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UniProtKB - O88278 (CELR3_RAT)

Entry version 170 (07 Apr 2021)
Sequence version 1 (01 Nov 1998)
Previous versions | rss
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Protein

Cadherin EGF LAG seven-pass G-type receptor 3

Gene

Celsr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 3
Alternative name(s):
Multiple epidermal growth factor-like domains protein 2
Short name:
Multiple EGF-like domains protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Celsr3
Synonyms:Megf2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...RGDi		621787, Celsr3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 2538ExtracellularSequence analysisAdd BLAST2507
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2539 – 2559Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini2560 – 2570CytoplasmicSequence analysisAdd BLAST11
Transmembranei2571 – 2591Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini2592 – 2599ExtracellularSequence analysis8
Transmembranei2600 – 2620Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini2621 – 2641CytoplasmicSequence analysisAdd BLAST21
Transmembranei2642 – 2662Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini2663 – 2679ExtracellularSequence analysisAdd BLAST17
Transmembranei2680 – 2700Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini2701 – 2724CytoplasmicSequence analysisAdd BLAST24
Transmembranei2725 – 2745Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini2746 – 2752ExtracellularSequence analysis7
Transmembranei2753 – 2773Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini2774 – 3313CytoplasmicSequence analysisAdd BLAST540

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001292032 – 3313Cadherin EGF LAG seven-pass G-type receptor 3Add BLAST3282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi623N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi838N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1308N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1318N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1370 ↔ 1381By similarity
Disulfide bondi1375 ↔ 1412By similarity
Disulfide bondi1414 ↔ 1423By similarity
Disulfide bondi1430 ↔ 1441By similarity
Disulfide bondi1435 ↔ 1450By similarity
Disulfide bondi1452 ↔ 1461By similarity
Disulfide bondi1470 ↔ 1481By similarity
Disulfide bondi1475 ↔ 1491By similarity
Disulfide bondi1493 ↔ 1504By similarity
Glycosylationi1640N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1684 ↔ 1710By similarity
Glycosylationi1704N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1717 ↔ 1728By similarity
Disulfide bondi1722 ↔ 1737By similarity
Disulfide bondi1739 ↔ 1748By similarity
Glycosylationi1761N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1906 ↔ 1935By similarity
Disulfide bondi1941 ↔ 1952By similarity
Disulfide bondi1946 ↔ 1961By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1954(3R)-3-hydroxyaspartateSequence analysis1
Disulfide bondi1963 ↔ 1972By similarity
Disulfide bondi1976 ↔ 1987By similarity
Disulfide bondi1981 ↔ 1999By similarity
Disulfide bondi2001 ↔ 2010By similarity
Disulfide bondi2018 ↔ 2031By similarity
Disulfide bondi2033 ↔ 2043By similarity
Glycosylationi2044N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2050 ↔ 2065By similarity
Disulfide bondi2052 ↔ 2068By similarity
Disulfide bondi2070 ↔ 2080By similarity
Disulfide bondi2089 ↔ 2098By similarity
Disulfide bondi2101 ↔ 2113By similarity
Modified residuei2117PhosphotyrosineCombined sources1
Glycosylationi2173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2382N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2472N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2504N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei3050PhosphotyrosineCombined sources1
Modified residuei3098PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O88278

PRoteomics IDEntifications database

More...PRIDEi		O88278

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O88278, 15 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O88278

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O88278

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain. Expressed in cerebellum, olfactory bulb, cerebral cortex, hippocampus and brain stem.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000053889, Expressed in frontal cortex and 12 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O88278, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000041011

