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Entry version 108 (16 Oct 2019)
Sequence version 1 (01 Nov 1998)
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Protein

Endo-1,4-beta-xylanase

Gene

xynA

Organism
Hungateiclostridium thermocellum (Clostridium thermocellum)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.PROSITE-ProRule annotation EC:3.2.1.8

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: xylan degradation

This protein is involved in the pathway xylan degradation, which is part of Glycan degradation.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway xylan degradation and in Glycan degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei122NucleophilePROSITE-ProRule annotation1
Active sitei212Proton donorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidasePROSITE-ProRule annotation, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation, Xylan degradationPROSITE-ProRule annotationImported

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00114

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM6 Carbohydrate-Binding Module Family 6
GH11 Glycoside Hydrolase Family 11

mycoCLAP, a database of fungal genes encoding lignocellulose-active proteins

More...
mycoCLAPi
XYN11A_CLOTH

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endo-1,4-beta-xylanasePROSITE-ProRule annotation (EC:3.2.1.8PROSITE-ProRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:xynAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHungateiclostridium thermocellum (Clostridium thermocellum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1515 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesHungateiclostridiaceaeHungateiclostridium

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500416029429 – 683Endo-1,4-beta-xylanaseSequence analysisAdd BLAST655

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O87119

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O87119

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 225GH11InterPro annotationAdd BLAST195
Domaini252 – 374CBM6InterPro annotationAdd BLAST123
Domaini388 – 456DockerinInterPro annotationAdd BLAST69
Domaini480 – 658NodB homologyInterPro annotationAdd BLAST179

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni229 – 249DisorderedSequence analysisAdd BLAST21
Regioni454 – 477DisorderedSequence analysisAdd BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 11 (cellulase G) family.PROSITE-ProRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4107T94 Bacteria
COG0726 LUCA
COG5498 LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1330.10, 1 hit
2.60.120.180, 1 hit
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006584 Cellulose-bd_IV
IPR005084 CMB_fam6
IPR013320 ConA-like_dom_sf
IPR002105 Dockerin_1_rpt
IPR016134 Dockerin_dom
IPR036439 Dockerin_dom_sf
IPR018247 EF_Hand_1_Ca_BS
IPR008979 Galactose-bd-like_sf
IPR013319 GH11/12
IPR018208 GH11_AS_1
IPR033119 GH11_AS_2
IPR033123 GH11_dom
IPR011330 Glyco_hydro/deAcase_b/a-brl
IPR001137 Glyco_hydro_11
IPR002509 NODB_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03422 CBM_6, 1 hit
PF00404 Dockerin_1, 1 hit
PF00457 Glyco_hydro_11, 1 hit
PF01522 Polysacc_deac_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00911 GLHYDRLASE11

