Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sortilin-related receptor

Gene

Sorl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. May play a role in neural organization, as well as the establishment of embryonic organ systems. Involved in APP trafficking to and from the Golgi apparatus (By similarity). It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta (By similarity). Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processCholesterol metabolism, Endocytosis, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sortilin-related receptor
Alternative name(s):
Gp250
Low-density lipoprotein receptor relative with 11 ligand-binding repeats
Short name:
LDLR relative with 11 ligand-binding repeats
Short name:
LR11
SorLA-1
Sorting protein-related receptor containing LDLR class A repeats
Short name:
mSorLA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sorl1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1202296 Sorl1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini82 – 2138ExtracellularSequence analysisAdd BLAST2057
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2139 – 2159HelicalSequence analysisAdd BLAST21
Topological domaini2160 – 2215CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Endosome, Golgi apparatus, LDL, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000003316629 – 81Removed in mature formBy similarityAdd BLAST53
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003316782 – 2215Sortilin-related receptorAdd BLAST2134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei114PhosphoserineBy similarity1
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi367N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi430N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi616N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi674N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi818N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi871N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1035N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1068N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1078 ↔ 1090PROSITE-ProRule annotation
Disulfide bondi1085 ↔ 1103PROSITE-ProRule annotation
Disulfide bondi1097 ↔ 1112PROSITE-ProRule annotation
Disulfide bondi1117 ↔ 1131PROSITE-ProRule annotation
Disulfide bondi1125 ↔ 1144PROSITE-ProRule annotation
Disulfide bondi1138 ↔ 1153PROSITE-ProRule annotation
Disulfide bondi1158 ↔ 1170PROSITE-ProRule annotation
Glycosylationi1164N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1165 ↔ 1183PROSITE-ProRule annotation
Disulfide bondi1177 ↔ 1192PROSITE-ProRule annotation
Glycosylationi1191N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1199 ↔ 1211PROSITE-ProRule annotation
Disulfide bondi1206 ↔ 1224PROSITE-ProRule annotation
Disulfide bondi1218 ↔ 1235PROSITE-ProRule annotation
Disulfide bondi1239 ↔ 1249PROSITE-ProRule annotation
Disulfide bondi1244 ↔ 1262PROSITE-ProRule annotation
Glycosylationi1246N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1256 ↔ 1271PROSITE-ProRule annotation
Disulfide bondi1275 ↔ 1289PROSITE-ProRule annotation
Disulfide bondi1283 ↔ 1302PROSITE-ProRule annotation
Disulfide bondi1296 ↔ 1315PROSITE-ProRule annotation
Disulfide bondi1325 ↔ 1337PROSITE-ProRule annotation
Disulfide bondi1332 ↔ 1350PROSITE-ProRule annotation
Disulfide bondi1344 ↔ 1359PROSITE-ProRule annotation
Glycosylationi1367N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1368 ↔ 1381PROSITE-ProRule annotation
Disulfide bondi1376 ↔ 1394PROSITE-ProRule annotation
Disulfide bondi1388 ↔ 1403PROSITE-ProRule annotation
Disulfide bondi1419 ↔ 1431PROSITE-ProRule annotation
Disulfide bondi1426 ↔ 1444PROSITE-ProRule annotation
Disulfide bondi1438 ↔ 1453PROSITE-ProRule annotation
Glycosylationi1458N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1471 ↔ 1484PROSITE-ProRule annotation
Disulfide bondi1478 ↔ 1497PROSITE-ProRule annotation
Disulfide bondi1491 ↔ 1506PROSITE-ProRule annotation
Disulfide bondi1514 ↔ 1527PROSITE-ProRule annotation
Disulfide bondi1521 ↔ 1540PROSITE-ProRule annotation
Disulfide bondi1534 ↔ 1549PROSITE-ProRule annotation
Glycosylationi1608N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1706N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1733N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1810N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1855N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1895N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1987N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2011N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2055N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2070N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2077N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2093N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2207Phosphoserine; by ROCK2By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O88307

