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Entry version 183 (07 Oct 2020)
Sequence version 2 (27 Jul 2011)
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Protein

Nidogen-2

Gene

Nid2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell adhesion glycoprotein. Might be involved in osteoblast differentiation. It probably has a role in cell-extracellular matrix interactions.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3000157, Laminin interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nidogen-2
Short name:
NID-2
Alternative name(s):
Entactin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nid2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1298229, Nid2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30By similarityAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000767231 – 1403Nidogen-2Add BLAST1373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi511 ↔ 524By similarity
Disulfide bondi518 ↔ 533By similarity
Disulfide bondi535 ↔ 546By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi681N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi716N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi726N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi786 ↔ 799By similarity
Disulfide bondi793 ↔ 809By similarity
Disulfide bondi811 ↔ 822By similarity
Disulfide bondi828 ↔ 841By similarity
Disulfide bondi835 ↔ 850By similarity
Disulfide bondi852 ↔ 865By similarity
Disulfide bondi875 ↔ 890By similarity
Disulfide bondi882 ↔ 900By similarity
Disulfide bondi902 ↔ 913By similarity
Disulfide bondi919 ↔ 930By similarity
Disulfide bondi924 ↔ 939By similarity
Disulfide bondi941 ↔ 952By similarity
Disulfide bondi968 ↔ 991By similarity
Disulfide bondi1002 ↔ 1009By similarity
Disulfide bondi1011 ↔ 1033By similarity
Disulfide bondi1047 ↔ 1071By similarity
Disulfide bondi1082 ↔ 1089By similarity
Disulfide bondi1091 ↔ 1112By similarity
Glycosylationi1152N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1336Omega-N-methylarginineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Highly N- and O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O88322

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O88322

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O88322

PeptideAtlas

More...
PeptideAtlasi
O88322

PRoteomics IDEntifications database

More...
PRIDEi
O88322

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O88322, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O88322

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O88322

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000021806, Expressed in humerus cartilage element and 281 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O88322, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O88322, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LAMA2.

Interacts with COL13A1 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
201771, 8 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000022340

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O88322, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O88322

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 274NIDOPROSITE-ProRule annotationAdd BLAST167
Domaini507 – 547EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini551 – 781Nidogen G2 beta-barrelPROSITE-ProRule annotationAdd BLAST231
Domaini782 – 823EGF-like 2PROSITE-ProRule annotationAdd BLAST42
Domaini824 – 862EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini871 – 914EGF-like 4PROSITE-ProRule annotationAdd BLAST44
Domaini915 – 953EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini965 – 1033Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST69
Domaini1044 – 1112Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST69
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1182 – 1225LDL-receptor class B 1Add BLAST44
Repeati1226 – 1268LDL-receptor class B 2Add BLAST43
Repeati1269 – 1313LDL-receptor class B 3Add BLAST45
Repeati1314 – 1355LDL-receptor class B 4Add BLAST42
Repeati1357 – 1401LDL-receptor class B 5Add BLAST45

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi946 – 948Cell attachment site3

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1214, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157901

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003163_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O88322

KEGG Orthology (KO)

