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Protein

Bromodomain adjacent to zinc finger domain protein 1A

Gene

Baz1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression (By similarity).By similarity
Component of the histone-fold protein complex CHRAC complex which facilitates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1149 – 1199PHD-typePROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: MGI
  • DNA-dependent DNA replication Source: MGI

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain adjacent to zinc finger domain protein 1A
Alternative name(s):
Cbp146
Gene namesi
Name:Baz1a
Synonyms:Cbp146
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1309478 Baz1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002111681 – 1555Bromodomain adjacent to zinc finger domain protein 1AAdd BLAST1555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270PhosphoserineBy similarity1
Modified residuei284PhosphoserineCombined sources1
Modified residuei732PhosphothreonineCombined sources1
Cross-linki954Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei962PhosphoserineCombined sources1
Modified residuei963PhosphoserineCombined sources1
Modified residuei1282PhosphoserineBy similarity1
Modified residuei1320PhosphoserineBy similarity1
Modified residuei1339PhosphoserineCombined sources1
Modified residuei1352PhosphoserineCombined sources1
Modified residuei1370PhosphoserineBy similarity1
Modified residuei1401PhosphoserineBy similarity1
Modified residuei1412PhosphoserineCombined sources1
Modified residuei1416PhosphoserineBy similarity1
Modified residuei1546PhosphothreonineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO88379
MaxQBiO88379
PaxDbiO88379
PeptideAtlasiO88379
PRIDEiO88379

PTM databases

iPTMnetiO88379
PhosphoSitePlusiO88379

Expressioni

Gene expression databases

BgeeiENSMUSG00000035021 Expressed in 204 organ(s), highest expression level in blastocyst
CleanExiMM_BAZ1A
ExpressionAtlasiO88379 baseline and differential
GenevisibleiO88379 MM

Interactioni

Subunit structurei

Component of the ACF chromatin remodeling complex that includes BAZ1A and SMARCA5. Additional this complex can form, together with CHRAC1 and POLE1, the histone-fold protein complex, CHRAC. Interacts with NCOR1 (via its RD1 domain); the interaction corepresses a number of NCOR1-regulated genes (By similarity).By similarity

Protein-protein interaction databases

ComplexPortaliCPX-444 ACF complex
CPX-858 CHRAC chromatin remodeling complex
IntActiO88379, 2 interactors
STRINGi10090.ENSMUSP00000133478

Structurei

3D structure databases

ProteinModelPortaliO88379
SMRiO88379
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 128WACPROSITE-ProRule annotationAdd BLAST107
Domaini422 – 488DDTPROSITE-ProRule annotationAdd BLAST67
Domaini1445 – 1515BromoPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 133Required for interaction with NCOR1By similarityAdd BLAST133
Regioni1 – 128Required for association with the CHRAC1/POLE3 complexBy similarityAdd BLAST128
Regioni668 – 935Interaction with SMARCA5By similarityAdd BLAST268

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili635 – 701Sequence analysisAdd BLAST67
Coiled coili773 – 798Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi315 – 496Glu-richAdd BLAST182
Compositional biasi1214 – 1251Glu-richAdd BLAST38
Compositional biasi1225 – 1256Asp-richAdd BLAST32

Sequence similaritiesi

Belongs to the WAL family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1149 – 1199PHD-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Bromodomain, Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1245 Eukaryota
COG5076 LUCA
GeneTreeiENSGT00930000150850
HOGENOMiHOG000095179
HOVERGENiHBG080889
InParanoidiO88379
OrthoDBiEOG091G06JE
TreeFamiTF316326

Family and domain databases

CDDicd05504 Bromo_Acf1_like, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR037325 Acf1_Bromo
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR018501 DDT_dom
IPR028942 WHIM1_dom
IPR028941 WHIM2_dom
IPR013136 WSTF_Acf1_Cbp146
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF02791 DDT, 1 hit
PF00628 PHD, 1 hit
PF10537 WAC_Acf1_DNA_bd, 1 hit
PF15612 WHIM1, 1 hit
PF15613 WSD, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00571 DDT, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS50827 DDT, 1 hit
PS51136 WAC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

