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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei637ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:TP_0586
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521091 – 878Leucine--tRNA ligaseAdd BLAST878

Proteomic databases

PRIDEiO83595

Interactioni

Protein-protein interaction databases

IntActiO83595, 24 interactors
STRINGi243276.TP0586

Structurei

3D structure databases

ProteinModelPortaliO83595
SMRiO83595
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 54"HIGH" regionAdd BLAST12
Motifi634 – 638"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

O83595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYPFRALEK KWQAYWRDKR VFCVSEDERF PPERRAYVLD MFPYPSAQGL
60 70 80 90 100
HVGHPEGYTA TDIYCRYLRM GGYNVLHPMG FDAFGLPAEN FALKTGTHPR
110 120 130 140 150
VSTSANCDTF RRQIQSFGFS YDWEREISTA DPEYYRWTQW LFLKLYEKGL
160 170 180 190 200
AYEATAPINW CPSCKTGLAN EEVRDACCER CGAEVTRRGV RQWMVRITAY
210 220 230 240 250
AERLLSDLDE LDWPESVKQM QRNWIGKSCG AEIDFPVDAP ACSVHDKLPQ
260 270 280 290 300
TIRVYTTRAD TLFGVTYLVL APEHEAVTAL TTHAQRAAVQ AYVQRAAKKN
310 320 330 340 350
DLERTDLAKE KTGVFTGAYV RNPINDMRIP VWVGDYVLVS YGTGAVMAVP
360 370 380 390 400
AHDQRDWDFA TRFGLPKLTV VSADYTATVP NSNSPQGAVL QRCVSDEGFV
410 420 430 440 450
VNSGAFNGLA SADARERIVA HLEMRGAGAR RVTYRLRDWV FSRQRYWGEP
460 470 480 490 500
IPLVHCPSCG VVPLPESALP LLLPETADFT PTEDGQGPLA RARTWLRVPC
510 520 530 540 550
PQCASDAVRE TNTMPQWAGS CWYYLRYMDP RNKTAFCAPE KERYWAPVAL
560 570 580 590 600
YVGGAEHAVL HLLYARFWHK VLYDLGLVST KEPFARLVNQ GMITSYAYRR
610 620 630 640 650
KNGALVPHDE VHTNAQGTYV HARTGEKLEC VVAKMSKALK NVVNPDDMIA
660 670 680 690 700
AYGADACRVY EMFMGPLEAS KPWNTQGLVG VFRFLEKIWV LAGRVAAANG
710 720 730 740 750
IPQDSRAEPP GDLHAQKKSC SMYALETLLH RTIQKVTDDT SALSFNTAIS
760 770 780 790 800
QMMIFVNEAT RVARRMPLPS KMWEMFVKIL SPYAPHLAEE LWEMCGHTHT
810 820 830 840 850
IAYEPWPQVD PARVAPHVCS VVVQVNGKVR DTFSVAPNAP NEELEQKARE
860 870
TAGARKFLGT QQPKRVVIVP NKLVNFVL
Length:878
Mass (Da):98,991
Last modified:November 1, 1998 - v1
Checksum:iDCD74E2DC3652B74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA Translation: AAC65562.1
PIRiC71305
RefSeqiWP_010882032.1, NC_021490.2

Genome annotation databases

EnsemblBacteriaiAAC65562; AAC65562; TP_0586
GeneIDi34331990
KEGGitpa:TP_0586

Similar proteinsi

Entry informationi

Entry nameiSYL_TREPA
AccessioniPrimary (citable) accession number: O83595
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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