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Protein

CD83 antigen

Gene

Cd83

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
CD83 antigen
Short name:
mCD83
Alternative name(s):
CD_antigen: CD83
Gene namesi
Name:Cd83
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1328316 Cd83

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 133ExtracellularSequence analysisAdd BLAST112
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Topological domaini155 – 196CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000037845122 – 196CD83 antigenAdd BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 98PROSITE-ProRule annotation
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88324
PRIDEiO88324

PTM databases

iPTMnetiO88324
PhosphoSitePlusiO88324

Expressioni

Tissue specificityi

Abundantly expressed in spleen and brain, but is also detected in most tissues analyzed.1 Publication

Gene expression databases

BgeeiENSMUSG00000015396 Expressed in 226 organ(s), highest expression level in mesenteric lymph node
GenevisibleiO88324 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015540

Structurei

3D structure databases

ProteinModelPortaliO88324
SMRiO88324
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 110Ig-like V-typeAdd BLAST89

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKX7 Eukaryota
ENOG410ZACF LUCA
GeneTreeiENSGT00390000007302
HOGENOMiHOG000057288
InParanoidiO88324
KOiK06510
OMAiAPWDPQV
OrthoDBiEOG091G0OEV
PhylomeDBiO88324
TreeFamiTF337861

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88324-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQGLQLLFL GCACSLAPAM AMREVTVACS ETADLPCTAP WDPQLSYAVS
60 70 80 90 100
WAKVSESGTE SVELPESKQN SSFEAPRRRA YSLTIQNTTI CSSGTYRCAL
110 120 130 140 150
QELGGQRNLS GTVVLKVTGC PKEATESTFR KYRAEAVLLF SLVVFYLTLI
160 170 180 190
IFTCKFARLQ SIFPDISKPG TEQAFLPVTS PSKHLGPVTL PKTETV
Length:196
Mass (Da):21,313
Last modified:November 1, 1998 - v1
Checksum:i026C1007BD7ABD1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001036 mRNA Translation: AAC83185.1
AF001041
, AF001037, AF001038, AF001039, AF001040 Genomic DNA Translation: AAC83186.1
AJ245551 mRNA Translation: CAB63843.1
AK075888 mRNA Translation: BAC36032.1
AK139410 mRNA Translation: BAE23999.1
AK154862 mRNA Translation: BAE32886.1
AK156386 mRNA Translation: BAE33694.1
AK171716 mRNA Translation: BAE42629.1
AK172396 mRNA Translation: BAE42984.1
AK172449 mRNA Translation: BAE43011.1
AK172466 mRNA Translation: BAE43020.1
CH466546 Genomic DNA Translation: EDL41001.1
BC107344 mRNA Translation: AAI07345.1
BC107345 mRNA Translation: AAI07346.1
CCDSiCCDS26481.1
RefSeqiNP_033986.1, NM_009856.3
UniGeneiMm.57175

Genome annotation databases

EnsembliENSMUST00000015540; ENSMUSP00000015540; ENSMUSG00000015396
GeneIDi12522
KEGGimmu:12522
UCSCiuc007qgj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001036 mRNA Translation: AAC83185.1
AF001041
, AF001037, AF001038, AF001039, AF001040 Genomic DNA Translation: AAC83186.1
AJ245551 mRNA Translation: CAB63843.1
AK075888 mRNA Translation: BAC36032.1
AK139410 mRNA Translation: BAE23999.1
AK154862 mRNA Translation: BAE32886.1
AK156386 mRNA Translation: BAE33694.1
AK171716 mRNA Translation: BAE42629.1
AK172396 mRNA Translation: BAE42984.1
AK172449 mRNA Translation: BAE43011.1
AK172466 mRNA Translation: BAE43020.1
CH466546 Genomic DNA Translation: EDL41001.1
BC107344 mRNA Translation: AAI07345.1
BC107345 mRNA Translation: AAI07346.1
CCDSiCCDS26481.1
RefSeqiNP_033986.1, NM_009856.3
UniGeneiMm.57175

3D structure databases

ProteinModelPortaliO88324
SMRiO88324
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015540

PTM databases

iPTMnetiO88324
PhosphoSitePlusiO88324

Proteomic databases

PaxDbiO88324
PRIDEiO88324

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015540; ENSMUSP00000015540; ENSMUSG00000015396
GeneIDi12522
KEGGimmu:12522
UCSCiuc007qgj.2 mouse

Organism-specific databases

CTDi9308
MGIiMGI:1328316 Cd83

Phylogenomic databases

eggNOGiENOG410IKX7 Eukaryota
ENOG410ZACF LUCA
GeneTreeiENSGT00390000007302
HOGENOMiHOG000057288
InParanoidiO88324
KOiK06510
OMAiAPWDPQV
OrthoDBiEOG091G0OEV
PhylomeDBiO88324
TreeFamiTF337861

Miscellaneous databases

PROiPR:O88324
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015396 Expressed in 226 organ(s), highest expression level in mesenteric lymph node
GenevisibleiO88324 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD83_MOUSE
AccessioniPrimary (citable) accession number: O88324
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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