Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-1 adrenergic receptor binding Source: UniProtKB
• kinesin binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 12097473
• phosphatase binding Source: UniProtKB
• protein-containing complex binding Source: RGDInferred from physical interactionⁱ
  • 15331416
• receptor signaling complex scaffold activity Source: UniProtKB
• SMAD binding Source: UniProtKB
• structural constituent of postsynaptic density Source: SynGO <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 22593065
• structural constituent of postsynaptic specialization Source: SynGOInferred from direct assayⁱ
  • 23751499
• type II activin receptor binding Source: UniProtKB

GO - Biological processⁱ

• cellular response to nerve growth factor stimulus Source: UniProtKBInferred from direct assayⁱ
  • 17724123
• glomerular filtration Source: UniProtKB <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence <br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • 15994232
• glomerular visceral epithelial cell development Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 15994232
• mitotic cell cycle arrest Source: UniProtKBInferred from direct assayⁱ
  • 17880912
• negative regulation of activin receptor signaling pathway Source: UniProtKB
• negative regulation of cell migration Source: UniProtKBInferred from direct assayⁱ
  • 17880912
• negative regulation of cell proliferation Source: UniProtKBInferred from direct assayⁱ
  • 17880912
• negative regulation of protein kinase B signaling Source: UniProtKB
• nerve growth factor signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • 17724123
• positive regulation of neuron projection development Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 17724123
• positive regulation of phosphoprotein phosphatase activity Source: UniProtKB
• positive regulation of receptor internalization Source: UniProtKB
• protein heterooligomerization Source: RGDInferred from direct assayⁱ
  • 10644767
• receptor clustering Source: RGDInferred from direct assayⁱ
  • 10644767
• regulation of neurotransmitter receptor localization to postsynaptic specialization membrane Source: SynGOInferred from direct assayⁱ
  • 22593065
• regulation of synaptic membrane adhesion Source: SynGOInferred from direct assayⁱ
  • 23751499
• SMAD protein signal transduction Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• beta-1 adrenergic receptor binding Source: UniProtKB
• kinesin binding Source: RGDInferred from physical interactionⁱ
  • 12097473
• phosphatase binding Source: UniProtKB
• receptor signaling complex scaffold activity Source: UniProtKB
• SMAD binding Source: UniProtKB
• type II activin receptor binding Source: UniProtKB

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSKSLKKKSH WTSKVHESVI GRNPEGQLGF ELKGGAENGQ FPYLGEVKPG 
        60         70         80         90        100
KVAYESGSKL VSEELLLEVN ETPVAGLTIR DVLAVIKHCK DPLRLKCVKQ 
       110        120        130        140        150
GGIVDKDLRH YLNLRFQKGS VDHELQQIIR DNLYLRTVPC TTRPHKEGEV 
       160        170        180        190        200
PGVDYIFITV EDFMELEKSG ALLESGTYED NYYGTPKPPA EPAPLLLNVT 
       210        220        230        240        250
DQILPGATPS AEGKRKRNKS VTNMEKASIE PPEEEEEERP VVNGNGVVIT 
       260        270        280        290        300
PESSEHEDKS AGASGETPSQ PYPAPVYSQP EELKDQMDDT KSTKPEENED 
       310        320        330        340        350
SDPLPDNWEM AYTEKGEVYF IDHNTKTTSW LDPRLAKKAK PAEECKENEL 
       360        370        380        390        400
PYGWEKIDDP IYGTYYVDHI NRRTQFENPV LEAKRKLQQH NMPHTELGTK 
       410        420        430        440        450
PLQAPGFREK PLFTRDASQL KGTFLSTTLK KSNMGFGFTI IGGDEPDEFL 
       460        470        480        490        500
QVKSVIPDGP AAQDGKMETG DVIVYINEVC VLGHTHADVV KLFQSVPIGQ 
       510        520        530        540        550
SVNLVLCRGY PLPFDPEDPA NSMVPPLAIM ERPPPVMVNG RHNYETYLEY 
       560        570        580        590        600
ISRTSQSVPD ITDRPPHSLH SMPADGQLDG TYPPPVHDDN VSVASSGATQ 
       610        620        630        640        650
AELMTLTIVK GAKGFGFTIA DSPTGQRVKQ ILDIQGCPGL CEGDLIVEIN 
       660        670        680        690        700
QQNVQNLSHT EVVDILKDCP VGSETSLIIH RGGFFSPWKT PKPMVDRWEN 
       710        720        730        740        750
QGSPQTSLSA PAVPQSLPFP PALHRSSFPD STEAFDPRKP DPYELYEKSR 
       760        770        780        790        800
AIYESRQQVP PRTSFRMDSS GPDYKELDVH LRRMESGFGF RILGGDEPGQ 
       810        820        830        840        850
PILIGAVIAM GSADRDGRLH PGDELVYVDG IPVAGKTHRY VIDLMHHAAR 
       860        870        880        890        900
NGQVNLTVRR KVLCGGEPCP ENGRSPGSVS THHSSPRSDY ATYANSNHAA 
       910        920        930        940        950
PSNNASPPEG FASHSLQTSD VIIHRKENEG FGFVIISSLN RPESGATITV 
       960        970        980        990       1000
PHKIGRIIDG SPADRCAKLK VGDRILAVNG QSIINMPHAD IVKLIKDAGL 
      1010       1020       1030       1040       1050
SVTLRIIPQE ELNNPTSAPS SEKQSPMAQQ HSPLAQQHSP LAQPSPATPN 
      1060       1070       1080       1090       1100
SPVAQPAPPQ PLQLQGHENS YRSEVKARQD VKPDIRQPPF TDYRQPPLDY 
      1110       1120       1130       1140       1150
RQPPGGDYSQ PSPLDYRQHS PDTRQYPLSD YRQPQDFDYF TVDMEKGAKG 
      1160       1170       1180       1190       1200
FGFSIRGGRE YKMDLYVLRL AEDGPAIRNG RMRVGDQIIE INGESTRDMT 
      1210       1220       1230       1240       1250
HARAIELIKS GGRRVRLLLK RGTGQVPEYG MVPSSLSMCM KSDKHGSPYF 
      1260       1270 
YLLGHPKDTT NPTPGALPLP PPQACRK                          

