Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 140 (07 Apr 2021)
Sequence version 2 (13 Aug 2002)
Previous versions | rss
Add a publicationFeedback
Protein

Argininosuccinate lyase

Gene

argH

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
CORYNE:G18NG-10980-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00068;UER00114

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Cgl1401, cg1588
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri196627 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000582 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001377641 – 477Argininosuccinate lyaseAdd BLAST477

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
196627.cg1588

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O88101

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0165, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027272_2_2_11

Identification of Orthologs from Complete Genome Data

More...
OMAi
MPGRTHL

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01359, Argininosuccinate_lyase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.275.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00006, Arg_succ_lyase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029419, Arg_succ_lyase_C
IPR009049, Argininosuccinate_lyase
IPR024083, Fumarase/histidase_N
IPR020557, Fumarate_lyase_CS
IPR000362, Fumarate_lyase_fam
IPR022761, Fumarate_lyase_N
IPR008948, L-Aspartase-like

The PANTHER Classification System

More...
PANTHERi
PTHR43814, PTHR43814, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14698, ASL_C2, 1 hit
PF00206, Lyase_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00149, FUMRATELYASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48557, SSF48557, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00838, argH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00163, FUMARATE_LYASES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O88101-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQHGTNEGA LWGGRFSGGP SEAMFALSVS THFDWVLAPY DVLASKAHAK
60 70 80 90 100
VLHQADLLSD EDLATMLAGL DQLGKDVADG TFGPLPSDED VHGAMERGLI
110 120 130 140 150
DRVGPEVGGR LRAGRSRNDQ VATLFRMWVR DAVRDIALGT TELVDALSAQ
160 170 180 190 200
AKAHAGAIMP GKTHFQAAQP VLLAHQLLAH AQPLLRDIDR IRDLDKRLAV
210 220 230 240 250
SPYGSGALAG SSLKLNPEAI AEELGFDSAA DNSIDATSSR DFASETAFVL
260 270 280 290 300
AQLAVDMSRL AEEIIAWCTP EFGYITLSDS WSTGSSIMPQ KKNPDVAELT
310 320 330 340 350
RGKSGRLIGN LTGLLATLKA QPLAYNRDLQ EDKEPIVDSV AQLNLLLPAM
360 370 380 390 400
TGLVSTLTFN TERMRELAPA GFTLATDLAE WMVRQGVPFR EAHEASGACV
410 420 430 440 450
RIAESRGVDL IDLTDEELSG VDARLTPEVR EVLTIDGAVA SRATRGGTAG
460 470
VRVAEQRARV DAASTAHAEW ARAGVRR
Length:477
Mass (Da):51,042
Last modified:August 13, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06364CA7FEE80E9B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10 – 13ALWG → GCGP in AAC24811 (Ref. 1) Curated4
Sequence conflicti10 – 13ALWG → GCGP in AAC24819 (Ref. 1) Curated4
Sequence conflicti41 – 66DVLAS…DLATM → HLHAPRAHTMVLFRAGLLTE EQRDGL in AAC24819 (Ref. 1) CuratedAdd BLAST26
Sequence conflicti72 – 75QLGK → SLAQ in AAC24811 (Ref. 1) Curated4
Sequence conflicti72 – 75QLGK → SLAQ in AAC24819 (Ref. 1) Curated4
Sequence conflicti81T → S in AAC24811 (Ref. 1) Curated1
Sequence conflicti81T → S in AAC24819 (Ref. 1) Curated1
Sequence conflicti86 – 87PS → VT in AAC24811 (Ref. 1) Curated2
Sequence conflicti86 – 87PS → VT in AAC24819 (Ref. 1) Curated2
Sequence conflicti93 – 95GAM → AAL in AAC24811 (Ref. 1) Curated3
Sequence conflicti93 – 95GAM → AAL in AAC24819 (Ref. 1) Curated3
Sequence conflicti152K → E in AAC24811 (Ref. 1) Curated1
Sequence conflicti152K → E in AAC24819 (Ref. 1) Curated1
Sequence conflicti214K → E in AAC24811 (Ref. 1) Curated1
Sequence conflicti214K → E in AAC24819 (Ref. 1) Curated1
Sequence conflicti299L → Q in AAC24811 (Ref. 1) Curated1
Sequence conflicti299L → Q in AAC24819 (Ref. 1) Curated1
Sequence conflicti302G → R in AAC24811 (Ref. 1) Curated1
Sequence conflicti302G → R in AAC24819 (Ref. 1) Curated1
Sequence conflicti305G → R in AAC24811 (Ref. 1) Curated1
Sequence conflicti305G → R in AAC24819 (Ref. 1) Curated1
Sequence conflicti308I → L in AAC24811 (Ref. 1) Curated1
Sequence conflicti308I → L in AAC24819 (Ref. 1) Curated1
Sequence conflicti315L → V in AAC24811 (Ref. 1) Curated1
Sequence conflicti315L → V in AAC24819 (Ref. 1) Curated1
Sequence conflicti319 – 321KAQ → EAH in AAC24811 (Ref. 1) Curated3
Sequence conflicti319 – 321KAQ → EAH in AAC24819 (Ref. 1) Curated3
Sequence conflicti326 – 328NRD → SRV in AAC24811 (Ref. 1) Curated3
Sequence conflicti326 – 328NRD → SRV in AAC24819 (Ref. 1) Curated3
Sequence conflicti337V → L in AAC24811 (Ref. 1) Curated1
Sequence conflicti337V → L in AAC24819 (Ref. 1) Curated1
Sequence conflicti340V → L in AAC24811 (Ref. 1) Curated1
Sequence conflicti340V → L in AAC24819 (Ref. 1) Curated1
Sequence conflicti361 – 369TERMRELAP → DQPDADLDR in AAC24811 (Ref. 1) Curated9
Sequence conflicti361 – 369TERMRELAP → DQPDADLDR in AAC24819 (Ref. 1) Curated9
Sequence conflicti375A → P in AAC24811 (Ref. 1) Curated1
Sequence conflicti375A → P in AAC24819 (Ref. 1) Curated1
Sequence conflicti379 – 390AEWMV…GVPFR → RERDRQGGSNSG in AAC24811 (Ref. 1) CuratedAdd BLAST12
Sequence conflicti379 – 390AEWMV…GVPFR → RERDRQGGSNSG in AAC24819 (Ref. 1) CuratedAdd BLAST12
Sequence conflicti396 – 419SGACV…DEELS → PARSGGSCGPSPGSGPYRSH RRRTR in AAC24811 (Ref. 1) CuratedAdd BLAST24
Sequence conflicti396 – 419SGACV…DEELS → PARSGGSCGPSPGSGPYRSH RRRTR in AAC24819 (Ref. 1) CuratedAdd BLAST24
Sequence conflicti425 – 465LTPEV…DAAST → PDPRGTGSAHHSWCSGFPSN RRWNRARAGCGATRTCRCRK Y in AAC24811 (Ref. 1) CuratedAdd BLAST41
Sequence conflicti425 – 465LTPEV…DAAST → PDPRGTGSAHHSWCSGFPSN RRWNRARAGCGATRTCRCRK Y in AAC24819 (Ref. 1) CuratedAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF048764 Genomic DNA Translation: AAC24811.1
AF049897 Genomic DNA Translation: AAC24819.1
BA000036 Genomic DNA Translation: BAB98794.1
BX927152 Genomic DNA Translation: CAF21412.1

