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Protein

Neurotensin receptor type 1

Gene

Ntsr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin receptor type 1
Short name:
NT-R-1
Short name:
NTR1
Gene namesi
Name:Ntsr1
Synonyms:Ntsr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:97386 Ntsr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 67ExtracellularBy similarityAdd BLAST67
Transmembranei68 – 88Helical; Name=1By similarityAdd BLAST21
Topological domaini89 – 102CytoplasmicBy similarityAdd BLAST14
Transmembranei103 – 122Helical; Name=2By similarityAdd BLAST20
Topological domaini123 – 142ExtracellularBy similarityAdd BLAST20
Transmembranei143 – 164Helical; Name=3By similarityAdd BLAST22
Topological domaini165 – 184CytoplasmicBy similarityAdd BLAST20
Transmembranei185 – 205Helical; Name=4By similarityAdd BLAST21
Topological domaini206 – 234ExtracellularBy similarityAdd BLAST29
Transmembranei235 – 259Helical; Name=5By similarityAdd BLAST25
Topological domaini260 – 308CytoplasmicBy similarityAdd BLAST49
Transmembranei309 – 330Helical; Name=6By similarityAdd BLAST22
Topological domaini331 – 348ExtracellularBy similarityAdd BLAST18
Transmembranei349 – 369Helical; Name=7By similarityAdd BLAST21
Topological domaini370 – 424CytoplasmicBy similarityAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3570
GuidetoPHARMACOLOGYi309

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699471 – 424Neurotensin receptor type 1Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi141 ↔ 224PROSITE-ProRule annotation
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi386S-palmitoyl cysteineBy similarity1
Lipidationi388S-palmitoyl cysteineBy similarity1

Post-translational modificationi

N-glycosylated.By similarity
Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO88319
PRIDEiO88319

PTM databases

iPTMnetiO88319
PhosphoSitePlusiO88319

Expressioni

Gene expression databases

BgeeiENSMUSG00000027568 Expressed in 72 organ(s), highest expression level in spinal cord
CleanExiMM_NTSR1
ExpressionAtlasiO88319 baseline and differential
GenevisibleiO88319 MM

Interactioni

Subunit structurei

Interacts (palmitoylated form) with GNA11.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029084

Chemistry databases

BindingDBiO88319

Structurei

3D structure databases

ProteinModelPortaliO88319
SMRiO88319
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni326 – 349Neurotensin bindingBy similarityAdd BLAST24

Domaini

The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembrane regions TM6 and TM7.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00700000104070
HOGENOMiHOG000231271
HOVERGENiHBG098285
InParanoidiO88319
KOiK04211
OMAiVPMLFTM
OrthoDBiEOG091G0Q6E
PhylomeDBiO88319
TreeFamiTF337167

Family and domain databases

CDDicd15355 7tmA_NTSR1, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003985 NT1_rcpt
IPR003984 NT_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01479 NEUROTENSINR
PR01480 NEUROTENSN1R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O88319-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLNSSVQQG APSEPGAQPF PHPQFGLETM LLALSLSNGS GNSSESILEP
60 70 80 90 100
NSNLDVNTDI YSKVLVTAVY LALFVVGTVG NSVTAFTLAR KKSLQSLQST
110 120 130 140 150
VHYHLGSLAL SDLLILLLAM PVELYNFIWV HHPWAFGDAG CRGYYFLRDA
160 170 180 190 200
CTYATALNVA SLSVERYLAI CHPFKAKTLM SRSRTKKFIS AIWLASALLA
210 220 230 240 250
VPMLFTMGLQ NRSADGQHPG GLVCTPTVDT ATVKVVIQVN TFMSFLFPML
260 270 280 290 300
IISILNTVIA NKLTVMVHQA AEQGRGVCTV GTHNSLEHST FNMSIEPGRV
310 320 330 340 350
QALRHGVLVL RAVVIAFVVC WLPYHVRRLM FCYISDEQWT TFLFDFYHYF
360 370 380 390 400
YMLTNALFYV SSAINPILYN LVSANFRQVF LSTLACLCPG WRRRRKKRPT
410 420
FSRKPNSMSS NHAFSTSATR ETLY
Length:424
Mass (Da):47,217
Last modified:November 1, 1998 - v1
Checksum:i8E9A723171A48711
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017027 mRNA Translation: BAA33013.1
CCDSiCCDS17177.1
RefSeqiNP_061236.1, NM_018766.2
UniGeneiMm.301712

Genome annotation databases

EnsembliENSMUST00000029084; ENSMUSP00000029084; ENSMUSG00000027568
ENSMUST00000170448; ENSMUSP00000127548; ENSMUSG00000027568
GeneIDi18216
KEGGimmu:18216
UCSCiuc008ojg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017027 mRNA Translation: BAA33013.1
CCDSiCCDS17177.1
RefSeqiNP_061236.1, NM_018766.2
UniGeneiMm.301712

3D structure databases

ProteinModelPortaliO88319
SMRiO88319
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029084

Chemistry databases

BindingDBiO88319
ChEMBLiCHEMBL3570
GuidetoPHARMACOLOGYi309

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO88319
PhosphoSitePlusiO88319

Proteomic databases

PaxDbiO88319
PRIDEiO88319

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029084; ENSMUSP00000029084; ENSMUSG00000027568
ENSMUST00000170448; ENSMUSP00000127548; ENSMUSG00000027568
GeneIDi18216
KEGGimmu:18216
UCSCiuc008ojg.1 mouse

Organism-specific databases

CTDi4923
MGIiMGI:97386 Ntsr1

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00700000104070
HOGENOMiHOG000231271
HOVERGENiHBG098285
InParanoidiO88319
KOiK04211
OMAiVPMLFTM
OrthoDBiEOG091G0Q6E
PhylomeDBiO88319
TreeFamiTF337167

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events

Miscellaneous databases

PROiPR:O88319
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027568 Expressed in 72 organ(s), highest expression level in spinal cord
CleanExiMM_NTSR1
ExpressionAtlasiO88319 baseline and differential
GenevisibleiO88319 MM

Family and domain databases

CDDicd15355 7tmA_NTSR1, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003985 NT1_rcpt
IPR003984 NT_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01479 NEUROTENSINR
PR01480 NEUROTENSN1R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNTR1_MOUSE
AccessioniPrimary (citable) accession number: O88319
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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