Bcl6b

Functionⁱ

Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6.2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	323 – 345	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	351 – 373	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	379 – 401	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	407 – 429	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	435 – 458	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 9632807
DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 9632807
metal ion binding Source: UniProtKB-KW
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 9632807

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 9632807

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: B-cell CLL/lymphoma 6 member B protein Alternative name(s): Bcl6-associated zinc finger protein
Gene namesⁱ	Name:Bcl6b Synonyms:Bazf
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:1278332 Bcl6b

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047101	1 – 474	B-cell CLL/lymphoma 6 member B proteinAdd BLAST		474

Proteomic databases

PaxDbⁱ	O88282
PRIDEⁱ	O88282

PTM databases

iPTMnetⁱ	O88282
PhosphoSitePlusⁱ	O88282

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed with higher expression found in heart and lung.1 Publication

Inductionⁱ

Induced in activated lymphocytes.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000000317 Expressed in 220 organ(s), highest expression level in brain blood vessel
CleanExⁱ	MM_BCL6B
ExpressionAtlasⁱ	O88282 baseline and differential
Genevisibleⁱ	O88282 MM

Interactionⁱ

Subunit structureⁱ

Associates with BCL6 through the BTB domain.

Protein-protein interaction databases

BioGridⁱ	198305, 2 interactors
STRINGⁱ	10090.ENSMUSP00000000326

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O88282
SMRⁱ	O88282
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	38 – 105	BTBPROSITE-ProRule annotationAdd BLAST		68

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	144 – 189	Pro-richAdd BLAST		46
Compositional biasⁱ	234 – 239	Poly-Ser		6

Domainⁱ

Amino acids 178-210 are essential for repression activity.

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	323 – 345	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	351 – 373	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	379 – 401	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	407 – 429	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	435 – 458	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150977
HOGENOMⁱ	HOG000001556
HOVERGENⁱ	HBG004831
InParanoidⁱ	O88282
KEGG Orthology (KO) More...KOⁱ	K22648
OMAⁱ	VCGARFN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G025U
PhylomeDBⁱ	O88282
TreeFamⁱ	TF330912

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 5 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O88282-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGSTAAPEGA LGYVREFTRH SSDVLSNLNE LRLRGILTDV TLLVGGQPLR 
        60         70         80         90        100
AHKAVLIACS GFFYSIFRGR AGLGVDVLSL PGGPEARGFA PLLDFMYTSR 
       110        120        130        140        150
LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPVEVEPP 
       160        170        180        190        200
RPPTVAPPGS PRRSEGHPDP PTESRSCSQG SPSPASPDPK ACNWKKYKFI 
       210        220        230        240        250
VLNSQTSQAG SLVGESSGQP CPQARLPSGD EACSSSSSSE EGTTPGLQSR 
       260        270        280        290        300
LSLATTTARF KCGALANNSY LFTPRAQETS LPASKQANPP PGSEFFSCQN 
       310        320        330        340        350
CEAVAGCSSG LELLAPGDED KPYKCQLCRS AFRYKGNLAS HRTVHTGEKP 
       360        370        380        390        400
YRCSICGARF NRPANLKTHS RIHSGEKPYK CETCGSRFVQ VAHLRAHVLI 
       410        420        430        440        450
HTGEKPYPCP TCGTRFRHLQ TLKSHVRIHT GEKPYHCDPC GLHFRHKSQL 
       460        470 
RLHLRQKHGA ATNTKVRYHI LGGP

Length:474

Mass (Da):51,339

Last modified:November 1, 1998 - v1

Checksum:ⁱ94886AB265B018D8

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A2CF73	A2CF73_MOUSE		B-cell CLL/lymphoma 6 member B prot... B-cell CLL/lymphoma 6 member B protein	Bcl6b	116	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB011665 mRNA Translation: BAA31223.1 AK032647 mRNA Translation: BAC27970.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24939.1
NCBI Reference Sequences More...RefSeqⁱ	NP_031554.1, NM_007528.3
UniGeneⁱ	Mm.12930

Genome annotation databases

Ensemblⁱ	ENSMUST00000000326; ENSMUSP00000000326; ENSMUSG00000000317
GeneIDⁱ	12029
KEGGⁱ	mmu:12029
UCSC genome browser More...UCSCⁱ	uc007juc.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O88282	B-cell CLL/lymphoma 6, member B		MOUSE		474	UniRef100_O88282
B-cell CLL/lymphoma 6 member B protein (Fragment)		MOUSE		116

Protein	Similar proteins		Species	Score	Length	Source
O88282	B-cell CLL/lymphoma 6, member B		MOUSE		474	UniRef90_O88282
Uncharacterized protein		NEOLE		488
UPI000A306D38		MUSPA		475
UPI000A31AB91		MUSCR		474
B-cell CLL/lymphoma 6 member B protein (Fragment)		MOUSE		116
+1

Protein	Similar proteins		Species	Score	Length	Source
O88282	B-cell CLL/lymphoma 6 member B protein		HUMAN		479	UniRef50_O88282
B-cell CLL/lymphoma 6, member B		MOUSE		474
Uncharacterized protein		NEOLE		488
B-cell CLL/lymphoma 6 member B protein		ALLSI		475
B-cell CLL/lymphoma 6 member B protein		FUKDA		473
+150

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB011665 mRNA Translation: BAA31223.1 AK032647 mRNA Translation: BAC27970.1
CCDSⁱ	CCDS24939.1
RefSeqⁱ	NP_031554.1, NM_007528.3
UniGeneⁱ	Mm.12930

3D structure databases

ProteinModelPortalⁱ	O88282
SMRⁱ	O88282
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198305, 2 interactors
STRINGⁱ	10090.ENSMUSP00000000326

PTM databases

iPTMnetⁱ	O88282
PhosphoSitePlusⁱ	O88282

Proteomic databases

PaxDbⁱ	O88282
PRIDEⁱ	O88282

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000000326; ENSMUSP00000000326; ENSMUSG00000000317
GeneIDⁱ	12029
KEGGⁱ	mmu:12029
UCSCⁱ	uc007juc.2 mouse

Organism-specific databases

CTDⁱ	255877
MGIⁱ	MGI:1278332 Bcl6b

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00930000150977
HOGENOMⁱ	HOG000001556
HOVERGENⁱ	HBG004831
InParanoidⁱ	O88282
KOⁱ	K22648
OMAⁱ	VCGARFN
OrthoDBⁱ	EOG091G025U
PhylomeDBⁱ	O88282
TreeFamⁱ	TF330912

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O88282
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000000317 Expressed in 220 organ(s), highest expression level in brain blood vessel
CleanExⁱ	MM_BCL6B
ExpressionAtlasⁱ	O88282 baseline and differential
Genevisibleⁱ	O88282 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 5 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BCL6B_MOUSE
Accessionⁱ	O88282Primary (citable) accession number: O88282 Secondary accession number(s): Q8CCJ6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O88282 (BCL6B_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

B-cell CLL/lymphoma 6 member B protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