O88379-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLLHRKPFV RQKPPGDLRP DEEVFYCKVT NEIFRHYDDF FERTILCNSL
60 70 80 90 100
VWSCAVTGRP GLTYQEALES ERKARQNLQS FPEPLIIPVL YLTNLTRRSR
110 120 130 140 150
LHEICDDIFA YVKDRYFVEE TVEVIRNNGT RLQCRILEVL PPLHQNGFAN
160 170 180 190 200
GHLSSADGET IVISDSDDSE TQSSSFHHGK KKDAIDPLLF RYRVQPTKKE
210 220 230 240 250
MYESAVVKAT QISRRKHLFS RDKLKLFLKQ HCEAQDGVIK IKASSFSAYN
260 270 280 290 300
IAEQDFSYFF PDDPPTFIFS PANRRRGRPP KRISFGQEDS IASKQTAARY
310 320 330 340 350
RNKAIKERDK LLKQEEMRAL AFEKAKLKRE RADALEARKR EKEDKEKKRE
360 370 380 390 400
ELKKMVEEER LKKKEEKERL KIEREKEREK LREEKRKYME YLKQWSKPRE
410 420 430 440 450
DMECDDLKEL PEPTPVKTRL PPEVFGDALM VLEFLNAFGE LFDLQDEFPE
460 470 480 490 500
GVTLAEVLEE ALVGNDSEGP LCELLFFFLT AIFQAMAEEE EEVAKEQITD
510 520 530 540 550
ADTKDLTEAL DEDADPTKSA LSAVAALAAA WPQLHQGCSL KSLDLDSCTL
560 570 580 590 600
SEILRLHILA SGADVTSANA KYRYQKRGGF DATDDACMEL RLSNPSLVKK
610 620 630 640 650
LSSTSVYDLT PGEKMKILHA LCGKLLTLVS TRDFIEDYVD VLRQAKQEFR
660 670 680 690 700
ELKAEQHRKE REATAARIRR RKEEKLKEQE QKMKEKQEKL KEDEQRNSAA
710 720 730 740 750
VPGYGEEERE DFDTSTENKN IEQKDLDPDV VTEDEDDPGS HKRSRRGKVG
760 770 780 790 800
QTAVKQCIKQ EEMNYCIKQE PLSADAEEAL RQEQQQKEKE LLDKIQSAIA
810 820 830 840 850
CTNIFPLGRD RLYRRYWIFP SIPGLFIEED YSGLTEDMLL PRPSSFHNNA
860 870 880 890 900
QPRDPQVSIK TEESFLSEST SSLDQGPFDD SVLLPKPVHK PNRWCFYSSC
910 920 930 940 950
AQLDQLIDAL NSRGHRESAL KETLLQEKSR ICAQLAHFSE EKFHFSDKPQ
960 970 980 990 1000
ADSKPVSSRG RSSGACDISQ MSAERQLELR LRDFLLDIED RIYQGTLGAI
1010 1020 1030 1040 1050
KVTDRQVWRS ALENGRYELL SEESKENGVI KTVNEDVEEM EMEQARVIVR
1060 1070 1080 1090 1100
DRLLGIKTET PSTISTSAST PQSVSNVVHY LALALFQIEQ GIERRFLKAP
1110 1120 1130 1140 1150
LDGNDSGRSY KTVLDRWRES LLSSASLSQV FLHLSTLDRS VMWSKSILNA
1160 1170 1180 1190 1200
RCKICRKKGD AENMVLCDGC DRGHHTYCVR PKLKAVPDGD WFCPECRPKQ
1210 1220 1230 1240 1250
RSRRLSSRQR PSLESDEEME EGMEDDDDEV DDDDEEGQSE EEEYEVEQDE
1260 1270 1280 1290 1300
EDSDDDEALS PPKRGRPQVR LPIKTKGRFG PSFPSRSQRQ DPGRYPSRSQ
1310 1320 1330 1340 1350
QSTPKNTAKS ASKNLRKTRS APPTETRSLR VGSRSTRHSP SALQDVFVEL
1360 1370 1380 1390 1400
LSPHSKRRGR KGADHTPEHS PSFTNFRVST SRSSRQLIPL NTAESLSLQH
1410 1420 1430 1440 1450
SESKRRGRKR QSTESSPVPL NRRSSGRQGG VHELSAFEQL VVELVRHDDS
1460 1470 1480 1490 1500
WPFLKLVSKI QVPDYYDIIK KPIALNIIRE KVNKCEYKLA SEFIDDIELM
1510 1520 1530 1540 1550
FSNCFEYNPR NTSEAKAGTR LQAFFHIQAQ KLGLHVSPST VDQVSTPLAA

KKSRI
Length:1,555
Mass (Da):178,459
Last modified:July 27, 2011 - v3
Checksum:iF7BE6227A420A842
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UWZ0G3UWZ0_MOUSE
Bromodomain adjacent to zinc finger...
Baz1a
1,552Annotation score:
G3UZ82G3UZ82_MOUSE
Bromodomain adjacent to zinc finger...
Baz1a
172Annotation score:
G3UXR5G3UXR5_MOUSE
Bromodomain adjacent to zinc finger...
Baz1a
86Annotation score:
G3UZD1G3UZD1_MOUSE
Bromodomain adjacent to zinc finger...
Baz1a
81Annotation score:
G3UWK3G3UWK3_MOUSE
Bromodomain adjacent to zinc finger...
Baz1a
79Annotation score:
G3UYS9G3UYS9_MOUSE
Bromodomain adjacent to zinc finger...
Baz1a
91Annotation score:

Sequence cautioni

The sequence BAE22607 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18 – 20LRP → EFR in AAC32043 (PubMed:9701556).Curated3
Sequence conflicti148 – 149FA → LL in BAE22607 (PubMed:16141072).Curated2
Sequence conflicti342 – 361KEDKE…EEERL → AGILTPDQLVMVATGAQLEF in AAC32043 (PubMed:9701556).CuratedAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138767 Genomic DNA No translation available.
AC154732 Genomic DNA No translation available.
CT030142 Genomic DNA No translation available.
AK135668 mRNA Translation: BAE22607.1 Different initiation.
AK166955 mRNA Translation: BAE39138.1
AF033664 mRNA Translation: AAC32043.1
UniGeneiMm.479583

Genome annotation databases

EnsembliENSMUST00000038926; ENSMUSP00000039757; ENSMUSG00000035021

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138767 Genomic DNA No translation available.
AC154732 Genomic DNA No translation available.
CT030142 Genomic DNA No translation available.
AK135668 mRNA Translation: BAE22607.1 Different initiation.
AK166955 mRNA Translation: BAE39138.1
AF033664 mRNA Translation: AAC32043.1
UniGeneiMm.479583

3D structure databases

ProteinModelPortaliO88379
SMRiO88379
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-444 ACF complex
CPX-858 CHRAC chromatin remodeling complex
IntActiO88379, 2 interactors
STRINGi10090.ENSMUSP00000133478

PTM databases

iPTMnetiO88379
PhosphoSitePlusiO88379

Proteomic databases

EPDiO88379
MaxQBiO88379
PaxDbiO88379
PeptideAtlasiO88379
PRIDEiO88379

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038926; ENSMUSP00000039757; ENSMUSG00000035021

Organism-specific databases

MGIiMGI:1309478 Baz1a

Phylogenomic databases

eggNOGiKOG1245 Eukaryota
COG5076 LUCA
GeneTreeiENSGT00930000150850
HOGENOMiHOG000095179
HOVERGENiHBG080889
InParanoidiO88379
OrthoDBiEOG091G06JE
TreeFamiTF316326

Miscellaneous databases

PROiPR:O88379
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035021 Expressed in 204 organ(s), highest expression level in blastocyst
CleanExiMM_BAZ1A
ExpressionAtlasiO88379 baseline and differential
GenevisibleiO88379 MM

Family and domain databases

CDDicd05504 Bromo_Acf1_like, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR037325 Acf1_Bromo
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR018501 DDT_dom
IPR028942 WHIM1_dom
IPR028941 WHIM2_dom
IPR013136 WSTF_Acf1_Cbp146
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF02791 DDT, 1 hit
PF00628 PHD, 1 hit
PF10537 WAC_Acf1_DNA_bd, 1 hit
PF15612 WHIM1, 1 hit
PF15613 WSD, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00571 DDT, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS50827 DDT, 1 hit
PS51136 WAC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBAZ1A_MOUSE
AccessioniPrimary (citable) accession number: O88379
Secondary accession number(s): Q3TKK7, Q3UXF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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