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Protein

Alpha-catulin

Gene

Ctnnal1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-catulin
Alternative name(s):
Alpha-catenin-related protein
Short name:
ACRP
Catenin alpha-like protein 1
Gene namesi
Name:Ctnnal1
Synonyms:Catnal1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1859649 Ctnnal1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642691 – 731Alpha-catulinAdd BLAST731

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei373PhosphoserineCombined sources1
Modified residuei537PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO88327
PaxDbiO88327
PeptideAtlasiO88327
PRIDEiO88327

PTM databases

iPTMnetiO88327
PhosphoSitePlusiO88327

Expressioni

Gene expression databases

BgeeiENSMUSG00000038816 Expressed in 261 organ(s), highest expression level in sciatic nerve
ExpressionAtlasiO88327 baseline and differential
GenevisibleiO88327 MM

Interactioni

Subunit structurei

Interacts with ARHGEF1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036487

Structurei

3D structure databases

ProteinModelPortaliO88327
SMRiO88327
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 13Poly-Gly6

Sequence similaritiesi

Belongs to the vinculin/alpha-catenin family.Curated

Phylogenomic databases

eggNOGiKOG3681 Eukaryota
ENOG410XSRU LUCA
GeneTreeiENSGT00550000074411
HOGENOMiHOG000020484
HOVERGENiHBG051219
InParanoidiO88327
OMAiCHQLQTI
OrthoDBiEOG091G0BL2
PhylomeDBiO88327
TreeFamiTF313686

Family and domain databases

InterProiView protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR001033 Alpha_catenin
IPR030045 CTNNAL1
IPR006077 Vinculin/catenin
PANTHERiPTHR18914 PTHR18914, 1 hit
PTHR18914:SF8 PTHR18914:SF8, 1 hit
PfamiView protein in Pfam
PF01044 Vinculin, 3 hits
PRINTSiPR00805 ALPHACATENIN
SUPFAMiSSF47220 SSF47220, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O88327-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASPVPGGG GAGAVHSSNA AGFTFDSGLE IRTRSVEQTL LPLVSQITTL
60 70 80 90 100
INHKDNTKKS DKTLQAIQRV GQAVNLAVGR FVKVGEAIAN ENWDLKEEIN
110 120 130 140 150
IACIEAKQAG ETIASLTDVT KRSHLESDGQ VTILTDKTGV VQAARLLLSS
160 170 180 190 200
VTKVLLLADR VVIKQIVTSR NKILATMERL EKVNSFQEFV QIFSQFGNEM
210 220 230 240 250
VEFAHLTGDR QNDLKDEKKK ARMAVARAVL EKGTMMLLTA SKTCLRHPSC
260 270 280 290 300
ESAHTNKEGV FDRMRVALEK VTEIVTDCRL SGETDSSSVS IFTGIKELKV
310 320 330 340 350
NIEALRENVC FESKENLSAA LEAVLEHVED FTDSAYTSHE HRERILELSS
360 370 380 390 400
QARTELQQLL SVWMQTQSRK TKSAAEELEL TVLKISHSLD ELRRELHCTA
410 420 430 440 450
MQLAADLLKF HADHVVLKAL KVTGVEGNLE ALAEYACKLS EQKEQLVETC
460 470 480 490 500
RLLRHISGTE PLEITCIHAE ETFQVTGQQI ISAAETLTLH PSSKIAKENL
510 520 530 540 550
DVFCEAWESQ MSDMATLLRE ISDVFEGRRG ERCDHLSLPK PTKNSANLKS
560 570 580 590 600
LKPDKPDSEE QAKIAKLGLK LGLLSSDADC EIEKWEDEEN EIVRHGRNMS
610 620 630 640 650
RMAYSLYLFT RGEGPLKTSQ DLIHFLEVFA AEGLKLTSSV QSFSKQLKDD
660 670 680 690 700
DKLMLLLEIN KLIPLCHQLQ TITKTSLQSK VFLKVDKCIT KIRSMMTLVV
710 720 730
QLLSLCYKLL KKMENNRWGS ATNKDTMDGQ N
Length:731
Mass (Da):81,462
Last modified:November 1, 1998 - v1
Checksum:i36CF25115E3EF1F3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AZA7B1AZA7_MOUSE
Alpha-catulin
Ctnnal1
219Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62K → R in AAH50070 (PubMed:15489334).Curated1
Sequence conflicti135T → S in AAH50070 (PubMed:15489334).Curated1
Sequence conflicti728D → N in AAH50070 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006071 mRNA Translation: AAC26012.1
BC050070 mRNA Translation: AAH50070.1
CCDSiCCDS18200.1
RefSeqiNP_061231.3, NM_018761.3
UniGeneiMm.218891

Genome annotation databases

EnsembliENSMUST00000045142; ENSMUSP00000036487; ENSMUSG00000038816
GeneIDi54366
KEGGimmu:54366
UCSCiuc008sxu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006071 mRNA Translation: AAC26012.1
BC050070 mRNA Translation: AAH50070.1
CCDSiCCDS18200.1
RefSeqiNP_061231.3, NM_018761.3
UniGeneiMm.218891

3D structure databases

ProteinModelPortaliO88327
SMRiO88327
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036487

PTM databases

iPTMnetiO88327
PhosphoSitePlusiO88327

Proteomic databases

MaxQBiO88327
PaxDbiO88327
PeptideAtlasiO88327
PRIDEiO88327

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045142; ENSMUSP00000036487; ENSMUSG00000038816
GeneIDi54366
KEGGimmu:54366
UCSCiuc008sxu.2 mouse

Organism-specific databases

CTDi8727
MGIiMGI:1859649 Ctnnal1

Phylogenomic databases

eggNOGiKOG3681 Eukaryota
ENOG410XSRU LUCA
GeneTreeiENSGT00550000074411
HOGENOMiHOG000020484
HOVERGENiHBG051219
InParanoidiO88327
OMAiCHQLQTI
OrthoDBiEOG091G0BL2
PhylomeDBiO88327
TreeFamiTF313686

Miscellaneous databases

ChiTaRSiCtnnal1 mouse
PROiPR:O88327
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038816 Expressed in 261 organ(s), highest expression level in sciatic nerve
ExpressionAtlasiO88327 baseline and differential
GenevisibleiO88327 MM

Family and domain databases

InterProiView protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR001033 Alpha_catenin
IPR030045 CTNNAL1
IPR006077 Vinculin/catenin
PANTHERiPTHR18914 PTHR18914, 1 hit
PTHR18914:SF8 PTHR18914:SF8, 1 hit
PfamiView protein in Pfam
PF01044 Vinculin, 3 hits
PRINTSiPR00805 ALPHACATENIN
SUPFAMiSSF47220 SSF47220, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCTNL1_MOUSE
AccessioniPrimary (citable) accession number: O88327
Secondary accession number(s): Q810J3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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