UniProtKB - O88346 (TNNT1_MOUSE)

BLAST

>sp|O88346|TNNT1_MOUSE Troponin T, slow skeletal muscle OS=Mus musculus OX=10090 GN=Tnnt1 PE=2 SV=3
MSDTEEQEYEEEQAEDEEAVEEEEAPEEPEPVAEREEERPKPSRPVVPPLIPPKIPEGER
VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELIALKDRIERRRAERAEQQRFRTEK
ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE
MKLRILSERKKPLNIDYMGEDQLREKAQELSEWIHQLESEKFDLMEKLKQQKYEINVLYN
RISHAQKFRKGAGKGRVGGRWK

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History
Entry version 106 (07 Nov 2018)
Sequence version 3 (23 Jan 2007)
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Protein

Troponin T, slow skeletal muscle

Gene

Tnnt1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

GO - Molecular functionⁱ

calcium ion binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
tropomyosin binding Source: MGI
troponin T binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cardiac muscle contraction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
muscle contraction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of muscle contraction Source: MGI
regulation of muscle contraction Source: MGI
sarcomere organization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
skeletal muscle contraction Source: MGI
slow-twitch skeletal muscle fiber contraction Source: MGI
transition between fast and slow fiber
Source: MGI
Inferred from direct assayⁱ
- 18978355

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Muscle protein

Molecular function

Muscle protein

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390522 Striated Muscle Contraction

Reactomeⁱ

R-MMU-390522 Striated Muscle Contraction

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Troponin T, slow skeletal muscle Short name: TnTs Alternative name(s): Slow skeletal muscle troponin T Short name: sTnT
Gene namesⁱ	Name:Tnnt1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1333868 Tnnt1

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000186169	1 – 262	Troponin T, slow skeletal muscleAdd BLAST		262

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	Phosphoserine; by CK2By similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O88346
PaxDbⁱ	O88346
PRIDEⁱ	O88346

PTM databases

iPTMnetⁱ	O88346
PhosphoSitePlusⁱ	O88346

Expressionⁱ

Tissue specificityⁱ

Expressed in adult soleus muscle.1 Publication

Developmental stageⁱ

In masseter expression decreases during development and becomes undetectable 3 weeks after birth.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000064179 Expressed in 207 organ(s), highest expression level in soleus muscle
CleanExⁱ	MM_TNNT1
ExpressionAtlasⁱ	O88346 baseline and differential
Genevisibleⁱ	O88346 MM

Interactionⁱ

GO - Molecular functionⁱ

tropomyosin binding Source: MGI
troponin T binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000071704

STRINGⁱ

10090.ENSMUSP00000071704

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O88346
SMRⁱ	O88346
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the troponin T family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3634 Eukaryota ENOG410XS6A LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013611
HOGENOMⁱ	HOG000231049
HOVERGENⁱ	HBG052790
InParanoidⁱ	O88346
KEGG Orthology (KO) More...KOⁱ	K10372
OMAⁱ	MYQLESE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0U67
PhylomeDBⁱ	O88346
TreeFamⁱ	TF313321

Family and domain databases

Gene3Dⁱ	1.20.5.350, 1 hit
InterProⁱ	View protein in InterPro IPR027707 TNNT IPR001978 Troponin IPR038077 Troponin_sf
PANTHERⁱ	PTHR11521 PTHR11521, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00992 Troponin, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O88346-1) [UniParc]FASTA Add to basket

Also known as: High Mr-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDTEEQEYE EEQAEDEEAV EEEEAPEEPE PVAEREEERP KPSRPVVPPL 
        60         70         80         90        100
IPPKIPEGER VDFDDIHRKR MEKDLLELQT LIDVHFEQRK KEEEELIALK 
       110        120        130        140        150
DRIERRRAER AEQQRFRTEK ERERQAKLAE EKMRKEEEEA KKRAEDDAKK 
       160        170        180        190        200
KKVLSNMGAH FGGYLVKAEQ KRGKRQTGRE MKLRILSERK KPLNIDYMGE 
       210        220        230        240        250
DQLREKAQEL SEWIHQLESE KFDLMEKLKQ QKYEINVLYN RISHAQKFRK 
       260 
GAGKGRVGGR WK

Note: Major.

Length:262

Mass (Da):31,344

Last modified:January 23, 2007 - v3

Checksum:ⁱE0B0FE519714FBE1

Isoform 2 (identifier: O88346-2) [UniParc]FASTA Add to basket

Also known as: High Mr-2

The sequence of this isoform differs from the canonical sequence as follows:
38-38: Missing.

