UniProtKB - O88346 (TNNT1_MOUSE)
Protein
Troponin T, slow skeletal muscle
Gene
Tnnt1
Organism
Mus musculus (Mouse)
Status
Functioni
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
GO - Molecular functioni
- calcium ion binding Source: GO_Central
- tropomyosin binding Source: MGI
- troponin T binding Source: MGI
GO - Biological processi
- cardiac muscle contraction Source: GO_Central
- muscle contraction Source: GO_Central
- negative regulation of muscle contraction Source: MGI
- regulation of muscle contraction Source: MGI
- sarcomere organization Source: GO_Central
- skeletal muscle contraction Source: MGI
- slow-twitch skeletal muscle fiber contraction Source: MGI
- transition between fast and slow fiber Source: MGI
Keywordsi
Molecular function | Muscle protein |
Enzyme and pathway databases
Reactomei | R-MMU-390522 Striated Muscle Contraction |
Names & Taxonomyi
Protein namesi | Recommended name: Troponin T, slow skeletal muscleShort name: TnTs Alternative name(s): Slow skeletal muscle troponin T Short name: sTnT |
Gene namesi | Name:Tnnt1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1333868 Tnnt1 |
Subcellular locationi
Cytoskeleton
- troponin complex Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186169 | 1 – 262 | Troponin T, slow skeletal muscleAdd BLAST | 262 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | Phosphoserine; by CK2By similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | O88346 |
PaxDbi | O88346 |
PRIDEi | O88346 |
PTM databases
iPTMneti | O88346 |
PhosphoSitePlusi | O88346 |
Expressioni
Tissue specificityi
Expressed in adult soleus muscle.1 Publication
Developmental stagei
In masseter expression decreases during development and becomes undetectable 3 weeks after birth.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000064179 Expressed in 207 organ(s), highest expression level in soleus muscle |
ExpressionAtlasi | O88346 baseline and differential |
Genevisiblei | O88346 MM |
Interactioni
GO - Molecular functioni
- tropomyosin binding Source: MGI
- troponin T binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000071704 |
Structurei
3D structure databases
ProteinModelPortali | O88346 |
SMRi | O88346 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the troponin T family.Curated
Phylogenomic databases
eggNOGi | KOG3634 Eukaryota ENOG410XS6A LUCA |
GeneTreei | ENSGT00940000160609 |
HOGENOMi | HOG000231049 |
HOVERGENi | HBG052790 |
InParanoidi | O88346 |
KOi | K10372 |
OMAi | MYQLESE |
OrthoDBi | 1480247at2759 |
PhylomeDBi | O88346 |
TreeFami | TF313321 |
Family and domain databases
Gene3Di | 1.20.5.350, 1 hit |
InterProi | View protein in InterPro IPR027707 TNNT IPR001978 Troponin IPR038077 Troponin_sf |
PANTHERi | PTHR11521 PTHR11521, 1 hit |
Pfami | View protein in Pfam PF00992 Troponin, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O88346-1) [UniParc]FASTAAdd to basket
Also known as: High Mr-1
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSDTEEQEYE EEQAEDEEAV EEEEAPEEPE PVAEREEERP KPSRPVVPPL
60 70 80 90 100
IPPKIPEGER VDFDDIHRKR MEKDLLELQT LIDVHFEQRK KEEEELIALK
110 120 130 140 150
DRIERRRAER AEQQRFRTEK ERERQAKLAE EKMRKEEEEA KKRAEDDAKK
160 170 180 190 200
KKVLSNMGAH FGGYLVKAEQ KRGKRQTGRE MKLRILSERK KPLNIDYMGE
210 220 230 240 250
DQLREKAQEL SEWIHQLESE KFDLMEKLKQ QKYEINVLYN RISHAQKFRK
260
GAGKGRVGGR WK
Note: Major.