More...
KOi
K06826

Identification of Orthologs from Complete Genome Data

More...
OMAi
CERWKES

Database of Orthologous Groups

More...
OrthoDBi
95286at2759

TreeFam database of animal gene trees

More...
TreeFami
TF320666

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00255, nidG2, 1 hit
cd00191, TY, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 1 hit
4.10.800.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR006605, G2_nidogen/fibulin_G2F
IPR009017, GFP
IPR009030, Growth_fac_rcpt_cys_sf
IPR000033, LDLR_classB_rpt
IPR003886, NIDO_dom
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07645, EGF_CA, 2 hits
PF07474, G2F, 1 hit
PF00058, Ldl_recept_b, 2 hits
PF06119, NIDO, 1 hit
PF00086, Thyroglobulin_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 5 hits
SM00179, EGF_CA, 5 hits
SM00682, G2F, 1 hit
SM00135, LY, 4 hits
SM00539, NIDO, 1 hit
SM00211, TY, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54511, SSF54511, 1 hit
SSF57184, SSF57184, 1 hit
SSF57610, SSF57610, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS01186, EGF_2, 4 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 2 hits
PS51120, LDLRB, 4 hits
PS51220, NIDO, 1 hit
PS50993, NIDOGEN_G2, 1 hit
PS00484, THYROGLOBULIN_1_1, 2 hits
PS51162, THYROGLOBULIN_1_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O88322-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRDPTAGWL TPPSPLSLLV MLLLLSRVGA LRPDELFPYG ESWGDQLLPE
60 70 80 90 100
GDDESSAAVK LAIPLRFYDA QFSSLYVGTN GIISTQDFPR ETQYVDDDFP
110 120 130 140 150
TDFPAIAPFL ADIDTSHSRG RILYREDTSG AVLSLAARYV RTGFPLSGSS
160 170 180 190 200
FTPTHAFLAT WEHVGAYEEV SRGAAPSGEL NTFQAVLASD ESDTYALFLY
210 220 230 240 250
PANGLQFFGT RPKESYNVQL QLPARVGFCR GEADDLKREA LYFSLTNTEQ
260 270 280 290 300
SVKNLYQLSN LGIPGVWAFH IGSRFALDNV RPATVGGDPS TARSSALEHP
310 320 330 340 350
FSHAAALESY TEDSFHYYDE NEEDVEYPPV EPGEAPEGHS RIDVSFNSKA
360 370 380 390 400
DPGLVDVGTS SPGSDRASPW PYPAPGNWPS YRETESASLD PQTKQGRPVG
410 420 430 440 450
EGEVLDFRDP AELLDQMGTR APAPPEADAA LLTPVNEDLG GRNTQSYPEA
460 470 480 490 500
GPVPSEPDVP VPPLEGEVLP HYPESGHVPP LRGGKYVIGL EDHVGSNDQV
510 520 530 540 550
FTYNGANLET CEHSHGRCSQ HAFCTDYTTG FCCHCQSRFY GNGKHCLPEG
560 570 580 590 600
APHRVNGKVS GRLRVGHIPV HFTDVDLHAY IVGNDGRAYT AISHVPQPAA
610 620 630 640 650
QALLPVLPIG GLFGWLFALE KPGSENGFSL TGATFVHDVE VTFHPGEERV
660 670 680 690 700
RITQTAEGLD PENYLSIKTN IEGQVPFIPA NFTAHITPYK EFYHYRDSVV
710 720 730 740 750
TSSSSRSFSL TSGSINQTWS YHIDQNITYQ ACRHAPRHLA IPATQQLTVD
760 770 780 790 800
RAFALYSEDE GVLRFAVTNQ IGPVEVDSAP VGVNPCYDGS HTCDTTARCH
810 820 830 840 850
PGTGVDYTCE CTPGFQGDGR SCVDVNECAT GFHRCGPNSV CVNLVGSYRC
860 870 880 890 900
ECRSGYEFAD DQHTCILIAP PPNPCLDGSH TCAPEGQARC IHHGGSSFSC
910 920 930 940 950
ACLPGFIGTG HQCSDVDECA ENRCHEAAIC YNTPGSFSCR CQPGYRGDGF
960 970 980 990 1000
HCTSDTVPED SISGLKPCEY QQRYAQTQHA YPGSRIHIPQ CDDQGNFVPL
1010 1020 1030 1040 1050
QCHGSTGFCW CVDRNGHEVP GTQTPPGSTP PHCGPPPEPT QRPRTVCERW
1060 1070 1080 1090 1100
RESLLEHYGG TPRDDQYVPQ CDDLGHFIPL QCHGKSDFCW CVDKDGRELQ
1110 1120 1130 1140 1150
GTRSQPGTRP ACIPTVAPPV VRPTPRPDVT PPSVGTFLLY AQGQQIGHLP
1160 1170 1180 1190 1200
LNGSRLQKDA ARTLLSLHGS IVVGIDYDCR ERMVYWTDVA GRTISRASLE
1210 1220 1230 1240 1250
AGAEPETIIT SGLISPEGLA IDHFRRTMYW TDSGLDKIER AELDGSERKV
1260 1270 1280 1290 1300
LFHTDLVNPR AITVDPIRGN LYWTDWNREA PKIETSSLDG ENRRILINKD
1310 1320 1330 1340 1350
IGLPNGLTFD PFSKLLCWAD AGTKKLECTL PDGTGRRVIQ NHLNYPFSIV
1360 1370 1380 1390 1400
SYADHFYHTD WRRDGVISVN KDSGQFTDEF LPEQRSHLYG ITAVYPYCPT

