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Protein

Cadherin-16

Gene

Cdh16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
  • cell adhesion Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-16
Alternative name(s):
Kidney-specific cadherin
Short name:
Ksp-cadherin
Gene namesi
Name:Cdh16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:106671 Cdh16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 788ExtracellularSequence analysisAdd BLAST767
Transmembranei789 – 809HelicalSequence analysisAdd BLAST21
Topological domaini810 – 830CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000381022 – 830Cadherin-16Add BLAST809

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi604N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi724N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei823PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO88338
PeptideAtlasiO88338
PRIDEiO88338

PTM databases

iPTMnetiO88338
PhosphoSitePlusiO88338

Expressioni

Tissue specificityi

Kidney specific.

Gene expression databases

BgeeiENSMUSG00000031881 Expressed in 95 organ(s), highest expression level in cortex of kidney
CleanExiMM_CDH16
ExpressionAtlasiO88338 baseline and differential
GenevisibleiO88338 MM

Interactioni

Protein-protein interaction databases

IntActiO88338, 3 interactors
MINTiO88338
STRINGi10090.ENSMUSP00000129663

Structurei

3D structure databases

ProteinModelPortaliO88338
SMRiO88338
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 128Cadherin 1PROSITE-ProRule annotationAdd BLAST102
Domaini133 – 237Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini244 – 338Cadherin 3PROSITE-ProRule annotationAdd BLAST95
Domaini343 – 451Cadherin 4PROSITE-ProRule annotationAdd BLAST109
Domaini457 – 566Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini571 – 667Cadherin 6PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni668 – 788Ectodomain GAdd BLAST121

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00740000115559
HOGENOMiHOG000231613
HOVERGENiHBG050766
InParanoidiO88338
KOiK06810
OrthoDBiEOG091G03CL
PhylomeDBiO88338
TreeFamiTF316817

Family and domain databases

InterProiView protein in InterPro
IPR030721 Cadherin-16
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
PANTHERiPTHR24028:SF1 PTHR24028:SF1, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 1 hit
PS50268 CADHERIN_2, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

