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Protein

Platelet glycoprotein IX

Gene

Gp9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processBlood coagulation, Cell adhesion, Hemostasis

Enzyme and pathway databases

ReactomeiR-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
R-MMU-430116 GP1b-IX-V activation signalling
R-MMU-75892 Platelet Adhesion to exposed collagen
R-MMU-76009 Platelet Aggregation (Plug Formation)

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein IX
Short name:
GP-IX
Short name:
GPIX
Alternative name(s):
Glycoprotein 9
CD_antigen: CD42a
Gene namesi
Name:Gp9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1860137 Gp9

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 147ExtracellularSequence analysisAdd BLAST131
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Topological domaini169 – 177CytoplasmicSequence analysis9

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16By similarityAdd BLAST16
ChainiPRO_000037845617 – 177Platelet glycoprotein IXAdd BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO88186
PaxDbiO88186
PRIDEiO88186

PTM databases

PhosphoSitePlusiO88186

Expressioni

Gene expression databases

BgeeiENSMUSG00000030054 Expressed in 70 organ(s), highest expression level in blood
GenevisibleiO88186 MM

Interactioni

Subunit structurei

Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage (By similarity).By similarity

Protein-protein interaction databases

ComplexPortaliCPX-115 Glycoprotein Ib-IX-V complex
CPX-118 Glycoprotein Ib-IX-V-Filamin-A complex
STRINGi10090.ENSMUSP00000032133

Structurei

3D structure databases

ProteinModelPortaliO88186
SMRiO88186
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 51LRRNTAdd BLAST35
Repeati60 – 83LRRAdd BLAST24
Domaini85 – 137LRRCTAdd BLAST53

Keywords - Domaini

Leucine-rich repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00530000064244
HOGENOMiHOG000089943
InParanoidiO88186
KOiK06263
OMAiILYLKLW
OrthoDBiEOG091G0XGH
PhylomeDBiO88186

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88186-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTWGLLFLL WPATTDTQAC PRPCTCQSLE TMGLKVNCEG QGLTALPVIP
60 70 80 90 100
AHTRQLLLAN NSLRSVPPGA FDHLPQLWDL DVTHNPWHCD CSLTYLRLWL
110 120 130 140 150
EDHMPEALMH VYCASPDLAT RRPLGQLTGY ELGSCGWKLP PSWAYPGVWW
160 170
DVSLVAVAVL GLILLAGLLN TFTESRN
Length:177
Mass (Da):19,664
Last modified:November 1, 1998 - v1
Checksum:iEB82B952BD3DD7C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007464 mRNA Translation: BAA31694.1
CH466523 Genomic DNA Translation: EDK99218.1
BC111106 mRNA Translation: AAI11107.1
CCDSiCCDS20328.1
RefSeqiNP_061232.1, NM_018762.1
UniGeneiMm.12897

Genome annotation databases

EnsembliENSMUST00000032133; ENSMUSP00000032133; ENSMUSG00000030054
GeneIDi54368
KEGGimmu:54368
UCSCiuc009ctv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007464 mRNA Translation: BAA31694.1
CH466523 Genomic DNA Translation: EDK99218.1
BC111106 mRNA Translation: AAI11107.1
CCDSiCCDS20328.1
RefSeqiNP_061232.1, NM_018762.1
UniGeneiMm.12897

3D structure databases

ProteinModelPortaliO88186
SMRiO88186
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-115 Glycoprotein Ib-IX-V complex
CPX-118 Glycoprotein Ib-IX-V-Filamin-A complex
STRINGi10090.ENSMUSP00000032133

PTM databases

PhosphoSitePlusiO88186

Proteomic databases

MaxQBiO88186
PaxDbiO88186
PRIDEiO88186

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032133; ENSMUSP00000032133; ENSMUSG00000030054
GeneIDi54368
KEGGimmu:54368
UCSCiuc009ctv.1 mouse

Organism-specific databases

CTDi2815
MGIiMGI:1860137 Gp9

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00530000064244
HOGENOMiHOG000089943
InParanoidiO88186
KOiK06263
OMAiILYLKLW
OrthoDBiEOG091G0XGH
PhylomeDBiO88186

Enzyme and pathway databases

ReactomeiR-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
R-MMU-430116 GP1b-IX-V activation signalling
R-MMU-75892 Platelet Adhesion to exposed collagen
R-MMU-76009 Platelet Aggregation (Plug Formation)

Miscellaneous databases

PROiPR:O88186
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030054 Expressed in 70 organ(s), highest expression level in blood
GenevisibleiO88186 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPIX_MOUSE
AccessioniPrimary (citable) accession number: O88186
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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