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Protein

Craniofacial development protein 1

Gene

Cfdp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role during embryogenesis. May modulate tooth organogenesis since alterations of this protein function affect tooth organs size as well as individual cell fate and survival. In embryonic cells, blockage of the function results in increased number of apoptotic cells, reduced proliferation, alterations in cell shape and fibronection matrix synthesis.3 Publications

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Craniofacial development protein 1
Alternative name(s):
27 kDa craniofacial protein
Bucentaur
Protein Cp27
Gene namesi
Name:Cfdp1
Synonyms:Bcnt, Cfdp, Cp27
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1344403 Cfdp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002124951 – 295Craniofacial development protein 1Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80PhosphoserineBy similarity1
Modified residuei83PhosphoserineBy similarity1
Modified residuei84PhosphoserineBy similarity1
Modified residuei112PhosphoserineCombined sources1
Cross-linki146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei212PhosphoserineBy similarity1
Modified residuei215N6-methyllysineBy similarity1
Modified residuei246PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO88271
MaxQBiO88271
PaxDbiO88271
PeptideAtlasiO88271
PRIDEiO88271

PTM databases

iPTMnetiO88271
PhosphoSitePlusiO88271

Expressioni

Tissue specificityi

Expressed in lung, liver and heart, with higher expression in teeth.1 Publication

Developmental stagei

Detected at E8 in developing organs, including brain, heart, lung and intestines. Expressed at E14 and E16 at the periphery of developing organs such as bones and teeth.1 Publication

Gene expression databases

BgeeiENSMUSG00000031954 Expressed in 293 organ(s), highest expression level in vestibular organ
CleanExiMM_CFDP1
GenevisibleiO88271 MM

Interactioni

Protein-protein interaction databases

IntActiO88271, 2 interactors
MINTiO88271
STRINGi10090.ENSMUSP00000034432

Structurei

3D structure databases

ProteinModelPortaliO88271
SMRiO88271
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini214 – 295BCNT-CPROSITE-ProRule annotationAdd BLAST82

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni174 – 213HydrophilicAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 108Glu-richAdd BLAST107

Phylogenomic databases

eggNOGiKOG4776 Eukaryota
ENOG4111H9K LUCA
GeneTreeiENSGT00390000018141
HOGENOMiHOG000247045
HOVERGENiHBG081120
InParanoidiO88271
OMAiMDWAGFV
OrthoDBiEOG091G0Z7H
PhylomeDBiO88271
TreeFamiTF313182

Family and domain databases

InterProiView protein in InterPro
IPR011421 BCNT-C
IPR027124 Swc5/CFDP
PANTHERiPTHR23227 PTHR23227, 1 hit
PfamiView protein in Pfam
PF07572 BCNT, 1 hit
PROSITEiView protein in PROSITE
PS51279 BCNT_C, 1 hit

Sequencei

Sequence statusi: Complete.

O88271-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEFDSEDFS TSDEDEDYLP SGGEYSEDDV NELVKEDEVD GEEQAEKTKG
60 70 80 90 100
KRRKAQGIPA RKRKQSGLLL EEEEDGKEDS GGSSSEEDEE EQEGGLGSEN
110 120 130 140 150
ARKKKEDELW ASFLNDVGPK SKAAPGSQTK VAEETEEISS NKPLVKADEL
160 170 180 190 200
DKPRESEKVK ITKVFDFAGE EVRVTKEVDA ASKEAKSFLK QTEREKPQAL
210 220 230 240 250
VTSPATPLPA GSGIKRASGM SSLLGKIGAK KQKMSTLEKS KLDWESFKEE
260 270 280 290
EGIGEELAIH NRGKEGYIER KAFLDRVDHR QFEIERDLRL SKMKP
Length:295
Mass (Da):32,921
Last modified:November 1, 1998 - v1
Checksum:i245D161EA56F9DB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94G → A in CAA69396 (PubMed:10415329).Curated1
Sequence conflicti264K → E in CAA69396 (PubMed:10415329).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010828 mRNA Translation: BAA31696.1
Y08219 mRNA Translation: CAA69396.1
AK160532 mRNA Translation: BAE35849.1
AK133989 mRNA Translation: BAE21971.1
BC005589 mRNA Translation: AAH05589.1
AB033766 Genomic DNA Translation: BAA94844.1
CCDSiCCDS22680.1
RefSeqiNP_035931.1, NM_011801.1
UniGeneiMm.279437

Genome annotation databases

EnsembliENSMUST00000034432; ENSMUSP00000034432; ENSMUSG00000031954
GeneIDi23837
KEGGimmu:23837
UCSCiuc009nmx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010828 mRNA Translation: BAA31696.1
Y08219 mRNA Translation: CAA69396.1
AK160532 mRNA Translation: BAE35849.1
AK133989 mRNA Translation: BAE21971.1
BC005589 mRNA Translation: AAH05589.1
AB033766 Genomic DNA Translation: BAA94844.1
CCDSiCCDS22680.1
RefSeqiNP_035931.1, NM_011801.1
UniGeneiMm.279437

3D structure databases

ProteinModelPortaliO88271
SMRiO88271
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88271, 2 interactors
MINTiO88271
STRINGi10090.ENSMUSP00000034432

PTM databases

iPTMnetiO88271
PhosphoSitePlusiO88271

Proteomic databases

EPDiO88271
MaxQBiO88271
PaxDbiO88271
PeptideAtlasiO88271
PRIDEiO88271

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034432; ENSMUSP00000034432; ENSMUSG00000031954
GeneIDi23837
KEGGimmu:23837
UCSCiuc009nmx.1 mouse

Organism-specific databases

CTDi10428
MGIiMGI:1344403 Cfdp1

Phylogenomic databases

eggNOGiKOG4776 Eukaryota
ENOG4111H9K LUCA
GeneTreeiENSGT00390000018141
HOGENOMiHOG000247045
HOVERGENiHBG081120
InParanoidiO88271
OMAiMDWAGFV
OrthoDBiEOG091G0Z7H
PhylomeDBiO88271
TreeFamiTF313182

Miscellaneous databases

ChiTaRSiCfdp1 mouse
PROiPR:O88271
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031954 Expressed in 293 organ(s), highest expression level in vestibular organ
CleanExiMM_CFDP1
GenevisibleiO88271 MM

Family and domain databases

InterProiView protein in InterPro
IPR011421 BCNT-C
IPR027124 Swc5/CFDP
PANTHERiPTHR23227 PTHR23227, 1 hit
PfamiView protein in Pfam
PF07572 BCNT, 1 hit
PROSITEiView protein in PROSITE
PS51279 BCNT_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCFDP1_MOUSE
AccessioniPrimary (citable) accession number: O88271
Secondary accession number(s): O70565, Q9JMA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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