous databases
BioGRID-ORCSi | 21814, 2 hits in 19 CRISPR screens |
ChiTaRSi | Tgfbr3, mouse |
PROi | PR:O88393 |
RNActi | O88393, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR001507, ZP_dom IPR017977, ZP_dom_CS |
Pfami | View protein in Pfam PF00100, Zona_pellucida, 1 hit |
PRINTSi | PR00023, ZPELLUCIDA |
SMARTi | View protein in SMART SM00241, ZP, 1 hit |
PROSITEi | View protein in PROSITE PS00682, ZP_1, 1 hit PS51034, ZP_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TGBR3_MOUSE | |
Accessioni | O88393Primary (citable) accession number: O88393 Secondary accession number(s): Q6NS72 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | November 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references