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q688 | E9Q688_MOUSE | Troponin T, slow skeletal muscle | Tnnt1 | 249 | Annotation score: | ||
J3QPC8 | J3QPC8_MOUSE | Troponin T, slow skeletal muscle | Tnnt1 | 261 | Annotation score: | ||
E9PZB4 | E9PZB4_MOUSE | Troponin T, slow skeletal muscle | Tnnt1 | 168 | Annotation score: | ||
E9Q0G9 | E9Q0G9_MOUSE | Troponin T, slow skeletal muscle | Tnnt1 | 191 | Annotation score: | ||
E9QA86 | E9QA86_MOUSE | Troponin T, slow skeletal muscle | Tnnt1 | 207 | Annotation score: | ||
E9PVN9 | E9PVN9_MOUSE | Troponin T, slow skeletal muscle | Tnnt1 | 118 | Annotation score: | ||
E9Q334 | E9Q334_MOUSE | Troponin T, slow skeletal muscle | Tnnt1 | 18 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013786 | 24 – 35 | Missing in isoform 3. 2 PublicationsAdd BLAST | 12 | |
Alternative sequenceiVSP_013787 | 38 | Missing in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF020946 mRNA Translation: AAC32546.1 U92883 mRNA Translation: AAC32540.1 U92884 mRNA Translation: AAC32541.1 AJ131711 mRNA Translation: CAB38082.1 U92882 Genomic DNA Translation: AAD00730.1 BC141142 mRNA Translation: AAI41143.1 BC145450 mRNA Translation: AAI45451.1 BC145451 mRNA Translation: AAI45452.1 |
CCDSi | CCDS51973.1 [O88346-2] CCDS71879.1 [O88346-3] CCDS71880.1 [O88346-1] |
RefSeqi | NP_001264832.1, NM_001277903.1 [O88346-1] NP_001264833.1, NM_001277904.1 [O88346-3] NP_035748.1, NM_011618.2 [O88346-2] |
UniGenei | Mm.358643 |
Genome annotation databases
Ensembli | ENSMUST00000071798; ENSMUSP00000071704; ENSMUSG00000064179 [O88346-2] ENSMUST00000108587; ENSMUSP00000104228; ENSMUSG00000064179 [O88346-1] ENSMUST00000163710; ENSMUSP00000129626; ENSMUSG00000064179 [O88346-3] |
GeneIDi | 21955 |
KEGGi | mmu:21955 |
UCSCi | uc009exu.2 mouse [O88346-1] uc012ewu.2 mouse [O88346-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF020946 mRNA Translation: AAC32546.1 U92883 mRNA Translation: AAC32540.1 U92884 mRNA Translation: AAC32541.1 AJ131711 mRNA Translation: CAB38082.1 U92882 Genomic DNA Translation: AAD00730.1 BC141142 mRNA Translation: AAI41143.1 BC145450 mRNA Translation: AAI45451.1 BC145451 mRNA Translation: AAI45452.1 |
CCDSi | CCDS51973.1 [O88346-2] CCDS71879.1 [O88346-3] CCDS71880.1 [O88346-1] |
RefSeqi | NP_001264832.1, NM_001277903.1 [O88346-1] NP_001264833.1, NM_001277904.1 [O88346-3] NP_035748.1, NM_011618.2 [O88346-2] |
UniGenei | Mm.358643 |
3D structure databases
ProteinModelPortali | O88346 |
SMRi | O88346 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000071704 |
PTM databases
iPTMneti | O88346 |
PhosphoSitePlusi | O88346 |
Proteomic databases
MaxQBi | O88346 |
PaxDbi | O88346 |
PRIDEi | O88346 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000071798; ENSMUSP00000071704; ENSMUSG00000064179 [O88346-2] ENSMUST00000108587; ENSMUSP00000104228; ENSMUSG00000064179 [O88346-1] ENSMUST00000163710; ENSMUSP00000129626; ENSMUSG00000064179 [O88346-3] |
GeneIDi | 21955 |
KEGGi | mmu:21955 |
UCSCi | uc009exu.2 mouse [O88346-1] uc012ewu.2 mouse [O88346-3] |
Organism-specific databases
CTDi | 7138 |
MGIi | MGI:1333868 Tnnt1 |
Phylogenomic databases
eggNOGi | KOG3634 Eukaryota ENOG410XS6A LUCA |
GeneTreei | ENSGT00940000160609 |
HOGENOMi | HOG000231049 |
HOVERGENi | HBG052790 |
InParanoidi | O88346 |
KOi | K10372 |
OMAi | MYQLESE |
OrthoDBi | 1480247at2759 |
PhylomeDBi | O88346 |
TreeFami | TF313321 |
Enzyme and pathway databases
Reactomei | R-MMU-390522 Striated Muscle Contraction |
Miscellaneous databases
PROi | PR:O88346 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000064179 Expressed in 207 organ(s), highest expression level in soleus muscle |
ExpressionAtlasi | O88346 baseline and differential |
Genevisiblei | O88346 MM |
Family and domain databases
Gene3Di | 1.20.5.350, 1 hit |
InterProi | View protein in InterPro IPR027707 TNNT IPR001978 Troponin IPR038077 Troponin_sf |
PANTHERi | PTHR11521 PTHR11521, 1 hit |
Pfami | View protein in Pfam PF00992 Troponin, 2 hits |
ProtoNeti | Search... |
Entry informationi
Entry namei | TNNT1_MOUSE | |
Accessioni | O88346Primary (citable) accession number: O88346 Secondary accession number(s): B7ZNV5 Q9QUP7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2005 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 13, 2019 | |
This is version 109 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot