Wdr1

Functionⁱ

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity). Enhances cofilin-mediated actin severing (PubMed:25915128). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (By similarity). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth at the postnatal and maintenance at the adult stage (PubMed:24840128). Involved in neutrophil actin dynamics and migration. Involved in megakaryocyte maturation and platelet shedding (PubMed:17515402). Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (PubMed:25915128). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity).By similarity2 Publications

GO - Molecular functionⁱ

actin binding
Source: MGI
Inferred from sequence orthologyⁱ
- 10036186
actin filament binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization
Source: MGI
Inferred from mutant phenotypeⁱ
- 24840128
actin filament depolymerization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
actin filament fragmentation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25915128
apical junction assembly Source: MGI
cortical cytoskeleton organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17515402
establishment of planar polarity of follicular epithelium
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25915128
locomotion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
maintenance of epithelial cell apical/basal polarity Source: MGI
neutrophil mediated immunity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17515402
neutrophil migration
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17515402
platelet formation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17515402
positive regulation of actin filament depolymerization
Source: MGI
Inferred from genetic interactionⁱ
- 24840128
regulation of actin filament depolymerization Source: MGI
regulation of cell shape
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25915128
regulation of oligodendrocyte differentiation
Source: MGI
Inferred from sequence orthologyⁱ
- 20631256
regulation of ventricular cardiac muscle cell membrane repolarization
Source: MGI
Inferred from mutant phenotypeⁱ
- 24840128
sarcomere organization
Source: MGI
Inferred from mutant phenotypeⁱ
- 24840128
sensory perception of sound
Source: MGI
Inferred from sequence orthologyⁱ
- 10036186

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding

Molecular function

Actin-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-114608 Platelet degranulation

Reactomeⁱ

R-MMU-114608 Platelet degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: WD repeat-containing protein 1 Alternative name(s): Actin-interacting protein 1 Short name: AIP1
Gene namesⁱ	Name:Wdr1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:1337100 Wdr1

Keywords - Cellular componentⁱ

Cell junction, Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Embryonic lethal. Partial deficiencies disrupt megakaryocyte maturation, platelet shedding and provoke neutrophilic autoinflammatory disease.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051342	1 – 606	WD repeat-containing protein 1Add BLAST		606

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	28	N6-acetyllysineBy similarity	1
Modified residueⁱ	81	N6-acetyllysineBy similarity	1
Modified residueⁱ	95	N6-acetyllysineCombined sources	1
Modified residueⁱ	115	N6-acetyllysineBy similarity	1
Modified residueⁱ	238	PhosphotyrosineCombined sources	1
Modified residueⁱ	480	N6-acetyllysineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	O88342
PaxDbⁱ	O88342
PeptideAtlas More...PeptideAtlasⁱ	O88342
PRIDEⁱ	O88342

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00314748 O88342
UCD-2DPAGEⁱ	O88342

PTM databases

iPTMnetⁱ	O88342
PhosphoSitePlusⁱ	O88342
SwissPalmⁱ	O88342

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000005103 Expressed in 299 organ(s), highest expression level in lymph node
CleanExⁱ	MM_WDR1
ExpressionAtlasⁱ	O88342 baseline and differential
Genevisibleⁱ	O88342 MM

Interactionⁱ

GO - Molecular functionⁱ

actin binding
Source: MGI
Inferred from sequence orthologyⁱ
- 10036186
actin filament binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204554, 8 interactors
IntActⁱ	O88342, 13 interactors
Molecular INTeraction database More...MINTⁱ	O88342
STRINGⁱ	10090.ENSMUSP00000005234

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O88342
SMRⁱ	O88342
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	4 – 45	WD 1Add BLAST	42
Repeatⁱ	48 – 87	WD 2Add BLAST	40
Repeatⁱ	93 – 135	WD 3Add BLAST	43
Repeatⁱ	138 – 176	WD 4Add BLAST	39
Repeatⁱ	180 – 218	WD 5Add BLAST	39
Repeatⁱ	224 – 263	WD 6Add BLAST	40
Repeatⁱ	270 – 306	WD 7Add BLAST	37
Repeatⁱ	311 – 351	WD 8Add BLAST	41
Repeatⁱ	358 – 408	WD 9Add BLAST	51
Repeatⁱ	432 – 474	WD 10Add BLAST	43
Repeatⁱ	480 – 518	WD 11Add BLAST	39
Repeatⁱ	523 – 561	WD 12Add BLAST	39
Repeatⁱ	566 – 604	WD 13Add BLAST	39

Sequence similaritiesⁱ

Belongs to the WD repeat AIP1 family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG0318 Eukaryota ENOG410XQN1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009416
HOVERGENⁱ	HBG000780
InParanoidⁱ	O88342
OMAⁱ	WDVNVNS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03SZ
PhylomeDBⁱ	O88342
TreeFamⁱ	TF300821