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O88307

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O88307

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O88307

PeptideAtlas

More...
PeptideAtlasi
O88307

PRoteomics IDEntifications database

More...
PRIDEi
O88307

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O88307

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O88307

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundant in brain, where it is mainly expressed in adult cerebellum, hippocampal ca regions, dentate gyrus, and to a much lesser extent in the cerebral cortex. Detectable in kidney, skeletal muscle, lung and spleen, but not in the liver.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed as early as embryonic day 6.5 (E6.5) and peaks at E11, the main location is in the CNS during development. At early stages, it is abundant in a subpopulation of neurons in the cerebral cortex, in the hippocampus, and granular and Purkinje cell layers in the cerebellum, whereas in the adult, expression in cerebellar granular cells and in the cerebral cortex is low. Expression occurs also in a variety of glands and organs during organogenesis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000049313 Expressed in 323 organ(s), highest expression level in cerebellum

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O88307 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GGA1 and ROCK2 (By similarity). Interacts with APP. Interacts with PLAUR (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Vps35Q9EQH32EBI-7540114,EBI-775825

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-42439N

Protein interaction database and analysis system

More...
IntActi
O88307, 1 interactor

Molecular INTeraction database

More...
MINTi
O88307

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000058613

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O88307

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O88307

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati136 – 147BNR 1Add BLAST12
Repeati232 – 243BNR 2Add BLAST12
Repeati441 – 452BNR 3Add BLAST12
Repeati521 – 532BNR 4Add BLAST12
Repeati562 – 573BNR 5Add BLAST12
Repeati800 – 843LDL-receptor class B 1Add BLAST44
Repeati844 – 887LDL-receptor class B 2Add BLAST44
Repeati888 – 932LDL-receptor class B 3Add BLAST45
Repeati933 – 972LDL-receptor class B 4Add BLAST40
Repeati973 – 1013LDL-receptor class B 5Add BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1026 – 1072EGF-likeAdd BLAST47
Domaini1076 – 1114LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST39
Domaini1115 – 1155LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST41
Domaini1156 – 1194LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST39
Domaini1198 – 1236LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST39
Domaini1238 – 1272LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST35
Domaini1273 – 1317LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST45
Domaini1323 – 1361LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST39
Domaini1366 – 1405LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST40
Domaini1417 – 1455LDL-receptor class A 9PROSITE-ProRule annotationAdd BLAST39
Domaini1469 – 1508LDL-receptor class A 10PROSITE-ProRule annotationAdd BLAST40
Domaini1512 – 1551LDL-receptor class A 11PROSITE-ProRule annotationAdd BLAST40
Domaini1557 – 1649Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST93
Domaini1653 – 1745Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST93
Domaini1747 – 1846Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST100
Domaini1844 – 1928Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST85
Domaini1935 – 2030Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST96
Domaini2031 – 2119Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2173 – 2178Endocytosis signalSequence analysis6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1215 Eukaryota
KOG3511 Eukaryota
ENOG410Y3W5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153473

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007009

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG017830

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O88307

Identification of Orthologs from Complete Genome Data

More...
OMAi
HNCLYWS

Database of Orthologous Groups

More...
OrthoDBi
1046610at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324918

