Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-type lectin domain family 11 member A

Gene

Clec11a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts. Important for repair and maintenance of adult bone.1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • growth factor activity Source: UniProtKB

GO - Biological processi

  • ossification Source: GO_Central
  • positive regulation of cell proliferation Source: UniProtKB

Keywordsi

Molecular functionGrowth factor
Biological processOsteogenesis
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 11 member A
Alternative name(s):
Lymphocyte secreted C-type lectin
Osteolectin1 Publication
Stem cell growth factor
Gene namesi
Name:Clec11a
Synonyms:Scgf
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1298219 Clec11a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Disruption phenotypei

Viable with no gross defects. Trabecular bone volume and bone mineral density is significantly reduced at two months of age, and progressively worsens with age. Bone strength is reduced and fracture healing is impaired. Hematopoiesis appears to be normal.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001746922 – 328C-type lectin domain family 11 member AAdd BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi209 ↔ 324PROSITE-ProRule annotation
Disulfide bondi301 ↔ 316PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated. Probably sulfated on the O-glycans (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO88200
PaxDbiO88200
PeptideAtlasiO88200
PRIDEiO88200

PTM databases

PhosphoSitePlusiO88200

Expressioni

Tissue specificityi

Detected in femur where it localizes to trabecular bone of the femur metaphysis, and cortical bone of the proximal femur. Also expressed in trabecular and cortical bone of vertebrae (at protein level). Strongly expressed in osteoblasts and bone marrow stromal cells. Also has very weak expression in B cell progenitors in the bone marrow and T cells in the spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000004473 Expressed in 152 organ(s), highest expression level in vault of skull
CleanExiMM_CLEC11A
GenevisibleiO88200 MM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO88200
SMRiO88200
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini188 – 325C-type lectinPROSITE-ProRule annotationAdd BLAST138

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IS3S Eukaryota
ENOG410YHP3 LUCA
GeneTreeiENSGT00610000086061
HOGENOMiHOG000273889
HOVERGENiHBG052365
InParanoidiO88200
KOiK17521
OMAiPADRQQM
OrthoDBiEOG091G0D5T
PhylomeDBiO88200
TreeFamiTF330481

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88200-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQAAWLLGAL VVPQLLSFGH GARGPGREWE GGWGGALEEE RERESQMLKN
60 70 80 90 100
LQEALGLPTG VGNEDNLAEN PEDKEVWETT ETQGEEEEEE ITTAPSSSPN
110 120 130 140 150
PFPSPSPTPE DTVTYILGRL ASLDAGLHQL HVRLHVLDTR VVELTQGLRQ
160 170 180 190 200
LRDAASDTRD SVQALKEVQD RAEQEHGRLE GCLKGLRLGH KCFLLSRDFE
210 220 230 240 250
TQAAAQARCK ARGGSLAQPA DRQQMDALSR YLRAALAPYN WPVWLGVHDR
260 270 280 290 300
RSEGLYLFEN GQRVSFFAWH RAFSLESGAQ PSAATHPLSP DQPNGGVLEN
310 320
CVAQASDDGS WWDHDCERRL YFVCEFPF
Length:328
Mass (Da):36,451
Last modified:November 1, 1998 - v1
Checksum:i309C17A861EE135C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114 – 117TYIL → FFTV in BAC31421 (PubMed:16141072).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009245 mRNA Translation: BAA32405.1
BC002001 mRNA Translation: AAH02001.3
AK042963 mRNA Translation: BAC31421.1
AK003813 mRNA Translation: BAB23010.1
CCDSiCCDS21203.1
RefSeqiNP_033157.1, NM_009131.3
UniGeneiMm.20428

Genome annotation databases

EnsembliENSMUST00000004587; ENSMUSP00000004587; ENSMUSG00000004473
GeneIDi20256
KEGGimmu:20256
UCSCiuc009gpb.2 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Stem cell growth factor

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009245 mRNA Translation: BAA32405.1
BC002001 mRNA Translation: AAH02001.3
AK042963 mRNA Translation: BAC31421.1
AK003813 mRNA Translation: BAB23010.1
CCDSiCCDS21203.1
RefSeqiNP_033157.1, NM_009131.3
UniGeneiMm.20428

3D structure databases

ProteinModelPortaliO88200
SMRiO88200
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiO88200

Proteomic databases

MaxQBiO88200
PaxDbiO88200
PeptideAtlasiO88200
PRIDEiO88200

Protocols and materials databases

DNASUi20256
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004587; ENSMUSP00000004587; ENSMUSG00000004473
GeneIDi20256
KEGGimmu:20256
UCSCiuc009gpb.2 mouse

Organism-specific databases

CTDi6320
MGIiMGI:1298219 Clec11a

Phylogenomic databases

eggNOGiENOG410IS3S Eukaryota
ENOG410YHP3 LUCA
GeneTreeiENSGT00610000086061
HOGENOMiHOG000273889
HOVERGENiHBG052365
InParanoidiO88200
KOiK17521
OMAiPADRQQM
OrthoDBiEOG091G0D5T
PhylomeDBiO88200
TreeFamiTF330481

Miscellaneous databases

PROiPR:O88200
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004473 Expressed in 152 organ(s), highest expression level in vault of skull
CleanExiMM_CLEC11A
GenevisibleiO88200 MM

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLC11_MOUSE
AccessioniPrimary (citable) accession number: O88200
Secondary accession number(s): Q8C946, Q9CTF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again