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Entry version 144 (02 Jun 2021)
Sequence version 2 (01 Jun 2002)
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Protein

Cell division control protein 6 homolog

Gene

CDC6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the initiation of DNA replication. May play a role in endoreduplication. Could act as one of the factors that contributes to maintain endoreduplication competence.

1 Publication

Miscellaneous

Cells expressing ectopically CDC6 have increased levels of endopolyploidy.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, DNA replication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell division control protein 6 homologCurated
Short name:
AtCDC61 Publication
Short name:
AtCDC6ACurated
Short name:
Cdc6At1 Publication
Short name:
Cell division control protein 6 homolog ACurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDC61 Publication
Ordered Locus Names:At2g29680Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G29680

The Arabidopsis Information Resource

More...
TAIRi
locus:2060659, AT2G29680

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004329831 – 539Cell division control protein 6 homologAdd BLAST539

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O82387

PRoteomics IDEntifications database

More...
PRIDEi
O82387

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
224386 [O82387-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O82387

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in roots, flower buds and etiolated seedlings. Expressed in leaves and stems (PubMed:11604464). Highly expressed in proliferating cells such as root meristems, leaf primordia and young growing leaves, as well as cells undergoing endoreduplication cycles (PubMed:11752380).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Cell cycle regulated. Up-regulated at the G1/S phase transition and then decreases rapidly as cells progress into S-phase (PubMed:11752380, PubMed:11669580). Degraded in a proteasome-dependent manner in proliferating cells, but not in endoreduplicating cells (PubMed:11752380).2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O82387, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O82387, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
O82387, 4 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT2G29680.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 40DisorderedSequence analysisAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi35 – 38Nuclear localization signalCurated4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CDC6/cdc18 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2227, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O82387

Identification of Orthologs from Complete Genome Data

More...
OMAi
TISIMAR

Database of Orthologous Groups

More...
OrthoDBi
935804at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O82387

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08768, Cdc6_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR041083, AAA_lid_10
IPR016314, Cdc6/18
IPR015163, Cdc6_C
IPR027417, P-loop_NTPase
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13401, AAA_22, 1 hit
PF17872, AAA_lid_10, 1 hit
PF09079, Cdc6_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001767, Cdc6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01074, Cdc6_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 1 hit
SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O82387-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPAIAGPSSS PQKHVVGSRS ESIGGVRSAE VNTSRKRKLI SDSAAEVSAT
60 70 80 90 100
VVLPVNSIST PMKWKSPRRC AVSIPKTSDE EIKEDSNEKL ENPVISVCLE
110 120 130 140 150
VKSKWNPKDD EQMKAVKEAL HVSKAPSTVV CREDEQRRVF EFVKGCMEQK
160 170 180 190 200
KAGSLYICGC PGTGKSLSME KVRLQAEEWA KQAGLHCPET VSVNCTSLTK
210 220 230 240 250
STDIFSKILG NYESGKKANG SFSPLQQLQR LFSQKQQQSR SKMMLIIADE
260 270 280 290 300
MDYLITRDRG VLHELFMLTT LPLSRCILIG TVFCVINVHF LKSVSYGQTS
310 320 330 340 350
FKFKVRICPP GVANAIDLAD RFLPKLKSLN CKPLVVTFRA YSKDQILRIL
360 370 380 390 400
QERLVALPFV AFQSNALEIC ARKVSAASGD MRKALCVCRS ALEILEIEVR
410 420 430 440 450
GSIDQEPKGP VPECQVVKMD HMIAALSKTF KSPIVDTIQS LPQHQQIIVC
460 470 480 490 500
SAAKAFRGSK KDRTIAELNK LYLEICKSSM ITPAGITEFS NMCTVLNDQG
510 520 530
ILKLSLARDD KLKRVSLRVD EADITFALKE IRFFRNCLL
Length:539
Mass (Da):59,841
Last modified:June 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D44B3BCEDC6E184
GO
Isoform 2 (identifier: O82387-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-310: Missing.

Show »
Length:508
Mass (Da):56,356
Checksum:i7981A6E8FC76BDFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti76K → N in AAK68875 (PubMed:11604464).Curated1
Sequence conflicti94V → E in AAK68875 (PubMed:11604464).Curated1
Sequence conflicti273L → F in AAK68875 (PubMed:11604464).Curated1
Sequence conflicti506L → H in AAK68875 (PubMed:11604464).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_057638280 – 310Missing in isoform 2. CuratedAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF275940 mRNA Translation: AAK68875.1
AJ271606 mRNA Translation: CAC81074.1
AJ293020 mRNA Translation: CAC59688.1
AC005496 Genomic DNA Translation: AAC35241.2
CP002685 Genomic DNA Translation: AEC08292.1
CP002685 Genomic DNA Translation: AEC08293.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C84699

NCBI Reference Sequences

More...
RefSeqi
NP_565686.1, NM_128522.1 [O82387-1]
NP_850137.1, NM_179806.2 [O82387-2]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G29680.1; AT2G29680.1; AT2G29680 [O82387-1]
AT2G29680.2; AT2G29680.2; AT2G29680 [O82387-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
817518

Gramene; a comparative resource for plants

More...
Gramenei
AT2G29680.1; AT2G29680.1; AT2G29680 [O82387-1]
AT2G29680.2; AT2G29680.2; AT2G29680 [O82387-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G29680

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275940 mRNA Translation: AAK68875.1
AJ271606 mRNA Translation: CAC81074.1
AJ293020 mRNA Translation: CAC59688.1
AC005496 Genomic DNA Translation: AAC35241.2
CP002685 Genomic DNA Translation: AEC08292.1
CP002685 Genomic DNA Translation: AEC08293.1
PIRiC84699
RefSeqiNP_565686.1, NM_128522.1 [O82387-1]
NP_850137.1, NM_179806.2 [O82387-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiO82387, 4 interactors
STRINGi3702.AT2G29680.1

PTM databases

iPTMnetiO82387

Proteomic databases

PaxDbiO82387
PRIDEiO82387
ProteomicsDBi224386 [O82387-1]

Genome annotation databases

EnsemblPlantsiAT2G29680.1; AT2G29680.1; AT2G29680 [O82387-1]
AT2G29680.2; AT2G29680.2; AT2G29680 [O82387-2]
GeneIDi817518
GrameneiAT2G29680.1; AT2G29680.1; AT2G29680 [O82387-1]
AT2G29680.2; AT2G29680.2; AT2G29680 [O82387-2]
KEGGiath:AT2G29680

Organism-specific databases

AraportiAT2G29680
TAIRilocus:2060659, AT2G29680

Phylogenomic databases

eggNOGiKOG2227, Eukaryota
InParanoidiO82387
OMAiTISIMAR
OrthoDBi935804at2759
PhylomeDBiO82387

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O82387

Gene expression databases

ExpressionAtlasiO82387, baseline and differential
GenevisibleiO82387, AT

Family and domain databases

CDDicd08768, Cdc6_C, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR041083, AAA_lid_10
IPR016314, Cdc6/18
IPR015163, Cdc6_C
IPR027417, P-loop_NTPase
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF13401, AAA_22, 1 hit
PF17872, AAA_lid_10, 1 hit
PF09079, Cdc6_C, 1 hit
PIRSFiPIRSF001767, Cdc6, 1 hit
SMARTiView protein in SMART
SM01074, Cdc6_C, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF52540, SSF52540, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDC6A_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O82387
Secondary accession number(s): Q94CM2, Q94G54
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2015
Last sequence update: June 1, 2002
Last modified: June 2, 2021
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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