« Hide

        10         20         30         40         50
MSDTEEQEYE EEQAEDEEAV EEEEAPEEPE PVAEREERPK PSRPVVPPLI 
        60         70         80         90        100
PPKIPEGERV DFDDIHRKRM EKDLLELQTL IDVHFEQRKK EEEELIALKD 
       110        120        130        140        150
RIERRRAERA EQQRFRTEKE RERQAKLAEE KMRKEEEEAK KRAEDDAKKK 
       160        170        180        190        200
KVLSNMGAHF GGYLVKAEQK RGKRQTGREM KLRILSERKK PLNIDYMGED 
       210        220        230        240        250
QLREKAQELS EWIHQLESEK FDLMEKLKQQ KYEINVLYNR ISHAQKFRKG 
       260 
AGKGRVGGRW K

Note: Major.

Show »

Length:261

Mass (Da):31,215

Checksum:ⁱ3D0608AED29C2C22

Isoform 3 (identifier: O88346-3) [UniParc]FASTA Add to basket

Also known as: Low Mr

The sequence of this isoform differs from the canonical sequence as follows:
24-35: Missing.

« Hide

        10         20         30         40         50
MSDTEEQEYE EEQAEDEEAV EEEEEERPKP SRPVVPPLIP PKIPEGERVD 
        60         70         80         90        100
FDDIHRKRME KDLLELQTLI DVHFEQRKKE EEELIALKDR IERRRAERAE 
       110        120        130        140        150
QQRFRTEKER ERQAKLAEEK MRKEEEEAKK RAEDDAKKKK VLSNMGAHFG 
       160        170        180        190        200
GYLVKAEQKR GKRQTGREMK LRILSERKKP LNIDYMGEDQ LREKAQELSE 
       210        220        230        240        250
WIHQLESEKF DLMEKLKQQK YEINVLYNRI SHAQKFRKGA GKGRVGGRWK

Note: Minor.

Show »

Length:250

Mass (Da):30,010

Checksum:ⁱ98B117AFB129755D

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9Q688	E9Q688_MOUSE	Troponin T, slow skeletal muscle Troponin T, slow skeletal muscle	Tnnt1	249	Annotation score:
J3QPC8	J3QPC8_MOUSE	Troponin T, slow skeletal muscle Troponin T, slow skeletal muscle	Tnnt1	261	Annotation score:
E9PZB4	E9PZB4_MOUSE	Troponin T, slow skeletal muscle Troponin T, slow skeletal muscle	Tnnt1	168	Annotation score:
E9PVN9	E9PVN9_MOUSE	Troponin T, slow skeletal muscle Troponin T, slow skeletal muscle	Tnnt1	118	Annotation score:
E9Q0G9	E9Q0G9_MOUSE	Troponin T, slow skeletal muscle Troponin T, slow skeletal muscle	Tnnt1	191	Annotation score:
E9QA86	E9QA86_MOUSE	Troponin T, slow skeletal muscle Troponin T, slow skeletal muscle	Tnnt1	207	Annotation score:
E9Q334	E9Q334_MOUSE	Troponin T, slow skeletal muscle Troponin T, slow skeletal muscle	Tnnt1	18	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_013786	24 – 35	Missing in isoform 3. 2 PublicationsAdd BLAST		12
Alternative sequenceⁱVSP_013787	38	Missing in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF020946 mRNA Translation: AAC32546.1 U92883 mRNA Translation: AAC32540.1 U92884 mRNA Translation: AAC32541.1 AJ131711 mRNA Translation: CAB38082.1 U92882 Genomic DNA Translation: AAD00730.1 BC141142 mRNA Translation: AAI41143.1 BC145450 mRNA Translation: AAI45451.1 BC145451 mRNA Translation: AAI45452.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS51973.1 [O88346-2] CCDS71879.1 [O88346-3] CCDS71880.1 [O88346-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001264832.1, NM_001277903.1 [O88346-1] NP_001264833.1, NM_001277904.1 [O88346-3] NP_035748.1, NM_011618.2 [O88346-2]
UniGeneⁱ	Mm.358643

Genome annotation databases

Ensemblⁱ	ENSMUST00000071798; ENSMUSP00000071704; ENSMUSG00000064179 [O88346-2] ENSMUST00000108587; ENSMUSP00000104228; ENSMUSG00000064179 [O88346-1] ENSMUST00000163710; ENSMUSP00000129626; ENSMUSG00000064179 [O88346-3]
GeneIDⁱ	21955
KEGGⁱ	mmu:21955
UCSC genome browser More...UCSCⁱ	uc009exu.2 mouse [O88346-1] uc012ewu.2 mouse [O88346-3]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
O88346	Troponin T, slow skeletal muscle (Fragment)		MOUSE		191	UniRef100_O88346
Troponin T, slow skeletal muscle (Fragment)		MOUSE		18
Uncharacterized protein (Fragment)		MOUSE		140
UPI0003D6F1D1		MOUSE		302
O88346-2	Troponin T1, skeletal, slow		MOUSE		261	UniRef100_Q3TVB8
Troponin T, slow skeletal muscle (Fragment)		MOUSE		168
UPI0003D77888		MOUSE		301
O88346-3	Isoform 4 of Troponin T, slow skeletal muscle		RAT		250	UniRef100_O88346-3
UPI0003D70178		MOUSE		290

