Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Multidrug resistance-associated protein 6

Gene

Abcc6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi661 – 668ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1298 – 1305ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity Source: RGD
  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATP binding Source: RGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-382556 ABC-family proteins mediated transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.208.1 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug resistance-associated protein 6
Alternative name(s):
ATP-binding cassette sub-family C member 6
MRP-like protein 1
Short name:
MLP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abcc6
Synonyms:Mlp1, Mrp6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
620268 Abcc6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini5 – 37ExtracellularBy similarityAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei38 – 58Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini59 – 78CytoplasmicBy similarityAdd BLAST20
Transmembranei79 – 99Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini100 – 104ExtracellularBy similarity5
Transmembranei105 – 125Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini126 – 137CytoplasmicBy similarityAdd BLAST12
Transmembranei138 – 155Helical; Name=4PROSITE-ProRule annotationAdd BLAST18
Topological domaini156 – 173ExtracellularBy similarityAdd BLAST18
Transmembranei174 – 194Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini195 – 300CytoplasmicBy similarityAdd BLAST106
Transmembranei301 – 321Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini322 – 347ExtracellularBy similarityAdd BLAST26
Transmembranei348 – 368Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini369 – 424CytoplasmicBy similarityAdd BLAST56
Transmembranei425 – 445Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini446 – 448ExtracellularBy similarity3
Transmembranei449 – 469Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini470 – 531CytoplasmicBy similarityAdd BLAST62
Transmembranei532 – 552Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini553 – 574ExtracellularBy similarityAdd BLAST22
Transmembranei575 – 595Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini596 – 938CytoplasmicBy similarityAdd BLAST343
Transmembranei939 – 959Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini960 – 996ExtracellularBy similarityAdd BLAST37
Transmembranei997 – 1017Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1018 – 1060CytoplasmicBy similarityAdd BLAST43
Transmembranei1061 – 1081Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1082ExtracellularBy similarity1
Transmembranei1083 – 1103Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1104 – 1174CytoplasmicBy similarityAdd BLAST71
Transmembranei1175 – 1195Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1196 – 1197ExtracellularBy similarity2
Transmembranei1198 – 1218Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1219 – 1502CytoplasmicBy similarityAdd BLAST284

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2073712

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933681 – 1502Multidrug resistance-associated protein 6Add BLAST1502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei891PhosphoserineCombined sources1
Modified residuei1285PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O88269

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O88269

PRoteomics IDEntifications database

More...
PRIDEi
O88269

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O88269

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O88269

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High in liver and lower in duodenum and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000028781 Expressed in 8 organ(s), highest expression level in liver

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O88269 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000051412

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O88269

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O88269

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini309 – 592ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini627 – 851ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini946 – 1227ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST282
Domaini1264 – 1498ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157145

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108314

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O88269

KEGG Orthology (KO)

More...
KOi
K05669

Identification of Orthologs from Complete Genome Data

More...
OMAi
LWADDPT

Database of Orthologous Groups

More...
OrthoDBi
138195at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O88269

TreeFam database of animal gene trees

More...
TreeFami
TF105199

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030239 ABCC6
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR24223:SF339 PTHR24223:SF339, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00957 MRP_assoc_pro, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O88269-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNGEHSMATP GESCAGLRVW NQTEQEPVAY HLLNLCFLRA AGSWVPPMYL
60 70 80 90 100
WVLGPIYLLY IHRHGCCYLR MSRLFKIKMV LGFALILLYT FNAAVPLWRI
110 120 130 140 150
HRGMPQAPEL LIHPTVWLTT MSFATFLIHM ERKKGVRASG LLFGYWLLCC
160 170 180 190 200
LVPAIDTVQQ ASAGSFRQEP LHHLATYLCL SLVVAELVLS CLVDQPPFFS
210 220 230 240 250
EDSKPLNPCP EAEASFPSKA MFWWASGLLW KGYRKLLGPK DLWSLERENS
260 270 280 290 300
SEELVSQLER EWRRNFSELP GHKGHSGMGT PETEAFLQPE RSQRGPLLRA
310 320 330 340 350
IWRVFRSTFL LGTLSLVISD AFRFAVPKLL SLFLEFMGDL ESSAWTGWLL
360 370 380 390 400
AVLMFLSACL QTLFEQQYMY RVKVLQMRLR TAITGLVYRK VLVLSSGSRK
410 420 430 440 450
SSAAGDVVNL VSVDVQRLVE SILHLNGLWL LFLWIIVCFV YLWQLLGPSA
460 470 480 490 500
LTAVAVFLSL LPLNFFITKK RSFHQEEQMR QKASRARLTS SMLRTVRTIK
510 520 530 540 550
SHGWECAFLE RLLHIRGQEL GALKTSAFLF SVSLVSFQVS TFLVALVVFA
560 570 580 590 600
VHTLVAEDNA MDAEKAFVTL TVLSILNKAQ AFLPFSVHCL VQARVSFDRL
610 620 630 640 650
AAFLCLEEVD PNGMVLSPSR CSSKDRISIH NGTFAWSQES PPCLHGINLT
660 670 680 690 700
VPQGCLLAVV GPVGAGKSSL LSALLGELLK VEGSVSIEGS VAYVPQEAWV
710 720 730 740 750
QNTSVVENVC FRQELDLPWL QEVLEACALG SDVASFPAGV HTPVGEQGMN
760 770 780 790 800
LSGGQKQRLS LARAVYRRAA VYLMDDPLAA LDAHVSQEVF KQVIGPSGLL
810 820 830 840 850
QGTTRILVTH TLHVLPQADQ ILVLANGTIA EMGSYQDLLH RNGALVGLLD
860 870 880 890 900
GARQPAGEGE GEAHAAATSD DLGGFSGGGT PTRRPERPRP SDAAPVKGST
910 920 930 940 950
SEAQMEPSLD DVEVTGLTAG EDSVQYGRVK SATYLSYLRA VGTPLCTYTL
960 970 980 990 1000
FLFLCQQVAS FCQGYWLSLW ADDPVVDGKQ MHSALRGSIF GLLGCLQAIG
1010 1020 1030 1040 1050
LFASMAAVFL GGARASCLLF RSLLWDVARS PIGFFERTPV GNLLNRFSKE
1060 1070 1080 1090 1100
TDIVDVDIPD KMRTLLTYAF GLLEVGLAVS MATPLAIVAI LPLMLLYAGF
1110 1120 1130 1140 1150
QSLYVATCCQ LRRLESASYS SVCSHLAETF QGSQVVRAFQ AQGPFTAQHD
1160 1170 1180 1190 1200
ALMDENQRIS FPRLVADRWL AANLELLGNG LVFVAATCAV LSKAHLSAGL
1210 1220 1230 1240 1250
AGFSVSAALQ VTQTLQWVVR SWTDLENSMV AVERVQDYVH TPKEAPWRLP
1260 1270 1280 1290 1300
SSAAQPLWPC GGQIEFRDFG LRHRPELPMA VQGVSLKIHA GEKVGIVGRT
1310 1320 1330 1340 1350
GAGKSSLTWG LLRLQEATEG GIWIDGVPIT DMGLHTLRSR ITIIPQDPVL
1360 1370 1380 1390 1400
FPGSLRMNLD LLQENTDEGI WAALETVQLK AFVTSLPGQL QYECSGQGDD
1410 1420 1430 1440 1450
LSVGQKQLLC LARALLRKTQ ILILDEATAS VDPGTEIQMQ AALERWFAQC
1460 1470 1480 1490 1500
TVLLIAHRLR SVMNCARVLV MDEGQVAESG SPAQLLAQKG LFYRLAQESG

LA
Length:1,502
Mass (Da):164,995
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i539901B674A74A28
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB010466 mRNA Translation: BAA28954.1
U73038 mRNA Translation: AAD12747.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T42216

NCBI Reference Sequences

More...
RefSeqi
NP_112275.1, NM_031013.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Rn.29976

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000042115; ENSRNOP00000051412; ENSRNOG00000028781

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
81642

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:81642

UCSC genome browser

More...
UCSCi
RGD:620268 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010466 mRNA Translation: BAA28954.1
U73038 mRNA Translation: AAD12747.1
PIRiT42216
RefSeqiNP_112275.1, NM_031013.1
UniGeneiRn.29976

3D structure databases

ProteinModelPortaliO88269
SMRiO88269
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051412

Chemistry databases

ChEMBLiCHEMBL2073712

Protein family/group databases

TCDBi3.A.1.208.1 the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiO88269
PhosphoSitePlusiO88269

Proteomic databases

jPOSTiO88269
PaxDbiO88269
PRIDEiO88269

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000042115; ENSRNOP00000051412; ENSRNOG00000028781
GeneIDi81642
KEGGirno:81642
UCSCiRGD:620268 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
368
RGDi620268 Abcc6

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000157145
HOVERGENiHBG108314
InParanoidiO88269
KOiK05669
OMAiLWADDPT
OrthoDBi138195at2759
PhylomeDBiO88269
TreeFamiTF105199

Enzyme and pathway databases

ReactomeiR-RNO-382556 ABC-family proteins mediated transport

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O88269

Gene expression databases

BgeeiENSRNOG00000028781 Expressed in 8 organ(s), highest expression level in liver
GenevisibleiO88269 RN

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030239 ABCC6
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase
PANTHERiPTHR24223:SF339 PTHR24223:SF339, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
TIGRFAMsiTIGR00957 MRP_assoc_pro, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRP6_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88269
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: January 16, 2019
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again