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Entry version 137 (02 Dec 2020)
Sequence version 1 (01 Nov 1998)
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Protein
Submitted name:

Class I SAM-dependent methyltransferase

Gene

E3149_28195

Organism
Escherichia coli O157:H7
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferaseImported, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Class I SAM-dependent methyltransferaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:E3149_28195Imported, E3150_28865Imported, E3151_28365Imported, E3152_27885Imported, E3153_28185Imported, E3154_27315Imported, E3159_29305Imported, E3160_27870Imported, E3161_28980Imported, E3162_28605Imported, E3163_28485Imported, E3164_28475Imported, E3165_28400Imported, E3166_27920Imported, E3167_27905Imported, E3168_29285Imported, E3169_28250Imported, E3170_28435Imported, E3172_28230Imported, E3173_28040Imported, E4T53_28470Imported, E4U08_29030Imported, E4U62_27690Imported, E4U63_27545Imported, E4U64_28685Imported, E4U65_28365Imported, E4U66_29625Imported, E4U67_28085Imported, E4U68_28940Imported, E4U69_28930Imported, E4U70_28325Imported, E4U72_28650Imported, E4U73_29885Imported, E4U74_29365Imported, E4U76_28685Imported, E4U78_28845Imported, E4U79_28880Imported, E4U80_28580Imported, E4U81_28250Imported, E4U84_29450Imported, E4U86_28455Imported, E4U87_29150Imported, E4U89_28765Imported, E4U90_28685Imported, EVY27_23055Imported, FCV42_28530Imported, FDZ86_28470Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid p17B6-1Imported
Plasmid p2571-1Imported
Plasmid p493-89-1Imported
Plasmid p611-1Imported
Plasmid p7409-1Imported
Plasmid p7636-1Imported
Plasmid p86-24-1Imported
Plasmid pATCC35150-1Imported
Plasmid pBB24-1Imported
Plasmid pDEC4E-1Imported
Plasmid pE32511-1Imported
Plasmid pEX262-1Imported
Plasmid pF1273-1Imported
Plasmid pF3113-1Imported
Plasmid pF6294-1Imported
Plasmid pF6321-1Imported
Plasmid pF6667-1Imported
Plasmid pF7349-1Imported
Plasmid pF7386-1Imported
Plasmid pF7508-1Imported
Plasmid pF8492-1Imported
Plasmid pF8797-1Imported
Plasmid pF8798-1Imported
Plasmid pF8952-1Imported
Plasmid pGM11-1Imported
Plasmid pGM351-1Imported
Plasmid pH2495-1Imported
Plasmid pH6437-1Imported
Plasmid pKS470-1Imported
Plasmid pLSU61-1Imported
Plasmid pMB41_1Imported
Plasmid pMB9_1Imported
Plasmid pN8B7-1Imported
Plasmid pNE1040-1Imported
Plasmid pNE1092-1Imported
Plasmid pNE1127-1Imported
Plasmid pNE1169-1Imported
Plasmid pNE122-1Imported
Plasmid pNE92-1Imported
Plasmid pO157Imported
Plasmid pOK1-1Imported
Plasmid pTB21-1Imported
Plasmid pTX265-1Imported
Plasmid pTX313-1Imported
Plasmid pTX376-1Imported
Plasmid pTX754-1Imported
Plasmid pYB14-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli O157:H7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83334 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000558 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Plasmid pO157

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
155864.EDL933_p0081

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 150MTSInterPro annotationAdd BLAST101

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0827, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_072995_1_0_6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002052, DNA_methylase_N6_adenine_CS
IPR029063, SAM-dependent_MTases
IPR007848, Small_mtfrase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05175, MTS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00092, N6_MTASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O82906-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHSQLKERIR LMRARLDNAA PVAEIRAESQ LFVTPAPVCD RLVTLAEISN
60 70 80 90 100
RDHILEPSAG TGAILRAIRD TAPEAMCDAV EINSGLVRYL RENFNGVRVQ
110 120 130 140 150
CGDFMEWQPV QYYSRVIINP PFSHGQDIRH ILRAFSLLRP GGVLVAVCLN
160 170 180
GPRQQEKLLP FSDVREELPR GTFAYTDVPT MIIRLRA
Length:187
Mass (Da):21,090
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94ACAA1428547F39
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB011549 Genomic DNA Translation: BAA31804.1
SEKQ01000028 Genomic DNA Translation: NEV33345.1
CP038283 Genomic DNA Translation: QJZ37930.1
CP038286 Genomic DNA Translation: QJZ43336.1
CP038289 Genomic DNA Translation: QJZ48707.1
CP038291 Genomic DNA Translation: QJZ54171.1
CP038293 Genomic DNA Translation: QJZ59511.1
CP038301 Genomic DNA Translation: QJZ69930.1
CP038304 Genomic DNA Translation: QJZ75481.1
CP038308 Genomic DNA Translation: QJZ80901.1
CP038312 Genomic DNA Translation: QJZ86419.1
CP038314 Genomic DNA Translation: QJZ91703.1
CP038318 Genomic DNA Translation: QJZ96944.1
CP038320 Genomic DNA Translation: QKA02173.1
CP038323 Genomic DNA Translation: QKA07681.1
CP038327 Genomic DNA Translation: QKA13193.1
CP038332 Genomic DNA Translation: QKA18777.1
CP038335 Genomic DNA Translation: QKA24206.1
CP038338 Genomic DNA Translation: QKA29550.1
CP038341 Genomic DNA Translation: QKA34939.1
CP038343 Genomic DNA Translation: QKA40303.1
CP038345 Genomic DNA Translation: QKA45449.1
CP038350 Genomic DNA Translation: QKA56169.1
CP038352 Genomic DNA Translation: QKA61592.1
CP038354 Genomic DNA Translation: QKA66903.1
CP038359 Genomic DNA Translation: QKA77666.1
CP038362 Genomic DNA Translation: QKA82946.1
CP038364 Genomic DNA Translation: QKA88283.1
CP038368 Genomic DNA Translation: QKA93667.1
CP038371 Genomic DNA Translation: QKA99041.1
CP038373 Genomic DNA Translation: QKB04507.1
CP038375 Genomic DNA Translation: QKB09688.1
CP038379 Genomic DNA Translation: QKB15189.1
CP038382 Genomic DNA Translation: QKB20537.1
CP038401 Genomic DNA Translation: QKB46041.1
CP038404 Genomic DNA Translation: QKB51509.1
CP038406 Genomic DNA Translation: QKB56819.1
CP038410 Genomic DNA Translation: QKB62126.1
CP038413 Genomic DNA Translation: QKB67465.1
CP038415 Genomic DNA Translation: QKB72831.1
CP038418 Genomic DNA Translation: QKB78217.1
CP038420 Genomic DNA Translation: QKB83618.1
CP038422 Genomic DNA Translation: QKB88890.1
CP038424 Genomic DNA Translation: QKB94227.1
CP038426 Genomic DNA Translation: QKB99655.1
CP038429 Genomic DNA Translation: QKC04979.1
CP039835 Genomic DNA Translation: QKQ83337.1
CP040108 Genomic DNA Translation: QKQ88662.1

