UniProtKB - O88377 (PI42B_RAT)
Protein
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Gene
Pip4k2b
Organism
Rattus norvegicus (Rat)
Status
Functioni
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:9685379). Preferentially utilizes GTP, rather than ATP, for PI5P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation (By similarity).By similarity1 Publication
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H+1 PublicationEC:2.7.1.1491 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H+By similarityThis reaction proceeds in the forwardBy similarity direction.
- 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H+By similarityThis reaction proceeds in the forwardBy similarity direction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 150 | ATP or GTPBy similarity | 1 | |
Binding sitei | 154 | ATP or GTPBy similarity | 1 | |
Binding sitei | 188 | ATP or GTPBy similarity | 1 | |
Binding sitei | 197 | ATP or GTPBy similarity | 1 | |
Binding sitei | 237 | GTPBy similarity | 1 | |
Binding sitei | 293 | ATP or GTPBy similarity | 1 | |
Binding sitei | 297 | ATP or GTPBy similarity | 1 | |
Binding sitei | 369 | ATP or GTPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 201 – 204 | ATP or GTPBy similarity | 4 | |
Nucleotide bindingi | 214 – 216 | ATP or GTPBy similarity | 3 |
GO - Molecular functioni
- 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: RGD
- 1-phosphatidylinositol-5-phosphate 4-kinase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
- protein homodimerization activity Source: RGD
GO - Biological processi
- phosphatidylinositol metabolic process Source: RGD
- positive regulation of autophagosome assembly Source: RGD
- regulation of autophagy Source: RGD
Keywordsi
Molecular function | Kinase, Transferase |
Ligand | ATP-binding, GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-RNO-1660499, Synthesis of PIPs at the plasma membrane R-RNO-6811555, PI5P Regulates TP53 Acetylation R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-RNO-8847453, Synthesis of PIPs in the nucleus |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol 5-phosphate 4-kinase type-2 betaCurated (EC:2.7.1.1491 Publication)Alternative name(s): 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta Diphosphoinositide kinase 2-beta Phosphatidylinositol 5-phosphate 4-kinase type II beta Short name: PI(5)P 4-kinase type II beta Short name: PIP4KII-beta Phosphatidylinositol-phosphate kinase IIgamma Short name: PIPKIIgamma PtdIns(5)P-4-kinase isoform 2-beta |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621710, Pip4k2b |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Peripheral membrane protein By similarity
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm By similarity
Note: Associated with the plasma membrane and the endoplasmic reticulum.By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Nucleus
- nucleoplasm Source: Ensembl
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- autophagosome Source: RGD
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000185472 | 2 – 416 | Phosphatidylinositol 5-phosphate 4-kinase type-2 betaAdd BLAST | 415 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 8 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 19 | PhosphoserineBy similarity | 1 | |
Modified residuei | 94 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 150 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 322 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 326 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels.By similarity
Phosphorylated on serine residues.By similarity
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | O88377 |
PaxDbi | O88377 |
PRIDEi | O88377 |
PTM databases
iPTMneti | O88377 |
PhosphoSitePlusi | O88377 |
SwissPalmi | O88377 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000013030, Expressed in skeletal muscle tissue and 20 other tissues |
Genevisiblei | O88377, RN |
Interactioni
Subunit structurei
Homodimer. Binds TNFRSF1A.
Interacts with PIP4K2A; the interaction suppresses ubiquitination by the SPOP/CUL3 complex.
