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Entry version 145 (29 Sep 2021)
Sequence version 2 (02 Mar 2010)
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Protein

E3 ubiquitin-protein ligase TTC3

Gene

Ttc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (By similarity).

Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (By similarity).

Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (By similarity).

Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (By similarity).

Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (By similarity).

Inhibits cell proliferation (By similarity).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1931 – 1971RING-type; atypicalPROSITE-ProRule annotationAdd BLAST41

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TTC3 (EC:2.3.2.27By similarity)
Alternative name(s):
RING-type E3 ubiquitin transferase TTC3Curated
TPR repeat protein D
Short name:
Mtprd
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ttc3
Synonyms:Kiaa4119
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1276539, Ttc3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003920341 – 1979E3 ubiquitin-protein ligase TTC3Add BLAST1979

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei378PhosphoserineBy similarity1
Modified residuei1009PhosphoserineCombined sources1
Modified residuei1060PhosphoserineCombined sources1
Modified residuei1794PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity.By similarity
Proteolytically cleaved into differently sized N- and C-terminal fragments.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O88196

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O88196

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O88196

PeptideAtlas

More...
PeptideAtlasi
O88196

PRoteomics IDEntifications database

More...
PRIDEi
O88196

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
300150 [O88196-1]
300151 [O88196-2]
300152 [O88196-3]
300153 [O88196-4]
300154 [O88196-5]
300155 [O88196-6]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2272, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O88196, 1 site, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O88196

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O88196

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (when phosphorylated on Ser-378) with AKT1, AKT2 and AKT3 (when phosphorylated) (By similarity).

Interacts with CIT (By similarity).

Interacts with POLG (By similarity).

Interacts with HSP70 (By similarity).

Interacts with SMURF2 (By similarity).

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
O88196, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000112801

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O88196, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O88196

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati231 – 264TPR 1Add BLAST34
Repeati266 – 298TPR 2Add BLAST33
Repeati536 – 572TPR 3Add BLAST37
Repeati576 – 609TPR 4Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 230Interaction with POLGBy similarityAdd BLAST230
Regioni422 – 457DisorderedSequence analysisAdd BLAST36
Regioni783 – 811DisorderedSequence analysisAdd BLAST29
Regioni1021 – 1067DisorderedSequence analysisAdd BLAST47
Regioni1214 – 1289DisorderedSequence analysisAdd BLAST76
Regioni1402 – 1427DisorderedSequence analysisAdd BLAST26
Regioni1574 – 1601DisorderedSequence analysisAdd BLAST28
Regioni1757 – 1776DisorderedSequence analysisAdd BLAST20
Regioni1788 – 1821DisorderedSequence analysisAdd BLAST34
Regioni1873 – 1927DisorderedSequence analysisAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1246 – 1264Polar residuesSequence analysisAdd BLAST19
Compositional biasi1873 – 1892Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1893 – 1908Polar residuesSequence analysisAdd BLAST16

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1931 – 1971RING-type; atypicalPROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0800, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O88196

