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UniProtKB - O88282 (BCL6B_MOUSE)
Protein
B-cell CLL/lymphoma 6 member B protein
Gene
Bcl6b
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6.
2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 323 – 345 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 351 – 373 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 379 – 401 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 407 – 429 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 435 – 458 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: MGI
- regulation of cell differentiation Source: GO_Central
- regulation of cell population proliferation Source: GO_Central
- regulation of cytokine production Source: GO_Central
- regulation of immune system process Source: GO_Central
- regulation of inflammatory response Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- type 2 immune response Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: B-cell CLL/lymphoma 6 member B proteinAlternative name(s): Bcl6-associated zinc finger protein |
Gene namesi | Name:Bcl6b Synonyms:Bazf |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1278332, Bcl6b |
VEuPathDBi | HostDB:ENSMUSG00000000317 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: GO_Central
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047101 | 1 – 474 | B-cell CLL/lymphoma 6 member B proteinAdd BLAST | 474 |
Proteomic databases
PaxDbi | O88282 |
PRIDEi | O88282 |
PTM databases
iPTMneti | O88282 |
PhosphoSitePlusi | O88282 |
Expressioni
Tissue specificityi
Ubiquitously expressed with higher expression found in heart and lung.1 Publication
Inductioni
Induced in activated lymphocytes.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000000317, Expressed in brain blood vessel and 251 other tissues |
ExpressionAtlasi | O88282, baseline and differential |
Genevisiblei | O88282, MM |
Interactioni
Subunit structurei
Associates with BCL6 through the BTB domain.
Protein-protein interaction databases
BioGRIDi | 198305, 2 interactors |
STRINGi | 10090.ENSMUSP00000000326 |
Miscellaneous databases
RNActi | O88282, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 105 | BTBPROSITE-ProRule annotationAdd BLAST | 68 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 144 – 190 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 210 – 249 | DisorderedSequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 146 – 165 | Pro residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 171 – 186 | Polar residuesSequence analysisAdd BLAST | 16 |
Domaini
Amino acids 178-210 are essential for repression activity.
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 323 – 345 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 351 – 373 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 379 – 401 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 407 – 429 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 435 – 458 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159844 |
HOGENOMi | CLU_024196_2_0_1 |
InParanoidi | O88282 |
OMAi | VCGARFN |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O88282 |
TreeFami | TF330912 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O88282-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSTAAPEGA LGYVREFTRH SSDVLSNLNE LRLRGILTDV TLLVGGQPLR
60 70 80 90 100
AHKAVLIACS GFFYSIFRGR AGLGVDVLSL PGGPEARGFA PLLDFMYTSR
110 120 130 140 150
LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPVEVEPP
160 170 180 190 200
RPPTVAPPGS PRRSEGHPDP PTESRSCSQG SPSPASPDPK ACNWKKYKFI
210 220 230 240 250
VLNSQTSQAG SLVGESSGQP CPQARLPSGD EACSSSSSSE EGTTPGLQSR
260 270 280 290 300
LSLATTTARF KCGALANNSY LFTPRAQETS LPASKQANPP PGSEFFSCQN
310 320 330 340 350
CEAVAGCSSG LELLAPGDED KPYKCQLCRS AFRYKGNLAS HRTVHTGEKP
360 370 380 390 400
YRCSICGARF NRPANLKTHS RIHSGEKPYK CETCGSRFVQ VAHLRAHVLI
410 420 430 440 450
HTGEKPYPCP TCGTRFRHLQ TLKSHVRIHT GEKPYHCDPC GLHFRHKSQL
460 470
RLHLRQKHGA ATNTKVRYHI LGGP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2CF73 | A2CF73_MOUSE | B-cell CLL/lymphoma 6 member B prot... | Bcl6b | 116 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB011665 mRNA Translation: BAA31223.1 AK032647 mRNA Translation: BAC27970.1 |
CCDSi | CCDS24939.1 |
RefSeqi | NP_031554.1, NM_007528.3 |
Genome annotation databases
Ensembli | ENSMUST00000000326; ENSMUSP00000000326; ENSMUSG00000000317 |
GeneIDi | 12029 |
KEGGi | mmu:12029 |
UCSCi | uc007juc.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB011665 mRNA Translation: BAA31223.1 AK032647 mRNA Translation: BAC27970.1 |
CCDSi | CCDS24939.1 |
RefSeqi | NP_031554.1, NM_007528.3 |
3D structure databases
SMRi | O88282 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198305, 2 interactors |
STRINGi | 10090.ENSMUSP00000000326 |
PTM databases
iPTMneti | O88282 |
PhosphoSitePlusi | O88282 |
Proteomic databases
PaxDbi | O88282 |
PRIDEi | O88282 |
Protocols and materials databases
Antibodypediai | 23875, 80 antibodies from 23 providers |
DNASUi | 12029 |
Genome annotation databases
Ensembli | ENSMUST00000000326; ENSMUSP00000000326; ENSMUSG00000000317 |
GeneIDi | 12029 |
KEGGi | mmu:12029 |
UCSCi | uc007juc.2, mouse |
Organism-specific databases
CTDi | 255877 |
MGIi | MGI:1278332, Bcl6b |
VEuPathDBi | HostDB:ENSMUSG00000000317 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159844 |
HOGENOMi | CLU_024196_2_0_1 |
InParanoidi | O88282 |
OMAi | VCGARFN |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O88282 |
TreeFami | TF330912 |
Miscellaneous databases
BioGRID-ORCSi | 12029, 0 hits in 64 CRISPR screens |
PROi | PR:O88282 |
RNActi | O88282, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000000317, Expressed in brain blood vessel and 251 other tissues |
ExpressionAtlasi | O88282, baseline and differential |
Genevisiblei | O88282, MM |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | BCL6B_MOUSE | |
Accessioni | O88282Primary (citable) accession number: O88282 Secondary accession number(s): Q8CCJ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot