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Protein
Submitted name:

Alpha-N-acetylglucosaminidase

Gene

Naglu

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-2024096 HS-GAG degradation

Protein family/group databases

CAZyiGH89 Glycoside Hydrolase Family 89

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-N-acetylglucosaminidaseImported
Submitted name:
Alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)Imported
Submitted name:
Alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB), isoform CRA_bImported
Submitted name:
N-acetyl-glucosaminidaseImported
Gene namesi
Name:NagluImported
ORF Names:mCG_20229Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1351641 Naglu

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501509683722 – 739Sequence analysisAdd BLAST718

Expressioni

Gene expression databases

BgeeiENSMUSG00000001751 Expressed in 195 organ(s), highest expression level in decidua

Interactioni

Protein-protein interaction databases

IntActiO88325, 1 interactor
O88325, 1 interactor
STRINGi10090.ENSMUSP00000001802

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 114NAGLU_NInterPro annotationAdd BLAST87
Domaini128 – 463NAGLUInterPro annotationAdd BLAST336
Domaini472 – 730NAGLU_CInterPro annotationAdd BLAST259

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2233 Eukaryota
ENOG410XNMK LUCA
GeneTreeiENSGT00390000005900
HOVERGENiHBG004225
KOiK01205
OMAiGIPFQQH
OrthoDBiEOG091G02QN
TreeFamiTF300689

Family and domain databases

Gene3Di3.30.379.10, 1 hit
InterProiView protein in InterPro
IPR029018 Hex-like_dom2
IPR007781 NAGLU
IPR024732 NAGLU_C
IPR024240 NAGLU_N
IPR024733 NAGLU_tim-barrel
PANTHERiPTHR12872 PTHR12872, 1 hit
PfamiView protein in Pfam
PF05089 NAGLU, 1 hit
PF12972 NAGLU_C, 1 hit
PF12971 NAGLU_N, 1 hit

Sequencei

Sequence statusi: Complete.

O88325-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAAGLAVIL GFLLLAGGSV GDEAREAKAV RELVVRLLGP GPAANFLVSV
60 70 80 90 100
ERALADESGL DTYSLSGGGG VPVLVRGSTG VAAAAGLHRY LRDFCGCQVA
110 120 130 140 150
WSSAQLHLPW PLPAVPDGLT ETTPNRYRYY QNVCTHSYSF VWWDWARWEQ
160 170 180 190 200
EIDWMALNGI NLALAWNGQE AIWQRVYLAL GLTQSEIDTY FTGPAFLAWG
210 220 230 240 250
RMGNLHTWDG PLPRSWHLSQ VYLQHRILDR MRSFGMIPVL PAFAGHVPKA
260 270 280 290 300
ITRVFPQVNV IKLGSWGHFN CSYSCSFLLA PGDPMFPLIG NLFLRELTKE
310 320 330 340 350
FGTDHIYGAD TFNEMQPPFS DPSYLAATTA AVYEAMVTVD PDAVWLLQGW
360 370 380 390 400
LFQHQPQFWG PSQIRAVLEA VPRGRLLVLD LFAESHPVYM HTASFHGQPF
410 420 430 440 450
IWCMLHNFGG NHGLFGALED VNRGPQAARL FPNSTMVGTG IAPEGIGQNE
460 470 480 490 500
VVYALMAELG WRKDPVPDLM AWVSSFAIRR YGVSQPDAVA AWKLLLRSVY
510 520 530 540 550
NCSGEACSGH NRSPLVKRPS LQMSTAVWYN RSDVFEAWRL LLTAAPNLTT
560 570 580 590 600
SPAFRYDLLD VTRQAVQELV SLCYEEARTA YLKQELDLLL RAGGLLVYKL
610 620 630 640 650
LPTLDELLAS SSHFLLGTWL DQARKAAVSE AEAQFYEQNS RYQITLWGPE
660 670 680 690 700
GNILDYANKQ LAGLVADYYQ PRWCLFLGTL AHSLARGVPF QQHEFEKNVF
710 720 730
PLEQAFVYNK KRYPSQPRGD TVDLSKKIFL KYHPQPDSL
Length:739
Mass (Da):82,596
Last modified:November 1, 1998 - v1
Checksum:i01C71966557CDE27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255926 Genomic DNA No translation available.
FQ790374 Genomic DNA No translation available.
AF003255 Genomic DNA Translation: AAC26842.1
BC055733 mRNA Translation: AAH55733.1
AF363242 Genomic DNA Translation: AAM21194.1
AK164125 mRNA Translation: BAE37639.1
AK170758 mRNA Translation: BAE42009.1
CH466677 Genomic DNA Translation: EDL03876.1
RefSeqiNP_038820.2, NM_013792.2
UniGeneiMm.95452

Genome annotation databases

EnsembliENSMUST00000001802; ENSMUSP00000001802; ENSMUSG00000001751
GeneIDi27419
KEGGimmu:27419
UCSCiuc007lmz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255926 Genomic DNA No translation available.
FQ790374 Genomic DNA No translation available.
AF003255 Genomic DNA Translation: AAC26842.1
BC055733 mRNA Translation: AAH55733.1
AF363242 Genomic DNA Translation: AAM21194.1
AK164125 mRNA Translation: BAE37639.1
AK170758 mRNA Translation: BAE42009.1
CH466677 Genomic DNA Translation: EDL03876.1
RefSeqiNP_038820.2, NM_013792.2
UniGeneiMm.95452

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88325, 1 interactor
O88325, 1 interactor
STRINGi10090.ENSMUSP00000001802

Protein family/group databases

CAZyiGH89 Glycoside Hydrolase Family 89

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001802; ENSMUSP00000001802; ENSMUSG00000001751
GeneIDi27419
KEGGimmu:27419
UCSCiuc007lmz.2 mouse

Organism-specific databases

CTDi4669
MGIiMGI:1351641 Naglu

Phylogenomic databases

eggNOGiKOG2233 Eukaryota
ENOG410XNMK LUCA
GeneTreeiENSGT00390000005900
HOVERGENiHBG004225
KOiK01205
OMAiGIPFQQH
OrthoDBiEOG091G02QN
TreeFamiTF300689

Enzyme and pathway databases

ReactomeiR-MMU-2024096 HS-GAG degradation

Miscellaneous databases

ChiTaRSiNaglu mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001751 Expressed in 195 organ(s), highest expression level in decidua

Family and domain databases

Gene3Di3.30.379.10, 1 hit
InterProiView protein in InterPro
IPR029018 Hex-like_dom2
IPR007781 NAGLU
IPR024732 NAGLU_C
IPR024240 NAGLU_N
IPR024733 NAGLU_tim-barrel
PANTHERiPTHR12872 PTHR12872, 1 hit
PfamiView protein in Pfam
PF05089 NAGLU, 1 hit
PF12972 NAGLU_C, 1 hit
PF12971 NAGLU_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO88325_MOUSE
AccessioniPrimary (citable) accession number: O88325
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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