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O88196

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.533.10, 1 hit
1.25.40.10, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR043866, TTC3/DZIP3_dom
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF19179, DUF5861, 1 hit
PF13639, zf-RING_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00184, RING, 1 hit
SM00028, TPR, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005, TPR, 3 hits
PS50293, TPR_REGION, 2 hits
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 25 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O88196-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDFAEGGLS LADDILLEDY PYEDDCICTP DFTTDDYVRV TQLYYEGVGM
60 70 80 90 100
QYKDYAQSEK NLEYDICNIW CSKPLSILQD YCDAIKLYIF WPLLFQHQHS
110 120 130 140 150
SIISRLHPCV EAIRSRAAEI SLKKLQHLEL MEDIVDLAKK VANDSFLIEG
160 170 180 190 200
LLKIGYKIEN KILAMEDALN WIKYTGDVTI LPKLGSVDNC WPMLSIFFTE
210 220 230 240 250
YKYHITRVVT ENCNLLEEFR RHSCMQCVKQ GELMKMRGNE EFSKEKFEIA
260 270 280 290 300
VIYYTRAIEY RPENHLLYGN RALCFLRMGQ FRNALSDGKR AIVLKNTWPK
310 320 330 340 350
GHYRYCDALC MLGEYDWALQ ANIKAQKLCK NDPEGIKDLI QQHVKLQKQI
360 370 380 390 400
EDLQGRTSNK NPIKAFYESR AYIPRNSSAP AFRTSLNFVE TERGFRKTKY
410 420 430 440 450
KMANGGDQNQ KVADEALKGD DCDCHPEFLP PPSQPPRHKG KQKSRNNESE
460 470 480 490 500
KPSFNSEVSL QVDLKSILEK QFSKSSRAAH QDFANIMKML RSLIQDGYTA
510 520 530 540 550
LLEQRCRSAA QAFTELLNGL DPQKIKQLNL AMINYVLVVY GLAVSLLGIG
560 570 580 590 600
RPEELSEAEN QFKRIIEHYP NEGLDCLAYC GIGKVYLKKN RFLEALNHFE
610 620 630 640 650
KAKTLISRLP GILTWPTSNV IIEESKPEKV KVMLEKFVEE CKFPPVPDAV
660 670 680 690 700
CCYQKCRGYS KIQIYLTDPD FKGFIRISCC QYCKVEFHMN CWKKLKTTTF
710 720 730 740 750
NDKIDKDFLQ GICLTPDCEG IISKIIIYSS GGQVKCEFEH KVIKEKVPSR
760 770 780 790 800
PVLKQKCSSL EKLRLKEDKK LKRKIQKQEA KKLAQERMEE DLRESNPPKN
810 820 830 840 850
EEPEETSDSA QRCQFLDDRI LQCIKQNADK IKSVVLNTST LLKELLSWKV
860 870 880 890 900
LSTEDYTTCF SSKNFVHEAV DYVIGHLIQE KNRVKTRIFL HVLSELKELD
910 920 930 940 950
PKLAPWIQRL NSFGLDAIGP FFTRYGASLK ELDFHVVTVL WDEKYGHKLG
960 970 980 990 1000
SIEGKQLDYF FEPASAMEAR CLIWLLEEHR DKFPALHSAL DEFFDIMDSR
1010 1020 1030 1040 1050
CTVLRKQDSD EMPFGCIKVK NKGKKKKPKD SKPMLVGSGA ASVAPSSEAV
1060 1070 1080 1090 1100
TPEDHSRRNS DSAGPFAVPD HLRQDVEEFE ALYDQHSSEY VVRNKKLWDI
1110 1120 1130 1140 1150
NPKQKCSTLY DYFSQLLEEH GPLDMSDRMF SEEYEFFPEE TRQILEKAGG
1160 1170 1180 1190 1200
LKSFLLGCPR FVVIDNCIAL KKVASRLKKK RKKKNMKAKV EDISKTGEYL
1210 1220 1230 1240 1250
RVKLPLNPTA REFQPDVKSE ALSEDVKSIP GPADSSTLAA EDLKAQLDSD
1260 1270 1280 1290 1300
SSSGSASEDS RLEVASPDSP TPLCEDASPS PTPAPEEAKP TYWAQSHLVT
1310 1320 1330 1340 1350
GFCTYLPFQG FGITQRPAYI NMVPSLSQFT SIYTPLANIS SEYPMQRSMP
1360 1370 1380 1390 1400
VVPSFVASNR ADENAAAYFE SPNLNTEHDS GDHMASETQI LEDTLGVCVR
1410 1420 1430 1440 1450
SQGSAADADP ALSEPEGNSE HSGSSDSLWE ASLENVSGTT DAPAAPSVAI
1460 1470 1480 1490 1500
QVSRSMVHQE VNTEPYEPFE TQQGDLSQKE KECHLLREQL KVACENCEQI
1510 1520 1530 1540 1550
ELRSSQEIKD LEEKLQRHTE ENKISKTELD WFLQDLDREI KKWQQEKKEI
1560 1570 1580 1590 1600
QERLKALKKK IKKVINTSEM SAQKNDGFDK ECEPHPDQSL GFSSALTDEK
1610 1620 1630 1640 1650
TKAEESVRKG KELYEESHQR AVAAEVSVLE NWKEREVCKL QGVASQSEAY
1660 1670 1680 1690 1700
LKSLKLMSSD SATYPDVEYD ILSWESFLST VREEIESKKS QFEEHIKAIK
1710 1720 1730 1740 1750
NGSRLSDLSS VQLSEVSFPG CSTIHPQFLS ESSGHEDPGL VACVDSMTGA
1760 1770 1780 1790 1800
VLNDPYMDSA SGCPEEVPEL SLGSPTHQPE VTQQLELKGA SQVSPSEQSP
1810 1820 1830 1840 1850
EADEKLSGQA TRSSQSPKKP SNSIIEHLSV IFPCYTSTEL AGFIKKVRNK
1860 1870 1880 1890 1900
TKNSFSGLTI EEIVEKVTEH IVDEQKKKKP NPGKDKKTSE AHSAASVAKS
1910 1920 1930 1940 1950
SQSPPLAAAG PSARTKGQKK DDVPAPDGNS CEICHEIFKS KNMRVLKCGH
1960 1970
KFHKGCFKQW LKGQSTCPTC GSSDLLSEE
Length:1,979
Mass (Da):223,931
Last modified:March 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i63A93E3CA1CECF00
GO
Isoform 2 (identifier: O88196-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1056-1056: Missing.

Show »
Length:1,978
Mass (Da):223,844
Checksum:i6FEC4D995E55FCE4
GO
Isoform 3 (identifier: O88196-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-160: Missing.

Show »
Length:1,961
Mass (Da):221,883
Checksum:i4047B16D85EE30C5
GO
Isoform 4 (identifier: O88196-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-160: Missing.
     1056-1056: Missing.
     1089-1110: Missing.

Show »
Length:1,938
Mass (Da):219,088
Checksum:i58B90EF9CA3D66E2
GO
Isoform 5 (identifier: O88196-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-401: Missing.

Show »
Length:1,578
Mass (Da):177,071
Checksum:iD6D2B19BA5ADB72A
GO
Isoform 6 (identifier: O88196-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1593-1593: Missing.

Show »
Length:1,978
Mass (Da):223,844
Checksum:i620F3D1A57F9C9DA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 25 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E8T2G5E8T2_MOUSE
RING-type E3 ubiquitin transferase
Ttc3
1,979Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P6W3A0A338P6W3_MOUSE
RING-type E3 ubiquitin transferase
Ttc3
1,624Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z485D3Z485_MOUSE
RING-type E3 ubiquitin transferase
Ttc3
622Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z2K0D3Z2K0_MOUSE
RING-type E3 ubiquitin transferase
Ttc3
382Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J1T2A0A0R4J1T2_MOUSE
RING-type E3 ubiquitin transferase
Ttc3
776Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHT6D6RHT6_MOUSE
RING-type E3 ubiquitin transferase
Ttc3
1,135Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RD03D6RD03_MOUSE
RING-type E3 ubiquitin transferase
Ttc3
1,179Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDD2D6RDD2_MOUSE
RING-type E3 ubiquitin transferase
Ttc3
1,162Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFU5D6RFU5_MOUSE
RING-type E3 ubiquitin transferase
Ttc3
1,197Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YZ03D3YZ03_MOUSE
RING-type E3 ubiquitin transferase
Ttc3
469Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH19173 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH57207 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC35513 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD90293 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE28586 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti94L → P in BAA31563 (PubMed:9603993).Curated1
Sequence conflicti454F → S in BAC35513 (PubMed:9603993).Curated1
Sequence conflicti454F → S in BAE38412 (PubMed:9603993).Curated1
Sequence conflicti1164I → F in BAE37809 (PubMed:9603993).Curated1
Sequence conflicti1177L → P in BAC40250 (PubMed:9603993).Curated1
Sequence conflicti1522N → S in BAE36675 (PubMed:9603993).Curated1
Sequence conflicti1571S → P in BAE36675 (PubMed:9603993).Curated1
Sequence conflicti1571S → P in BAE37630 (PubMed:9603993).Curated1
Sequence conflicti1571S → P in BAE37809 (PubMed:9603993).Curated1
Sequence conflicti1603A → V in BAE36675 (PubMed:9603993).Curated1
Sequence conflicti1603A → V in BAE37630 (PubMed:9603993).Curated1
Sequence conflicti1603A → V in BAE37809 (PubMed:9603993).Curated1
Sequence conflicti1822N → S in BAE36675 (PubMed:9603993).Curated1
Sequence conflicti1847V → F in BAE36675 (PubMed:9603993).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0387741 – 401Missing in isoform 5. 1 PublicationAdd BLAST401
Alternative sequenceiVSP_038775143 – 160Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_0387761056Missing in isoform 2 and isoform 4. 2 Publications1
Alternative sequenceiVSP_0387771089 – 1110Missing in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0387781593Missing in isoform 6. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB008516 mRNA Translation: BAA31563.1
AK053765 mRNA Translation: BAC35513.1 Different initiation.
AK088273 mRNA Translation: BAC40250.1
AK162004 mRNA Translation: BAE36675.1
AK163496 mRNA Translation: BAE37372.1
AK164106 mRNA Translation: BAE37630.1
AK164492 mRNA Translation: BAE37809.1
AK165850 mRNA Translation: BAE38412.1
AK148494 mRNA Translation: BAE28586.1 Different initiation.
AK220495 mRNA Translation: BAD90293.1 Different initiation.
BC019173 mRNA Translation: AAH19173.1 Sequence problems.
BC057207 mRNA Translation: AAH57207.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37407.1 [O88196-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JW0059

