Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei603ATPUniRule annotation1

GO - Molecular functioni

  • aminoacyl-tRNA editing activity Source: InterPro
  • ATP binding Source: UniProtKB-UniRule
  • leucine-tRNA ligase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-221-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CT_209
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520001 – 819Leucine--tRNA ligaseAdd BLAST819

Structurei

3D structure databases

ProteinModelPortaliO84211
SMRiO84211
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi600 – 604"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
InParanoidiO84211
KOiK01869
OMAiALSMFPY

Family and domain databases

Gene3Di3.40.50.620, 1 hit
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

O84211-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRYDPGLIEE KWQKFWENEQ VFKAEEDETK TKYYVLDMFP YPSGAGLHVG
60 70 80 90 100
HLIGYTATDI VARYKRAQGF SVLHPMGWDS FGLPAEQYAI RTGTHPRETT
110 120 130 140 150
EKNIANFKKQ LTAMGFSYDE SREFATSDPE YYKWTQKLFL ILYEKGLAYM
160 170 180 190 200
ADMAVNYCPE LGTVLSNEEI ENGFSVDGGY PVERRMLRQW VLRITAFADQ
210 220 230 240 250
LLEGLDELDW PESVKQLQKN WIGKSSGASV NFATEHGVIE VFTTRPDTLI
260 270 280 290 300
GVSFLALAPE HPLVDLLTSD EQKAVVAQYI KETQSKSERD RISEMKTKSG
310 320 330 340 350
VFTGSYAKHP VTHKLIPIWI ADYVLIGFGS GAVMGVPAHD ERDLLFAEQF
360 370 380 390 400
NLPVVSVLNK EGVCINSCCE GFHLDGLSGE EAKQYVINFL EENHLGAAKI
410 420 430 440 450
AYKLRDWLFS RQRYWGEPIP IIHFEDGSCR PLRDYELPLL PPEIQDYRPE
460 470 480 490 500
GVGQGPLAKV REWVQVFDTE TQRAGKRETH TMPQWAGSCW YYLRFCDAHN
510 520 530 540 550
SAAPWAKEKE QYWMPVDLYI GGAEHAVLHL LYARFWHQVF YEAGIVSTPE
560 570 580 590 600
PFKKLVNQGL VLATSYRIPG KGYIYPEIAK EENGKWVAPS GEELDVRQEK
610 620 630 640 650
MSKSKLNGVD PQILIDEFGA DAVRMYAMFS GPLDKNKLWS NQGVAGCRRF
660 670 680 690 700
LNRFYEMVSS DRVKEDNNFE GLSLAHKLVQ RVTDAIEKLS LNTIPSSFME
710 720 730 740 750
FINDFVKLAV YPKSAVEMAV RALAPIAPHI SEELWVLLGN SPGVQKSGWP
760 770 780 790 800
SVLPEYLEGQ TVTIVVQVNG KLRARLDIMK DASKEEVLAL ARESASKYLE
810
GCEVKKAIFV PARLVNFVV
Length:819
Mass (Da):92,903
Last modified:November 1, 1998 - v1
Checksum:i82412A659AFAFECF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC67801.1
PIRiC71544
RefSeqiNP_219713.1, NC_000117.1
WP_010725124.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC67801; AAC67801; CT_209
GeneIDi884917
KEGGictr:CT_209
PATRICifig|272561.5.peg.224

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC67801.1
PIRiC71544
RefSeqiNP_219713.1, NC_000117.1
WP_010725124.1, NC_000117.1

3D structure databases

ProteinModelPortaliO84211
SMRiO84211
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67801; AAC67801; CT_209
GeneIDi884917
KEGGictr:CT_209
PATRICifig|272561.5.peg.224

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
InParanoidiO84211
KOiK01869
OMAiALSMFPY

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-221-MONOMER

Family and domain databases

Gene3Di3.40.50.620, 1 hit
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYL_CHLTR
AccessioniPrimary (citable) accession number: O84211
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again