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Protein
Submitted name:

Alpha-N-acetylglucosaminidase

Gene

Naglu

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2024096 HS-GAG degradation

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH89 Glycoside Hydrolase Family 89

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Alpha-N-acetylglucosaminidaseImported
Submitted name:
Alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)Imported
Submitted name:
Alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB), isoform CRA_bImported
Submitted name:
N-acetyl-glucosaminidaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NagluImported
ORF Names:mCG_20229Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1351641 Naglu

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509683722 – 739Sequence analysisAdd BLAST718

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000001751 Expressed in 195 organ(s), highest expression level in decidua

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
O88325, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000001802

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 114NAGLU_NInterPro annotationAdd BLAST87
Domaini128 – 463NAGLUInterPro annotationAdd BLAST336
Domaini472 – 730NAGLU_CInterPro annotationAdd BLAST259

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2233 Eukaryota
ENOG410XNMK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005900

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004225

KEGG Orthology (KO)

More...
KOi
K01205

Identification of Orthologs from Complete Genome Data

More...
OMAi
GIPFQQH

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02QN

TreeFam database of animal gene trees

More...
TreeFami
TF300689

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.379.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029018 Hex-like_dom2
IPR007781 NAGLU
IPR024732 NAGLU_C
IPR024240 NAGLU_N
IPR024733 NAGLU_tim-barrel

The PANTHER Classification System

More...
PANTHERi
PTHR12872 PTHR12872, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05089 NAGLU, 1 hit
PF12972 NAGLU_C, 1 hit
PF12971 NAGLU_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O88325-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAAGLAVIL GFLLLAGGSV GDEAREAKAV RELVVRLLGP GPAANFLVSV
60 70 80 90 100
ERALADESGL DTYSLSGGGG VPVLVRGSTG VAAAAGLHRY LRDFCGCQVA
110 120 130 140 150
WSSAQLHLPW PLPAVPDGLT ETTPNRYRYY QNVCTHSYSF VWWDWARWEQ
160 170 180 190 200
EIDWMALNGI NLALAWNGQE AIWQRVYLAL GLTQSEIDTY FTGPAFLAWG
210 220 230 240 250
RMGNLHTWDG PLPRSWHLSQ VYLQHRILDR MRSFGMIPVL PAFAGHVPKA
260 270 280 290 300
ITRVFPQVNV IKLGSWGHFN CSYSCSFLLA PGDPMFPLIG NLFLRELTKE
310 320 330 340 350
FGTDHIYGAD TFNEMQPPFS DPSYLAATTA AVYEAMVTVD PDAVWLLQGW
360 370 380 390 400
LFQHQPQFWG PSQIRAVLEA VPRGRLLVLD LFAESHPVYM HTASFHGQPF
410 420 430 440 450
IWCMLHNFGG NHGLFGALED VNRGPQAARL FPNSTMVGTG IAPEGIGQNE
460 470 480 490 500
VVYALMAELG WRKDPVPDLM AWVSSFAIRR YGVSQPDAVA AWKLLLRSVY
510 520 530 540 550
NCSGEACSGH NRSPLVKRPS LQMSTAVWYN RSDVFEAWRL LLTAAPNLTT
560 570 580 590 600
SPAFRYDLLD VTRQAVQELV SLCYEEARTA YLKQELDLLL RAGGLLVYKL
610 620 630 640 650
LPTLDELLAS SSHFLLGTWL DQARKAAVSE AEAQFYEQNS RYQITLWGPE
660 670 680 690 700
GNILDYANKQ LAGLVADYYQ PRWCLFLGTL AHSLARGVPF QQHEFEKNVF
710 720 730
PLEQAFVYNK KRYPSQPRGD TVDLSKKIFL KYHPQPDSL
Length:739
Mass (Da):82,596
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01C71966557CDE27
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX255926 Genomic DNA No translation available.
FQ790374 Genomic DNA No translation available.
AF003255 Genomic DNA Translation: AAC26842.1
BC055733 mRNA Translation: AAH55733.1
AF363242 Genomic DNA Translation: AAM21194.1
AK164125 mRNA Translation: BAE37639.1
AK170758 mRNA Translation: BAE42009.1
CH466677 Genomic DNA Translation: EDL03876.1

NCBI Reference Sequences

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RefSeqi
NP_038820.2, NM_013792.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.95452

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000001802; ENSMUSP00000001802; ENSMUSG00000001751

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27419

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:27419

UCSC genome browser

More...
UCSCi
uc007lmz.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255926 Genomic DNA No translation available.
FQ790374 Genomic DNA No translation available.
AF003255 Genomic DNA Translation: AAC26842.1
BC055733 mRNA Translation: AAH55733.1
AF363242 Genomic DNA Translation: AAM21194.1
AK164125 mRNA Translation: BAE37639.1
AK170758 mRNA Translation: BAE42009.1
CH466677 Genomic DNA Translation: EDL03876.1
RefSeqiNP_038820.2, NM_013792.2
UniGeneiMm.95452

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

IntActiO88325, 1 interactor
STRINGi10090.ENSMUSP00000001802

Protein family/group databases

CAZyiGH89 Glycoside Hydrolase Family 89

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001802; ENSMUSP00000001802; ENSMUSG00000001751
GeneIDi27419
KEGGimmu:27419
UCSCiuc007lmz.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4669
MGIiMGI:1351641 Naglu

Phylogenomic databases

eggNOGiKOG2233 Eukaryota
ENOG410XNMK LUCA
GeneTreeiENSGT00390000005900
HOVERGENiHBG004225
KOiK01205
OMAiGIPFQQH
OrthoDBiEOG091G02QN
TreeFamiTF300689

Enzyme and pathway databases

ReactomeiR-MMU-2024096 HS-GAG degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Naglu mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000001751 Expressed in 195 organ(s), highest expression level in decidua

Family and domain databases

Gene3Di3.30.379.10, 1 hit
InterProiView protein in InterPro
IPR029018 Hex-like_dom2
IPR007781 NAGLU
IPR024732 NAGLU_C
IPR024240 NAGLU_N
IPR024733 NAGLU_tim-barrel
PANTHERiPTHR12872 PTHR12872, 1 hit
PfamiView protein in Pfam
PF05089 NAGLU, 1 hit
PF12972 NAGLU_C, 1 hit
PF12971 NAGLU_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO88325_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88325
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: December 5, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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