Genome annotation databases

UCSC genome browser

More...
UCSCi
uc008aau.1, mouse [O88196-2]
uc008aaw.1, mouse [O88196-3]
uc008aax.1, mouse [O88196-4]
uc012aiu.1, mouse [O88196-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008516 mRNA Translation: BAA31563.1
AK053765 mRNA Translation: BAC35513.1 Different initiation.
AK088273 mRNA Translation: BAC40250.1
AK162004 mRNA Translation: BAE36675.1
AK163496 mRNA Translation: BAE37372.1
AK164106 mRNA Translation: BAE37630.1
AK164492 mRNA Translation: BAE37809.1
AK165850 mRNA Translation: BAE38412.1
AK148494 mRNA Translation: BAE28586.1 Different initiation.
AK220495 mRNA Translation: BAD90293.1 Different initiation.
BC019173 mRNA Translation: AAH19173.1 Sequence problems.
BC057207 mRNA Translation: AAH57207.1 Sequence problems.
CCDSiCCDS37407.1 [O88196-1]
PIRiJW0059

3D structure databases

SMRiO88196
ModBaseiSearch...

Protein-protein interaction databases

IntActiO88196, 4 interactors
STRINGi10090.ENSMUSP00000112801

PTM databases

GlyConnecti2272, 1 N-Linked glycan (1 site)
GlyGeniO88196, 1 site, 1 N-linked glycan (1 site)
iPTMnetiO88196
PhosphoSitePlusiO88196

Proteomic databases

jPOSTiO88196
MaxQBiO88196
PaxDbiO88196
PeptideAtlasiO88196
PRIDEiO88196
ProteomicsDBi300150 [O88196-1]
300151 [O88196-2]
300152 [O88196-3]
300153 [O88196-4]
300154 [O88196-5]
300155 [O88196-6]

Genome annotation databases

UCSCiuc008aau.1, mouse [O88196-2]
uc008aaw.1, mouse [O88196-3]
uc008aax.1, mouse [O88196-4]
uc012aiu.1, mouse [O88196-1]

Organism-specific databases

MGIiMGI:1276539, Ttc3

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0800, Eukaryota
InParanoidiO88196
PhylomeDBiO88196

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ttc3, mouse

Protein Ontology

More...
PROi
PR:O88196
RNActiO88196, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di1.10.533.10, 1 hit
1.25.40.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR043866, TTC3/DZIP3_dom
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF19179, DUF5861, 1 hit
PF13639, zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184, RING, 1 hit
SM00028, TPR, 4 hits
SUPFAMiSSF48452, SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005, TPR, 3 hits
PS50293, TPR_REGION, 2 hits
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTC3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88196
Secondary accession number(s): Q05D15
, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: March 2, 2010
Last modified: September 29, 2021
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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