O88338-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISARPWLLY LSVIQAFTTE AQPAESLHTE VPENYGGNFP FYILKLPLPL
60 70 80 90 100
GRDEGHIVLS GDSNTADQNT FAVDTDSGFL VATRTLDREE KAEYQLQVTL
110 120 130 140 150
ESEDGRILWG PQLVTVHVKD ENDQVPQFSQ AIYRAQLSQG TRPGVPFLFL
160 170 180 190 200
EASDGDAPGT ANSDLRFHIL SQSPPQPLPD MFQLDPHLGA LALSPSGSTS
210 220 230 240 250
LDHALEETYQ LLVQVKDMGD QPSGHQAIAT VEISIVENSW APLEPVHLAE
260 270 280 290 300
NLKVVYPHSI AQVHWSGGDV HYQLESQPPG PFDVDTEGML HVTMELDREA
310 320 330 340 350
QAEYQLQVRA QNSHGEDYAE PLELQVVVMD ENDNAPVCSP HDPTVNIPEL
360 370 380 390 400
SPPGTEIARL SAEDLDAPGS PNSHIVYQLL SPEPEEGAEN KAFELDPTSG
410 420 430 440 450
SVTLGTAPLH AGQSILLQVL AVDLAGSESG LSSTCEVTVM VTDVNNHAPE
460 470 480 490 500
FINSQIGPVT LPEDVKPGAL VATLMATDAD LEPAFRLMDF AIEEGDPEGI
510 520 530 540 550
FDLSWEPDSD HVQLRLRKNL SYEAAPDHKV VVVVSNIEEL VGPGPGPAAT
560 570 580 590 600
ATVTILVERV VAPLKLDQES YETSIPVSTP AGSLLLTIQP SDPMSRTLRF
610 620 630 640 650
SLVNDSEGWL CIKEVSGEVH TAQSLQGAQP GDTYTVLVEA QDTDKPGLST
660 670 680 690 700
SATVVIHFLK ASPVPALTLS AGPSRHLCTP RQDYGVVVSG VSEDPDLANR
710 720 730 740 750
NGPYSFALGP NPTVQRDWRL QPLNDSHAYL TLALHWVEPG EYMVPVVVHH
760 770 780 790 800
DTHMWQLQVK VIVCRCNVEG QCMRKVGRMK GMPTKLSAVG VLLGTLAAIG
810 820 830
FILILVFTHL ALARKDLDQP ADSVPLKAAV
Length:830
Mass (Da):89,860
Last modified:November 1, 1998 - v1
Checksum:i5EB1F06B5B7C2F25
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TPA4Q3TPA4_MOUSE
Cadherin-16
Cdh16
800Annotation score:
Q8C730Q8C730_MOUSE
Cadherin-16
Cdh16
815Annotation score:
A0A1D5RMM2A0A1D5RMM2_MOUSE
Cadherin-16
Cdh16
223Annotation score:
A0A1D5RMI6A0A1D5RMI6_MOUSE
Cadherin-16
Cdh16
163Annotation score:
A0A1D5RLG9A0A1D5RLG9_MOUSE
Cadherin-16
Cdh16
141Annotation score:
A0A1D5RLS8A0A1D5RLS8_MOUSE
Cadherin-16
Cdh16
93Annotation score:
A0A1D5RMB7A0A1D5RMB7_MOUSE
Cadherin-16
Cdh16
142Annotation score:
A0A1D5RMK0A0A1D5RMK0_MOUSE
Cadherin-16
Cdh16
58Annotation score:
A0A1D5RM27A0A1D5RM27_MOUSE
Cadherin-16
Cdh16
149Annotation score:
A0A1D5RMA8A0A1D5RMA8_MOUSE
Cadherin-16
Cdh16
179Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016271 mRNA Translation: AAC34254.1
BC015251 mRNA Translation: AAH15251.1
AF118228 Genomic DNA Translation: AAF28836.1
CCDSiCCDS22583.1
RefSeqiNP_031689.1, NM_007663.3
UniGeneiMm.19423

Genome annotation databases

EnsembliENSMUST00000211903; ENSMUSP00000148478; ENSMUSG00000031881
GeneIDi12556
KEGGimmu:12556
UCSCiuc009nax.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016271 mRNA Translation: AAC34254.1
BC015251 mRNA Translation: AAH15251.1
AF118228 Genomic DNA Translation: AAF28836.1
CCDSiCCDS22583.1
RefSeqiNP_031689.1, NM_007663.3
UniGeneiMm.19423

3D structure databases

ProteinModelPortaliO88338
SMRiO88338
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88338, 3 interactors
MINTiO88338
STRINGi10090.ENSMUSP00000129663

PTM databases

iPTMnetiO88338
PhosphoSitePlusiO88338

Proteomic databases

PaxDbiO88338
PeptideAtlasiO88338
PRIDEiO88338

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000211903; ENSMUSP00000148478; ENSMUSG00000031881
GeneIDi12556
KEGGimmu:12556
UCSCiuc009nax.2 mouse

Organism-specific databases

CTDi1014
MGIiMGI:106671 Cdh16

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00740000115559
HOGENOMiHOG000231613
HOVERGENiHBG050766
InParanoidiO88338
KOiK06810
OrthoDBiEOG091G03CL
PhylomeDBiO88338
TreeFamiTF316817

Miscellaneous databases

PROiPR:O88338
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031881 Expressed in 95 organ(s), highest expression level in cortex of kidney
CleanExiMM_CDH16
ExpressionAtlasiO88338 baseline and differential
GenevisibleiO88338 MM

Family and domain databases

InterProiView protein in InterPro
IPR030721 Cadherin-16
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
PANTHERiPTHR24028:SF1 PTHR24028:SF1, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 1 hit
PS50268 CADHERIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCAD16_MOUSE
AccessioniPrimary (citable) accession number: O88338
Secondary accession number(s): Q9JLZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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