UniProtKB - O87954 (O87954_XANCA)
Protein
Bifunctional chorismate mutase/prephenate dehydratase
Gene
aroQ/pheA
Organism
Xanthomonas campestris
Status
Functioni
Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.ARBA annotation
Catalytic activityi
: L-phenylalanine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes phenylpyruvate from prephenate.ARBA annotationProteins known to be involved in this subpathway in this organism are:
- Bifunctional chorismate mutase/prephenate dehydratase (XcmpCFBP7700_10750), Bifunctional chorismate mutase/prephenate dehydratase (D0A35_12180), Bifunctional chorismate mutase/prephenate dehydratase (RT95_18175), Bifunctional chorismate mutase/prephenate dehydratase (pheA), Bifunctional chorismate mutase/prephenate dehydratase (aroQ/pheA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phenylpyruvate from prephenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.
Pathwayi: prephenate biosynthesis
This protein is involved in step 1 of the subpathway that synthesizes prephenate from chorismate.ARBA annotationProteins known to be involved in this subpathway in this organism are:
- Chorismate mutase (RT95_00340), Bifunctional chorismate mutase/prephenate dehydratase (pheA), Bifunctional chorismate mutase/prephenate dehydratase (aroQ/pheA), Bifunctional chorismate mutase/prephenate dehydratase (XcmpCFBP7700_10750), Chorismate mutase (XcmpCFBP7700_01300), Bifunctional chorismate mutase/prephenate dehydratase (D0A35_12180), Bifunctional chorismate mutase/prephenate dehydratase (RT95_18175), Chorismate mutase (D0A35_10380)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes prephenate from chorismate, the pathway prephenate biosynthesis and in Metabolic intermediate biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 300 | Essential for prephenate dehydratase activityUniRule annotation | 1 |
GO - Molecular functioni
- chorismate mutase activity Source: UniProtKB-EC
- prephenate dehydratase activity Source: UniProtKB-EC
GO - Biological processi
- chorismate metabolic process Source: InterPro
- L-phenylalanine biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | IsomeraseARBA annotation, LyaseARBA annotation, Multifunctional enzymeARBA annotation |
Biological process | Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesisARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00120;UER00203 UPA00121;UER00345 |
Names & Taxonomyi
Protein namesi | Recommended name: Bifunctional chorismate mutase/prephenate dehydrataseARBA annotation (EC:4.2.1.51ARBA annotation, EC:5.4.99.5ARBA annotation)Alternative name(s): Chorismate mutaseARBA annotation Chorismate mutase-prephenate dehydrataseARBA annotation Prephenate dehydrataseARBA annotation p-proteinARBA annotation |
Gene namesi | Name:aroQ/pheAImported |
Organismi | Xanthomonas campestrisImported |
Taxonomic identifieri | 339 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas |
Subcellular locationi
- Cytoplasm ARBA annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 131 | Chorismate mutaseInterPro annotationAdd BLAST | 93 | |
Domaini | 131 – 307 | Prephenate dehydrataseInterPro annotationAdd BLAST | 177 | |
Domaini | 319 – 396 | ACTInterPro annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 33 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 24 | PolarSequence analysisAdd BLAST | 15 |
Family and domain databases
Gene3Di | 1.20.59.10, 1 hit |
InterProi | View protein in InterPro IPR002912, ACT_dom IPR008242, Chor_mutase/pphenate_deHydtase IPR036263, Chorismate_II_sf IPR036979, CM_dom_sf IPR002701, CM_II_prokaryot IPR010957, G/b/e-P-prot_chorismate_mutase IPR001086, Preph_deHydtase |
Pfami | View protein in Pfam PF01842, ACT, 1 hit PF01817, CM_2, 1 hit PF00800, PDT, 1 hit |
PIRSFi | PIRSF001500, Chor_mut_pdt_Ppr, 1 hit |
SMARTi | View protein in SMART SM00830, CM_2, 1 hit |
SUPFAMi | SSF48600, SSF48600, 1 hit |
TIGRFAMsi | TIGR01807, CM_P2, 1 hit |
PROSITEi | View protein in PROSITE PS51671, ACT, 1 hit PS51168, CHORISMATE_MUT_2, 1 hit PS51171, PREPHENATE_DEHYDR_3, 1 hit |
i Sequence
Sequence statusi: Complete.
O87954-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPKPKNTNA AGGTAKSATK ASSKKATKLA GKDSAKPLAT AAPVLADVRA
60 70 80 90 100
KIDEIDRGIQ ALIAERANFA HQVGKAKGKL AAAVDYYRPE REAQVLRMVV
110 120 130 140 150
DRNEGPLSDE VLVHVFREIM SACLAQQEPL KIGYLGPEGT FSQQAVLKHF
160 170 180 190 200
GRSAVGLPMA TIEEVFQEVE AGNADFGVVP VENSGQGTIQ VTLDMFLTSN
210 220 230 240 250
LKICGEVELR VHQYLLSRNG RLEDIERIYA HSQSFAQTAG WLRSHLPKVE
260 270 280 290 300
KIAVSSNAEG ARRARNAEDA AAIGGESAAH VYGLKKVIMK SIEDDDDNTT
310 320 330 340 350
RFLVIGRQIF PSSGHDRTSV LVFIHDKPGA LFDVLSPFAR HGISMNRIES
360 370 380 390 400
RPSHQAKWEY GFFIDLAGHV EDESMKQALA ELEAHSAQIK VLGSYPVAIP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U64518 Genomic DNA Translation: AAC38578.1 |
RefSeqi | WP_016944749.1, NZ_MBDP01000011.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U64518 Genomic DNA Translation: AAC38578.1 |
RefSeqi | WP_016944749.1, NZ_MBDP01000011.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Enzyme and pathway databases
UniPathwayi | UPA00120;UER00203 UPA00121;UER00345 |
Family and domain databases
Gene3Di | 1.20.59.10, 1 hit |
InterProi | View protein in InterPro IPR002912, ACT_dom IPR008242, Chor_mutase/pphenate_deHydtase IPR036263, Chorismate_II_sf IPR036979, CM_dom_sf IPR002701, CM_II_prokaryot IPR010957, G/b/e-P-prot_chorismate_mutase IPR001086, Preph_deHydtase |
Pfami | View protein in Pfam PF01842, ACT, 1 hit PF01817, CM_2, 1 hit PF00800, PDT, 1 hit |
PIRSFi | PIRSF001500, Chor_mut_pdt_Ppr, 1 hit |
SMARTi | View protein in SMART SM00830, CM_2, 1 hit |
SUPFAMi | SSF48600, SSF48600, 1 hit |
TIGRFAMsi | TIGR01807, CM_P2, 1 hit |
PROSITEi | View protein in PROSITE PS51671, ACT, 1 hit PS51168, CHORISMATE_MUT_2, 1 hit PS51171, PREPHENATE_DEHYDR_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O87954_XANCA | |
Accessioni | O87954Primary (citable) accession number: O87954 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1998 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |