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Protein

Anterior gradient protein 2 homolog

Gene

Agr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth (By similarity). Promotes cell adhesion (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Anterior gradient protein 2 homolog
Short name:
AG-2
Short name:
mAG-2
Alternative name(s):
Protein Gob-4
Secreted cement gland protein XAG-2 homolog
Gene namesi
Name:Agr2
Synonyms:Gob4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1344405 Agr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice are viable but display altered production of mucus with loss of production of MUC2 despite expression of its mRNA. They also display an increase in mast cells in the intestine, an increased expression of inflammation-specific genes, and frequent rectal prolapse. This is associated with a higher susceptibility to colitis.1 Publication

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000000103821 – 175Anterior gradient protein 2 homologAdd BLAST155

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiO88312
PaxDbiO88312
PeptideAtlasiO88312
PRIDEiO88312

PTM databases

iPTMnetiO88312
PhosphoSitePlusiO88312

Expressioni

Tissue specificityi

Expressed in lung, skeletal muscle, testis, liver, stomach, colon, small intestine, the goblet cells of the intestine and the mucuous neck cells of the stomach.2 Publications

Developmental stagei

Expressed in embryo at 15 dpc onwards.

Gene expression databases

BgeeiENSMUSG00000020581 Expressed in 138 organ(s), highest expression level in colon
CleanExiMM_AGR2
GenevisibleiO88312 MM

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO88312, 2 interactors
MINTiO88312
STRINGi10090.ENSMUSP00000020898

Structurei

3D structure databases

ProteinModelPortaliO88312
SMRiO88312
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 40Required to promote cell adhesionBy similarityAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 54Homodimer stabilization; interchainBy similarity10
Motifi60 – 67Homodimer stabilization; interchainBy similarity8

Sequence similaritiesi

Belongs to the AGR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVR8 Eukaryota
ENOG4111K70 LUCA
GeneTreeiENSGT00530000063273
HOGENOMiHOG000231100
HOVERGENiHBG006516
InParanoidiO88312
KOiK20356
OMAiYSNMQKA
OrthoDBiEOG091G0RHV
PhylomeDBiO88312
TreeFamiTF321449

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
SUPFAMiSSF52833 SSF52833, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88312-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKFSVSAIL LLVAISGTLA KDTTVKSGAK KDPKDSRPKL PQTLSRGWGD
60 70 80 90 100
QLIWTQTYEE ALYRSKTSNR PLMVIHHLDE CPHSQALKKV FAEHKEIQKL
110 120 130 140 150
AEQFVLLNLV YETTDKHLSP DGQYVPRIVF VDPSLTVRAD ITGRYSNRLY
160 170
AYEPSDTALL YDNMKKALKL LKTEL
Length:175
Mass (Da):19,920
Last modified:November 1, 1998 - v1
Checksum:iACC3CFE429B668CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044262 mRNA Translation: AAC72705.1
AB016592 mRNA Translation: BAA32044.1
AK007677 mRNA Translation: BAB25181.1
CT030196 Genomic DNA No translation available.
BC013334 mRNA Translation: AAH13334.1
CCDSiCCDS25881.1
RefSeqiNP_035913.1, NM_011783.2
UniGeneiMm.7244

Genome annotation databases

EnsembliENSMUST00000020898; ENSMUSP00000020898; ENSMUSG00000020581
GeneIDi23795
KEGGimmu:23795
UCSCiuc007njm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044262 mRNA Translation: AAC72705.1
AB016592 mRNA Translation: BAA32044.1
AK007677 mRNA Translation: BAB25181.1
CT030196 Genomic DNA No translation available.
BC013334 mRNA Translation: AAH13334.1
CCDSiCCDS25881.1
RefSeqiNP_035913.1, NM_011783.2
UniGeneiMm.7244

3D structure databases

ProteinModelPortaliO88312
SMRiO88312
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88312, 2 interactors
MINTiO88312
STRINGi10090.ENSMUSP00000020898

PTM databases

iPTMnetiO88312
PhosphoSitePlusiO88312

Proteomic databases

MaxQBiO88312
PaxDbiO88312
PeptideAtlasiO88312
PRIDEiO88312

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020898; ENSMUSP00000020898; ENSMUSG00000020581
GeneIDi23795
KEGGimmu:23795
UCSCiuc007njm.1 mouse

Organism-specific databases

CTDi10551
MGIiMGI:1344405 Agr2

Phylogenomic databases

eggNOGiENOG410IVR8 Eukaryota
ENOG4111K70 LUCA
GeneTreeiENSGT00530000063273
HOGENOMiHOG000231100
HOVERGENiHBG006516
InParanoidiO88312
KOiK20356
OMAiYSNMQKA
OrthoDBiEOG091G0RHV
PhylomeDBiO88312
TreeFamiTF321449

Miscellaneous databases

PROiPR:O88312
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020581 Expressed in 138 organ(s), highest expression level in colon
CleanExiMM_AGR2
GenevisibleiO88312 MM

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
SUPFAMiSSF52833 SSF52833, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAGR2_MOUSE
AccessioniPrimary (citable) accession number: O88312
Secondary accession number(s): A2CGA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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