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O88278

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini317 – 424Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini425 – 536Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini537 – 642Cadherin 3PROSITE-ProRule annotationAdd BLAST106
Domaini643 – 747Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini748 – 849Cadherin 5PROSITE-ProRule annotationAdd BLAST102
Domaini850 – 952Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini953 – 1058Cadherin 7PROSITE-ProRule annotationAdd BLAST106
Domaini1059 – 1160Cadherin 8PROSITE-ProRule annotationAdd BLAST102
Domaini1161 – 1257Cadherin 9PROSITE-ProRule annotationAdd BLAST97
Domaini1366 – 1424EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST59
Domaini1426 – 1462EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1466 – 1505EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1506 – 1710Laminin G-like 1PROSITE-ProRule annotationAdd BLAST205
Domaini1713 – 1749EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1753 – 1935Laminin G-like 2PROSITE-ProRule annotationAdd BLAST183
Domaini1937 – 1972EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini1973 – 2011EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini2012 – 2044EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST33
Domaini2046 – 2081EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini2068 – 2115Laminin EGF-likePROSITE-ProRule annotationAdd BLAST48
Domaini2475 – 2527GPSPROSITE-ProRule annotationAdd BLAST53

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.Curated

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4289, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160077

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000158_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O88278

Identification of Orthologs from Complete Genome Data

More...OMAi		WTARDCD

Database of Orthologous Groups

More...OrthoDBi		23882at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O88278

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR002049, Laminin_EGF
IPR001791, Laminin_G

