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Protein

Cytolethal distending toxin subunit A

Gene

cdtA

Organism
Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionToxin
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Cytolethal distending toxin subunit A
Short name:
CDT A
Gene namesi
Name:cdtA
OrganismiAggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Taxonomic identifieri714 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15PROSITE-ProRule annotationAdd BLAST15
ChainiPRO_000001336816 – 222Cytolethal distending toxin subunit AAdd BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi16N-palmitoyl cysteineCurated1
Lipidationi16S-diacylglycerol cysteineCurated1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiO87120

Interactioni

Subunit structurei

Heterotrimer of 3 subunits, CdtA, CdtB and CdtC. May form higher oligomers.2 Publications

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi73 – 75Combined sources3
Beta strandi77 – 81Combined sources5
Beta strandi84 – 89Combined sources6
Beta strandi97 – 102Combined sources6
Helixi103 – 105Combined sources3
Helixi107 – 113Combined sources7
Beta strandi115 – 119Combined sources5
Beta strandi126 – 130Combined sources5
Turni131 – 133Combined sources3
Beta strandi136 – 140Combined sources5
Beta strandi143 – 147Combined sources5
Helixi154 – 156Combined sources3
Beta strandi158 – 163Combined sources6
Beta strandi168 – 172Combined sources5
Turni173 – 175Combined sources3
Beta strandi178 – 181Combined sources4
Beta strandi186 – 195Combined sources10
Beta strandi208 – 212Combined sources5
Beta strandi218 – 220Combined sources3

3D structure databases

DisProtiDP01002
ProteinModelPortaliO87120
SMRiO87120
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO87120

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 211Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni90 – 101Mediates binding to target cellsBy similarityAdd BLAST12

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106BMH Bacteria
ENOG410Y0HS LUCA

Family and domain databases

InterProiView protein in InterPro
IPR015957 CDtoxinA
IPR003558 CDtoxinA/C
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF03498 CDtoxinA, 1 hit
PIRSFiPIRSF036516 CDT_A, 1 hit
PRINTSiPR01387 CDTOXINA
SUPFAMiSSF50370 SSF50370, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit
PS50231 RICIN_B_LECTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O87120-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKFLPGLLL MGLVACSSNQ RMSDYSQPES QSDLAPKSST TQFQPQPLLS
60 70 80 90 100
KASSMPLNLL SSSKNGQVSP SEPSNFMTLM GQNGALLTVW ALAKRNWLWA
110 120 130 140 150
YPNIYSQDFG NIRNWKIEPG KHREYFRFVN QSLGTCIEAY GNGLIHDTCS
160 170 180 190 200
LDKLAQEFEL LPTDSGAVVI KSVSQGRCVT YNPVSPTYYS TVTLSTCDGA
210 220
TEPLRDQTWY LAPPVLEATA VN
Length:222
Mass (Da):24,514
Last modified:November 1, 1998 - v1
Checksum:iD8267171A2EA4774
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011405 Genomic DNA Translation: BAA33485.1
AF006830 Genomic DNA Translation: AAC70897.1
AF102554 Genomic DNA Translation: AAG09113.1
AB017807 Genomic DNA Translation: BAA35116.1
RefSeqiWP_005540930.1, NZ_PCGW01000001.1

Genome annotation databases

GeneIDi31675180

Similar proteinsi

Entry informationi

Entry nameiCDTA_AGGAC
AccessioniPrimary (citable) accession number: O87120
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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