By similarityGO - Molecular functioni
- protein homodimerization activity Source: RGD
Protein-protein interaction databases
BioGRIDi | 250135, 1 interactor |
IntActi | O88377, 1 interactor |
STRINGi | 10116.ENSRNOP00000017989 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 415 | PIPKPROSITE-ProRule annotationAdd BLAST | 378 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 303 – 308 | Poly-Glu | 6 |
Phylogenomic databases
eggNOGi | KOG0229, Eukaryota |
GeneTreei | ENSGT00940000159874 |
HOGENOMi | CLU_004312_7_0_1 |
InParanoidi | O88377 |
OMAi | HEKWDIK |
OrthoDBi | 1562683at2759 |
PhylomeDBi | O88377 |
TreeFami | TF354315 |
Family and domain databases
Gene3Di | 3.30.800.10, 1 hit 3.30.810.10, 2 hits |
InterProi | View protein in InterPro IPR023610, PInositol-4-P-5-kinase IPR027483, PInositol-4-P-5-kinase_C IPR002498, PInositol-4-P-5-kinase_core IPR027484, PInositol-4-P-5-kinase_N |
PANTHERi | PTHR23086, PTHR23086, 1 hit |
Pfami | View protein in Pfam PF01504, PIP5K, 1 hit |
SMARTi | View protein in SMART SM00330, PIPKc, 1 hit |
PROSITEi | View protein in PROSITE PS51455, PIPK, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O88377-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSNCTSTTA VAVAPLSASK TKTKKKHFVC QKVKLFRASE PILSVLMWGV
60 70 80 90 100
NHTINELSNV PVPVMLMPDD FKAYSKIKVD NHLFNKENLP SRFKFKEYCP
110 120 130 140 150
MVFRNLRERF GIDDQDYQNS VTRSAPINSD SQGRCGTRFL TTYDRRFVIK
160 170 180 190 200
TVSSEDVAEM HNILKKYHQF IVECHGNTLL PQFLGMYRLT VDGVETYMVV
210 220 230 240 250
TRNVFSHRLT VHRKYDLKGS TVAREASDKE KAKDLPTFKD NDFLNEGQKL
260 270 280 290 300
RVGEESKKNF LEKLKRDVEF LAQLKIMDYS LLVGIHDVDR AEQEETEVED
310 320 330 340 350
RAEEEECEND GVGGGLLCSY GTPPDSPGNL LSFPRFFGPG EFDPSVDVYA
360 370 380 390 400
MKSHESAPKK EVYFMAIIDI LTPYDAKKKA AHAAKTVKHG AGAEISTVNP
410
EQYSKRFNEF MSNILT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF033355 mRNA Translation: AAC40203.1 |
RefSeqi | NP_446002.1, NM_053550.1 |
Genome annotation databases
Ensembli | ENSRNOT00000017989; ENSRNOP00000017989; ENSRNOG00000013030 |
GeneIDi | 89812 |
KEGGi | rno:89812 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF033355 mRNA Translation: AAC40203.1 |
RefSeqi | NP_446002.1, NM_053550.1 |
3D structure databases
SMRi | O88377 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 250135, 1 interactor |
IntActi | O88377, 1 interactor |
STRINGi | 10116.ENSRNOP00000017989 |
PTM databases
iPTMneti | O88377 |
PhosphoSitePlusi | O88377 |
SwissPalmi | O88377 |
Proteomic databases
jPOSTi | O88377 |
PaxDbi | O88377 |
PRIDEi | O88377 |
Genome annotation databases
Ensembli | ENSRNOT00000017989; ENSRNOP00000017989; ENSRNOG00000013030 |
GeneIDi | 89812 |
KEGGi | rno:89812 |
Organism-specific databases
CTDi | 8396 |
RGDi | 621710, Pip4k2b |
Phylogenomic databases
eggNOGi | KOG0229, Eukaryota |
GeneTreei | ENSGT00940000159874 |
HOGENOMi | CLU_004312_7_0_1 |
InParanoidi | O88377 |
OMAi | HEKWDIK |
OrthoDBi | 1562683at2759 |
PhylomeDBi | O88377 |
TreeFami | TF354315 |
Enzyme and pathway databases
Reactomei | R-RNO-1660499, Synthesis of PIPs at the plasma membrane R-RNO-6811555, PI5P Regulates TP53 Acetylation R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-RNO-8847453, Synthesis of PIPs in the nucleus |
Miscellaneous databases
PROi | PR:O88377 |
Gene expression databases
Bgeei | ENSRNOG00000013030, Expressed in skeletal muscle tissue and 20 other tissues |
Genevisiblei | O88377, RN |
Family and domain databases
Gene3Di | 3.30.800.10, 1 hit 3.30.810.10, 2 hits |
InterProi | View protein in InterPro IPR023610, PInositol-4-P-5-kinase IPR027483, PInositol-4-P-5-kinase_C IPR002498, PInositol-4-P-5-kinase_core IPR027484, PInositol-4-P-5-kinase_N |
PANTHERi | PTHR23086, PTHR23086, 1 hit |
Pfami | View protein in Pfam PF01504, PIP5K, 1 hit |
SMARTi | View protein in SMART SM00330, PIPKc, 1 hit |
PROSITEi | View protein in PROSITE PS51455, PIPK, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PI42B_RAT | |
Accessioni | O88377Primary (citable) accession number: O88377 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | November 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |