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Entry version 166 (02 Jun 2021)
Sequence version 1 (01 Nov 1998)
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Protein

ATP-binding cassette sub-family C member 6

Gene

Abcc6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro) (By similarity).

Transports also an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed:10692506).

By similarity1 Publication

Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=17 µM for BQ-1231 Publication

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi661 – 668ATP 1PROSITE-ProRule annotation8
    Nucleotide bindingi1298 – 1305ATP 2PROSITE-ProRule annotation8

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionTranslocase
    Biological processTransport
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-RNO-382556, ABC-family proteins mediated transport

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    3.A.1.208.1, the atp-binding cassette (abc) superfamily

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    ATP-binding cassette sub-family C member 6 (EC:7.6.2.-1 Publication, EC:7.6.2.3By similarity)
    Alternative name(s):
    MRP-like protein 1
    Short name:
    MLP-1
    Multidrug resistance-associated protein 6
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Abcc6
    Synonyms:Mlp1, Mrp6
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Rat genome database

    More...
    RGDi
    620268, Abcc6

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini5 – 37ExtracellularBy similarityAdd BLAST33
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei38 – 58Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
    Topological domaini59 – 78CytoplasmicBy similarityAdd BLAST20
    Transmembranei79 – 99Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
    Topological domaini100 – 104ExtracellularBy similarity5
    Transmembranei105 – 125Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
    Topological domaini126 – 137CytoplasmicBy similarityAdd BLAST12
    Transmembranei138 – 155Helical; Name=4PROSITE-ProRule annotationAdd BLAST18
    Topological domaini156 – 173ExtracellularBy similarityAdd BLAST18
    Transmembranei174 – 194Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
    Topological domaini195 – 300CytoplasmicBy similarityAdd BLAST106
    Transmembranei301 – 321Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
    Topological domaini322 – 347ExtracellularBy similarityAdd BLAST26
    Transmembranei348 – 368Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
    Topological domaini369 – 424CytoplasmicBy similarityAdd BLAST56
    Transmembranei425 – 445Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
    Topological domaini446 – 448ExtracellularBy similarity3
    Transmembranei449 – 469Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
    Topological domaini470 – 531CytoplasmicBy similarityAdd BLAST62
    Transmembranei532 – 552Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
    Topological domaini553 – 574ExtracellularBy similarityAdd BLAST22
    Transmembranei575 – 595Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
    Topological domaini596 – 938CytoplasmicBy similarityAdd BLAST343
    Transmembranei939 – 959Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
    Topological domaini960 – 996ExtracellularBy similarityAdd BLAST37
    Transmembranei997 – 1017Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
    Topological domaini1018 – 1060CytoplasmicBy similarityAdd BLAST43
    Transmembranei1061 – 1081Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
    Topological domaini1082ExtracellularBy similarity1
    Transmembranei1083 – 1103Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
    Topological domaini1104 – 1174CytoplasmicBy similarityAdd BLAST71
    Transmembranei1175 – 1195Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
    Topological domaini1196 – 1197ExtracellularBy similarity2
    Transmembranei1198 – 1218Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
    Topological domaini1219 – 1502CytoplasmicBy similarityAdd BLAST284

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Deficient rats develop ectopic mineralization in the skin, eyes, and the arterial blood vessels. Plasma inorganic pyrophosphate (PPi) level is reduced by 70 % in deficient rats leading to a lowered PPi/Pi ratio.1 Publication

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1426E → Q: Does not affect plasma membrane localization. Abolishes cellular ATP release. 1 Publication1

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL2073712

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933681 – 1502ATP-binding cassette sub-family C member 6Add BLAST1502

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei891PhosphoserineCombined sources1
    Modified residuei1285PhosphoserineBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    O88269

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O88269

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O88269

    PTM databases

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...
    GlyGeni
    O88269, 1 site

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O88269

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    O88269

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Predominantly expressed in the liver and to a lesser extent in kidney, small intestine, and colon.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSRNOG00000028781, Expressed in liver and 20 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O88269, RN

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    10116.ENSRNOP00000051412

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    O88269

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini309 – 592ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
    Domaini627 – 851ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
    Domaini946 – 1227ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST282
    Domaini1264 – 1498ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni854 – 909DisorderedSequence analysisAdd BLAST56

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0054, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157145

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_000604_27_3_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O88269

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ALRGWIF

    Database of Orthologous Groups

    More...
    OrthoDBi
    138195at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O88269

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF105199

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.20.1560.10, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR003593, AAA+_ATPase
    IPR011527, ABC1_TM_dom
    IPR036640, ABC1_TM_sf
    IPR003439, ABC_transporter-like
    IPR017871, ABC_transporter_CS
    IPR030239, ABCC6
    IPR005292, Multidrug-R_assoc
    IPR027417, P-loop_NTPase

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR24223:SF339, PTHR24223:SF339, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00664, ABC_membrane, 2 hits
    PF00005, ABC_tran, 2 hits

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00382, AAA, 2 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52540, SSF52540, 2 hits
    SSF90123, SSF90123, 2 hits

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00957, MRP_assoc_pro, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50929, ABC_TM1F, 2 hits
    PS00211, ABC_TRANSPORTER_1, 2 hits
    PS50893, ABC_TRANSPORTER_2, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    O88269-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MNGEHSMATP GESCAGLRVW NQTEQEPVAY HLLNLCFLRA AGSWVPPMYL
    60 70 80 90 100
    WVLGPIYLLY IHRHGCCYLR MSRLFKIKMV LGFALILLYT FNAAVPLWRI
    110 120 130 140 150
    HRGMPQAPEL LIHPTVWLTT MSFATFLIHM ERKKGVRASG LLFGYWLLCC
    160 170 180 190 200
    LVPAIDTVQQ ASAGSFRQEP LHHLATYLCL SLVVAELVLS CLVDQPPFFS
    210 220 230 240 250
    EDSKPLNPCP EAEASFPSKA MFWWASGLLW KGYRKLLGPK DLWSLERENS
    260 270 280 290 300
    SEELVSQLER EWRRNFSELP GHKGHSGMGT PETEAFLQPE RSQRGPLLRA
    310 320 330 340 350
    IWRVFRSTFL LGTLSLVISD AFRFAVPKLL SLFLEFMGDL ESSAWTGWLL
    360 370 380 390 400
    AVLMFLSACL QTLFEQQYMY RVKVLQMRLR TAITGLVYRK VLVLSSGSRK
    410 420 430 440 450
    SSAAGDVVNL VSVDVQRLVE SILHLNGLWL LFLWIIVCFV YLWQLLGPSA
    460 470 480 490 500
    LTAVAVFLSL LPLNFFITKK RSFHQEEQMR QKASRARLTS SMLRTVRTIK
    510 520 530 540 550
    SHGWECAFLE RLLHIRGQEL GALKTSAFLF SVSLVSFQVS TFLVALVVFA
    560 570 580 590 600
    VHTLVAEDNA MDAEKAFVTL TVLSILNKAQ AFLPFSVHCL VQARVSFDRL
    610 620 630 640 650
    AAFLCLEEVD PNGMVLSPSR CSSKDRISIH NGTFAWSQES PPCLHGINLT
    660 670 680 690 700
    VPQGCLLAVV GPVGAGKSSL LSALLGELLK VEGSVSIEGS VAYVPQEAWV
    710 720 730 740 750
    QNTSVVENVC FRQELDLPWL QEVLEACALG SDVASFPAGV HTPVGEQGMN
    760 770 780 790 800
    LSGGQKQRLS LARAVYRRAA VYLMDDPLAA LDAHVSQEVF KQVIGPSGLL
    810 820 830 840 850
    QGTTRILVTH TLHVLPQADQ ILVLANGTIA EMGSYQDLLH RNGALVGLLD
    860 870 880 890 900
    GARQPAGEGE GEAHAAATSD DLGGFSGGGT PTRRPERPRP SDAAPVKGST
    910 920 930 940 950
    SEAQMEPSLD DVEVTGLTAG EDSVQYGRVK SATYLSYLRA VGTPLCTYTL
    960 970 980 990 1000
    FLFLCQQVAS FCQGYWLSLW ADDPVVDGKQ MHSALRGSIF GLLGCLQAIG
    1010 1020 1030 1040 1050
    LFASMAAVFL GGARASCLLF RSLLWDVARS PIGFFERTPV GNLLNRFSKE
    1060 1070 1080 1090 1100
    TDIVDVDIPD KMRTLLTYAF GLLEVGLAVS MATPLAIVAI LPLMLLYAGF
    1110 1120 1130 1140 1150
    QSLYVATCCQ LRRLESASYS SVCSHLAETF QGSQVVRAFQ AQGPFTAQHD
    1160 1170 1180 1190 1200
    ALMDENQRIS FPRLVADRWL AANLELLGNG LVFVAATCAV LSKAHLSAGL
    1210 1220 1230 1240 1250
    AGFSVSAALQ VTQTLQWVVR SWTDLENSMV AVERVQDYVH TPKEAPWRLP
    1260 1270 1280 1290 1300
    SSAAQPLWPC GGQIEFRDFG LRHRPELPMA VQGVSLKIHA GEKVGIVGRT
    1310 1320 1330 1340 1350
    GAGKSSLTWG LLRLQEATEG GIWIDGVPIT DMGLHTLRSR ITIIPQDPVL
    1360 1370 1380 1390 1400
    FPGSLRMNLD LLQENTDEGI WAALETVQLK AFVTSLPGQL QYECSGQGDD
    1410 1420 1430 1440 1450
    LSVGQKQLLC LARALLRKTQ ILILDEATAS VDPGTEIQMQ AALERWFAQC
    1460 1470 1480 1490 1500
    TVLLIAHRLR SVMNCARVLV MDEGQVAESG SPAQLLAQKG LFYRLAQESG

    LA
    Length:1,502
    Mass (Da):164,995
    Last modified:November 1, 1998 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i539901B674A74A28
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB010466 mRNA Translation: BAA28954.1
    U73038 mRNA Translation: AAD12747.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T42216

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_112275.1, NM_031013.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSRNOT00000042115; ENSRNOP00000051412; ENSRNOG00000028781

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    81642

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    rno:81642

    UCSC genome browser

    More...
    UCSCi
    RGD:620268, rat

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB010466 mRNA Translation: BAA28954.1
    U73038 mRNA Translation: AAD12747.1
    PIRiT42216
    RefSeqiNP_112275.1, NM_031013.1

    3D structure databases

    SMRiO88269
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000051412

    Chemistry databases

    ChEMBLiCHEMBL2073712

    Protein family/group databases

    TCDBi3.A.1.208.1, the atp-binding cassette (abc) superfamily

    PTM databases

    GlyGeniO88269, 1 site
    iPTMnetiO88269
    PhosphoSitePlusiO88269

    Proteomic databases

    jPOSTiO88269
    PaxDbiO88269
    PRIDEiO88269

    Genome annotation databases

    EnsembliENSRNOT00000042115; ENSRNOP00000051412; ENSRNOG00000028781
    GeneIDi81642
    KEGGirno:81642
    UCSCiRGD:620268, rat

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    368
    RGDi620268, Abcc6

    Phylogenomic databases

    eggNOGiKOG0054, Eukaryota
    GeneTreeiENSGT00940000157145
    HOGENOMiCLU_000604_27_3_1
    InParanoidiO88269
    OMAiALRGWIF
    OrthoDBi138195at2759
    PhylomeDBiO88269
    TreeFamiTF105199

    Enzyme and pathway databases

    ReactomeiR-RNO-382556, ABC-family proteins mediated transport

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:O88269

    Gene expression databases

    BgeeiENSRNOG00000028781, Expressed in liver and 20 other tissues
    GenevisibleiO88269, RN

    Family and domain databases

    Gene3Di1.20.1560.10, 2 hits
    InterProiView protein in InterPro
    IPR003593, AAA+_ATPase
    IPR011527, ABC1_TM_dom
    IPR036640, ABC1_TM_sf
    IPR003439, ABC_transporter-like
    IPR017871, ABC_transporter_CS
    IPR030239, ABCC6
    IPR005292, Multidrug-R_assoc
    IPR027417, P-loop_NTPase
    PANTHERiPTHR24223:SF339, PTHR24223:SF339, 1 hit
    PfamiView protein in Pfam
    PF00664, ABC_membrane, 2 hits
    PF00005, ABC_tran, 2 hits
    SMARTiView protein in SMART
    SM00382, AAA, 2 hits
    SUPFAMiSSF52540, SSF52540, 2 hits
    SSF90123, SSF90123, 2 hits
    TIGRFAMsiTIGR00957, MRP_assoc_pro, 1 hit
    PROSITEiView protein in PROSITE
    PS50929, ABC_TM1F, 2 hits
    PS00211, ABC_TRANSPORTER_1, 2 hits
    PS50893, ABC_TRANSPORTER_2, 2 hits

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRP6_RAT
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88269
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: June 2, 2021
    This is version 166 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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