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Protein

Troponin T, slow skeletal muscle

Gene

Tnnt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

GO - Molecular functioni

  • calcium ion binding Source: GO_Central
  • tropomyosin binding Source: MGI
  • troponin T binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionMuscle protein

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin T, slow skeletal muscle
Short name:
TnTs
Alternative name(s):
Slow skeletal muscle troponin T
Short name:
sTnT
Gene namesi
Name:Tnnt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1333868 Tnnt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861691 – 262Troponin T, slow skeletal muscleAdd BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Phosphoserine; by CK2By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO88346
PaxDbiO88346
PRIDEiO88346

PTM databases

iPTMnetiO88346
PhosphoSitePlusiO88346

Expressioni

Tissue specificityi

Expressed in adult soleus muscle.1 Publication

Developmental stagei

In masseter expression decreases during development and becomes undetectable 3 weeks after birth.1 Publication

Gene expression databases

BgeeiENSMUSG00000064179 Expressed in 207 organ(s), highest expression level in soleus muscle
CleanExiMM_TNNT1
ExpressionAtlasiO88346 baseline and differential
GenevisibleiO88346 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071704

Structurei

3D structure databases

ProteinModelPortaliO88346
SMRiO88346
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

eggNOGiKOG3634 Eukaryota
ENOG410XS6A LUCA
GeneTreeiENSGT00390000013611
HOGENOMiHOG000231049
HOVERGENiHBG052790
InParanoidiO88346
KOiK10372
OMAiMYQLESE
OrthoDBiEOG091G0U67
PhylomeDBiO88346
TreeFamiTF313321

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR027707 TNNT
IPR001978 Troponin
IPR038077 Troponin_sf
PANTHERiPTHR11521 PTHR11521, 1 hit
PfamiView protein in Pfam
PF00992 Troponin, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O88346-1) [UniParc]FASTAAdd to basket
Also known as: High Mr-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDTEEQEYE EEQAEDEEAV EEEEAPEEPE PVAEREEERP KPSRPVVPPL
60 70 80 90 100
IPPKIPEGER VDFDDIHRKR MEKDLLELQT LIDVHFEQRK KEEEELIALK
110 120 130 140 150
DRIERRRAER AEQQRFRTEK ERERQAKLAE EKMRKEEEEA KKRAEDDAKK
160 170 180 190 200
KKVLSNMGAH FGGYLVKAEQ KRGKRQTGRE MKLRILSERK KPLNIDYMGE
210 220 230 240 250
DQLREKAQEL SEWIHQLESE KFDLMEKLKQ QKYEINVLYN RISHAQKFRK
260
GAGKGRVGGR WK
Note: Major.
Length:262
Mass (Da):31,344
Last modified:January 23, 2007 - v3
Checksum:iE0B0FE519714FBE1
GO
Isoform 2 (identifier: O88346-2) [UniParc]FASTAAdd to basket
Also known as: High Mr-2

The sequence of this isoform differs from the canonical sequence as follows:
     38-38: Missing.

Note: Major.
Show »
Length:261
Mass (Da):31,215
Checksum:i3D0608AED29C2C22
GO
Isoform 3 (identifier: O88346-3) [UniParc]FASTAAdd to basket
Also known as: Low Mr

The sequence of this isoform differs from the canonical sequence as follows:
     24-35: Missing.

Note: Minor.
Show »
Length:250
Mass (Da):30,010
Checksum:i98B117AFB129755D
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q688E9Q688_MOUSE
Troponin T, slow skeletal muscle
Tnnt1
249Annotation score:
J3QPC8J3QPC8_MOUSE
Troponin T, slow skeletal muscle
Tnnt1
261Annotation score:
E9PZB4E9PZB4_MOUSE
Troponin T, slow skeletal muscle
Tnnt1
168Annotation score:
E9PVN9E9PVN9_MOUSE
Troponin T, slow skeletal muscle
Tnnt1
118Annotation score:
E9Q0G9E9Q0G9_MOUSE
Troponin T, slow skeletal muscle
Tnnt1
191Annotation score:
E9QA86E9QA86_MOUSE
Troponin T, slow skeletal muscle
Tnnt1
207Annotation score:
E9Q334E9Q334_MOUSE
Troponin T, slow skeletal muscle
Tnnt1
18Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01378624 – 35Missing in isoform 3. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_01378738Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020946 mRNA Translation: AAC32546.1
U92883 mRNA Translation: AAC32540.1
U92884 mRNA Translation: AAC32541.1
AJ131711 mRNA Translation: CAB38082.1
U92882 Genomic DNA Translation: AAD00730.1
BC141142 mRNA Translation: AAI41143.1
BC145450 mRNA Translation: AAI45451.1
BC145451 mRNA Translation: AAI45452.1
CCDSiCCDS51973.1 [O88346-2]
CCDS71879.1 [O88346-3]
CCDS71880.1 [O88346-1]
RefSeqiNP_001264832.1, NM_001277903.1 [O88346-1]
NP_001264833.1, NM_001277904.1 [O88346-3]
NP_035748.1, NM_011618.2 [O88346-2]
UniGeneiMm.358643

Genome annotation databases

EnsembliENSMUST00000071798; ENSMUSP00000071704; ENSMUSG00000064179 [O88346-2]
ENSMUST00000108587; ENSMUSP00000104228; ENSMUSG00000064179 [O88346-1]
ENSMUST00000163710; ENSMUSP00000129626; ENSMUSG00000064179 [O88346-3]
GeneIDi21955
KEGGimmu:21955
UCSCiuc009exu.2 mouse [O88346-1]
uc012ewu.2 mouse [O88346-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020946 mRNA Translation: AAC32546.1
U92883 mRNA Translation: AAC32540.1
U92884 mRNA Translation: AAC32541.1
AJ131711 mRNA Translation: CAB38082.1
U92882 Genomic DNA Translation: AAD00730.1
BC141142 mRNA Translation: AAI41143.1
BC145450 mRNA Translation: AAI45451.1
BC145451 mRNA Translation: AAI45452.1
CCDSiCCDS51973.1 [O88346-2]
CCDS71879.1 [O88346-3]
CCDS71880.1 [O88346-1]
RefSeqiNP_001264832.1, NM_001277903.1 [O88346-1]
NP_001264833.1, NM_001277904.1 [O88346-3]
NP_035748.1, NM_011618.2 [O88346-2]
UniGeneiMm.358643

3D structure databases

ProteinModelPortaliO88346
SMRiO88346
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071704

PTM databases

iPTMnetiO88346
PhosphoSitePlusiO88346

Proteomic databases

MaxQBiO88346
PaxDbiO88346
PRIDEiO88346

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071798; ENSMUSP00000071704; ENSMUSG00000064179 [O88346-2]
ENSMUST00000108587; ENSMUSP00000104228; ENSMUSG00000064179 [O88346-1]
ENSMUST00000163710; ENSMUSP00000129626; ENSMUSG00000064179 [O88346-3]
GeneIDi21955
KEGGimmu:21955
UCSCiuc009exu.2 mouse [O88346-1]
uc012ewu.2 mouse [O88346-3]

Organism-specific databases

CTDi7138
MGIiMGI:1333868 Tnnt1

Phylogenomic databases

eggNOGiKOG3634 Eukaryota
ENOG410XS6A LUCA
GeneTreeiENSGT00390000013611
HOGENOMiHOG000231049
HOVERGENiHBG052790
InParanoidiO88346
KOiK10372
OMAiMYQLESE
OrthoDBiEOG091G0U67
PhylomeDBiO88346
TreeFamiTF313321

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Miscellaneous databases

PROiPR:O88346
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064179 Expressed in 207 organ(s), highest expression level in soleus muscle
CleanExiMM_TNNT1
ExpressionAtlasiO88346 baseline and differential
GenevisibleiO88346 MM

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR027707 TNNT
IPR001978 Troponin
IPR038077 Troponin_sf
PANTHERiPTHR11521 PTHR11521, 1 hit
PfamiView protein in Pfam
PF00992 Troponin, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTNNT1_MOUSE
AccessioniPrimary (citable) accession number: O88346
Secondary accession number(s): B7ZNV5
, B7ZNV6, O88795, Q9QUP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 106 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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