Protein	Similar proteins		Species	Score	Length	Source
O88346	Troponin T, slow skeletal muscle		RAT		261	UniRef90_Q7TNB2
Troponin T, slow skeletal muscle		BOVIN		263
Troponin T, slow skeletal muscle		PIG		262
Troponin T1, slow skeletal type		OTOGA		264
troponin T, slow skeletal muscle isoform X1		MESAU		264
+175

Protein	Similar proteins		Species	Score	Length	Source
O88346	Troponin T, slow skeletal muscle		RAT		261	UniRef50_Q7TNB2
Troponin T, slow skeletal muscle		BOVIN		263
Troponin T, slow skeletal muscle		PIG		262
Troponin T, slow skeletal muscle isoform c		HETGA		264
troponin T, slow skeletal muscle isoform X1		MESAU		264
+416

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF020946 mRNA Translation: AAC32546.1 U92883 mRNA Translation: AAC32540.1 U92884 mRNA Translation: AAC32541.1 AJ131711 mRNA Translation: CAB38082.1 U92882 Genomic DNA Translation: AAD00730.1 BC141142 mRNA Translation: AAI41143.1 BC145450 mRNA Translation: AAI45451.1 BC145451 mRNA Translation: AAI45452.1
CCDSⁱ	CCDS51973.1 [O88346-2] CCDS71879.1 [O88346-3] CCDS71880.1 [O88346-1]
RefSeqⁱ	NP_001264832.1, NM_001277903.1 [O88346-1] NP_001264833.1, NM_001277904.1 [O88346-3] NP_035748.1, NM_011618.2 [O88346-2]
UniGeneⁱ	Mm.358643

3D structure databases

ProteinModelPortalⁱ	O88346
SMRⁱ	O88346
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000071704

STRINGⁱ

10090.ENSMUSP00000071704

PTM databases

iPTMnetⁱ	O88346
PhosphoSitePlusⁱ	O88346

Proteomic databases

MaxQBⁱ	O88346
PaxDbⁱ	O88346
PRIDEⁱ	O88346

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000071798; ENSMUSP00000071704; ENSMUSG00000064179 [O88346-2] ENSMUST00000108587; ENSMUSP00000104228; ENSMUSG00000064179 [O88346-1] ENSMUST00000163710; ENSMUSP00000129626; ENSMUSG00000064179 [O88346-3]
GeneIDⁱ	21955
KEGGⁱ	mmu:21955
UCSCⁱ	uc009exu.2 mouse [O88346-1] uc012ewu.2 mouse [O88346-3]

Organism-specific databases

CTDⁱ	7138
MGIⁱ	MGI:1333868 Tnnt1

Phylogenomic databases

eggNOGⁱ	KOG3634 Eukaryota ENOG410XS6A LUCA
GeneTreeⁱ	ENSGT00390000013611
HOGENOMⁱ	HOG000231049
HOVERGENⁱ	HBG052790
InParanoidⁱ	O88346
KOⁱ	K10372
OMAⁱ	MYQLESE
OrthoDBⁱ	EOG091G0U67
PhylomeDBⁱ	O88346
TreeFamⁱ	TF313321

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390522 Striated Muscle Contraction

Reactomeⁱ

R-MMU-390522 Striated Muscle Contraction

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O88346
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000064179 Expressed in 207 organ(s), highest expression level in soleus muscle
CleanExⁱ	MM_TNNT1
ExpressionAtlasⁱ	O88346 baseline and differential
Genevisibleⁱ	O88346 MM

Family and domain databases

Gene3Dⁱ	1.20.5.350, 1 hit
InterProⁱ	View protein in InterPro IPR027707 TNNT IPR001978 Troponin IPR038077 Troponin_sf
PANTHERⁱ	PTHR11521 PTHR11521, 1 hit
Pfamⁱ	View protein in Pfam PF00992 Troponin, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TNNT1_MOUSE
Accessionⁱ	O88346Primary (citable) accession number: O88346 Secondary accession number(s): B7ZNV5 , B7ZNV6, O88795, Q9QUP7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 24, 2005
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 106 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O88346 (TNNT1_MOUSE)

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Troponin T, slow skeletal muscle

Tnnt1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