NCBI Reference Sequences

More...
RefSeqi
NP_600620.1, NC_003450.3
WP_011014337.1, NC_006958.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAB98794; BAB98794; BAB98794

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cgb:cg1588
cgl:NCgl1347

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|196627.13.peg.1370

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF048764 Genomic DNA Translation: AAC24811.1
AF049897 Genomic DNA Translation: AAC24819.1
BA000036 Genomic DNA Translation: BAB98794.1
BX927152 Genomic DNA Translation: CAF21412.1
RefSeqiNP_600620.1, NC_003450.3
WP_011014337.1, NC_006958.1

3D structure databases

SMRiO88101
ModBaseiSearch...

Protein-protein interaction databases

STRINGi196627.cg1588

Genome annotation databases

EnsemblBacteriaiBAB98794; BAB98794; BAB98794
KEGGicgb:cg1588
cgl:NCgl1347
PATRICifig|196627.13.peg.1370

Phylogenomic databases

eggNOGiCOG0165, Bacteria
HOGENOMiCLU_027272_2_2_11
OMAiMPGRTHL

Enzyme and pathway databases

UniPathwayiUPA00068;UER00114
BioCyciCORYNE:G18NG-10980-MONOMER

Family and domain databases

CDDicd01359, Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 1 hit
HAMAPiMF_00006, Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419, Arg_succ_lyase_C
IPR009049, Argininosuccinate_lyase
IPR024083, Fumarase/histidase_N
IPR020557, Fumarate_lyase_CS
IPR000362, Fumarate_lyase_fam
IPR022761, Fumarate_lyase_N
IPR008948, L-Aspartase-like
PANTHERiPTHR43814, PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698, ASL_C2, 1 hit
PF00206, Lyase_1, 1 hit
PRINTSiPR00149, FUMRATELYASE
SUPFAMiSSF48557, SSF48557, 1 hit
TIGRFAMsiTIGR00838, argH, 1 hit
PROSITEiView protein in PROSITE
PS00163, FUMARATE_LYASES, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARLY_CORGL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88101
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 13, 2002
Last modified: April 7, 2021
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again