NCBI Reference Sequences

More...
RefSeqi
NP_052654.1, NC_002128.1
WP_001302171.1, NZ_SWKA01000002.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC70150; AAC70150; Z_L7082
BAA31804; BAA31804; BAA31804

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1789684

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecs:pO157p47

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|386585.9.peg.54

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011549 Genomic DNA Translation: BAA31804.1
SEKQ01000028 Genomic DNA Translation: NEV33345.1
CP038283 Genomic DNA Translation: QJZ37930.1
CP038286 Genomic DNA Translation: QJZ43336.1
CP038289 Genomic DNA Translation: QJZ48707.1
CP038291 Genomic DNA Translation: QJZ54171.1
CP038293 Genomic DNA Translation: QJZ59511.1
CP038301 Genomic DNA Translation: QJZ69930.1
CP038304 Genomic DNA Translation: QJZ75481.1
CP038308 Genomic DNA Translation: QJZ80901.1
CP038312 Genomic DNA Translation: QJZ86419.1
CP038314 Genomic DNA Translation: QJZ91703.1
CP038318 Genomic DNA Translation: QJZ96944.1
CP038320 Genomic DNA Translation: QKA02173.1
CP038323 Genomic DNA Translation: QKA07681.1
CP038327 Genomic DNA Translation: QKA13193.1
CP038332 Genomic DNA Translation: QKA18777.1
CP038335 Genomic DNA Translation: QKA24206.1
CP038338 Genomic DNA Translation: QKA29550.1
CP038341 Genomic DNA Translation: QKA34939.1
CP038343 Genomic DNA Translation: QKA40303.1
CP038345 Genomic DNA Translation: QKA45449.1
CP038350 Genomic DNA Translation: QKA56169.1
CP038352 Genomic DNA Translation: QKA61592.1
CP038354 Genomic DNA Translation: QKA66903.1
CP038359 Genomic DNA Translation: QKA77666.1
CP038362 Genomic DNA Translation: QKA82946.1
CP038364 Genomic DNA Translation: QKA88283.1
CP038368 Genomic DNA Translation: QKA93667.1
CP038371 Genomic DNA Translation: QKA99041.1
CP038373 Genomic DNA Translation: QKB04507.1
CP038375 Genomic DNA Translation: QKB09688.1
CP038379 Genomic DNA Translation: QKB15189.1
CP038382 Genomic DNA Translation: QKB20537.1
CP038401 Genomic DNA Translation: QKB46041.1
CP038404 Genomic DNA Translation: QKB51509.1
CP038406 Genomic DNA Translation: QKB56819.1
CP038410 Genomic DNA Translation: QKB62126.1
CP038413 Genomic DNA Translation: QKB67465.1
CP038415 Genomic DNA Translation: QKB72831.1
CP038418 Genomic DNA Translation: QKB78217.1
CP038420 Genomic DNA Translation: QKB83618.1
CP038422 Genomic DNA Translation: QKB88890.1
CP038424 Genomic DNA Translation: QKB94227.1
CP038426 Genomic DNA Translation: QKB99655.1
CP038429 Genomic DNA Translation: QKC04979.1
CP039835 Genomic DNA Translation: QKQ83337.1
CP040108 Genomic DNA Translation: QKQ88662.1
RefSeqiNP_052654.1, NC_002128.1
WP_001302171.1, NZ_SWKA01000002.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi155864.EDL933_p0081

Genome annotation databases

EnsemblBacteriaiAAC70150; AAC70150; Z_L7082
BAA31804; BAA31804; BAA31804
GeneIDi1789684
KEGGiecs:pO157p47
PATRICifig|386585.9.peg.54

Phylogenomic databases

eggNOGiCOG0827, Bacteria
HOGENOMiCLU_072995_1_0_6

Family and domain databases

InterProiView protein in InterPro
IPR002052, DNA_methylase_N6_adenine_CS
IPR029063, SAM-dependent_MTases
IPR007848, Small_mtfrase_dom
PfamiView protein in Pfam
PF05175, MTS, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS00092, N6_MTASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO82906_ECO57
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O82906
Secondary accession number(s): A0A0H3JF36, A0A6M0JQQ5, Q7BST3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: December 2, 2020
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

PlasmidImported, Reference proteomeImported
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