        10         20         30         40         50
MELEKSGALL ESGTYEDNYY GTPKPPAEPA PLLLNVTDQI LPGATPSAEG 
        60         70         80         90        100
KRKRNKSVTN MEKASIEPPE EEEEERPVVN GNGVVITPES SEHEDKSAGA 
       110        120        130        140        150
SGETPSQPYP APVYSQPEEL KDQMDDTKST KPEENEDSDP LPDNWEMAYT 
       160        170        180        190        200
EKGEVYFIDH NTKTTSWLDP RLAKKAKPAE ECKENELPYG WEKIDDPIYG 
       210        220        230        240        250
TYYVDHINRR TQFENPVLEA KRKLQQHNMP HTELGTKPLQ APGFREKPLF 
       260        270        280        290        300
TRDASQLKGT FLSTTLKKSN MGFGFTIIGG DEPDEFLQVK SVIPDGPAAQ 
       310        320        330        340        350
DGKMETGDVI VYINEVCVLG HTHADVVKLF QSVPIGQSVN LVLCRGYPLP 
       360        370        380        390        400
FDPEDPANSM VPPLAIMERP PPVMVNGRHN YETYLEYISR TSQSVPDITD 
       410        420        430        440        450
RPPHSLHSMP ADGQLDGTYP PPVHDDNVSV ASSGATQAEL MTLTIVKGAK 
       460        470        480        490        500
GFGFTIADSP TGQRVKQILD IQGCPGLCEG DLIVEINQQN VQNLSHTEVV 
       510        520        530        540        550
DILKDCPVGS ETSLIIHRGG FFSPWKTPKP MVDRWENQGS PQTSLSAPAV 
       560        570        580        590        600
PQSLPFPPAL HRSSFPDSTE AFDPRKPDPY ELYEKSRAIY ESRQQVPPRT 
       610        620        630        640        650
SFRMDSSGPD YKELDVHLRR MESGFGFRIL GGDEPGQPIL IGAVIAMGSA 
       660        670        680        690        700
DRDGRLHPGD ELVYVDGIPV AGKTHRYVID LMHHAARNGQ VNLTVRRKVL 
       710        720        730        740        750
CGGEPCPENG RSPGSVSTHH SSPRSDYATY ANSNHAAPSN NASPPEGFAS 
       760        770        780        790        800
HSLQTSDVII HRKENEGFGF VIISSLNRPE SGATITVPHK IGRIIDGSPA 
       810        820        830        840        850
DRCAKLKVGD RILAVNGQSI INMPHADIVK LIKDAGLSVT LRIIPQEELN 
       860        870        880        890        900
NPTSAPSSEK QSPMAQQHSP LAQQHSPLAQ PSPATPNSPV AQPAPPQPLQ 
       910        920        930        940        950
LQGHENSYRS EVKARQDVKP DIRQPPFTDY RQPPLDYRQP PGGDYSQPSP 
       960        970        980        990       1000
LDYRQHSPDT RQYPLSDYRQ PQDFDYFTVD MEKGAKGFGF SIRGGREYKM 
      1010       1020       1030       1040       1050
DLYVLRLAED GPAIRNGRMR VGDQIIEING ESTRDMTHAR AIELIKSGGR 
      1060       1070       1080       1090       1100
RVRLLLKRGT GQVPEYGMVP SSLSMCMKSD KHGSPYFYLL GHPKDTTNPT 
      1110 
PGALPLPPPQ ACRK                                        