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002, 7tm_2, 1 hit
PF00028, Cadherin, 8 hits
PF00008, EGF, 3 hits
PF16489, GAIN, 1 hit
PF02793, HRM, 1 hit
PF00053, Laminin_EGF, 1 hit
PF02210, Laminin_G_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00205, CADHERIN
PR00249, GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00112, CA, 9 hits
SM00181, EGF, 6 hits
SM00179, EGF_CA, 5 hits
SM00180, EGF_Lam, 1 hit
SM00303, GPS, 1 hit
SM00008, HormR, 1 hit
SM00282, LamG, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111418, SSF111418, 1 hit
SSF49313, SSF49313, 9 hits
SSF49899, SSF49899, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00232, CADHERIN_1, 7 hits
PS50268, CADHERIN_2, 8 hits
PS00022, EGF_1, 6 hits
PS01186, EGF_2, 4 hits
PS50026, EGF_3, 6 hits
PS01248, EGF_LAM_1, 1 hit
PS50027, EGF_LAM_2, 1 hit
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS50025, LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O88278-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARRPLWWGL PGPSTPLLLL LLFSLFPSSR EEMGGGGDQG WDPGVATATG 
        60         70         80         90        100
PRAQIGSGAV ALCPESPGVW EDGDPGLGVR EPVFMKLRVG RQNARNGRGA 
       110        120        130        140        150
PEQPNREPVV QALGSREQEA GQGSGYLLCW HPEISSCGRT GHLRRGSLPL 
       160        170        180        190        200
DALSPGDSDL RNSSPHPSEL LAQPDSPRPV AFQRNGRRSI RKRVETFRCC 
       210        220        230        240        250
GKLWEPGHKG QGERSATSTV DRGPLRRDCL PGSLGSGLGE DSAPRAVRTA 
       260        270        280        290        300
PAPGSAPHES RTAPERMRSR GLFRRGFLFE RPGPRPPGFP TGAEAKRILS 
       310        320        330        340        350
TNQARSRRAA NRHPQFPQYN YQTLVPENEA AGTAVLRVVA QDPDPGEAGR 
       360        370        380        390        400
LVYSLAALMN SRSLELFSID PQSGLIRTAA ALDRESMERH YLRVTAQDHG 
       410        420        430        440        450
SPRLSATTMV AVTVADRNDH APVFEQAQYR ETLRENVEEG YPILQLRATD 
       460        470        480        490        500
GDAPPNANLR YRFVGSPAAR TAAAAAFEID PRSGLISTSG RVDREHMESY 
       510        520        530        540        550
ELVVEASDQG QEPGPRSATV RVHITVLDEN DNAPQFSEKR YVAQVREDVR 
       560        570        580        590        600
PHTVVLRVTA TDKDKDANGL VHYNIISGNS RGHFAIDSLT GEIQVMAPLD 
       610        620        630        640        650
FEAEREYALR IRAQDAGRPP LSNNTGLASI QVVDINDHSP IFVSTPFQVS 
       660        670        680        690        700
VLENAPLGHS VIHIQAVDAD HGENSRLEYS LTGVASDTPF VINSATGWVS 
       710        720        730        740        750
VSGPLDRESV EHYFFGVEAR DHGSPPLSAS ASVTVTVLDV NDNRPEFTMK 
       760        770        780        790        800
EYHLRLNEDA AVGTSVVSVT AVDRDANSAI SYQITGGNTR NRFAISTQGG 
       810        820        830        840        850
MGLVTLALPL DYKQERYFKL VLTASDRALH DHCYVHINIT DANTHRPVFQ 
       860        870        880        890        900
SAHYSVSMNE DRPVGSTVVV ISASDDDVGE NARITYLLED NLPQFRIDAD 
       910        920        930        940        950
SGAITLQAPL DYEDQVTYTL AITARDNGIP QKADTTYVEV MVNDVNDNAP 
       960        970        980        990       1000
QFVASHYTGL VSEDAPPFTS VLQISATDRD AHANGRVQYT FQNGEDGDGD 
      1010       1020       1030       1040       1050
FTIEPTSGIV RTVRRLDREA VPVYELTAYA VDRGVPPLRT PVSIQVTVQD 
      1060       1070       1080       1090       1100
VNDNAPVFPA EEFEVRVKEN SIVGSVVAQI TAVDPDDGPN AHIMYQIVEG 
      1110       1120       1130       1140       1150
NIPELFQMDI FSGELTALID LDYEARQEYV IVVQATSAPL VSRATVHVRL 
      1160       1170       1180       1190       1200
VDQNDNSPVL NNFQILFNNY VSNRSDTFPS GIIGRIPAYD PDVSDHLFYS 
      1210       1220       1230       1240       1250
FERGNELQLL VVNQTSGELR LSRKLDNNRP LVASMLVTVT DGLHSVTAQC 
      1260       1270       1280       1290       1300
VLRVVIITEE LLANSLTVRL ENMWQERFLS PLLGHFLEGV AAVLATPTED 
      1310       1320       1330       1340       1350
VFIFNIQNDT DVGGTVLNVS FSALAPRGAG AGAAGPWFSS EELQEQLYVR 
      1360       1370       1380       1390       1400
RAALAARSLL DVLPFDDNVC LREPCENYMK CVSVLRFDSS APFLASASTL 
      1410       1420       1430       1440       1450
FRPIQPIAGL RCRCPPGFTG DFCETELDLC YSNPCRNGGA CARREGGYTC 
      1460       1470       1480       1490       1500
