Transforming growth factor beta receptor type 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• activin binding Source: MGI
• coreceptor activity Source: MGI
• fibroblast growth factor binding Source: MGI
• glycosaminoglycan binding Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol Cell Biol 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• heparin binding Source: MGI
• PDZ domain binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC."
    Blobe G.C., Liu X., Fang S.J., How T., Lodish H.F.
    J Biol Chem 276:39608-39617(2001) [PubMed] [Europe PMC] [Abstract]
• SMAD binding Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Functional role of transforming growth factor-beta type III receptor during palatal fusion."
    Nakajima A., Ito Y., Asano M., Maeno M., Iwata K., Mitsui N., Shimizu N., Cui X.M., Shuler C.F.
    Dev Dyn 236:791-801(2007) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta-activated receptor activity Source: MGIInferred from direct assayⁱ
  • Ref.1

    "Murine betaglycan primary structure, expression and glycosaminoglycan attachment sites."
    Ponce-Castaneda M.V., Esparza-Lopez J., Vilchis-Landeros M.M., Mendoza V., Lopez-Casillas F.
    Biochim. Biophys. Acta 1384:189-196(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION AT SER-533 AND SER-544, MUTAGENESIS OF SER-533 AND SER-544.
• transforming growth factor beta binding Source: BHF-UCLInferred from direct assayⁱ
  • "Functional role of transforming growth factor-beta type III receptor during palatal fusion."
    Nakajima A., Ito Y., Asano M., Maeno M., Iwata K., Mitsui N., Shimizu N., Cui X.M., Shuler C.F.
    Dev Dyn 236:791-801(2007) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor activity, type III Source: MGI
• transforming growth factor beta receptor binding Source: MGI
• type II transforming growth factor beta receptor binding Source: MGI

GO - Biological processⁱ

• angiogenesis Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• blastocyst development Source: MGIInferred from direct assayⁱ
  • "Identification of two distinct functions for TGF-beta in early mouse development."
    Roelen B.A., Goumans M.J., Zwijsen A., Mummery C.L.
    Differentiation 64:19-31(1998) [PubMed] [Europe PMC] [Abstract]
• blood vessel development Source: MGIInferred from mutant phenotypeⁱ
  • "Coronary vessel development is dependent on the type III transforming growth factor beta receptor."
    Compton L.A., Potash D.A., Brown C.B., Barnett J.V.
    Circ Res 101:784-791(2007) [PubMed] [Europe PMC] [Abstract]
• blood vessel diameter maintenance Source: DFLAT <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Epicardial-myocardial signaling directing coronary vasculogenesis."
    Olivey H.E., Svensson E.C.
    Circ Res 106:818-832(2010) [PubMed] [Europe PMC] [Abstract]
• blood vessel remodeling Source: MGIInferred from mutant phenotypeⁱ
  • "Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis."
    Hill C.R., Jacobs B.H., Brown C.B., Barnett J.V., Goudy S.L.
    Dev Dyn 244:122-133(2015) [PubMed] [Europe PMC] [Abstract]
• BMP signaling pathway Source: MGI
• cardiac epithelial to mesenchymal transition Source: MGI
• cardiac muscle cell proliferation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol Cell Biol 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• cell migration Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• collagen metabolic process Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "A novel reciprocal loop between microRNA-21 and TGFbetaRIII is involved in cardiac fibrosis."
    Liang H., Zhang C., Ban T., Liu Y., Mei L., Piao X., Zhao D., Lu Y., Chu W., Yang B.
    Int J Biochem Cell Biol 44:2152-2160(2012) [PubMed] [Europe PMC] [Abstract]
• coronary vasculature development Source: DFLATTraceable author statementⁱ
  • "Epicardial-myocardial signaling directing coronary vasculogenesis."
    Olivey H.E., Svensson E.C.
    Circ Res 106:818-832(2010) [PubMed] [Europe PMC] [Abstract]
• coronary vasculature morphogenesis Source: DFLATTraceable author statementⁱ
  • "Epicardial-myocardial signaling directing coronary vasculogenesis."
    Olivey H.E., Svensson E.C.
    Circ Res 106:818-832(2010) [PubMed] [Europe PMC] [Abstract]
• definitive erythrocyte differentiation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol Cell Biol 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• definitive hemopoiesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol Cell Biol 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• epicardial cell to mesenchymal cell transition Source: DFLATTraceable author statementⁱ
  • "Epicardial-myocardial signaling directing coronary vasculogenesis."
    Olivey H.E., Svensson E.C.
    Circ Res 106:818-832(2010) [PubMed] [Europe PMC] [Abstract]
• epicardium-derived cardiac fibroblast cell development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Coronary vessel development is dependent on the type III transforming growth factor beta receptor."
    Compton L.A., Potash D.A., Brown C.B., Barnett J.V.
    Circ Res 101:784-791(2007) [PubMed] [Europe PMC] [Abstract]
• epithelial to mesenchymal transition Source: MGI
• heart trabecula formation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol Cell Biol 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• heart trabecula morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol Cell Biol 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• immune response Source: MGI
• intracellular signal transduction Source: MGI
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • "Coronary vessel development is dependent on the type III transforming growth factor beta receptor."
