Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vesicle transport through interaction with t-SNAREs homolog 1B

Gene

Vti1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers.1 Publication

GO - Molecular functioni

  • chloride channel inhibitor activity Source: MGI
  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: MGI

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport through interaction with t-SNAREs homolog 1B
Alternative name(s):
Vesicle transport v-SNARE protein Vti1-like 1
Vti1-rp1
Gene namesi
Name:Vti1b
Synonyms:Vti1l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1855688 Vti1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 208CytoplasmicSequence analysisAdd BLAST207
Transmembranei209 – 229Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini230 – 232VesicularSequence analysis3

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002182292 – 232Vesicle transport through interaction with t-SNAREs homolog 1BAdd BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei107Omega-N-methylarginineBy similarity1
Modified residuei138PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiO88384
MaxQBiO88384
PaxDbiO88384
PeptideAtlasiO88384
PRIDEiO88384

PTM databases

iPTMnetiO88384
PhosphoSitePlusiO88384
SwissPalmiO88384

Expressioni

Tissue specificityi

Broadly expressed.

Interactioni

Subunit structurei

Forms a SNARE complex with STX7, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VIT1B that is required for heterotypic fusion of late endosomes with lysosomes (PubMed:11786915, PubMed:15363411). May interact with STX17. Interacts with CLINT1 (By similarity).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

CORUMiO88384
DIPiDIP-32212N
IntActiO88384, 12 interactors
MINTiO88384
STRINGi10090.ENSMUSP00000057462

Structurei

Secondary structure

1232
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO88384
SMRiO88384
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO88384

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 23Interaction with CLINT1By similarityAdd BLAST22
Regioni69 – 73Interaction with CLINT1By similarity5

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili36 – 98Sequence analysisAdd BLAST63
Coiled coili160 – 201Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the VTI1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1666 Eukaryota
ENOG4111J90 LUCA
HOGENOMiHOG000116573
HOVERGENiHBG058837
InParanoidiO88384
PhylomeDBiO88384

Family and domain databases

Gene3Di1.20.58.400, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR000727 T_SNARE_dom
IPR038407 v-SNARE_N_sf
IPR007705 Vesicle_trsprt_v-SNARE_N
PfamiView protein in Pfam
PF05008 V-SNARE, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O88384-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASAASSEH FEKLHEIFRG LLEDLQGVPE RLLGTAGTEE KKKLVRDFDE
60 70 80 90 100
NQQEANETLA EMEEELRYAP LTFRNPMMSK LRNYRKDLAK LHREVRSTPL
110 120 130 140 150
TAAPGGRGDL KYGTYTLENE HLNRLQSQRA LLLQGTESLN RATQSIERSH
160 170 180 190 200
RIATETDQIG TEIIEELGEQ RDQLERTKSR LVNTNENLSK SRKILRSMSR
210 220 230
KVITNKLLLS VIILLELAIL VGLVYYKFFR HH
Length:232
Mass (Da):26,713
Last modified:November 1, 1998 - v1
Checksum:i6827DCAF9650DFC6
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q91XH6Q91XH6_MOUSE
Vesicle transport through interacti...
Vti1b mCG_5809
232Annotation score:
F6UHS3F6UHS3_MOUSE
Vesicle transport through interacti...
Vti1b
182Annotation score:
F6T4B9F6T4B9_MOUSE
Vesicle transport through interacti...
Vti1b
74Annotation score:
E0CYE5E0CYE5_MOUSE
Vesicle transport through interacti...
Vti1b
54Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035208 mRNA Translation: AAC23483.1
CCDSiCCDS26008.1
UniGeneiMm.265929

Genome annotation databases

UCSCiuc007nzy.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035208 mRNA Translation: AAC23483.1
CCDSiCCDS26008.1
UniGeneiMm.265929

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GL2X-ray1.90C140-200[»]
2QYWX-ray2.00A1-96[»]
ProteinModelPortaliO88384
SMRiO88384
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiO88384
DIPiDIP-32212N
IntActiO88384, 12 interactors
MINTiO88384
STRINGi10090.ENSMUSP00000057462

PTM databases

iPTMnetiO88384
PhosphoSitePlusiO88384
SwissPalmiO88384

Proteomic databases

EPDiO88384
MaxQBiO88384
PaxDbiO88384
PeptideAtlasiO88384
PRIDEiO88384

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc007nzy.2 mouse

Organism-specific databases

MGIiMGI:1855688 Vti1b

Phylogenomic databases

eggNOGiKOG1666 Eukaryota
ENOG4111J90 LUCA
HOGENOMiHOG000116573
HOVERGENiHBG058837
InParanoidiO88384
PhylomeDBiO88384

Miscellaneous databases

ChiTaRSiVti1b mouse
EvolutionaryTraceiO88384
PROiPR:O88384
SOURCEiSearch...

Family and domain databases

Gene3Di1.20.58.400, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR000727 T_SNARE_dom
IPR038407 v-SNARE_N_sf
IPR007705 Vesicle_trsprt_v-SNARE_N
PfamiView protein in Pfam
PF05008 V-SNARE, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVTI1B_MOUSE
AccessioniPrimary (citable) accession number: O88384
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: June 20, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again