VCRPRFTGED CELDTEAGRC VPGVCRNGGT CTNAPNGGFR CQCPAGGAFE 
      1510       1520       1530       1540       1550
GPRCEVAARS FPPSSFVMFR GLRQRFHLTL SLSFATVQPS GLLFYNGRLN 
      1560       1570       1580       1590       1600
EKHDFLALEL VAGQVRLTYS TGESSTVVSP TVPGGLSDGQ WHTVHLRYYN 
      1610       1620       1630       1640       1650
KPRTDALGGA QGPSKDKVAV LSVDDCNVAV ALRFGAEIGN YSCAAAGVQT 
      1660       1670       1680       1690       1700
SSKKSLDLTG PLLLGGVPNL PENFPVSRKD FIGCMRDLHI DGRRVDMAAF 
      1710       1720       1730       1740       1750
VANNGTTAGC QAKSHFCASG PCKNGGLCSE RWGGFSCDCP VGFGGKDCRL 
      1760       1770       1780       1790       1800
TMAHPYHFQG NGTLSWDFGN DMPVSVPWYL GLSFRTRATK GVLMQVQLGP 
      1810       1820       1830       1840       1850
HSVLLCKLDQ GLLSVTLSRA SGHAVHLLLD QMTVSDGRWH DLRLELQEEP 
      1860       1870       1880       1890       1900
GGRRGHHIFM VSLDFTLFQD TMAMGSELEG LKVKHLHVGG PPPSSKEEGP 
      1910       1920       1930       1940       1950
QGLVGCIQGV WTGFTPFGSS ALPPPSHRIN VEPGCTVTNP CASGPCPPHA 
      1960       1970       1980       1990       2000
NCKDLWQTFS CTCWPGYYGP GCVDACLLNP CQNQGSCRHL QGGPHGYTCD 
      2010       2020       2030       2040       2050
CASGYFGQHC EHRMDQQCPR GWWGSPTCGP CNCDVHKGFD PNCNKTSGQC 
      2060       2070       2080       2090       2100
HCKEFHYRPR GSDSCLPCDC YPVGSTSRSC APHSGQCPCR PGALGRQCNS 
      2110       2120       2130       2140       2150
CDSPFAEVTA SGCRVLYDAC PKSLRSGVWW PQTKFGVLAT VPCPRGALGL 
      2160       2170       2180       2190       2200
RGTGAAVRLC DEDHGWLEPD FFNCTSPAFR ELSLLLDGLE LNKTALDTVE 
      2210       2220       2230       2240       2250
AKKLAQRLRE VTGQTDHYFS QDVRVTARLL AYLLAFESHQ QGFGLTATQD 
      2260       2270       2280       2290       2300
AHFNENLLWA GSALLAPETG DLWAALGQRA PGGSPGSAGL VRHLEEYAAT 
      2310       2320       2330       2340       2350
LARNMDLTYL NPVGLVTPNI MLSIDRMEQP SSSQGAHRYP RYHSNLFRGQ 
      2360       2370       2380       2390       2400
DAWDPHTHVL LPSQSPQPSP SEVLPTSSNA ENATASGVVS PPAPLEPESE 
      2410       2420       2430       2440       2450
PGISIVILLV YRALGGLLPA QFQAERRGAR LPQNPVMNSP VVSVAVFRGR 
      2460       2470       2480       2490       2500
NFLRGALVSP INLEFRLLQT ANRSKAICVQ WDPPGPADQH GMWTARDCEL 
      2510       2520       2530       2540       2550
VHRNGSHARC RCSRTGTFGV LMDASPRERL EGDLELLAVF THVVVAASVT 
      2560       2570       2580       2590       2600
ALVLTAAVLL SLRSLKSNVR GIHANVAAAL GVAELLFLLG IHRTHNQLLC 
      2610       2620       2630       2640       2650
TVVAILLHYF FLSTFAWLLV QGLHLYRMQV EPRNVDRGAM RFYHALGWGV 
      2660       2670       2680       2690       2700
PAVLLGLAVG LDPEGYGNPD FCWISIHEPL IWSFAGPIVL VIVMNGIMFL 
      2710       2720       2730       2740       2750
LAARTSCSTG QREAKKTSVL RTLRSSFLLL LLVSASWLFG LLAVNHSVLA 
      2760       2770       2780       2790       2800
FHYLHAGLCG LQGLAVLLLF CVLNADARAA WTPACLGKKA APEETRPAPG 
      2810       2820       2830       2840       2850
PGSGAYNNTA LFEESGLIRI TLGASTVSSV SSARSGRAQD QDSQRGRSYL 
      2860       2870       2880       2890       2900
RDNVLVRHGS TAEHAEHSLQ AHAGPTDLDV AMFHRDAGAD SDSDSDLSLE 
      2910       2920       2930       2940       2950
EERSLSIPSS ESEDNGRTRG RFQRPLRRAA QSERLLAHPK DVDGNDLLSY 
      2960       2970       2980       2990       3000
WPALGECEAA PCALQAWGSE RRLGLDSNKD AANNNQPELA LTSGDETSLG 
      3010       3020       3030       3040       3050
RAQRQRKGIL KNRLQYPLVP QTRGTPELSW CRAATLGHRA VPAASYGRIY 
      3060       3070       3080       3090       3100
AGGGTGSLSQ PASRYSSREQ LDLLLRRQLS RERLEEVPVP APVLHPLSRP 
      3110       3120       3130       3140       3150
GSQERLDTAP ARLEPRDRGS TLPRRQPPRD YPGTMAGRFG SRDALDLGAP 
      3160       3170       3180       3190       3200
REWLSTLPPP RRNRDLDPQH PPLPLSPQRP LSRDPLLPSR PLDSLSRISN 
      3210       3220       3230       3240       3250
SRERLDQVPS RHPSREALGP APQLLRARED PASGPSHGPS TEQLDILSSI 
      3260       3270       3280       3290       3300
LASFNSSALS SVQSSSTPSG PHTTATPSAT ASALGPSTPR SATSHSISEL 
      3310 
SPDSEVPRSE GHS
Length:3,313
Mass (Da):359,355
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB11DA09517288764
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB011528 mRNA Translation: BAA32459.1