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00606 CBD_IV, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 1 hit
SSF49899 SSF49899, 1 hit
SSF63446 SSF63446, 1 hit
SSF88713 SSF88713, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51175 CBM6, 1 hit
PS00448 CLOS_CELLULOSOME_RPT, 1 hit
PS51766 DOCKERIN, 1 hit
PS00018 EF_HAND_1, 1 hit
PS00776 GH11_1, 1 hit
PS00777 GH11_2, 1 hit
PS51761 GH11_3, 1 hit
PS51677 NODB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O87119-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRQKLLITFL ILITFTVSLT LFPVNVRADV VITSNQTGTH GGYNFEYWKD
60 70 80 90 100
TGNGTMVLKD GGAFSCEWSN INNILFRKGF KYDETKTHDQ LGYITVTYSC
110 120 130 140 150
NYQPNGNSYL GVYGWTSNPL VEYYIIESWG TWRPPGATPK GTITVDGGTY
160 170 180 190 200
EIYETTRVNQ PSIKGTATFQ QYWSVRTSKR TSGTISVTEH FKAWERLGMK
210 220 230 240 250
MGKMYEVALV VEGYQSSGKA DVTSMTITVG NAPSTSSPPG PTPEPTPRSA
260 270 280 290 300
FSKIEAEEYN SLKSSTIQTI GTSDGGSGIG YIESGDYLVF NKINFGNGAN
310 320 330 340 350
SFKARVASGA DTPTNIQLRL GSPTGTLIGT LTVASTGGWN NYEEKSCSIT
360 370 380 390 400
NTTGQHDLYL VFSGPVNIDY FIFDSNGVNP TPTSQPQQGQ VLGDLNGDKQ
410 420 430 440 450
VNSTDYTALK RHLLNITRLS GTALANADLN GDGKVDSTDL MILHRYLLGI
460 470 480 490 500
ISSFPRSNPQ PSSNPQPSSN PQPTINPNAK LVALTFDDGP DNVLTARVLD
510 520 530 540 550
KLDKYNVKAT FMVVGQRVND STAAIIRRMV NSGHEIGNHS WSYSGMANMS
560 570 580 590 600
PDQIRKSIAD TNAVIQKYAG TTPKFFRPPN LETSPTLFNN VDLVFVGGLT
610 620 630 640 650
ANDWIPSTTA EQRAAAVING VRDGTIILLH DVQPEPHPTP EALDIIIPTL
660 670 680
KSRGYEFVTL TELFTLKGVP IDPSVKRMYN SVP
Length:683
Mass (Da):74,513
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC5F39D05C2145ABF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB010958 Genomic DNA Translation: BAA33543.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010958 Genomic DNA Translation: BAA33543.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C71X-ray1.05A477-683[»]
2C79X-ray1.50A477-683[»]
SMRiO87119
ModBaseiSearch...
PDBe-KBiSearch...

Protein family/group databases

CAZyiCBM6 Carbohydrate-Binding Module Family 6
GH11 Glycoside Hydrolase Family 11
mycoCLAPiXYN11A_CLOTH

Phylogenomic databases

eggNOGiENOG4107T94 Bacteria
COG0726 LUCA
COG5498 LUCA

Enzyme and pathway databases

UniPathwayiUPA00114

Miscellaneous databases

EvolutionaryTraceiO87119

Family and domain databases

Gene3Di1.10.1330.10, 1 hit
2.60.120.180, 1 hit
2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR006584 Cellulose-bd_IV
IPR005084 CMB_fam6
IPR013320 ConA-like_dom_sf
IPR002105 Dockerin_1_rpt
IPR016134 Dockerin_dom
IPR036439 Dockerin_dom_sf
IPR018247 EF_Hand_1_Ca_BS
IPR008979 Galactose-bd-like_sf
IPR013319 GH11/12
IPR018208 GH11_AS_1
IPR033119 GH11_AS_2
IPR033123 GH11_dom
IPR011330 Glyco_hydro/deAcase_b/a-brl
IPR001137 Glyco_hydro_11
IPR002509 NODB_dom
PfamiView protein in Pfam
PF03422 CBM_6, 1 hit
PF00404 Dockerin_1, 1 hit
PF00457 Glyco_hydro_11, 1 hit
PF01522 Polysacc_deac_1, 1 hit
PRINTSiPR00911 GLHYDRLASE11
SMARTiView protein in SMART
SM00606 CBD_IV, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF49899 SSF49899, 1 hit
SSF63446 SSF63446, 1 hit
SSF88713 SSF88713, 1 hit
PROSITEiView protein in PROSITE
PS51175 CBM6, 1 hit
PS00448 CLOS_CELLULOSOME_RPT, 1 hit
PS51766 DOCKERIN, 1 hit
PS00018 EF_HAND_1, 1 hit
PS00776 GH11_1, 1 hit
PS00777 GH11_2, 1 hit
PS51761 GH11_3, 1 hit
PS51677 NODB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO87119_HUNTH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O87119
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: October 16, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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