    Compton L.A., Potash D.A., Brown C.B., Barnett J.V.
    Circ Res 101:784-791(2007) [PubMed] [Europe PMC] [Abstract]
• liver development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol Cell Biol 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• muscular septum morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol Cell Biol 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process involved in morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis."
    Hill C.R., Jacobs B.H., Brown C.B., Barnett J.V., Goudy S.L.
    Dev Dyn 244:122-133(2015) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cellular component movement Source: MGI
• negative regulation of epithelial cell migration Source: MGIInferred from mutant phenotypeⁱ
  • "Modulation of NFkappaB activity and E-cadherin by the type III transforming growth factor beta receptor regulates cell growth and motility."
    Criswell T.L., Arteaga C.L.
    J Biol Chem 282:32491-32500(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of epithelial cell proliferation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Functional role of transforming growth factor-beta type III receptor during palatal fusion."
    Nakajima A., Ito Y., Asano M., Maeno M., Iwata K., Mitsui N., Shimizu N., Cui X.M., Shuler C.F.
    Dev Dyn 236:791-801(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of epithelial to mesenchymal transition Source: MGIInferred from mutant phenotypeⁱ
  • "Modulation of NFkappaB activity and E-cadherin by the type III transforming growth factor beta receptor regulates cell growth and motility."
    Criswell T.L., Arteaga C.L.
    J Biol Chem 282:32491-32500(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: BHF-UCLInferred from direct assayⁱ
  • "A novel reciprocal loop between microRNA-21 and TGFbetaRIII is involved in cardiac fibrosis."
    Liang H., Zhang C., Ban T., Liu Y., Mei L., Piao X., Zhao D., Lu Y., Chu W., Yang B.
    Int J Biochem Cell Biol 44:2152-2160(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
• osteoblast differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis."
    Hill C.R., Jacobs B.H., Brown C.B., Barnett J.V., Goudy S.L.
    Dev Dyn 244:122-133(2015) [PubMed] [Europe PMC] [Abstract]
• outflow tract morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Coronary vessel development is dependent on the type III transforming growth factor beta receptor."
    Compton L.A., Potash D.A., Brown C.B., Barnett J.V.
    Circ Res 101:784-791(2007) [PubMed] [Europe PMC] [Abstract]
• pathway-restricted SMAD protein phosphorylation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Functional role of transforming growth factor-beta type III receptor during palatal fusion."
    Nakajima A., Ito Y., Asano M., Maeno M., Iwata K., Mitsui N., Shimizu N., Cui X.M., Shuler C.F.
    Dev Dyn 236:791-801(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of BMP signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis."
    Hill C.R., Jacobs B.H., Brown C.B., Barnett J.V., Goudy S.L.
    Dev Dyn 244:122-133(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cardiac muscle cell proliferation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol Cell Biol 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis."
    Hill C.R., Jacobs B.H., Brown C.B., Barnett J.V., Goudy S.L.
    Dev Dyn 244:122-133(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of NF-kappaB transcription factor activity Source: MGIInferred from mutant phenotypeⁱ
  • "Modulation of NFkappaB activity and E-cadherin by the type III transforming growth factor beta receptor regulates cell growth and motility."
    Criswell T.L., Arteaga C.L.
    J Biol Chem 282:32491-32500(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transforming growth factor beta receptor signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis."
    Hill C.R., Jacobs B.H., Brown C.B., Barnett J.V., Goudy S.L.
    Dev Dyn 244:122-133(2015) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex assembly Source: MGI
• regulation of protein binding Source: MGI
• regulation of transforming growth factor beta receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to follicle-stimulating hormone Source: MGI
• response to luteinizing hormone Source: MGI
• response to prostaglandin E Source: MGI
• roof of mouth development Source: MGIInferred from mutant phenotypeⁱ
  • "Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis."
    Hill C.R., Jacobs B.H., Brown C.B., Barnett J.V., Goudy S.L.
    Dev Dyn 244:122-133(2015) [PubMed] [Europe PMC] [Abstract]
• secondary palate development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Functional role of transforming growth factor-beta type III receptor during palatal fusion."
    Nakajima A., Ito Y., Asano M., Maeno M., Iwata K., Mitsui N., Shimizu N., Cui X.M., Shuler C.F.
    Dev Dyn 236:791-801(2007) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor complex assembly Source: MGI
• transforming growth factor beta receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC."
    Blobe G.C., Liu X., Fang S.J., How T., Lodish H.F.
    J Biol Chem 276:39608-39617(2001) [PubMed] [Europe PMC] [Abstract]
  • "Functional role of transforming growth factor-beta type III receptor during palatal fusion."
    Nakajima A., Ito Y., Asano M., Maeno M., Iwata K., Mitsui N., Shimizu N., Cui X.M., Shuler C.F.
    Dev Dyn 236:791-801(2007) [PubMed] [Europe PMC] [Abstract]
• vasculogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis."