Family and domain databases

Gene3Dⁱ	2.130.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR011045 N2O_reductase_N IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400 WD40, 4 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 11 hits
SUPFAMⁱ	SSF50974 SSF50974, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 1 hit PS50082 WD_REPEATS_2, 5 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O88342-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPYEIKKVFA SLPQVERGVS KILGGDPKGD HFLYTNGKCV ILRNIDNPAI 
        60         70         80         90        100
ADIYTEHAHQ VVVAKYAPSG FYIASGDISG KLRIWDTTQK EHLLKYEYQP 
       110        120        130        140        150
FAGKIKDIAW TEDSKRIAVV GEGREKFGAV FLWDTGSSVG EITGHNKVIN 
       160        170        180        190        200
SVDIKQTRPY RLATGSDDNC AAFFEGPPFK FKFTIGDHSR FVNCVRFSPD 
       210        220        230        240        250
GNRFATASAD GQIFIYDGKT GEKVCALGES KAHDGGIYAI SWSPDSTHLL 
       260        270        280        290        300
SASGDKTSKI WDVNVNSVVS TFPMGSNVLD QQLGCLWQKD HLLSISLSGY 
       310        320        330        340        350
INYLDKNNPS KPLRVIKGHS KSIQCLTVHR NGGKSYIYSG SHDGHINYWD 
       360        370        380        390        400
SETGENDSFS GKGHTNQVSR MTVNESEQLV SCSMDDTVRY TNLTLRDYSG 
       410        420        430        440        450
QGVVKLDVQP KCVAVGPGGY TVVVCIGQIV LLKDQKKCFS IDNPGYEPEV 
       460        470        480        490        500
VAVHPGGDTV AVGGTDGNVR VYSILASTLK DEGKLLEAKG PVTDVAYSHD 
       510        520        530        540        550
GAFLAVCDAS KVVTVFSVAD GYSENNVFYG HHAKIVCLAW SPDNEHFASG 
       560        570        580        590        600
GMDMMVYVWT LSDPETKVKI QDAHRLHHVS SLAWLDEHTL VTTSHDASVK 

EWTITY

Length:606

Mass (Da):66,407

Last modified:January 23, 2007 - v3

Checksum:ⁱ573CEA1DCD7CA80E

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0J9YU05	A0A0J9YU05_MOUSE		WD repeat-containing protein 1 WD repeat-containing protein 1	Wdr1	333	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF020055 mRNA Translation: AAD05043.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS51485.1
NCBI Reference Sequences More...RefSeqⁱ	NP_035845.1, NM_011715.2
UniGeneⁱ	Mm.2654 Mm.406120

Genome annotation databases

Ensemblⁱ	ENSMUST00000005234; ENSMUSP00000005234; ENSMUSG00000005103
GeneIDⁱ	22388
KEGGⁱ	mmu:22388
UCSC genome browser More...UCSCⁱ	uc033ije.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O88342	WD repeat domain 1		MOUSE		606	UniRef100_O88342
Uncharacterized protein (Fragment)		MOUSE		580
WD repeat-containing protein 1		MOUSE		333

Protein	Similar proteins		Species	Score	Length	Source
O88342	WD repeat-containing protein 1		HUMAN		606	UniRef90_O75083
WD repeat-containing protein 1		BOVIN		606
WD repeat-containing protein 1		RAT		606
WD repeat-containing protein 1		Florida manatee		623
Uncharacterized protein		MACMU		618
+108

Protein	Similar proteins		Species	Score	Length	Source
O88342	WD repeat-containing protein 1		HUMAN		606	UniRef50_O75083
WD repeat-containing protein 1		BOVIN		606
WD repeat-containing protein 1		RAT		606
WD repeat-containing protein 1		CHICK		609
WD repeat-containing protein 1		Florida manatee		623
+250

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF020055 mRNA Translation: AAD05043.1
CCDSⁱ	CCDS51485.1
RefSeqⁱ	NP_035845.1, NM_011715.2
UniGeneⁱ	Mm.2654 Mm.406120

3D structure databases

ProteinModelPortalⁱ	O88342
SMRⁱ	O88342
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204554, 8 interactors
IntActⁱ	O88342, 13 interactors
MINTⁱ	O88342
STRINGⁱ	10090.ENSMUSP00000005234

PTM databases

iPTMnetⁱ	O88342
PhosphoSitePlusⁱ	O88342
SwissPalmⁱ	O88342

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00314748 O88342
UCD-2DPAGEⁱ	O88342

Proteomic databases

EPDⁱ	O88342
PaxDbⁱ	O88342
PeptideAtlasⁱ	O88342
PRIDEⁱ	O88342

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000005234; ENSMUSP00000005234; ENSMUSG00000005103
GeneIDⁱ	22388
KEGGⁱ	mmu:22388
UCSCⁱ	uc033ije.1 mouse

Organism-specific databases

CTDⁱ	9948
MGIⁱ	MGI:1337100 Wdr1

Phylogenomic databases

eggNOGⁱ	KOG0318 Eukaryota ENOG410XQN1 LUCA
GeneTreeⁱ	ENSGT00390000009416
HOVERGENⁱ	HBG000780
InParanoidⁱ	O88342
OMAⁱ	WDVNVNS
OrthoDBⁱ	EOG091G03SZ
PhylomeDBⁱ	O88342
TreeFamⁱ	TF300821

Enzyme and pathway databases

Reactomeⁱ	R-MMU-114608 Platelet degranulation

Reactomeⁱ

R-MMU-114608 Platelet degranulation

Miscellaneous databases

ChiTaRSⁱ	Wdr1 mouse
Protein Ontology More...PROⁱ	PR:O88342
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000005103 Expressed in 299 organ(s), highest expression level in lymph node
CleanExⁱ	MM_WDR1
ExpressionAtlasⁱ	O88342 baseline and differential
Genevisibleⁱ	O88342 MM

Family and domain databases

Gene3Dⁱ	2.130.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR011045 N2O_reductase_N IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom
Pfamⁱ	View protein in Pfam PF00400 WD40, 4 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 11 hits
SUPFAMⁱ	SSF50974 SSF50974, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 1 hit PS50082 WD_REPEATS_2, 5 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WDR1_MOUSE
Accessionⁱ	O88342Primary (citable) accession number: O88342
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O88342 (WDR1_MOUSE)

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WD repeat-containing protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