        10         20         30         40         50
MEKASIEPPE EEEEERPVVN GNGVVITPES SEHEDKSAGA SGETPSQPYP 
        60         70         80         90        100
APVYSQPEEL KDQMDDTKST KPEENEDSDP LPDNWEMAYT EKGEVYFIDH 
       110        120        130        140        150
NTKTTSWLDP RLAKKAKPAE ECKENELPYG WEKIDDPIYG TYYVDHINRR 
       160        170        180        190        200
TQFENPVLEA KRKLQQHNMP HTELGTKPLQ APGFREKPLF TRDASQLKGT 
       210        220        230        240        250
FLSTTLKKSN MGFGFTIIGG DEPDEFLQVK SVIPDGPAAQ DGKMETGDVI 
       260        270        280        290        300
VYINEVCVLG HTHADVVKLF QSVPIGQSVN LVLCRGYPLP FDPEDPANSM 
       310        320        330        340        350
VPPLAIMERP PPVMVNGRHN YETYLEYISR TSQSVPDITD RPPHSLHSMP 
       360        370        380        390        400
ADGQLDGTYP PPVHDDNVSV ASSGATQAEL MTLTIVKGAK GFGFTIADSP 
       410        420        430        440        450
TGQRVKQILD IQGCPGLCEG DLIVEINQQN VQNLSHTEVV DILKDCPVGS 
       460        470        480        490        500
ETSLIIHRGG FFSPWKTPKP MVDRWENQGS PQTSLSAPAV PQSLPFPPAL 
       510        520        530        540        550
HRSSFPDSTE AFDPRKPDPY ELYEKSRAIY ESRQQVPPRT SFRMDSSGPD 
       560        570        580        590        600
YKELDVHLRR MESGFGFRIL GGDEPGQPIL IGAVIAMGSA DRDGRLHPGD 
       610        620        630        640        650
ELVYVDGIPV AGKTHRYVID LMHHAARNGQ VNLTVRRKVL CGGEPCPENG 
       660        670        680        690        700
RSPGSVSTHH SSPRSDYATY ANSNHAAPSN NASPPEGFAS HSLQTSDVII 
       710        720        730        740        750
HRKENEGFGF VIISSLNRPE SGATITVPHK IGRIIDGSPA DRCAKLKVGD 
       760        770        780        790        800
RILAVNGQSI INMPHADIVK LIKDAGLSVT LRIIPQEELN NPTSAPSSEK 
       810        820        830        840        850
QSPMAQQHSP LAQQHSPLAQ PSPATPNSPV AQPAPPQPLQ LQGHENSYRS 
       860        870        880        890        900
EVKARQDVKP DIRQPPFTDY RQPPLDYRQP PGGDYSQPSP LDYRQHSPDT 
       910        920        930        940        950
RQYPLSDYRQ PQDFDYFTVD MEKGAKGFGF SIRGGREYKM DLYVLRLAED 
       960        970        980        990       1000
GPAIRNGRMR VGDQIIEING ESTRDMTHAR AIELIKSGGR RVRLLLKRGT 
      1010       1020       1030       1040       1050
GQVPEYGMVP SSLSMCMKSD KHGSPYFYLL GHPKDTTNPT PGALPLPPPQ 

ACRK                                                   

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families