    Hill C.R., Jacobs B.H., Brown C.B., Barnett J.V., Goudy S.L.
    Dev Dyn 244:122-133(2015) [PubMed] [Europe PMC] [Abstract]
• vasculogenesis involved in coronary vascular morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Coronary vessel development is dependent on the type III transforming growth factor beta receptor."
    Compton L.A., Potash D.A., Brown C.B., Barnett J.V.
    Circ Res 101:784-791(2007) [PubMed] [Europe PMC] [Abstract]
• ventricular cardiac muscle tissue morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol Cell Biol 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• ventricular compact myocardium morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol Cell Biol 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
  • "Coronary vessel development is dependent on the type III transforming growth factor beta receptor."
    Compton L.A., Potash D.A., Brown C.B., Barnett J.V.
    Circ Res 101:784-791(2007) [PubMed] [Europe PMC] [Abstract]
• ventricular septum morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Coronary vessel development is dependent on the type III transforming growth factor beta receptor."
    Compton L.A., Potash D.A., Brown C.B., Barnett J.V.
    Circ Res 101:784-791(2007) [PubMed] [Europe PMC] [Abstract]
• visceral serous pericardium development Source: DFLATTraceable author statementⁱ
  • "Epicardial-myocardial signaling directing coronary vasculogenesis."
    Olivey H.E., Svensson E.C.
    Circ Res 106:818-832(2010) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• fibroblast growth factor binding Source: MGI
• PDZ domain binding Source: BHF-UCLInferred from physical interactionⁱ
  • "A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC."
    Blobe G.C., Liu X., Fang S.J., How T., Lodish H.F.
    J Biol Chem 276:39608-39617(2001) [PubMed] [Europe PMC] [Abstract]
• SMAD binding Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Functional role of transforming growth factor-beta type III receptor during palatal fusion."
    Nakajima A., Ito Y., Asano M., Maeno M., Iwata K., Mitsui N., Shimizu N., Cui X.M., Shuler C.F.
    Dev Dyn 236:791-801(2007) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta binding Source: BHF-UCLInferred from direct assayⁱ
  • "Functional role of transforming growth factor-beta type III receptor during palatal fusion."
    Nakajima A., Ito Y., Asano M., Maeno M., Iwata K., Mitsui N., Shimizu N., Cui X.M., Shuler C.F.
    Dev Dyn 236:791-801(2007) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor binding Source: MGI
• type II transforming growth factor beta receptor binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MAVTSHHMVP VFVLMSACLA TAGPEPSTRC ELSPISASHP VQALMESFTV 
        60         70         80         90        100
LSGCASRGTT GLPREVHILN LRSTDQGLGQ PQREVTLHLN PIASVHTHHK 
       110        120        130        140        150
PVVFLLNSPQ PLVWHVKTER LAAGVPRLFL VSEGSVVQFS SGNFSLTAET 
       160        170        180        190        200
EERSFPQENE HLLHWAQKEY GAVTSFTELK IARNIYIKVG EDQVFPPTCN 
       210        220        230        240        250
IGKNFLSLNY LAEYLQPKAA EGCVLASQPH EKEVHIIELI SPNSNPYSTF 
       260        270        280        290        300
QVDIIIDIRP AREDPEVVKN LVLILKCKKS VNWVIKSFDV KGNLKVIAPD 
       310        320        330        340        350
SIGFGKESER SMTVTKLVRN DYPSTQENLM KWALDNGYSP VTSYTIAPVA 
       360        370        380        390        400
NRFHLRLENN EEMRDEEVHT IPPELRILLG PDHLPALDSP PFQGEIPNGG 
       410        420        430        440        450
FPFPFPDIPR RGWKEGEDRI PRPKEPIIPR VQLLPDHREP EEVQGGVNIA 
       460        470        480        490        500
LSVKCDNEKM VVAVDKDSFQ TNGYSGMELT LLDPSCKAKM NGTHFVLESP 
       510        520        530        540        550
LNGCGTRHRR SAPDGVVYYN SIVVQAPSPG DSSGWPDGYE DLESGDNGFP 
       560        570        580        590        600
GDTDEGETAP LSRAGVVVFN CSLRQLRSPS GFQDQLDGNA TFNMELYNTD 
       610        620        630        640        650
LFLVPSPGVF SVAENEHVYV EVSVTKADQD LGFAIQTCFI SPYSNPDRMS 
       660        670        680        690        700
DYTIIENICP KDDSVKFYSS KRVHFPIPHA EVDKKRFSFV FKSVFNTSLL 
       710        720        730        740        750
FLHCELTLCS RNKGSQKLPK CVTPDDACTS LDATMIWTMM QNKKTFTKPL 
       760        770        780        790        800
AVVLQVDYKE NVPNMKESSP VPPPPQIFHG LDTLTVMGIA FAAFVIGALL 
       810        820        830        840        850
TGALWYIYSH TGETARRQQV PTSPPASENS SAAHSIGSTQ STPCSSSSTA 

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references