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 5 hits
cd00112 LDLa, 11 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 1 hit
2.130.10.10, 1 hit
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt
IPR031777 Sortilin_C
IPR031778 Sortilin_N
IPR006581 VPS10
IPR015943 WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 3 hits
PF00057 Ldl_recept_a, 10 hits
PF00058 Ldl_recept_b, 2 hits
PF15902 Sortilin-Vps10, 1 hit
PF15901 Sortilin_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 6 hits
SM00192 LDLa, 11 hits
SM00135 LY, 5 hits
SM00602 VPS10, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 3 hits
SSF57424 SSF57424, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01186 EGF_2, 1 hit
PS50853 FN3, 4 hits
PS01209 LDLRA_1, 10 hits
PS50068 LDLRA_2, 11 hits
PS51120 LDLRB, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O88307-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATRSSRRES RLPFLFALVA LLPRGALGGG WTQRLHGGPA PLPQDRGFFV
60 70 80 90 100
VQGDPRDLRL GTHGDAPGAS PAARKPLRTR RSAALQPQPI QVYGQVSLND
110 120 130 140 150
SHNQMVVHWA GEKSNVIVAL ARDSLALARP KSSDVYVSYD YGKSFSKISE
160 170 180 190 200
KLNFGVGNNS EAVISQFYHS PADNKRYIFV DAYAQYLWIT FDFCSTIHGF
210 220 230 240 250
SIPFRAADLL LHSKASNLLL GFDRSHPNKQ LWKSDDFGQT WIMIQEHVKS
260 270 280 290 300
FSWGIDPYDQ PNAIYIERHE PFGFSTVLRS TDFFQSRENQ EVILEEVRDF
310 320 330 340 350
QLRDKYMFAT KVVHLPGSQQ QSSVQLWVSF GRKPMRAAQF VTKHPINEYY
360 370 380 390 400
IADAAEDQVF VCVSHSNNST NLYISEAEGL KFSLSLENVL YYSPGGAGSD
410 420 430 440 450
TLVRYFANEP FADFHRVEGL QGVYIATLIN GSMNEENMRS VITFDKGGTW
460 470 480 490 500
EFLQAPAFTG YGEKINCELS QGCSLHLAQR LSQLLNLQLR RMPILSKESA
510 520 530 540 550
PGLIIATGSV GKNLASKTNV YISSSAGARW REALPGPHYY TWGDHGGIIM
560 570 580 590 600
AIAQGMETNE LKYSTNEGET WKTFVFSEKP VFVYGLLTEP GEKSTVFTIF
610 620 630 640 650
GSNKESVHSW LILQVNATDA LGVPCTENDY KLWSPSDERG NECLLGHKTV
660 670 680 690 700
FKRRTPHATC FNGEDFDRPV VVSNCSCTRE DYECDFGFKM SEDLSLEVCV
710 720 730 740 750
PDPEFSGKPY SPPVPCPVGS SYRRTRGYRK ISGDTCSGGD VEARLEGELV
760 770 780 790 800
PCPLAEENEF ILYAMRKSIY RYDLASGATE QLPLSGLRAA VALDFDYERN
810 820 830 840 850
CLYWSDLALD TIQRLCLNGS TGQEVIINSG LETVEALAFE PLSQLLYWVD
860 870 880 890 900
AGFKKIEVAN PDGDFRLTIV NSSVLDRPRA LVLVPQEGVM FWTDWGDLKP
910 920 930 940 950
GIYRSYMDGS AAYRLVSEDV KWPNGISVDS QWIYWTDAYL DCIERITFSG
960 970 980 990 1000
QQRSVILDSL PHPYAIAVFK NEIYWDDWSQ LSIFRASKHS RSQVEILASQ
1010 1020 1030 1040 1050
LTGLMDMKVF YKGKNAGSNA CVPQPCSLLC LPKANNSKSC RCPEGVASSV
1060 1070 1080 1090 1100
LPSGDLMCDC PQGYQRKNNT CVKEENTCLR NQYRCSNGNC INSIWWCDFD
1110 1120 1130 1140 1150
NDCGDMSDER NCPTTVCDAD TQFRCQESGT CIPLSYKCDL EDDCGDNSDE
1160 1170 1180 1190 1200
SHCEMHQCRS DEFNCSSGMC IRSSWVCDGD NDCRDWSDEA NCTAIYHTCE
1210 1220 1230 1240 1250
ASNFQCHNGH CIPQRWACDG DADCQDGSDE DPVSCEKKCN GFHCPNGTCI
1260 1270 1280 1290 1300
PSSKHCDGLR DCPDGSDEQH CEPFCTRFMD FVCKNRQQCL FHSMVCDGIV
1310 1320 1330 1340 1350
QCRDGSDEDA AFAGCSQDPE FHKECDEFGF QCQNGVCISL IWKCDGMDDC
1360 1370 1380 1390 1400
GDYSDEANCE NPTEAPNCSR YFQFHCENGH CIPNRWKCDR ENDCGDWSDE
1410 1420 1430 1440 1450
KDCGDSHVLP SPTPGPSTCL PNYFHCSSGA CVMGTWVCDG YRDCADGSDE
1460 1470 1480 1490 1500
EACPSLANST AASTPTQFGQ CDRFEFECHQ PKKCIPNWKR CDGHQDCQDG
1510 1520 1530 1540 1550
QDEANCPTHS TLTCTSREFK CEDGEACIVL SERCDGFLDC SDESDEKACS
1560 1570 1580 1590 1600
DELTVYKVQN LQWTADFSGD VTLTWMRPKK MPSASCVYNV YYRVVGESIW
1610 1620 1630 1640 1650
KTLETHSNKT STVLKVLKPD TTYQVKVQVH CLNKVHNTND FVTLRTPEGL
1660 1670 1680 1690 1700
PDAPRNLQLS LNSEEEGVIL GHWAPPVHTH GLIREYIVEY SRSGSKMWAS
1710 1720 1730 1740 1750
QRAASNSTEI KNLLLNALYT VRVAAVTSRG IGNWSDSKSI TTIKGKVIQA
1760 1770 1780 1790 1800
PNIHIDSYDE NSLSFTLTMD GDIKVNGYVV NLFWSFDAHK QEKKTLSFRG
1810 1820 1830 1840 1850
GSALSHRVSN LTAHTSYEIS AWAKTDLGDS PLAFEHILTR GSSPPAPSLK
1860 1870 1880 1890 1900
AKAINQTAVE CIWTGPKNVV YGIFYATSFL DLYRNPKSVT TSLHNKTVIV
1910 1920 1930 1940 1950
SKDEQYLFLV RVLIPYQGPS SDYVVVKMIP DSRLPPRHLH AVHIGKTSAL
1960 1970 1980 1990 2000
IKWESPYDSP DQDLFYAIAV KDLIRKTDRS YKVRSRNSTV EYSLSKLEPG
2010 2020 2030 2040 2050
GKYHIIVQLG NMSKDSSIKI TTVSLSAPDA LKIITENDHV LLFWKSLALK
2060 2070 2080 2090 2100
EKQFNETRGY EIHMSDSAVN LTAYLGNTTD NFFKVSNLKM GHNYTFTVQA
2110 2120 2130 2140 2150
RCLFGSQICG EPAVLLYDEL SSGADAAVIQ AARSTDVAAV VVPILFLILL
2160 2170 2180 2190 2200
SLGVGFAILY TKHRRLQSSF SAFANSHYSS RLGSAIFSSG DDLGEDDEDA
2210
PMITGFSDDV PMVIA
Length:2,215
Mass (Da):247,086
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D7F53806EFE2CB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti706S → F in AAC16739 (PubMed:9510025).Curated1
Sequence conflicti768S → F in AAC16739 (PubMed:9510025).Curated1
Sequence conflicti785S → W in BAA31219 (PubMed:9726247).Curated1
Sequence conflicti796D → G in AAC16739 (PubMed:9510025).Curated1
Sequence conflicti953R → G in BAA31219 (PubMed:9726247).Curated1
Sequence conflicti1268 – 1269EQ → DE in BAA31219 (PubMed:9726247).Curated2
Sequence conflicti1425H → A in BAA31219 (PubMed:9726247).Curated1
Sequence conflicti1425H → R in AAC16739 (PubMed:9510025).Curated1
Sequence conflicti1425H → R in CAA72732 (Ref. 4) Curated1
Sequence conflicti1468F → L in BAA31219 (PubMed:9726247).Curated1
Sequence conflicti1468F → L in AAC16739 (PubMed:9510025).Curated1
Sequence conflicti1468F → L in CAA72732 (Ref. 4) Curated1
Sequence conflicti1663S → R in BAA31219 (PubMed:9726247).Curated1
Sequence conflicti1663S → R in AAC16739 (PubMed:9510025).Curated1
Sequence conflicti1663S → R in CAA72732 (Ref. 4) Curated1
Sequence conflicti1709 – 1713EIKNL → KKKKK in CAA72732 (Ref. 4) Curated5
Sequence conflicti1807R → K in BAA31219 (PubMed:9726247).Curated1
Sequence conflicti1807R → K in AAC16739 (PubMed:9510025).Curated1
Sequence conflicti2130Q → H in BAA31219 (PubMed:9726247).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB015790 mRNA Translation: BAA31219.1
AK147303 mRNA Translation: BAE27834.1
AF031816 mRNA Translation: AAC16739.1
Y12004 mRNA Translation: CAA72732.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40594.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T00348

NCBI Reference Sequences

More...
RefSeqi
NP_035566.2, NM_011436.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.121920

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000060989; ENSMUSP00000058613; ENSMUSG00000049313

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20660

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20660

UCSC genome browser

More...
UCSCi
uc009pap.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015790 mRNA Translation: BAA31219.1
AK147303 mRNA Translation: BAE27834.1
AF031816 mRNA Translation: AAC16739.1
Y12004 mRNA Translation: CAA72732.1
CCDSiCCDS40594.1
PIRiT00348
RefSeqiNP_035566.2, NM_011436.3
UniGeneiMm.121920

3D structure databases

ProteinModelPortaliO88307
SMRiO88307
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-42439N
IntActiO88307, 1 interactor
MINTiO88307
STRINGi10090.ENSMUSP00000058613

PTM databases

iPTMnetiO88307
PhosphoSitePlusiO88307

Proteomic databases

EPDiO88307
jPOSTiO88307
MaxQBiO88307
PaxDbiO88307
PeptideAtlasiO88307
PRIDEiO88307

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060989; ENSMUSP00000058613; ENSMUSG00000049313
GeneIDi20660
KEGGimmu:20660
UCSCiuc009pap.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6653
MGIiMGI:1202296 Sorl1

Phylogenomic databases

eggNOGiKOG1215 Eukaryota
KOG3511 Eukaryota
ENOG410Y3W5 LUCA
GeneTreeiENSGT00940000153473
HOGENOMiHOG000007009
HOVERGENiHBG017830
InParanoidiO88307
OMAiHNCLYWS
OrthoDBi1046610at2759
TreeFamiTF324918

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sorl1 mouse

Protein Ontology

More...
PROi
PR:O88307

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000049313 Expressed in 323 organ(s), highest expression level in cerebellum
GenevisibleiO88307 MM

Family and domain databases

CDDicd00063 FN3, 5 hits
cd00112 LDLa, 11 hits
Gene3Di2.120.10.30, 1 hit
2.130.10.10, 1 hit
2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt
IPR031777 Sortilin_C
IPR031778 Sortilin_N
IPR006581 VPS10
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF00057 Ldl_recept_a, 10 hits
PF00058 Ldl_recept_b, 2 hits
PF15902 Sortilin-Vps10, 1 hit
PF15901 Sortilin_C, 1 hit
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00192 LDLa, 11 hits
SM00135 LY, 5 hits
SM00602 VPS10, 1 hit
SUPFAMiSSF49265 SSF49265, 3 hits
SSF57424 SSF57424, 11 hits
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS50853 FN3, 4 hits
PS01209 LDLRA_1, 10 hits
PS50068 LDLRA_2, 11 hits
PS51120 LDLRB, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSORL_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88307
Secondary accession number(s): O54711, O70581, Q3UHM3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: January 16, 2019
This is version 167 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again