NCBI Reference Sequences

More...RefSeqi		NP_112610.1, NM_031320.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000084220; ENSRNOP00000068821; ENSRNOG00000053889

Database of genes from NCBI RefSeq genomes

More...GeneIDi		83466

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:83466

UCSC genome browser

More...UCSCi		RGD:621787, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011528 mRNA Translation: BAA32459.1
RefSeqiNP_112610.1, NM_031320.1

3D structure databases

SMRiO88278
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041011

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniO88278, 15 sites
iPTMnetiO88278
PhosphoSitePlusiO88278

Proteomic databases

PaxDbiO88278
PRIDEiO88278

Genome annotation databases

EnsembliENSRNOT00000084220; ENSRNOP00000068821; ENSRNOG00000053889
GeneIDi83466
KEGGirno:83466
UCSCiRGD:621787, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1951
RGDi621787, Celsr3

Phylogenomic databases

eggNOGiKOG4289, Eukaryota
GeneTreeiENSGT00940000160077
HOGENOMiCLU_000158_1_0_1
InParanoidiO88278
OMAiWTARDCD
OrthoDBi23882at2759
PhylomeDBiO88278

Miscellaneous databases

Protein Ontology

More...PROi		PR:O88278

Gene expression databases

BgeeiENSRNOG00000053889, Expressed in frontal cortex and 12 other tissues
GenevisibleiO88278, RN

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR002049, Laminin_EGF
IPR001791, Laminin_G
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF00028, Cadherin, 8 hits
PF00008, EGF, 3 hits
PF16489, GAIN, 1 hit
PF02793, HRM, 1 hit
PF00053, Laminin_EGF, 1 hit
PF02210, Laminin_G_2, 2 hits
PRINTSiPR00205, CADHERIN
PR00249, GPCRSECRETIN
SMARTiView protein in SMART
SM00112, CA, 9 hits
SM00181, EGF, 6 hits
SM00179, EGF_CA, 5 hits
SM00180, EGF_Lam, 1 hit
SM00303, GPS, 1 hit
SM00008, HormR, 1 hit
SM00282, LamG, 2 hits
SUPFAMiSSF111418, SSF111418, 1 hit
SSF49313, SSF49313, 9 hits
SSF49899, SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00232, CADHERIN_1, 7 hits
PS50268, CADHERIN_2, 8 hits
PS00022, EGF_1, 6 hits
PS01186, EGF_2, 4 hits
PS50026, EGF_3, 6 hits
PS01248, EGF_LAM_1, 1 hit
PS50027, EGF_LAM_2, 1 hit
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS50025, LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCELR3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88278
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: November 1, 1998
Last modified: April 7, 2021
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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