GRK
Length:1,403
Mass (Da):153,913
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABA0B1DB2C84A27A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YCQ5A0A286YCQ5_MOUSE
Nidogen-2
Nid2
1,171Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti197L → F in BAA32609 (PubMed:9633511).Curated1
Sequence conflicti251S → F in BAA32609 (PubMed:9633511).Curated1
Sequence conflicti367A → V in BAA32609 (PubMed:9633511).Curated1
Sequence conflicti375P → H in BAA32609 (PubMed:9633511).Curated1
Sequence conflicti386S → W in BAA32609 (PubMed:9633511).Curated1
Sequence conflicti496S → F in BAA32609 (PubMed:9633511).Curated1
Sequence conflicti651R → C in BAA32609 (PubMed:9633511).Curated1
Sequence conflicti876L → F in BAA32609 (PubMed:9633511).Curated1
Sequence conflicti1151L → F in BAA32609 (PubMed:9633511).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB017202 mRNA Translation: BAA32609.1
CH466613 Genomic DNA Translation: EDL01537.1
BC054746 mRNA Translation: AAH54746.1
BC057016 mRNA Translation: AAH57016.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36813.1

NCBI Reference Sequences

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RefSeqi
NP_032721.2, NM_008695.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000022340; ENSMUSP00000022340; ENSMUSG00000021806

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18074

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:18074

UCSC genome browser

More...
UCSCi
uc007siu.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017202 mRNA Translation: BAA32609.1
CH466613 Genomic DNA Translation: EDL01537.1
BC054746 mRNA Translation: AAH54746.1
BC057016 mRNA Translation: AAH57016.1
CCDSiCCDS36813.1
RefSeqiNP_032721.2, NM_008695.2

3D structure databases

SMRiO88322
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi201771, 8 interactors
STRINGi10090.ENSMUSP00000022340

PTM databases

GlyGeniO88322, 4 sites
iPTMnetiO88322
PhosphoSitePlusiO88322

Proteomic databases

jPOSTiO88322
MaxQBiO88322
PaxDbiO88322
PeptideAtlasiO88322
PRIDEiO88322

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
10737, 164 antibodies

Genome annotation databases

EnsembliENSMUST00000022340; ENSMUSP00000022340; ENSMUSG00000021806
GeneIDi18074
KEGGimmu:18074
UCSCiuc007siu.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22795
MGIiMGI:1298229, Nid2

Phylogenomic databases

eggNOGiKOG1214, Eukaryota
GeneTreeiENSGT00940000157901
HOGENOMiCLU_003163_1_0_1
InParanoidiO88322
KOiK06826
OMAiCERWKES
OrthoDBi95286at2759
TreeFamiTF320666

Enzyme and pathway databases

ReactomeiR-MMU-3000157, Laminin interactions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
18074, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Nid2, mouse

Protein Ontology

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PROi
PR:O88322
RNActiO88322, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000021806, Expressed in humerus cartilage element and 281 other tissues
ExpressionAtlasiO88322, baseline and differential
GenevisibleiO88322, MM

Family and domain databases

CDDicd00255, nidG2, 1 hit
cd00191, TY, 2 hits
Gene3Di2.120.10.30, 1 hit
4.10.800.10, 2 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR006605, G2_nidogen/fibulin_G2F
IPR009017, GFP
IPR009030, Growth_fac_rcpt_cys_sf
IPR000033, LDLR_classB_rpt
IPR003886, NIDO_dom
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf
PfamiView protein in Pfam
PF07645, EGF_CA, 2 hits
PF07474, G2F, 1 hit
PF00058, Ldl_recept_b, 2 hits
PF06119, NIDO, 1 hit
PF00086, Thyroglobulin_1, 2 hits
SMARTiView protein in SMART
SM00181, EGF, 5 hits
SM00179, EGF_CA, 5 hits
SM00682, G2F, 1 hit
SM00135, LY, 4 hits
SM00539, NIDO, 1 hit
SM00211, TY, 2 hits
SUPFAMiSSF54511, SSF54511, 1 hit
SSF57184, SSF57184, 1 hit
SSF57610, SSF57610, 2 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS01186, EGF_2, 4 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 2 hits
PS51120, LDLRB, 4 hits
PS51220, NIDO, 1 hit
PS50993, NIDOGEN_G2, 1 hit
PS00484, THYROGLOBULIN_1_1, 2 hits
PS51162, THYROGLOBULIN_1_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNID2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88322
Secondary accession number(s): Q7TQF0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: October 7, 2020
This is version 183 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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